| miR-23a-3p is involved in drug resistance by directly targeting the influx drug transporter organic anion-transporting polypeptide 2. | miR-23a-3p is involved in drug resistance by directly targeting the influx drug transporter organic anion-transporting polypeptide 2.
Guo Y, Li J, Kang Y, Jiang L. | 09/18/2021 |
| Organic anion transporting polypeptide 1A2 mediates fentanyl uptake in cultured cells. | Organic anion transporting polypeptide 1A2 mediates fentanyl uptake in cultured cells.
Huo XC, Yang HW, Huang LH, Zhang F, Pan ZY, Liao Q. | 10/31/2020 |
| optimal rOATP1A4 trafficking to the cell surface is dependent upon coexpression and interaction with rOATP1A1. | Rat Organic Anion Transport Protein 1A1 Interacts Directly With Organic Anion Transport Protein 1A4 Facilitating Its Maturation and Trafficking to the Hepatocyte Plasma Membrane.
Wang P, Wang WJ, Choi-Nurvitadhi J, Lescaille Y, Murray JW, Wolkoff AW., Free PMC Article | 07/4/2020 |
| Oatp1a4 appears to play a major role in Cerebrospinal Fluid detoxification by limiting the distribution of organic anions to the brain and spinal cord. | Organic Anion-Transporting Polypeptide 1a4 (Oatp1a4/Slco1a4) at the Blood-Arachnoid Barrier is the Major Pathway of Sulforhodamine-101 Clearance from Cerebrospinal Fluid of Rats.
Yaguchi Y, Tachikawa M, Zhang Z, Terasaki T. | 03/14/2020 |
| The Oatp1a4 function is dominant in the region around the hepatic CV in rat hepatic lobules. | Organic anion-transporting polypeptide 1a4-mediated heterogeneous distribution of sulforhodamine-101 in rat hepatic lobules.
Akanuma SI, Kida R, Tsuchiyama A, Tachikawa M, Kubo Y, Hosoya KI. | 02/8/2020 |
| Oatp1a4 transport activity at the BBB is directly regulated by TGF-beta/ALK1 signaling. | Functional Expression of Organic Anion Transporting Polypeptide 1a4 Is Regulated by Transforming Growth Factor-β/Activin Receptor-like Kinase 1 Signaling at the Blood-Brain Barrier.
Abdullahi W, Brzica H, Hirsch NA, Reilly BG, Ronaldson PT., Free PMC Article | 05/4/2019 |
| Study finds sex-specific differences in organic anion transporting polypeptide 1a4 (Oatp1a4) functional expression at the blood-brain barrier in Sprague-Dawley rats. | Sex-specific differences in organic anion transporting polypeptide 1a4 (Oatp1a4) functional expression at the blood-brain barrier in Sprague-Dawley rats.
Brzica H, Abdullahi W, Reilly BG, Ronaldson PT., Free PMC Article | 02/16/2019 |
| Upon chronic/sub-chronic loss of bile excretion, rocuronium clearance via the kidneys is enhanced, by Oatp2 up-regulation. | Increased Renal Clearance of Rocuronium Compensates for Chronic Loss of Bile Excretion, via upregulation of Oatp2.
Wang L, Zhou MT, Chen CY, Yin W, Wen DX, Cheung CW, Yang LQ, Yu WF., Free PMC Article | 10/20/2018 |
| This study demostrated that transport of VPA is mediated by Oatp2. Oatp2 may play an important role in influencing the pharmacological activity of VPA by affecting its uptake and distribution in the brain. | Organic anion transporting polypeptide 2 transports valproic acid in rat brain microvascular endothelial cells.
Guo Y, Jiang L. | 01/28/2017 |
| These findings suggest the possibility that ABCC2-mediated hepatobiliary excretion and OATP1/OATP2-mediated hepatic uptake do not play important roles in the disposition of regorafenib. | Lack of Contribution of Multidrug Resistance-associated Protein and Organic Anion-transporting Polypeptide to Pharmacokinetics of Regorafenib, a Novel Multi-Kinase Inhibitor, in Rats.
Hotta K, Ueyama J, Tatsumi Y, Tsukiyama I, Sugiura Y, Saito H, Matsuura K, Hasegawa T. | 04/30/2016 |
| Gene and protein expressions of analyzed transporters increase as the brain matures, with no variation in their activity for P-gp and bcrp, while the transport activity of oat3 and oatp1a4 increases during brain maturation from preterm up to adulthood. | P-glycoprotein, breast cancer resistance protein, Organic Anion Transporter 3, and Transporting Peptide 1a4 during blood-brain barrier maturation: involvement of Wnt/β-catenin and endothelin-1 signaling.
Harati R, Benech H, Villégier AS, Mabondzo A. | 12/21/2013 |
| In olfactory epithelium, high levels of expression of xenobiotic transporters Mrp1, Mrp3, Mrp5, Mdr1a, Oatp2 and Oat6 are expressed. | Expression and differential localization of xenobiotic transporters in the rat olfactory neuro-epithelium.
Thiebaud N, Menetrier F, Belloir C, Minn AL, Neiers F, Artur Y, Le Bon AM, Heydel JM. | 08/18/2012 |
| Changes in Oatp1a4 functional expression suggest that inflammation in the periphery can modulate blood-brain barrier transporters. | Inflammatory pain signals an increase in functional expression of organic anion transporting polypeptide 1a4 at the blood-brain barrier.
Ronaldson PT, Finch JD, Demarco KM, Quigley CE, Davis TP., Free PMC Article | 04/23/2011 |
| Our data provide a basis for the assessment of the role of P-glycoprotein and Oatp2 uptake transporters and efflux pumps in the development of intractable epilepsy. | Drug transporters are altered in brain, liver and kidney of rats with chronic epilepsy induced by lithium-pilocarpine.
Guo Y, Jiang L. | 03/29/2010 |
| The statin transporters Oatp1a4 and Oatp2b1 are expressed in rat skeletal myofibres, but not in satellite cells, fibroblasts or in L6 myoblasts | Involvement of organic anion transporting polypeptides in the toxicity of hydrophilic pravastatin and lipophilic fluvastatin in rat skeletal myofibres.
Sakamoto K, Mikami H, Kimura J., Free PMC Article | 01/21/2010 |
| Suggest that Oatp2 plays a key role in the hepatic uptake of nafcillin and most other beta-lactam antibiotics in rats. | Predominant contribution of rat organic anion transporting polypeptide-2 (Oatp2) to hepatic uptake of beta-lactam antibiotics.
Nakakariya M, Shimada T, Irokawa M, Koibuchi H, Iwanaga T, Yabuuchi H, Maeda T, Tamai I. | 01/21/2010 |
| Oatp2 and Oatp4 levels were unaffected during obstructive cholestasis. | Extrahepatic cholestasis downregulates Oatp1 by TNF-alpha signalling without affecting Oatp2 and Oatp4 expression and sodium-independent bile salt uptake in rat liver.
Geier A, Dietrich CG, Trauner M, Gartung C. | 01/21/2010 |
| 24S-hydroxycholesterol undergoes elimination from the brain to blood across the blood-brain barrier (BBB) via a carrier-mediated process, which involves oatp2 expressed at the BBB in rats. | Brain-to-blood elimination of 24S-hydroxycholesterol from rat brain is mediated by organic anion transporting polypeptide 2 (oatp2) at the blood-brain barrier.
Ohtsuki S, Ito S, Matsuda A, Hori S, Abe T, Terasaki T. | 01/21/2010 |
| Upregulation of the basolateral bile acid transporters Ntcp, Oatp1, and Oatp2 in fasted rats is mediated via the HNF4alpha/PGC-1alpha pathway. | Fasting induces basolateral uptake transporters of the SLC family in the liver via HNF4alpha and PGC1alpha.
Dietrich CG, Martin IV, Porn AC, Voigt S, Gartung C, Trautwein C, Geier A. | 01/21/2010 |
| Mrp2 and Oatp2 expression are decreased in fatty livers and may impair metabolism, transport,and biliary secretion of endogenous and xenobiotic substances in livers of obese Zucker rats. | Characterization of organic anion transporter regulation, glutathione metabolism and bile formation in the obese Zucker rat.
Geier A, Dietrich CG, Grote T, Beuers U, Prüfer T, Fraunberger P, Matern S, Gartung C, Gerbes AL, Bilzer M. | 01/21/2010 |