| Inhibition of 7-dehydrocholesterol reductase prevents hepatic ferroptosis under an active state of sterol synthesis. | Inhibition of 7-dehydrocholesterol reductase prevents hepatic ferroptosis under an active state of sterol synthesis.
Yamada N, Karasawa T, Ito J, Yamamuro D, Morimoto K, Nakamura T, Komada T, Baatarjav C, Saimoto Y, Jinnouchi Y, Watanabe K, Miura K, Yahagi N, Nakagawa K, Matsumura T, Yamada KI, Ishibashi S, Sata N, Conrad M, Takahashi M., Free PMC Article | 03/14/2024 |
| DHCR7 promotes lymph node metastasis in cervical cancer through cholesterol reprogramming-mediated activation of the KANK4/PI3K/AKT axis and VEGF-C secretion. | DHCR7 promotes lymph node metastasis in cervical cancer through cholesterol reprogramming-mediated activation of the KANK4/PI3K/AKT axis and VEGF-C secretion.
Mei X, Xiong J, Liu J, Huang A, Zhu D, Huang Y, Wang H. | 02/28/2024 |
| Zika virus non-structural protein 4B interacts with DHCR7 to facilitate viral infection. | Zika virus non-structural protein 4B interacts with DHCR7 to facilitate viral infection.
Chen W, Li Y, Yu X, Wang Z, Wang W, Rao M, Li Y, Luo Z, Zhang Q, Liu J, Wu J., Free PMC Article | 03/2/2023 |
| Integrated multi-dimensional analysis highlights DHCR7 mutations involving in cholesterol biosynthesis and contributing therapy of gastric cancer. | Integrated multi-dimensional analysis highlights DHCR7 mutations involving in cholesterol biosynthesis and contributing therapy of gastric cancer.
Chen Y, Yan W, Yang K, Qian Y, Chen Y, Wang R, Zhu J, He Y, Wu H, Zhang G, Shi T, Chen W., Free PMC Article | 02/4/2023 |
| High DHCR7 Expression Predicts Poor Prognosis for Cervical Cancer. | High DHCR7 Expression Predicts Poor Prognosis for Cervical Cancer.
Zou J, Liu S, Long J, Yan B., Free PMC Article | 10/15/2022 |
| Genetic variants of vitamin D metabolism-related DHCR7/NADSYN1 locus and CYP2R1 gene are associated with clinical features of Parkinson's disease. | Genetic variants of vitamin D metabolism-related DHCR7/NADSYN1 locus and CYP2R1 gene are associated with clinical features of Parkinson's disease.
Alaylıoğlu M, Dursun E, Genç G, Şengül B, Bilgiç B, Gündüz A, Apaydın H, Kızıltan G, Gürvit H, Hanağası H, Öztop Çakmak Ö, Ertan S, Yılmazer S, Gezen-Ak D. | 06/11/2022 |
| Association of Polymorphisms in Vitamin D-Metabolizing Enzymes DHCR7 and CYP2R1 with Cancer Susceptibility: A Systematic Review and Meta-Analysis. | Association of Polymorphisms in Vitamin D-Metabolizing Enzymes DHCR7 and CYP2R1 with Cancer Susceptibility: A Systematic Review and Meta-Analysis.
Wen J, Li J, Liang X, Wang A., Free PMC Article | 12/11/2021 |
| Vitamin D pathway gene polymorphisms, vitamin D level, and cytokines in children with type 1 diabetes. | Vitamin D pathway gene polymorphisms, vitamin D level, and cytokines in children with type 1 diabetes.
Tangjittipokin W, Umjai P, Khemaprasit K, Charoentawornpanich P, Chanprasert C, Teerawattanapong N, Narkdontri T, Santiprabhob J. | 07/10/2021 |
| Occurrence of c.976 G>T (p.Val326Leu) and c.452 G>A (p.Trp151Ter) variants in DHCR7 gene in population of polish women with recurrent miscarriage. | Occurrence of c.976 G>T (p.Val326Leu) and c.452 G>A (p.Trp151Ter) variants in DHCR7 gene in population of polish women with recurrent miscarriage.
Chrzanowska-Steglińska M, Moczulska H, Skoczylas B, Pietrusiński M, Antosik K, Jakiel P, Kacprzak M, Borowiec M, Sieroszewski P. | 07/3/2021 |
| Smith-Lemli-Opitz syndrome: what is the actual risk for couples carriers of the DHCR7:c.964-1G>C variant? | Smith-Lemli-Opitz syndrome: what is the actual risk for couples carriers of the DHCR7:c.964-1G>C variant?
Daum H, Meiner V, Michaelson-Cohen R, Sukenik-Halevy R, Zalcberg ML, Bar-Ziv A, Weiden AT, Scher SY, Shohat M, Zlotogora J., Free PMC Article | 05/29/2021 |
| Vitamin D Pathway Genetic Variation and Type 1 Diabetes: A Case-Control Association Study. | Vitamin D Pathway Genetic Variation and Type 1 Diabetes: A Case-Control Association Study.
Almeida JT, Rodrigues D, Guimarães J, Lemos MC., Free PMC Article | 03/20/2021 |
| Genetic Variation in Cytochrome P450 2R1 and Vitamin D Binding Protein Genes are associated with Vitamin D Deficiency in Adolescents. | Genetic Variation in Cytochrome P450 2R1 and Vitamin D Binding Protein Genes are associated with Vitamin D Deficiency in Adolescents.
Kelishadi R, Heidari-Beni M, Akbarian SA, Hasan Tajadini M, Haghjooy Javanmard S. | 11/28/2020 |
| [Clinical and genetic analysis of a Chinese pedigree affected with Smith-Lemli-Opitz syndrome]. | [Clinical and genetic analysis of a Chinese pedigree affected with Smith-Lemli-Opitz syndrome].
Gao C, Duan J, Zhang P, Gao Y, Zhang Y, Wang Y, An S, Huang J. | 11/21/2020 |
| Twin enzymes, divergent control: The cholesterogenic enzymes DHCR14 and LBR are differentially regulated transcriptionally and post-translationally. | Twin enzymes, divergent control: The cholesterogenic enzymes DHCR14 and LBR are differentially regulated transcriptionally and post-translationally.
Capell-Hattam IM, Sharpe LJ, Qian L, Hart-Smith G, Prabhu AV, Brown AJ., Free PMC Article | 10/24/2020 |
| Vitamin D Receptor Polymorphism and DHCR7 Contribute to the Abnormal Interplay Between Vitamin D and Lipid Profile in Rheumatoid Arthritis. | Vitamin D Receptor Polymorphism and DHCR7 Contribute to the Abnormal Interplay Between Vitamin D and Lipid Profile in Rheumatoid Arthritis.
Rodríguez-Carrio J, Alperi-López M, Naves-Díaz M, Dusso A, López P, Ballina-García FJ, Cannata-Andía JB, Suárez A., Free PMC Article | 09/19/2020 |
| The authors propose that the DHCR7 inhibitors and 7-dehydrocholesterol are potential therapeutics against emerging or highly pathogenic viruses. | Targeting 7-Dehydrocholesterol Reductase Integrates Cholesterol Metabolism and IRF3 Activation to Eliminate Infection.
Xiao J, Li W, Zheng X, Qi L, Wang H, Zhang C, Wan X, Zheng Y, Zhong R, Zhou X, Lu Y, Li Z, Qiu Y, Liu C, Zhang F, Zhang Y, Xu X, Yang Z, Chen H, Zhai Q, Wei B, Wang H. | 02/8/2020 |
| DHCR7 rs12785878 minor allele was associated with thyroid cancer in Portuguese population. | Association of Vitamin D Pathway Genetic Variation and Thyroid Cancer.
Carvalho IS, Gonçalves CI, Almeida JT, Azevedo T, Martins T, Rodrigues FJ, Lemos MC., Free PMC Article | 01/11/2020 |
| The study detected Smith-Lemli-Opitz syndrome (SLOS) mutations in only 0.7% of stillbirths. This does not support a strong association between unrecognized DHCR7 mutations and stillbirth. | Smith-Lemli-Opitz Mutations in Unexplained Stillbirths.
Gibbins KJ, Reddy UM, Saade GR, Goldenberg RL, Dudley DJ, Parker CB, Thorsten V, Pinar H, Bukowski R, Hogue CJ, Silver RM., Free PMC Article | 10/19/2019 |
| A genetic risk score (GRS) was calculated based on 3 genetic variants [i.e., 7-dehydrocholesterol reductase (DHCR7) rs12785878, cytochrome P450 2R1 (CYP2R1) rs10741657 and group-specific component globulin (GC) rs2282679] related to circulating vitamin D levels. We found a significant interaction between dietary fat intake and vitamin D GRS on 2-y changes in whole-body bone mineral density. | Genetically determined vitamin D levels and change in bone density during a weight-loss diet intervention: the Preventing Overweight Using Novel Dietary Strategies (POUNDS Lost) Trial.
Zhou T, Sun D, Heianza Y, Li X, Champagne CM, LeBoff MS, Shang X, Pei X, Bray GA, Sacks FM, Qi L., Free PMC Article | 09/14/2019 |
| DHCR7 mutations for 2 female fetuses with Smith-Lemli- Opitz syndrome and metatarsal bony syndactyly were analyzed. | Metatarsal bony syndactyly in 2 fetuses with Smith-Lemli-Opitz syndrome: An under-recognized part of the clinical spectrum.
Moosa S, Loeys B, Altmüller J, Mortier G, Nürnberg P, Li Y, Wollnik B, Vogel I. | 07/27/2019 |
| DHCR7 polymorphism is associated with rheumatoid arthritis. | Genotypic variability based association identifies novel non-additive loci DHCR7 and IRF4 in sero-negative rheumatoid arthritis.
Wei WH, Viatte S, Merriman TR, Barton A, Worthington J., Free PMC Article | 02/16/2019 |
| SNPs rs6720173 (ABCG5), rs3808607 (CYP7A1), and rs760241 (DHCR7) may work in conjunction with each other to amplify individual genotyping impacts on serum cholesterol responses to dairy consumption. | The combination of single nucleotide polymorphisms rs6720173 (ABCG5), rs3808607 (CYP7A1), and rs760241 (DHCR7) is associated with differing serum cholesterol responses to dairy consumption.
Abdullah MMH, Eck PK, Couture P, Lamarche B, Jones PJH. | 02/2/2019 |
| aim of this study was to determine the association between single nucleotide polymorphisms (SNPs) of PNPLA3 (rs738409), COX-2 (rs689465) and DHCR7 (rs12785878) and advanced liver fibrosis in Thai patients | The Association of PNPLA3, COX-2 and DHCR7 Polymorphisms with Advanced Liver Fibrosis in Patients with HCV Mono- Infection and HCV/HIV Co-Infection.
Kiatbumrung R, Chuaypen N, Payungporn S, Avihingsanon A, Tangkijvanich P., Free PMC Article | 12/22/2018 |
| pathogenic mutations in DHCR7 protein are located either within the transmembrane region or are near the ligand-binding site, and are highly conserved among species. | Computational Investigation of the Missense Mutations in DHCR7 Gene Associated with Smith-Lemli-Opitz Syndrome.
Peng Y, Myers R, Zhang W, Alexov E., Free PMC Article | 08/4/2018 |
| The DHCR7 polymorphism may be a pre-treatment predictive marker for response to PEG-IFN-based therapy in chronic HCV genotype 1 infection. | Vitamin D-related gene polymorphism predict treatment response to pegylated interferon-based therapy in Thai chronic hepatitis C patients.
Thanapirom K, Suksawatamnuay S, Sukeepaisarnjaroen W, Tangkijvanich P, Treeprasertsuk S, Thaimai P, Wasitthankasem R, Poovorawan Y, Komolmit P., Free PMC Article | 03/24/2018 |