| TENT2, TUT4, and TUT7 selectively regulate miRNA sequence and abundance. | TENT2, TUT4, and TUT7 selectively regulate miRNA sequence and abundance.
Yang A, Bofill-De Ros X, Stanton R, Shao TJ, Villanueva P, Gu S., Free PMC Article | 09/17/2022 |
| DDX6 is a positive regulator of Ataxin-2/PAPD4 cytoplasmic polyadenylation machinery. | DDX6 is a positive regulator of Ataxin-2/PAPD4 cytoplasmic polyadenylation machinery.
Inagaki H, Hosoda N, Hoshino SI. | 07/10/2021 |
| The RNA-binding protein QKI-7 recruits the poly(A) polymerase GLD-2 for 3' adenylation and selective stabilization of microRNA-122. | The RNA-binding protein QKI-7 recruits the poly(A) polymerase GLD-2 for 3' adenylation and selective stabilization of microRNA-122.
Hojo H, Yashiro Y, Noda Y, Ogami K, Yamagishi R, Okada S, Hoshino SI, Suzuki T., Free PMC Article | 09/19/2020 |
| The data demonstrate a novel phosphorylation-dependent mechanism to regulate Gld2 activity, revealing tumour suppressor miRNAs(miR-122) as a previously unknown target of Akt1-dependent signalling | Gld2 activity is regulated by phosphorylation in the N-terminal domain.
Chung CZ, Balasuriya N, Manni E, Liu X, Li SS, O'Donoghue P, Heinemann IU., Free PMC Article | 03/21/2020 |
| our results propose a novel feedback regulatory mechanism for controlling HCV RNA abundance by the viral capsid protein, which is capable of modulating miR-122 activity and stability through the inhibition of GLD-2. | Hepatitis C Virus Core Protein Promotes miR-122 Destabilization by Inhibiting GLD-2.
Kim GW, Lee SH, Cho H, Kim M, Shin EC, Oh JW., Free PMC Article | 06/10/2017 |
| QKI-7 recruits PAPD4 to regulate post-transcriptional polyadenylation of target mRNAs. | The STAR protein QKI-7 recruits PAPD4 to regulate post-transcriptional polyadenylation of target mRNAs.
Yamagishi R, Tsusaka T, Mitsunaga H, Maehata T, Hoshino S., Free PMC Article | 09/3/2016 |
| HBx is a critical protein derived from HBV, which regulates miR-122 via down-regulating Gld2 | HBx down-regulated Gld2 plays a critical role in HBV-related dysregulation of miR-122.
Peng F, Xiao X, Jiang Y, Luo K, Tian Y, Peng M, Zhang M, Xu Y, Gong G., Free PMC Article | 01/31/2015 |
| The noncanonical polymerase Gld2 has been implicated in the stabilization of miR-122, possibly through catalyzing 3' monoadenylation | Specific miRNA stabilization by Gld2-catalyzed monoadenylation.
D'Ambrogio A, Gu W, Udagawa T, Mello CC, Richter JD., Free PMC Article | 06/8/2013 |
| Study identified TUT7, TUT4, and TUT2 as novel components of the miRNA biogenesis pathway. | Mono-uridylation of pre-microRNA as a key step in the biogenesis of group II let-7 microRNAs.
Heo I, Ha M, Lim J, Yoon MJ, Park JE, Kwon SC, Chang H, Kim VN. | 01/12/2013 |
| poly(A) polymerase Gld2, deadenylase PARN, and translation inhibitory factor neuroguidin (Ngd) are components of a dendritic CPEB-associated polyadenylation apparatus | Bidirectional control of mRNA translation and synaptic plasticity by the cytoplasmic polyadenylation complex.
Udagawa T, Swanger SA, Takeuchi K, Kim JH, Nalavadi V, Shin J, Lorenz LJ, Zukin RS, Bassell GJ, Richter JD., Free PMC Article | 10/13/2012 |
| human CPE-binding protein 1 and hGLD-2 are antagonizing factors regulating p53 mRNA stability. | Involvement of hGLD-2 in cytoplasmic polyadenylation of human p53 mRNA.
Glahder JA, Norrild B. | 12/3/2011 |
| The authors show that the human CPEB1 can repress the activity of the reporter construct containing the HPV-16 early sequences. This repression can be counteracted by a human cytoplasmic poly(A) polymerase, hGLD-2 fused to CPEB1. | The early noncoding region of human papillomavirus type 16 is regulated by cytoplasmic polyadenylation factors.
Glahder JA, Kristiansen K, Durand M, Vinther J, Norrild B. | 06/28/2010 |