| Differentiation of mouse embryonic stem cells into cells with spermatogonia-like morphology with chemical intervention-dependent increased gene expression of LIM homeobox 1 (Lhx1). | Differentiation of mouse embryonic stem cells into cells with spermatogonia-like morphology with chemical intervention-dependent increased gene expression of LIM homeobox 1 (Lhx1).
Moshfegh C, Rambow SG, Domenig SA, Pieńkowska-Schelling A, Bleul U, Vogel V. | 05/7/2022 |
| Neuronal Lhx1 expression is regulated by DNMT1-dependent modulation of histone marks. | Neuronal Lhx1 expression is regulated by DNMT1-dependent modulation of histone marks.
Symmank J, Bayer C, Reichard J, Pensold D, Zimmer-Bensch G., Free PMC Article | 06/19/2021 |
| Study shows the Transcription Factor LHX1 Regulates the Survival and Directed Migration of POA-derived Cortical Interneurons. | The Transcription Factor LHX1 Regulates the Survival and Directed Migration of POA-derived Cortical Interneurons.
Symmank J, Gölling V, Gerstmann K, Zimmer G. | 05/23/2020 |
| data are the first to reveal that the Lhx1 transcription factor contributes to normal glucose homeostasis and Glp1 responses. | The islet-expressed Lhx1 transcription factor interacts with Islet-1 and contributes to glucose homeostasis.
Bethea M, Liu Y, Wade AK, Mullen R, Gupta R, Gelfanov V, DiMarchi R, Bhatnagar S, Behringer R, Habegger KM, Hunter CS., Free PMC Article | 12/21/2019 |
| Findings suggest that Lhx1/5, through regulating Espin protein expression, control dendritogenesis and spine morphogenesis in postnatal Purkinje cells (PCs). | Lhx1/5 control dendritogenesis and spine morphogenesis of Purkinje cells via regulation of Espin.
Lui NC, Tam WY, Gao C, Huang JD, Wang CC, Jiang L, Yung WH, Kwan KM., Free PMC Article | 12/1/2018 |
| Loss of LHX1 is associated with loss of acute light control of sleep. | An LHX1-Regulated Transcriptional Network Controls Sleep/Wake Coupling and Thermal Resistance of the Central Circadian Clockworks.
Bedont JL, LeGates TA, Buhr E, Bathini A, Ling JP, Bell B, Wu MN, Wong PC, Van Gelder RN, Mongrain V, Hattar S, Blackshaw S., Free PMC Article | 07/21/2018 |
| Smad4/Eomes-dependent Lhx1 expression in the epiblast marks the entire definitive endoderm lineage, the anterior mesendoderm, and midline progenitors. | Lhx1 functions together with Otx2, Foxa2, and Ldb1 to govern anterior mesendoderm, node, and midline development.
Costello I, Nowotschin S, Sun X, Mould AW, Hadjantonakis AK, Bikoff EK, Robertson EJ., Free PMC Article | 01/30/2016 |
| LHX1 is required in the anterior mesendoderm, but not in the mesoderm, for formation of the head. | Context-specific function of the LIM homeobox 1 transcription factor in head formation of the mouse embryo.
Fossat N, Ip CK, Jones VJ, Studdert JB, Khoo PL, Lewis SL, Power M, Tourle K, Loebel DA, Kwan KM, Behringer RR, Tam PP. | 08/15/2015 |
| Lhx1 maintains synchrony among circadian oscillator neurons of the suprachiasmatic nucleus. | Lhx1 maintains synchrony among circadian oscillator neurons of the SCN.
Hatori M, Gill S, Mure LS, Goulding M, O'Leary DD, Panda S., Free PMC Article | 05/16/2015 |
| Lhx1 is necessary for SCN terminal differentiation, including expression of neuropeptides profoundly important for circadian function. | Lhx1 controls terminal differentiation and circadian function of the suprachiasmatic nucleus.
Bedont JL, LeGates TA, Slat EA, Byerly MS, Wang H, Hu J, Rupp AC, Qian J, Wong GW, Herzog ED, Hattar S, Blackshaw S., Free PMC Article | 01/10/2015 |
| OTX2 has a role in regulating Dkk1 and Lhx1 activity in the anterior mesendoderm | Head formation: OTX2 regulates Dkk1 and Lhx1 activity in the anterior mesendoderm.
Ip CK, Fossat N, Jones V, Lamonerie T, Tam PP. | 12/20/2014 |
| These studies identify LHX1 as the first transcription factor that is essential in the Mullerian duct epithelial progenitor cells for female reproductive tract development. | Lhx1 is required in Müllerian duct epithelium for uterine development.
Huang CC, Orvis GD, Kwan KM, Behringer RR., Free PMC Article | 06/7/2014 |
| a core regulatory subcircuit composed of Pax2/8, Gata3 and Lim1 turns on a deeper layer of transcriptional regulators while activating effector genes responsible for cell signaling and tissue organization. | A core transcriptional network composed of Pax2/8, Gata3 and Lim1 regulates key players of pro/mesonephros morphogenesis.
Boualia SK, Gaitan Y, Tremblay M, Sharma R, Cardin J, Kania A, Bouchard M. | 12/14/2013 |
| Lim1/LIM1 expression in neonatal, adult mouse and human endometrium suggesting Lim1/LIM1 may have a role in endometrial development and remodelling | Lim1/LIM1 is expressed in developing and adult mouse and human endometrium.
Ye L, Evans J, Gargett CE. | 10/6/2012 |
| Lhx1 therefore may influence the localization of primordial germ cells by modulating Ifitm1-mediated repulsive activity. | Loss of Lhx1 activity impacts on the localization of primordial germ cells in the mouse.
Tanaka SS, Yamaguchi YL, Steiner KA, Nakano T, Nishinakamura R, Kwan KM, Behringer RR, Tam PP. | 02/5/2011 |
| The response of LMC motor neurons to Reelin is gated by Foxp1- and Lhx1-mediated regulation of expression of the critical Reelin signalling intermediate Dab1. | Foxp1 and lhx1 coordinate motor neuron migration with axon trajectory choice by gating Reelin signalling.
Palmesino E, Rousso DL, Kao TJ, Klar A, Laufer E, Uemura O, Okamoto H, Novitch BG, Kania A., Free PMC Article | 01/1/2011 |
| Data show that Lhx1 is regionally enriched in the Cerebellum, Purkinje Cell Layer of mouse brain. | Identification of a set of genes showing regionally enriched expression in the mouse brain.
D'Souza CA, Chopra V, Varhol R, Xie YY, Bohacec S, Zhao Y, Lee LL, Bilenky M, Portales-Casamar E, He A, Wasserman WW, Goldowitz D, Marra MA, Holt RA, Simpson EM, Jones SJ., Free PMC Article | 01/21/2010 |
| Lim1 lies downstream of horizontal cell fate determination factors and functions in a cell-autonomous manner to instruct differentiating horizontal cells to the appropriate laminar position in the developing retina. | Lim1 is essential for the correct laminar positioning of retinal horizontal cells.
Poché RA, Kwan KM, Raven MA, Furuta Y, Reese BE, Behringer RR., Free PMC Article | 01/21/2010 |
| GDNF up-regulation of Bcl6b, Erm, and Lhx1 expression through Src family kinase signaling is a key component of the intracellular mechanism for spermatogonial stem cells self-renewal. | Glial cell line-derived neurotrophic factor regulation of genes essential for self-renewal of mouse spermatogonial stem cells is dependent on Src family kinase signaling.
Oatley JM, Avarbock MR, Brinster RL., Free PMC Article | 01/21/2010 |
| Lhx1 and Lhx5, and their cofactor Ldb1, control Purkinje cell differentiation in the developing cerebellum. | LIM-homeodomain proteins Lhx1 and Lhx5, and their cofactor Ldb1, control Purkinje cell differentiation in the developing cerebellum.
Zhao Y, Kwan KM, Mailloux CM, Lee WK, Grinberg A, Wurst W, Behringer RR, Westphal H., Free PMC Article | 01/21/2010 |
| Lim1 has essential roles in multiple steps of epithelial tubular morphogenesis during kidney organogenesis | Distinct and sequential tissue-specific activities of the LIM-class homeobox gene Lim1 for tubular morphogenesis during kidney development.
Kobayashi A, Kwan KM, Carroll TJ, McMahon AP, Mendelsohn CL, Behringer RR. | 01/21/2010 |
| Lim 1 influences nephric duct extension and ureteric bud outgrowth by regulating and or maintaining the differentiation of the nephric epithelium. | Lim 1 is required for nephric duct extension and ureteric bud morphogenesis.
Pedersen A, Skjong C, Shawlot W. | 01/21/2010 |
| Conserved requirement of Lim1 function for cell movements during gastrulation | Conserved requirement of Lim1 function for cell movements during gastrulation.
Hukriede NA, Tsang TE, Habas R, Khoo PL, Steiner K, Weeks DL, Tam PP, Dawid IB. | 01/21/2010 |
| LIM homeodomain proteins establish motor neuron topography by coordinating the mediolateral settling position of motor neurons within the LMC with the dorsoventral selection of axon pathways in the limb. | Topographic motor projections in the limb imposed by LIM homeodomain protein regulation of ephrin-A:EphA interactions.
Kania A, Jessell TM. | 01/21/2010 |
| Lhx1 and Lhx5 function together with Pax2, Pax5 and Pax8 to establish a GABAergic inhibitory-neurotransmitter program in dorsal horn interneurons. | Lhx1 and Lhx5 maintain the inhibitory-neurotransmitter status of interneurons in the dorsal spinal cord.
Pillai A, Mansouri A, Behringer R, Westphal H, Goulding M. | 01/21/2010 |