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    DIAPH2 diaphanous related formin 2 [ Homo sapiens (human) ]

    Gene ID: 1730, updated on 2-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    DIAPH2 gene polymorphisms and laryngeal cancer risk in men.

    DIAPH2 gene polymorphisms and laryngeal cancer risk in men.
    Cichocka E, Górczyńska-Kosiorz S, Misiołek M, Ścierski W, Koniewska A, Stryjewska-Makuch G, Gumprecht J., Free PMC Article

    06/14/2024
    DIAPH2, PTPRD and HIC1 Gene Polymorphisms and Laryngeal Cancer Risk.

    DIAPH2, PTPRD and HIC1 Gene Polymorphisms and Laryngeal Cancer Risk.
    Śnit M, Misiołek M, Ścierski W, Koniewska A, Stryjewska-Makuch G, Okła S, Grzeszczak W., Free PMC Article

    08/14/2021
    Low DIAPH2 expression is associated with metastasis of laryngeal squamous cell carcinoma.

    DIAPH2 alterations increase cellular motility and may contribute to the metastatic potential of laryngeal squamous cell carcinoma.
    Kostrzewska-Poczekaj M, Byzia E, Soloch N, Jarmuz-Szymczak M, Janiszewska J, Kowal E, Paczkowska J, Kiwerska K, Wierzbicka M, Bartochowska A, Ustaszewski A, Greczka G, Grenman R, Szyfter K, Giefing M.

    05/30/2020
    DIAPH2 gene expression was an independent prognostic factors of clinical pregnancy rate and live birth in ICSI pregnancies.

    Association between early embryo morphokinetics plus cumulus cell gene expression and assisted reproduction outcomes in polycystic ovary syndrome women.
    Tabibnejad N, Sheikhha MH, Ghasemi N, Fesahat F, Soleimani M, Aflatoonian A.

    04/4/2020
    Low DIA2 expression is associated with breast cancer.

    Carcinoma associated fibroblasts (CAFs) promote breast cancer motility by suppressing mammalian Diaphanous-related formin-2 (mDia2).
    Dvorak KM, Pettee KM, Rubinic-Minotti K, Su R, Nestor-Kalinoski A, Eisenmann KM., Free PMC Article

    07/28/2018
    Data show that diaphanous related formin 1 protein (Dia1) and diaphanous related formin 2 protein (Dia2) facilitated HIV-1-induced microtubule (MT) stabilization and the intracellular motility of virus particles.

    Distinct functions of diaphanous-related formins regulate HIV-1 uncoating and transport.
    Delaney MK, Malikov V, Chai Q, Zhao G, Naghavi MH., Free PMC Article

    06/2/2018
    Dia1, Dia2, and Dia3 are involved in ErbB2-dependent capture of microtubules at the cell leading edge and ErbB2-driven guided migration.

    Essential and nonredundant roles for Diaphanous formins in cortical microtubule capture and directed cell migration.
    Daou P, Hasan S, Breitsprecher D, Baudelet E, Camoin L, Audebert S, Goode BL, Badache A., Free PMC Article

    11/29/2014
    DIAPH2 has been associated with premature ovarian insufficiency, an aging phenotype in humans.

    Identification of genes promoting skin youthfulness by genome-wide association study.
    Chang ALS, Atzmon G, Bergman A, Brugmann S, Atwood SX, Chang HY, Barzilai N., Free PMC Article

    04/12/2014
    In podocytes, INF2 appears to be an important modulator of actin-dependent behaviors that are under the control of Rho/mDia signaling.

    Inverted formin 2 regulates actin dynamics by antagonizing Rho/diaphanous-related formin signaling.
    Sun H, Schlondorff J, Higgs HN, Pollak MR., Free PMC Article

    08/10/2013
    Dia2 and DIP co-tether to nascent blebs and this linkage is required for bleb formation.

    Dia-interacting protein (DIP) imposes migratory plasticity in mDia2-dependent tumor cells in three-dimensional matrices.
    Wyse MM, Lei J, Nestor-Kalinoski AL, Eisenmann KM., Free PMC Article

    02/16/2013
    Long HIV filopodial formation in infected dendritic cells was dependent on the formin diaphanous 2 (Diaph2)

    Mobilization of HIV spread by diaphanous 2 dependent filopodia in infected dendritic cells.
    Aggarwal A, Iemma TL, Shih I, Newsome TP, McAllery S, Cunningham AL, Turville SG., Free PMC Article

    11/17/2012
    Our results indicated that DIAPH2 may be a polygenic pleiotropy for premature ovarian failure (POF) and AMD.

    Simple strategies for haplotype analysis of the X chromosome with application to age-related macular degeneration.
    Jiang R, Dong J, Joo J, Geller NL, Zheng G., Free PMC Article

    10/8/2011
    Observational study of gene-disease association. (HuGE Navigator)

    A large-scale candidate gene association study of age at menarche and age at natural menopause.
    He C, Kraft P, Chasman DI, Buring JE, Chen C, Hankinson SE, Paré G, Chanock S, Ridker PM, Hunter DJ., Free PMC Article

    12/5/2010
    Dia2 plays an important role in formation of lamellipodia.

    Novel roles of formin mDia2 in lamellipodia and filopodia formation in motile cells.
    Yang C, Czech L, Gerboth S, Kojima S, Scita G, Svitkina T., Free PMC Article

    08/5/2010
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