| Leukotriene B4 receptor knockdown affects PI3K/AKT/mTOR signaling and apoptotic responses in colorectal cancer. | Leukotriene B4 receptor knockdown affects PI3K/AKT/mTOR signaling and apoptotic responses in colorectal cancer.
Tang C, Wang A, Zhao Y, Mou W, Jiang J, Kuang J, Sun B, Tang E., Free PMC Article | 09/9/2024 |
| n-3 Polyunsaturated Fatty Acids Modulate LPS-Induced ARDS and the Lung-Brain Axis of Communication in Wild-Type versus Fat-1 Mice Genetically Modified for Leukotriene B4 Receptor 1 or Chemerin Receptor 23 Knockout. | n-3 Polyunsaturated Fatty Acids Modulate LPS-Induced ARDS and the Lung-Brain Axis of Communication in Wild-Type versus Fat-1 Mice Genetically Modified for Leukotriene B4 Receptor 1 or Chemerin Receptor 23 Knockout.
Hernandez J, Schäffer J, Herden C, Pflieger FJ, Reiche S, Körber S, Kitagawa H, Welter J, Michels S, Culmsee C, Bier J, Sommer N, Kang JX, Mayer K, Hecker M, Rummel C., Free PMC Article | 09/20/2023 |
| Hepatocyte leukotriene B4 receptor 1 promotes NAFLD development in obesity. | Hepatocyte leukotriene B4 receptor 1 promotes NAFLD development in obesity.
Liu X, Wang K, Wang L, Kong L, Hou S, Wan Y, Ma C, Chen J, Xing X, Xing C, Jiang Q, Zhao Q, Cui B, Huang Z, Li P. | 07/20/2023 |
| Expression of leukotriene B4 receptor 1 defines functionally distinct DCs that control allergic skin inflammation. | Expression of leukotriene B(4) receptor 1 defines functionally distinct DCs that control allergic skin inflammation.
Koga T, Sasaki F, Saeki K, Tsuchiya S, Okuno T, Ohba M, Ichiki T, Iwamoto S, Uzawa H, Kitajima K, Meno C, Nakamura E, Tada N, Fukui Y, Kikuta J, Ishii M, Sugimoto Y, Nakao M, Yokomizo T., Free PMC Article | 01/29/2022 |
| Up-regulating microRNA-138-5p enhances the protective role of dexmedetomidine on myocardial ischemia-reperfusion injury mice via down-regulating Ltb4r1. | Up-regulating microRNA-138-5p enhances the protective role of dexmedetomidine on myocardial ischemia-reperfusion injury mice via down-regulating Ltb4r1.
Chang Y, Xing L, Zhou W, Zhang W., Free PMC Article | 12/4/2021 |
| Acceleration of Trichinella spiralis worm expulsion by leukotriene B4 receptor binding inhibition. | Acceleration of Trichinella spiralis worm expulsion by leukotriene B4 receptor binding inhibition.
Kang SA, Yu HS. | 12/4/2021 |
| Leukotriene B4 receptors contribute to house dust mite-induced eosinophilic airway inflammation via TH2 cytokine production. | Leukotriene B4 receptors contribute to house dust mite-induced eosinophilic airway inflammation via TH2 cytokine production.
Park D, Kwak DW, Kim JH., Free PMC Article | 10/16/2021 |
| Constitutive activation of the NEAT1/miR-22-3p/Ltb4r1 signaling pathway in mice with myocardial injury following acute myocardial infarction. | Constitutive activation of the NEAT1/miR-22-3p/Ltb4r1 signaling pathway in mice with myocardial injury following acute myocardial infarction.
Wang L, Wang L, Wang Q., Free PMC Article | 07/24/2021 |
| Leukotriene B4 receptors play critical roles in house dust mites-induced neutrophilic airway inflammation and IL-17 production. | Leukotriene B(4) receptors play critical roles in house dust mites-induced neutrophilic airway inflammation and IL-17 production.
Kwak DW, Park D, Kim JH. | 04/24/2021 |
| The LTB4-BLT1 axis regulates actomyosin and beta2-integrin dynamics during neutrophil extravasation. | The LTB4-BLT1 axis regulates actomyosin and β2-integrin dynamics during neutrophil extravasation.
Subramanian BC, Melis N, Chen D, Wang W, Gallardo D, Weigert R, Parent CA., Free PMC Article | 03/28/2021 |
| Leukotriene B4 receptor 1 exacerbates inflammation following myocardial infarction. | Leukotriene B(4) receptor 1 exacerbates inflammation following myocardial infarction.
Horii Y, Nakaya M, Ohara H, Nishihara H, Watari K, Nagasaka A, Nakaya T, Sugiura Y, Okuno T, Koga T, Tanaka A, Yokomizo T, Kurose H. | 01/16/2021 |
| Leukotriene B4 receptor BLT1 signaling is critical for neutrophil apoptosis and resolution of experimental Lyme arthritis. | Leukotriene B4 receptor BLT1 signaling is critical for neutrophil apoptosis and resolution of experimental Lyme arthritis.
Hilliard KA, Blaho VA, Jackson CD, Brown CR. | 10/3/2020 |
| These results indicate that BLT1 enhances the proliferation of commensal bacteria-dependent IgA(+) plasma cells through the induction of MyD88 and thereby plays a key role in the production of antigen-specific intestinal IgA. | BLT1 mediates commensal bacteria-dependent innate immune signals to enhance antigen-specific intestinal IgA responses.
Nagatake T, Hirata SI, Koga T, Kuroda E, Kobari S, Suzuki H, Hosomi K, Matsumoto N, Yanrismet Y, Shimojou M, Morimoto S, Sasaki F, Ishii KJ, Yokomizo T, Kunisawa J. | 04/25/2020 |
| LTB4-BLT1 signaling plays a critical role in fibrosis in UUO kidneys by increasing accumulation of macrophages and fibroblasts. | Role of the high-affinity leukotriene B4 receptor signaling in fibrosis after unilateral ureteral obstruction in mice.
Kamata M, Amano H, Ito Y, Fujita T, Otaka F, Hosono K, Kamata K, Takeuchi Y, Yokomizo T, Shimizu T, Majima M., Free PMC Article | 12/7/2019 |
| Interruption of the LTB4-BLT1 axis could be useful for preventing PM2.5-induced inflammation. | Diesel exhaust particle promotes tumor lung metastasis via the induction of BLT1-mediated neutrophilic lung inflammation.
Li W, Liu T, Xiong Y, Lv J, Cui X, He R. | 11/16/2019 |
| this study shows that BLT1 in dendritic cells promotes Th1/Th17 differentiation and its deficiency ameliorates TNBS-induced colitis | BLT1 in dendritic cells promotes Th1/Th17 differentiation and its deficiency ameliorates TNBS-induced colitis.
Zhou J, Lai W, Yang W, Pan J, Shen H, Cai Y, Yang C, Ma N, Zhang Y, Zhang R, Xie X, Dong Z, Gao Y, Du C., Free PMC Article | 11/2/2019 |
| Inhibiting the LTB4/BLT1 signaling pathway via AMPK activation is a potential treatment strategy for septic cardiac dysfunction because it efficiently attenuates cardiac apoptosis, which may occur via the inhibition of inflammation and mitochondrial dysfunction. | Inhibition of leukotriene B4 receptor 1 attenuates lipopolysaccharide-induced cardiac dysfunction: role of AMPK-regulated mitochondrial function.
Sun M, Wang R, Han Q., Free PMC Article | 11/10/2018 |
| BLT1 signalling dampens the progression of APAP hepatotoxicity. | BLT1 signalling protects the liver against acetaminophen hepatotoxicity by preventing excessive accumulation of hepatic neutrophils.
Kojo K, Ito Y, Eshima K, Nishizawa N, Ohkubo H, Yokomizo T, Shimizu T, Watanabe M, Majima M., Free PMC Article | 05/19/2018 |
| LTB4-BLT1 axis contributes to cisplatin-induced acute kidney injury by mediating kidney recruitment of neutrophils, which induce inflammation and apoptosis in the kidney. | The leukotriene B(4)-leukotriene B(4) receptor axis promotes cisplatin-induced acute kidney injury by modulating neutrophil recruitment.
Deng B, Lin Y, Ma S, Zheng Y, Yang X, Li B, Yu W, Xu Q, Liu T, Hao C, He R, Ding F. | 04/7/2018 |
| These results demonstrate the importance of ATB2 cells in obesity-induced insulin resistance and suggest that inhibition of the LTB4/LTB4R1 axis might be a useful approach for developing insulin-sensitizing therapeutics | Adipose tissue B2 cells promote insulin resistance through leukotriene LTB4/LTB4R1 signaling.
Ying W, Wollam J, Ofrecio JM, Bandyopadhyay G, El Ouarrat D, Lee YS, Oh DY, Li P, Osborn O, Olefsky JM., Free PMC Article | 09/9/2017 |
| study demonstrates that the LTB4/BLT1 axis plays a critical role in acute injury phase to promote bleomycin -induced lung fibrosis, and it suggests that early interruption of the LTB4/BLT1 axis in some inflammatory diseases could prevent the later development of tissue fibrosis | BLT1 Mediates Bleomycin-Induced Lung Fibrosis Independently of Neutrophils and CD4+ T Cells.
Lv J, Xiong Y, Li W, Yang W, Zhao L, He R. | 09/2/2017 |
| This study demonstrates that LTB4 promotes macrophage phagocytosis of bacteria via BLT1, and that BLT2 can fulfill this role in the absence of BL | Macrophage LTB(4) drives efficient phagocytosis of Borrelia burgdorferi via BLT1 or BLT2.
Zhang Y, Olson RM, Brown CR., Free PMC Article | 09/2/2017 |
| These results demonstrate a critical role for both BLT1 and CXCR3 in cytotoxic T lymphocyte (CTL) migration to tumors and thus may be targeted to enhance efficacy of CTL-based immunotherapies. | Chemoattractant Receptors BLT1 and CXCR3 Regulate Antitumor Immunity by Facilitating CD8+ T Cell Migration into Tumors.
Chheda ZS, Sharma RK, Jala VR, Luster AD, Haribabu B., Free PMC Article | 08/26/2017 |
| Our data show that LTB4 and its receptor BLT1 exacerbate synovial inflammation in vivo and bone resorption in vitro | Critical Role of LTB4/BLT1 in IL-23-Induced Synovial Inflammation and Osteoclastogenesis via NF-κB.
Bouchareychas L, Grössinger EM, Kang M, Qiu H, Adamopoulos IE., Free PMC Article | 08/12/2017 |
| the data show that the two leukotriene B4 receptors have opposing roles in the sensitization of peripheral sensory neurons forming a self-restricting system. | The leukotriene B4 receptors BLT1 and BLT2 form an antagonistic sensitizing system in peripheral sensory neurons.
Zinn S, Sisignano M, Kern K, Pierre S, Tunaru S, Jordan H, Suo J, Treutlein EM, Angioni C, Ferreiros N, Leffler A, DeBruin N, Offermanns S, Geisslinger G, Scholich K., Free PMC Article | 04/29/2017 |