| TLR8-activating miR-146a-3p is an intermediate signal contributing to fetal membrane inflammation in response to bacterial LPS. | TLR8-activating miR-146a-3p is an intermediate signal contributing to fetal membrane inflammation in response to bacterial LPS.
Georges HM, Cassin C, Tong M, Abrahams VM., | 07/26/2024 |
| Gender Control of Mouse Embryos by Activation of TLR7/8 on X Sperm via Ligands dsRNA-40 and dsRNA-DR. | Gender Control of Mouse Embryos by Activation of TLR7/8 on X Sperm via Ligands dsRNA-40 and dsRNA-DR.
Hou Y, Peng J, Hong L, Wu Z, Zheng E, Li Z., Free PMC Article | 06/24/2024 |
| CD8 T Cell-Derived Exosomal miR-186-5p Elicits Renal Inflammation via Activating Tubular TLR7/8 Signal Axis. | CD8 T Cell-Derived Exosomal miR-186-5p Elicits Renal Inflammation via Activating Tubular TLR7/8 Signal Axis.
Xu X, Qu S, Zhang C, Zhang M, Qin W, Ren G, Bao H, Li L, Zen K, Liu Z., Free PMC Article | 09/29/2023 |
| TLR7/8 stress response drives histiocytosis in SLC29A3 disorders. | TLR7/8 stress response drives histiocytosis in SLC29A3 disorders.
Shibata T, Sato R, Taoka M, Saitoh SI, Komine M, Yamaguchi K, Goyama S, Motoi Y, Kitaura J, Izawa K, Yamauchi Y, Tsukamoto Y, Ichinohe T, Fujita E, Hiranuma R, Fukui R, Furukawa Y, Kitamura T, Takai T, Tojo A, Ohtsuki M, Ohto U, Shimizu T, Ozawa M, Yoshida N, Isobe T, Latz E, Mukai K, Taguchi T, Hemmi H, Akira S, Miyake K., Free PMC Article | 07/24/2023 |
| Expression of toll like receptor 8 (TLR8) in specific groups of mouse hippocampal interneurons. | Expression of toll like receptor 8 (TLR8) in specific groups of mouse hippocampal interneurons.
Seizer L, Rahimi S, Santos-Sierra S, Drexel M., Free PMC Article | 05/14/2022 |
| Therapeutic efficacy of cancer vaccine adjuvanted with nanoemulsion loaded with TLR7/8 agonist in lung cancer model. | Therapeutic efficacy of cancer vaccine adjuvanted with nanoemulsion loaded with TLR7/8 agonist in lung cancer model.
Koh J, Kim S, Lee SN, Kim SY, Kim JE, Lee KY, Kim MS, Heo JY, Park YM, Ku BM, Sun JM, Lee SH, Ahn JS, Park K, Yang S, Ha SJ, Lim YT, Ahn MJ. | 02/12/2022 |
| TLR8 in the Trigeminal Ganglion Contributes to the Maintenance of Trigeminal Neuropathic Pain in Mice. | TLR8 in the Trigeminal Ganglion Contributes to the Maintenance of Trigeminal Neuropathic Pain in Mice.
Zhao LX, Jiang M, Bai XQ, Cao DL, Wu XB, Zhang J, Guo JS, Chen TT, Wang J, Wu H, Gao YJ, Zhang ZJ., Free PMC Article | 09/4/2021 |
| Podocyte Injury Through Interaction Between Tlr8 and Its Endogenous Ligand miR-21 in Obstructed and Its Collateral Kidney. | Podocyte Injury Through Interaction Between Tlr8 and Its Endogenous Ligand miR-21 in Obstructed and Its Collateral Kidney.
Masum MA, Ichii O, Elewa YHA, Kon Y., Free PMC Article | 06/26/2021 |
| TLR7/8 in the Pathogenesis of Parkinson's Disease. | TLR7/8 in the Pathogenesis of Parkinson's Disease.
Campolo M, Filippone A, Biondo C, Mancuso G, Casili G, Lanza M, Cuzzocrea S, Esposito E, Paterniti I., Free PMC Article | 03/6/2021 |
| Development of RNA/DNA Hydrogel Targeting Toll-Like Receptor 7/8 for Sustained RNA Release and Potent Immune Activation. | Development of RNA/DNA Hydrogel Targeting Toll-Like Receptor 7/8 for Sustained RNA Release and Potent Immune Activation.
Komura F, Okuzumi K, Takahashi Y, Takakura Y, Nishikawa M., Free PMC Article | 11/21/2020 |
| TLR7 and TLR8 Differentially Activate the IRF and NF-kappaB Pathways in Specific Cell Types to Promote Inflammation. | TLR7 and TLR8 Differentially Activate the IRF and NF-κB Pathways in Specific Cell Types to Promote Inflammation.
Bender AT, Tzvetkov E, Pereira A, Wu Y, Kasar S, Przetak MM, Vlach J, Niewold TB, Jensen MA, Okitsu SL. | 10/10/2020 |
| The functional differences between Y-sperm and X-sperm motility were revealed and related to different gene expression patterns, specifically TLR7/8 on X-sperm. | Activation of Toll-like receptor 7/8 encoded by the X chromosome alters sperm motility and provides a novel simple technology for sexing sperm.
Umehara T, Tsujita N, Shimada M., Free PMC Article | 02/29/2020 |
| The present study reveals a previously unknown role of TLR8 in the maintenance of neuropathic pain, suggesting that miR-21-TLR8 signaling may be potential new targets for drug development against this type of chronic pain. | TLR8 and its endogenous ligand miR-21 contribute to neuropathic pain in murine DRG.
Zhang ZJ, Guo JS, Li SS, Wu XB, Cao DL, Jiang BC, Jing PB, Bai XQ, Li CH, Wu ZH, Lu Y, Gao YJ., Free PMC Article | 09/7/2019 |
| The activation of TLR8, TLR7, or TLR3 results in dendritic shortening, and TLR7 and TLR3 but not TLR8 also control axonal growth. | Endosomal TLR3, TLR7, and TLR8 control neuronal morphology through different transcriptional programs.
Hung YF, Chen CY, Shih YC, Liu HY, Huang CM, Hsueh YP., Free PMC Article | 07/20/2019 |
| Evaluation of the adjuvant effect of agonists of toll-like receptor 4 and 7/8 in a vaccine against leishmaniasis | Evaluation of the adjuvant effect of agonists of toll-like receptor 4 and 7/8 in a vaccine against leishmaniasis in BALB/c mice.
Rostamian M, Niknam HM. | 10/28/2017 |
| TLR8 coupling with SOCS-1 inhibits TLR7-mediated antiviral immunity during WNV infection in mice. | TLR8 Couples SOCS-1 and Restrains TLR7-Mediated Antiviral Immunity, Exacerbating West Nile Virus Infection in Mice.
Paul AM, Acharya D, Le L, Wang P, Stokic DS, Leis AA, Alexopoulou L, Town T, Flavell RA, Fikrig E, Bai F., Free PMC Article | 07/29/2017 |
| this study shows that beta,beta-dimethylacryloyl alkannin could inhibit psoriasis-activated dendritic cells via the TLR7/8 pathway | Suppressive effect of β,β-dimethylacryloyl alkannin on activated dendritic cells in psoriasis by the TLR7/8 pathway.
Wang Y, Zhao J, Di T, Wang M, Ruan Z, Zhang L, Xie X, Meng Y, Lin Y, Liu X, Wang N, Li P. | 04/22/2017 |
| mTLR8 is functional and is vital role in the activation of innate immune responses. | Molecular cloning and functional characterization of murine toll‑like receptor 8.
Li T, He X, Jia H, Chen G, Zeng S, Fang Y, Jin Q, Jing Z., Free PMC Article | 11/5/2016 |
| an important role of 2'-O-methylation for shaping differential TLR7 or TLR8 activation | A single naturally occurring 2'-O-methylation converts a TLR7- and TLR8-activating RNA into a TLR8-specific ligand.
Jung S, von Thülen T, Laukemper V, Pigisch S, Hangel D, Wagner H, Kaufmann A, Bauer S., Free PMC Article | 02/6/2016 |
| Hepatic expression of Tlr6, but not that of Tlr8 is epigenetically controlled, and that the dysregulations of Tlr6 and Tlr8 critically contribute to Testosterone (T)-induced persistent susceptibility to P. chabaudi malaria. | Testosterone persistently dysregulates hepatic expression of Tlr6 and Tlr8 induced by Plasmodium chabaudi malaria.
Al-Quraishy S, Dkhil MA, Abdel-Baki AA, Araúzo-Bravo MJ, Delic D, Wunderlich F. | 10/31/2015 |
| The urinary levels of Tlr8 mRNA were also higher in BXSB-Yaa mice. | Overexpression of Toll-like receptor 8 correlates with the progression of podocyte injury in murine autoimmune glomerulonephritis.
Kimura J, Ichii O, Miyazono K, Nakamura T, Horino T, Otsuka-Kanazawa S, Kon Y., Free PMC Article | 10/10/2015 |
| TLR8 deletion accelerated autoimmunity in lupus-prone mice in response to TLR7 activation. | Toll-like receptor 8 deletion accelerates autoimmunity in a mouse model of lupus through a Toll-like receptor 7-dependent mechanism.
Tran NL, Manzin-Lorenzi C, Santiago-Raber ML., Free PMC Article | 07/4/2015 |
| TLR8 activation has direct anti-leukemic effects independent of its immunomodulating properties. | The role of TLR8 signaling in acute myeloid leukemia differentiation.
Ignatz-Hoover JJ, Wang H, Moreton SA, Chakrabarti A, Agarwal MK, Sun K, Gupta K, Wald DN., Free PMC Article | 06/6/2015 |
| We suggest that giant cell formation may be a unique feature of TLR9- and TLR7/8-mediated macrophage activation. | TLR9 and TLR7/8 activation induces formation of keratic precipitates and giant macrophages in the mouse cornea.
Chinnery HR, Leong CM, Chen W, Forrester JV, McMenamin PG. | 03/21/2015 |
| These results suggest that IL-23-driven inflammation in mouse skin may be dependent on signaling mediated by TLRs 7, 8, and 9 | Suppression of molecular inflammatory pathways by Toll-like receptor 7, 8, and 9 antagonists in a model of IL-23-induced skin inflammation.
Suárez-Fariñas M, Arbeit R, Jiang W, Ortenzio FS, Sullivan T, Krueger JG., Free PMC Article | 02/28/2015 |