| Synaptopodin-2 Isoforms Have Specific Binding Partners and Display Distinct, Muscle Cell Type-Specific Expression Patterns. | Synaptopodin-2 Isoforms Have Specific Binding Partners and Display Distinct, Muscle Cell Type-Specific Expression Patterns.
Lohanadan K, Assent M, Linnemann A, Schuld J, Heukamp LC, Krause K, Vorgerd M, Reimann J, Schänzer A, Kirfel G, Fürst DO, Van der Ven PFM., Free PMC Article | 01/16/2024 |
| SYNPO2 promotes the development of BLCA by upregulating the infiltration of resting mast cells and increasing the resistance to immunotherapy. | SYNPO2 promotes the development of BLCA by upregulating the infiltration of resting mast cells and increasing the resistance to immunotherapy.
Ye G, Tu L, Li Z, Li X, Zheng X, Song Y., Free PMC Article | 12/5/2023 |
| SYNPO2 suppresses hypoxia-induced proliferation and migration of colorectal cancer cells by regulating YAP-KLF5 axis. | SYNPO2 suppresses hypoxia-induced proliferation and migration of colorectal cancer cells by regulating YAP-KLF5 axis.
OuYang C, Xie Y, Fu Q, Xu G. | 03/5/2022 |
| Synaptopodin-2 promotes hepatocellular carcinoma metastasis via calcineurin-induced nuclear-cytoplasmic translocation. | Synaptopodin-2 promotes hepatocellular carcinoma metastasis via calcineurin-induced nuclear-cytoplasmic translocation.
Gao J, Zhang HP, Sun YH, Guo WZ, Li J, Tang HW, Guo DF, Zhang JK, Shi XY, Yu DS, Zhang XD, Wen PH, Shi JH, Zhang SJ. | 01/9/2021 |
| These findings uncover a suppressive role of SYNPO2 in triple-negative breast cancer (TNBC) metastasis via inhibition of YAP/TAZ, and suggest that SYNPO2 might provide a potential prognosis marker and novel therapeutic strategy. | Synaptopodin-2 suppresses metastasis of triple-negative breast cancer via inhibition of YAP/TAZ activity.
Liu J, Ye L, Li Q, Wu X, Wang B, Ouyang Y, Yuan Z, Li J, Lin C. | 01/13/2018 |
| LMOD1, SYNPO2, PDLIM7, PLN, and SYNM down-regulation reflect the altered phenotype of smooth muscle cells in vascular disease and could be early sensitive markers of SMC dedifferentiation. | Phenotypic Modulation of Smooth Muscle Cells in Atherosclerosis Is Associated With Downregulation of LMOD1, SYNPO2, PDLIM7, PLN, and SYNM.
Perisic Matic L, Rykaczewska U, Razuvaev A, Sabater-Lleal M, Lengquist M, Miller CL, Ericsson I, Röhl S, Kronqvist M, Aldi S, Magné J, Paloschi V, Vesterlund M, Li Y, Jin H, Diez MG, Roy J, Baldassarre D, Veglia F, Humphries SE, de Faire U, Tremoli E, Odeberg J, Vukojević V, Lehtiö J, Maegdefessel L, Ehrenborg E, Paulsson-Berne G, Hansson GK, Lindeman JH, Eriksson P, Quertermous T, Hamsten A, Hedin U., Free PMC Article | 06/24/2017 |
| Results show that SYNPO2 gene plays an important role in the etiology of epithelial ovarian cancer, suggesting that this gene may be a potential genetic modifier for developing epithelial ovarian cancer. | Association of a common variant of SYNPO2 gene with increased risk of serous epithelial ovarian cancer.
Ma L, Zhang W, Ding Z, Wu SG, Jin Y, Jiang N, Du H, Cai D, Miao L, Chen X. | 04/1/2017 |
| High Myopodin methylation is associated with metastasis in kidney cancer. | Myopodin methylation is a prognostic biomarker and predicts antiangiogenic response in advanced kidney cancer.
Pompas-Veganzones N, Sandonis V, Perez-Lanzac A, Beltran M, Beardo P, Juárez A, Vazquez F, Cozar JM, Alvarez-Ossorio JL, Sanchez-Carbayo M. | 03/4/2017 |
| High Synaptopodin-2 induces assembly of peripheral actin bundles and immature focal adhesions to promote lamellipodia formation and prostate cancer cell migration. | Synaptopodin-2 induces assembly of peripheral actin bundles and immature focal adhesions to promote lamellipodia formation and prostate cancer cell migration.
Kai F, Fawcett JP, Duncan R., Free PMC Article | 03/19/2016 |
| Promoter hypermethylation and down regulation of SYNPO2 has significance in the prognosis of melanoma patients. | Prognostic Significance of Promoter Hypermethylation and Diminished Gene Expression of SYNPO2 in Melanoma.
Gao L, van den Hurk K, Nsengimana J, Laye JP, van den Oord JJ, Beck S, Gruis NA, Zoutman WH, van Engeland M, Newton-Bishop JA, Winnepenninckx VJ, van Doorn R. | 11/21/2015 |
| myopodin is epigenetically modified in colon cancer | Diagnostic and prognostic utility of methylation and protein expression patterns of myopodin in colon cancer.
Esteban S, Moya P, Fernandez-Suarez A, Vidaurreta M, González-Peramato P, Sánchez-Carbayo M. | 05/5/2012 |
| the N-terminus of myopodin binds integrin-linked kinase (ILK) both in vivo and in vitro | Phosphorylation and interaction of myopodin by integrin-link kinase lead to suppression of cell growth and motility in prostate cancer cells.
Yu YP, Luo JH., Free PMC Article | 01/28/2012 |
| Observational study of gene-disease association. (HuGE Navigator) | A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts.
Kalsi G, Kuo PH, Aliev F, Alexander J, McMichael O, Patterson DG, Walsh D, Zhao Z, Schuckit M, Nurnberger J Jr, Edenberg H, Kramer J, Hesselbrock V, Tischfield JA, Vladimirov V, Prescott CA, Dick DM, Kendler KS, Riley BP., Free PMC Article | 06/30/2010 |
| The subcellular localization of myopodin is involved in its suppressor or activator function in tumorigenesis. | Down-regulation of myopodin expression reduces invasion and motility of PC-3 prostate cancer cells.
De Ganck A, De Corte V, Bruyneel E, Bracke M, Vandekerckhove J, Gettemans J. | 01/21/2010 |
| The myopodin new isoform (Myo2), in addition to the two predicted isoforms (Myo1 and Myo3), are transcribed in various mammalian tumor cell lines. | Multiple isoforms of the tumor suppressor myopodin are simultaneously transcribed in cancer cells.
De Ganck A, De Corte V, Staes A, Gevaert K, Vandekerckhove J, Gettemans J. | 01/21/2010 |
| Imp13 functions in myopodin import and the regulation of this event is critical for normal and abnormal cellular differentiation. | Interaction between importin 13 and myopodin suggests a nuclear import pathway for myopodin.
Liang J, Ke G, You W, Peng Z, Lan J, Kalesse M, Tartakoff AM, Kaplan F, Tao T. | 01/21/2010 |
| myopodin functions as a tumor suppressor gene to limit the growth and to inhibit the metastasis of cancer cells | Expression of myopodin induces suppression of tumor growth and metastasis.
Jing L, Liu L, Yu YP, Dhir R, Acquafondada M, Landsittel D, Cieply K, Wells A, Luo JH., Free PMC Article | 01/21/2010 |