| Downregulation of B4GALT5 attenuates cardiac fibrosis through Lumican and Akt/GSK-3beta/beta-catenin pathway. | Downregulation of B4GALT5 attenuates cardiac fibrosis through Lumican and Akt/GSK-3β/β-catenin pathway.
Zhang X, Cui S, Ding Y, Li Y, Wu B, Gao J, Li M, Xu L, Xia H. | 01/26/2024 |
| Impaired healing in an incision wound in corneal stroma in a lumican-null mouse. | Impaired healing in an incision wound in corneal stroma in a lumican-null mouse.
Suzuki E, Sumioka T, Saika S, Miyajima M, Yasuda S, Iwanishi H, Takada Y, Ichikawa K, Venkatakrishnan J, Liu CY, Whei-Yang Kao W, Okada Y. | 12/22/2023 |
| Lumican, an Exerkine, Protects against Skeletal Muscle Loss. | Lumican, an Exerkine, Protects against Skeletal Muscle Loss.
Cho HJ, Lee YS, Kim DA, Moon SA, Lee SE, Lee SH, Koh JM., Free PMC Article | 10/1/2022 |
| Matrix lumican endocytosed by immune cells controls receptor ligand trafficking to promote TLR4 and restrict TLR9 in sepsis. | Matrix lumican endocytosed by immune cells controls receptor ligand trafficking to promote TLR4 and restrict TLR9 in sepsis.
Maiti G, Frikeche J, Lam CY, Biswas A, Shinde V, Samanovic M, Kagan JC, Mulligan MJ, Chakravarti S., Free PMC Article | 12/4/2021 |
| Lumican Inhibits In Vivo Melanoma Metastasis by Altering Matrix-Effectors and Invadopodia Markers. | Lumican Inhibits In Vivo Melanoma Metastasis by Altering Matrix-Effectors and Invadopodia Markers.
Karamanou K, Franchi M, Proult I, Rivet R, Vynios D, Brézillon S., Free PMC Article | 10/23/2021 |
| Moderate Loss of the Extracellular Matrix Proteoglycan Lumican Attenuates Cardiac Fibrosis in Mice Subjected to Pressure Overload. | Moderate Loss of the Extracellular Matrix Proteoglycan Lumican Attenuates Cardiac Fibrosis in Mice Subjected to Pressure Overload.
Mohammadzadeh N, Melleby AO, Palmero S, Sjaastad I, Chakravarti S, Engebretsen KVT, Christensen G, Lunde IG, Tønnessen T., Free PMC Article | 10/31/2020 |
| The extracellular matrix proteoglycan lumican improves survival and counteracts cardiac dilatation and failure in mice subjected to pressure overload. | The extracellular matrix proteoglycan lumican improves survival and counteracts cardiac dilatation and failure in mice subjected to pressure overload.
Mohammadzadeh N, Lunde IG, Andenæs K, Strand ME, Aronsen JM, Skrbic B, Marstein HS, Bandlien C, Nygård S, Gorham J, Sjaastad I, Chakravarti S, Christensen G, Engebretsen KVT, Tønnessen T., Free PMC Article | 10/24/2020 |
| this study shows that Lum negatively regulates encephalitic TH17 cells, implicating a potential therapeutic pathway in TH17 cell mediated autoimmune and inflammatory diseases | Lumican negatively controls the pathogenicity of murine encephalitic TH17 cells.
Castillo EF, Zheng H, Van Cabanlong C, Dong F, Luo Y, Yang Y, Liu M, Kao WW, Yang XO., Free PMC Article | 07/8/2017 |
| ectopic mutant lumican (L199P) may induce enlargement of axial lengths and abnormal structures and distributions of collagen fibrils in mouse sclera | Enlargement of the Axial Length and Altered Ultrastructural Features of the Sclera in a Mutant Lumican Transgenic Mouse Model.
Song Y, Zhang F, Zhao Y, Sun M, Tao J, Liang Y, Ma L, Yu Y, Wang J, Hao J., Free PMC Article | 06/24/2017 |
| alternations of lumican might be implicated in the pathogenesis of cardiac fibrosis | Lumican-null mice are susceptible to aging and isoproterenol-induced myocardial fibrosis.
Chen SW, Tung YC, Jung SM, Chu Y, Lin PJ, Kao WW, Chu PH. | 06/10/2017 |
| LUM may coordinate multiple factors of collagen assembly in the murine heart. | Lumican deficiency results in cardiomyocyte hypertrophy with altered collagen assembly.
Dupuis LE, Berger MG, Feldman S, Doucette L, Fowlkes V, Chakravarti S, Thibaudeau S, Alcala NE, Bradshaw AD, Kern CB., Free PMC Article | 04/9/2016 |
| Lumican and biglycan influence corneal keratocyte lamellipodia organization and are critical in the regulation of stromal collagen fibrillogenesis. | Interclass small leucine-rich repeat proteoglycan interactions regulate collagen fibrillogenesis and corneal stromal assembly.
Chen S, Young MF, Chakravarti S, Birk DE., Free PMC Article | 01/17/2015 |
| Alterations in glycosylated lumican core protein might be implicated in myocardial remodeling and reverse remodeling, with a potential important role for CS/DS GAG chain-synthesizing enzymes. | Decorin, lumican, and their GAG chain-synthesizing enzymes are regulated in myocardial remodeling and reverse remodeling in the mouse.
Engebretsen KV, Waehre A, Bjørnstad JL, Skrbic B, Sjaastad I, Behmen D, Marstein HS, Yndestad A, Aukrust P, Christensen G, Tønnessen T. | 10/19/2013 |
| pro-inflammatory cytokine TNF-alpha was comparably low 24 hours after infection, but significantly higher in the Lum(-/-) compared to Lum(+/-) infected corneas by 2-5 days after infection | Extracellular matrix protein lumican promotes clearance and resolution of Pseudomonas aeruginosa keratitis in a mouse model.
Shao H, Scott SG, Nakata C, Hamad AR, Chakravarti S., Free PMC Article | 09/7/2013 |
| lumican present in the reactive stroma surrounding prostate primary tumors plays a restrictive role on cancer progression | Lumican expression, localization and antitumor activity in prostate cancer.
Coulson-Thomas VJ, Coulson-Thomas YM, Gesteira TF, Andrade de Paula CA, Carneiro CR, Ortiz V, Toma L, Kao WW, Nader HB., Free PMC Article | 05/18/2013 |
| To investigate the functional role of lumican in hepatic fibrosis, lumican null (Null) and wild-type (WT) littermates were administered carbon tetrachloride intra-peritoneally. Hepatic fibrosis was greatly reduced in null animals. | Lumican, an extracellular matrix proteoglycan, is a novel requisite for hepatic fibrosis.
Krishnan A, Li X, Kao WY, Viker K, Butters K, Masuoka H, Knudsen B, Gores G, Charlton M., Free PMC Article | 04/20/2013 |
| lumican has a major protective role in gram-negative bacterial infections, a novel function for small leucine-rich repeat proteoglycans. | Extracellular matrix lumican promotes bacterial phagocytosis, and Lum-/- mice show increased Pseudomonas aeruginosa lung infection severity.
Shao H, Lee S, Gae-Scott S, Nakata C, Chen S, Hamad AR, Chakravarti S., Free PMC Article | 12/29/2012 |
| Lumican regulates neutrophils migration through interactions with integrin beta2. | Extracellular matrix lumican deposited on the surface of neutrophils promotes migration by binding to beta2 integrin.
Lee S, Bowrin K, Hamad AR, Chakravarti S., Free PMC Article | 01/21/2010 |
| Homologous sequence in lumican and fibromodulin leucine-rich repeat 5-7 competes for collagen binding. | Homologous sequence in lumican and fibromodulin leucine-rich repeat 5-7 competes for collagen binding.
Kalamajski S, Oldberg Å. | 01/21/2010 |
| lumican and keratocan core proteins bind the CXC chemokine KC during a corneal inflammatory response, indicating that corneal KSPGs mediate neutrophil recruitment to the cornea by regulating chemokine gradient formation. | Keratocan and lumican regulate neutrophil infiltration and corneal clarity in lipopolysaccharide-induced keratitis by direct interaction with CXCL1.
Carlson EC, Lin M, Liu CY, Kao WW, Perez VL, Pearlman E., Free PMC Article | 01/21/2010 |
| Lumican is identified as a novel regulator of angiogenesis. | Transcriptome analysis of endothelial cell gene expression induced by growth on matrigel matrices: identification and characterization of MAGP-2 and lumican as novel regulators of angiogenesis.
Albig AR, Roy TG, Becenti DJ, Schiemann WP. | 01/21/2010 |
| a novel role for lumican in the presentation of bacterial lipopolysaccharide to CD14 and host response to this bacterial endotoxin. | A novel role of the lumican core protein in bacterial lipopolysaccharide-induced innate immune response.
Wu F, Vij N, Roberts L, Lopez-Briones S, Joyce S, Chakravarti S. | 01/21/2010 |
| the posterior stroma of the cornea, which is most vulnerable to lumican-deficiency, demonstrates an early developmental defect in fibril structure and architecture in the Lum-/- genotype | Collagen fibril assembly during postnatal development and dysfunctional regulation in the lumican-deficient murine cornea.
Chakravarti S, Zhang G, Chervoneva I, Roberts L, Birk DE. | 01/21/2010 |
| lumican has a novel regulatory role in keratocan expression at the transcriptional level | Keratocan, a cornea-specific keratan sulfate proteoglycan, is regulated by lumican.
Carlson EC, Liu CY, Chikama T, Hayashi Y, Kao CW, Birk DE, Funderburgh JL, Jester JV, Kao WW., Free PMC Article | 01/21/2010 |
| The results indicate that the cysteine-rich domain of lumican is important in collagen fibrillogenesis and stromal matrix assembly | Role of Cys41 in the N-terminal domain of lumican in ex vivo collagen fibrillogenesis by cultured corneal stromal cells.
Carlson EC, Mamiya K, Liu CY, Gendron RL, Birk DE, Funderburgh JL, Kao WW., Free PMC Article | 01/21/2010 |