| Lymphocyte-Activation Gene 3 Facilitates Pathological Tau Neuron-to-Neuron Transmission. | Lymphocyte-Activation Gene 3 Facilitates Pathological Tau Neuron-to-Neuron Transmission.
Chen C, Kumbhar R, Wang H, Yang X, Gadhave K, Rastegar C, Kimura Y, Behensky A, Kotha S, Kuo G, Katakam S, Jeong D, Wang L, Wang A, Chen R, Zhang S, Jin L, Workman CJ, Vignali DAA, Pletinkova O, Jia H, Peng W, Nauen DW, Wong PC, Redding-Ochoa J, Troncoso JC, Ying M, Dawson VL, Dawson TM, Mao X., Free PMC Article | 05/3/2024 |
| [Effect of LAG3 deficiency on natural killer cell function and hepatic fibrosis in mice infected with Echinococcus multilocularis]. | [Effect of LAG3 deficiency on natural killer cell function and hepatic fibrosis in mice infected with Echinococcus multilocularis].
Zibigu R, Abidan A, Adilai D, Li Y, Kang X, Yu Q, Deng B, Zheng X, Wang M, Li J, Wang H, Zhang C. | 04/30/2024 |
| Structural insights reveal interplay between LAG-3 homodimerization, ligand binding, and function. | Structural insights reveal interplay between LAG-3 homodimerization, ligand binding, and function.
Silberstein JL, Du J, Chan KW, Frank JA, Mathews II, Kim YB, You J, Lu Q, Liu J, Philips EA, Liu P, Rao E, Fernandez D, Rodriguez GE, Kong XP, Wang J, Cochran JR., Free PMC Article | 03/19/2024 |
| Cerebral Microvascular Injury Induced by Lag3-Dependent alpha-Synuclein Fibril Endocytosis Exacerbates Cognitive Impairment in a Mouse Model of alpha-Synucleinopathies. | Cerebral Microvascular Injury Induced by Lag3-Dependent α-Synuclein Fibril Endocytosis Exacerbates Cognitive Impairment in a Mouse Model of α-Synucleinopathies.
Zhang Q, Duan Q, Gao Y, He P, Huang R, Huang H, Li Y, Ma G, Zhang Y, Nie K, Wang L., Free PMC Article | 09/7/2023 |
| [LAG3 intracytoplasmic acidic environment locally disrupts the association of the Lck kinase to CD4 and CD8, two co-receptors of the TCR]. | [LAG3 intracytoplasmic acidic environment locally disrupts the association of the Lck kinase to CD4 and CD8, two co-receptors of the TCR].
Hivroz C. | 02/4/2023 |
| LAG3 ectodomain structure reveals functional interfaces for ligand and antibody recognition. | LAG3 ectodomain structure reveals functional interfaces for ligand and antibody recognition.
Ming Q, Celias DP, Wu C, Cole AR, Singh S, Mason C, Dong S, Tran TH, Amarasinghe GK, Ruffell B, Luca VC., Free PMC Article | 07/23/2022 |
| Binding of LAG-3 to stable peptide-MHC class II limits T cell function and suppresses autoimmunity and anti-cancer immunity. | Binding of LAG-3 to stable peptide-MHC class II limits T cell function and suppresses autoimmunity and anti-cancer immunity.
Maruhashi T, Sugiura D, Okazaki IM, Shimizu K, Maeda TK, Ikubo J, Yoshikawa H, Maenaka K, Ishimaru N, Kosako H, Takemoto T, Okazaki T. | 05/21/2022 |
| T cells expressing multiple co-inhibitory molecules in acute malaria are not exhausted but exert a suppressive function in mice. | T cells expressing multiple co-inhibitory molecules in acute malaria are not exhausted but exert a suppressive function in mice.
Brandi J, Lehmann C, Kaminski LC, Schulze Zur Wiesch J, Addo M, Ramharter M, Mackroth M, Jacobs T, Riehn M. | 02/12/2022 |
| Mechanistic basis for receptor-mediated pathological alpha-synuclein fibril cell-to-cell transmission in Parkinson's disease. | Mechanistic basis for receptor-mediated pathological α-synuclein fibril cell-to-cell transmission in Parkinson's disease.
Zhang S, Liu YQ, Jia C, Lim YJ, Feng G, Xu E, Long H, Kimura Y, Tao Y, Zhao C, Wang C, Liu Z, Hu JJ, Ma MR, Liu Z, Jiang L, Li D, Wang R, Dawson VL, Dawson TM, Li YM, Mao X, Liu C., Free PMC Article | 12/4/2021 |
| Lymphocyte Activation Gene-3 Regulates Dendritic Cell Metabolic Programing and T Cell Priming Function. | Lymphocyte Activation Gene-3 Regulates Dendritic Cell Metabolic Programing and T Cell Priming Function.
Garcia Cruz D, Giri RR, Gamiotea Turro D, Balsbaugh JL, Adler AJ, Rodriguez A., Free PMC Article | 11/13/2021 |
| LAG3 is not expressed in human and murine neurons and does not modulate alpha-synucleinopathies. | LAG3 is not expressed in human and murine neurons and does not modulate α-synucleinopathies.
Emmenegger M, De Cecco E, Hruska-Plochan M, Eninger T, Schneider MM, Barth M, Tantardini E, de Rossi P, Bacioglu M, Langston RG, Kaganovich A, Bengoa-Vergniory N, Gonzalez-Guerra A, Avar M, Heinzer D, Reimann R, Häsler LM, Herling TW, Matharu NS, Landeck N, Luk K, Melki R, Kahle PJ, Hornemann S, Knowles TPJ, Cookson MR, Polymenidou M, Jucker M, Aguzzi A., Free PMC Article | 10/30/2021 |
| Small Molecule Inhibition of GSK-3 Specifically Inhibits the Transcription of Inhibitory Co-receptor LAG-3 for Enhanced Anti-tumor Immunity. | Small Molecule Inhibition of GSK-3 Specifically Inhibits the Transcription of Inhibitory Co-receptor LAG-3 for Enhanced Anti-tumor Immunity.
Rudd CE, Chanthong K, Taylor A. | 03/13/2021 |
| LAG-3 deficiency enhances the metabolic profile of naive CD4(+) T cells by elevating levels of mitochondrial biogenesis. | Lymphocyte Activation Gene-3 Maintains Mitochondrial and Metabolic Quiescence in Naive CD4(+) T Cells.
Previte DM, Martins CP, O'Connor EC, Marre ML, Coudriet GM, Beck NW, Menk AV, Wright RH, Tse HM, Delgoffe GM, Piganelli JD. | 06/6/2020 |
| Analogous studies in a murine syngeneic tumor model using surrogate antibodies demonstrated significant synergy between LAG-3 and PD-1 blockade-combination treatment led to a marked improvement in therapeutic efficacy, increased T-cell proliferation, IFNgamma production, and elicited durable immunologic memory upon tumor rechallenge. | TSR-033, a Novel Therapeutic Antibody Targeting LAG-3, Enhances T-Cell Function and the Activity of PD-1 Blockade In Vitro and In Vivo.
Ghosh S, Sharma G, Travers J, Kumar S, Choi J, Jun HT, Kehry M, Ramaswamy S, Jenkins D. | 03/14/2020 |
| Lag3 contributes to Class II histocompatibility antigen recognition and trogocytosis, thereby modulating the antigen-specific immune regulation by CD4(-)CD8(-) double negative T-cells. | Double negative T cells mediate Lag3-dependent antigen-specific protection in allergic asthma.
Tian D, Yang L, Wang S, Zhu Y, Shi W, Zhang C, Jin H, Tian Y, Xu H, Sun G, Liu K, Zhang Z, Zhang D., Free PMC Article | 01/4/2020 |
| Lag3 expression is increased in a mouse scrapie but does not modify disease progression. | Lymphocyte activation gene 3 (Lag3) expression is increased in prion infections but does not modify disease progression.
Liu Y, Sorce S, Nuvolone M, Domange J, Aguzzi A., Free PMC Article | 11/2/2019 |
| LAG-3 transduces two independent inhibitory signals through an FXXL motif in the membrane-proximal region and the C-terminal EX repeat. These motifs have not been reported previously for inhibitory co-receptors, suggesting that LAG-3 inhibits T cell activation through a nonredundant inhibitory mechanisms along with the other inhibitory co-receptors. | Atypical motifs in the cytoplasmic region of the inhibitory immune co-receptor LAG-3 inhibit T cell activation.
Maeda TK, Sugiura D, Okazaki IM, Maruhashi T, Okazaki T., Free PMC Article | 10/19/2019 |
| Dual PD1/LAG3 immune checkpoint blockade limits tumor development in a murine model of chronic lymphocytic leukemia | Dual PD1/LAG3 immune checkpoint blockade limits tumor development in a murine model of chronic lymphocytic leukemia.
Wierz M, Pierson S, Guyonnet L, Viry E, Lequeux A, Oudin A, Niclou SP, Ollert M, Berchem G, Janji B, Guérin C, Paggetti J, Moussay E., Free PMC Article | 05/18/2019 |
| findings demonstrate that LAG-3 regulates the specificity of immune response by its structural conformation-dependent recognition of pMHCII | LAG-3 inhibits the activation of CD4(+) T cells that recognize stable pMHCII through its conformation-dependent recognition of pMHCII.
Maruhashi T, Okazaki IM, Sugiura D, Takahashi S, Maeda TK, Shimizu K, Okazaki T. | 04/27/2019 |
| A natural plasma cell subset expressing the inhibitory receptor LAG-3 is developed from various B cell subsets in a B cell receptor-dependent manner. After challenge they upregulate IL-10 expression via a Toll-like receptor-driven mechanism. This function is associated with a unique transcriptome and epigenome, including the lowest amount of DNA methylation at the Il10 locus compared to other B cell subsets. | LAG-3 Inhibitory Receptor Expression Identifies Immunosuppressive Natural Regulatory Plasma Cells.
Lino AC, Dang VD, Lampropoulou V, Welle A, Joedicke J, Pohar J, Simon Q, Thalmensi J, Baures A, Flühler V, Sakwa I, Stervbo U, Ries S, Jouneau L, Boudinot P, Tsubata T, Adachi T, Hutloff A, Dörner T, Zimber-Strobl U, de Vos AF, Dahlke K, Loh G, Korniotis S, Goosmann C, Weill JC, Reynaud CA, Kaufmann SHE, Walter J, Fillatreau S., Free PMC Article | 03/9/2019 |
| upregulated in the central nervous system by intraepithelial lymphocytes from the gut epithelium of myelin oligodendrocyte glycoprotein(35-55)-specific T-cell receptor transgenic mice | Gut environment-induced intraepithelial autoreactive CD4(+) T cells suppress central nervous system autoimmunity via LAG-3.
Kadowaki A, Miyake S, Saga R, Chiba A, Mochizuki H, Yamamura T., Free PMC Article | 09/22/2018 |
| thi study shows that LAG-3 directly modulates the size of the T cell response and support the use of LAG-3 blockade regimens to enhance CD8+ T cell responses | LAG-3 Confers a Competitive Disadvantage upon Antiviral CD8+ T Cell Responses.
Cook KD, Whitmire JK., Free PMC Article | 08/12/2017 |
| Study suggests that expression of the inhibitory receptors PD-1 and LAG-3 on CD4(+) T cells and their reduced IL-2 production are common characteristic features of Plasmodium infection. | Expression of PD-1/LAG-3 and cytokine production by CD4(+) T cells during infection with Plasmodium parasites.
Doe HT, Kimura D, Miyakoda M, Kimura K, Akbari M, Yui K. | 11/12/2016 |
| An IL-27/Lag3 axis enhances Foxp3+ regulatory T cell-suppressive function and therapeutic efficacy. | An IL-27/Lag3 axis enhances Foxp3+ regulatory T cell-suppressive function and therapeutic efficacy.
Do JS, Visperas A, Sanogo YO, Bechtel JJ, Dvorina N, Kim S, Jang E, Stohlman SA, Shen B, Fairchild RL, Baldwin WM III, Vignali DA, Min B., Free PMC Article | 10/1/2016 |
| LAG3 and PD1 co-inhibitory molecules have roles in collaborating to limit CD8+ T cell signaling and dampen antitumor immunity in a murine ovarian cancer model | LAG3 and PD1 co-inhibitory molecules collaborate to limit CD8+ T cell signaling and dampen antitumor immunity in a murine ovarian cancer model.
Huang RY, Eppolito C, Lele S, Shrikant P, Matsuzaki J, Odunsi K., Free PMC Article | 08/27/2016 |