| Mogat1 is a fasting-induced PPARalpha target gene that may feed forward to regulate liver PPARalpha activity during food deprivation | Hepatic monoacylglycerol acyltransferase 1 is induced by prolonged food deprivation to modulate the hepatic fasting response.
Lutkewitte AJ, McCommis KS, Schweitzer GG, Chambers KT, Graham MJ, Wang L, Patti GJ, Hall AM, Finck BN., Free PMC Article | 06/20/2020 |
| Mgat1KO provides a model for investigating the relationship between systemic reductions in glycosylation and cardiac disease, showing that clinically relevant changes in cardiomyocyte hybrid/complex N-glycosylation are sufficient to cause DCM and early death | Reduced myocyte complex N-glycosylation causes dilated cardiomyopathy.
Ednie AR, Deng W, Yip KP, Bennett ES., Free PMC Article | 09/21/2019 |
| MGAT1 activity may play a role in regulating basal adipocyte FFA retention | Metabolic importance of adipose tissue monoacylglycerol acyltransferase 1 in mice and humans.
Liss KHH, Lutkewitte AJ, Pietka T, Finck BN, Franczyk M, Yoshino J, Klein S, Hall AM., Free PMC Article | 09/14/2019 |
| MGAT1 is required to regulate ERK1/2 signaling during spermatogenesis, potentially via different mechanisms. | MGAT1 and Complex N-Glycans Regulate ERK Signaling During Spermatogenesis.
Biswas B, Batista F, Sundaram S, Stanley P., Free PMC Article | 12/22/2018 |
| The MGAT1 interacts with DGAT2, which serves to synergistically increase the TAG biosynthesis and LD expansion, leading to enhancement of lipid accumulation in the liver and fat. | Monoacylglycerol O-acyltransferase 1 (MGAT1) localizes to the ER and lipid droplets promoting triacylglycerol synthesis.
Lee YJ, Kim JW., Free PMC Article | 03/17/2018 |
| this study shows that loss of O-GlcNAc transferase blocks T cell progenitor renewal, malignant transformation and peripheral T cell clonal expansion | Glucose and glutamine fuel protein O-GlcNAcylation to control T cell self-renewal and malignancy.
Swamy M, Pathak S, Grzes KM, Damerow S, Sinclair LV, van Aalten DM, Cantrell DA., Free PMC Article | 06/3/2017 |
| Inhibition of hepatic Mogat1 improves hepatic metabolic abnormalities without attenuating liver inflammation and injury. | Inhibiting monoacylglycerol acyltransferase 1 ameliorates hepatic metabolic abnormalities but not inflammation and injury in mice.
Soufi N, Hall AM, Chen Z, Yoshino J, Collier SL, Mathews JC, Brunt EM, Albert CJ, Graham MJ, Ford DA, Finck BN., Free PMC Article | 02/14/2015 |
| Data from transgenic mice suggest that a lack of complex N- and O-glycans impairs early embryo development and viability in vivo leading to delayed implantation and embryo loss; Mgat1 and C1galt1 are required for embryo development and implantation. | Embryos generated from oocytes lacking complex N- and O-glycans have compromised development and implantation.
Grasa P, Kaune H, Williams SA., Free PMC Article | 03/9/2013 |
| analysis of suppression of cancer progression by MGAT1 shRNA knockdown | Suppression of cancer progression by MGAT1 shRNA knockdown.
Beheshti Zavareh R, Sukhai MA, Hurren R, Gronda M, Wang X, Simpson CD, Maclean N, Zih F, Ketela T, Swallow CJ, Moffat J, Rose DR, Schachter H, Schimmer AD, Dennis JW., Free PMC Article | 02/16/2013 |
| the MGAT1 pathway induced by hepatic PPARgamma is critically important in the development of hepatic steatosis during diet-induced obesity | Nuclear receptor PPARĪ³-regulated monoacylglycerol O-acyltransferase 1 (MGAT1) expression is responsible for the lipid accumulation in diet-induced hepatic steatosis.
Lee YJ, Ko EH, Kim JE, Kim E, Lee H, Choi H, Yu JH, Kim HJ, Seong JK, Kim KS, Kim JW., Free PMC Article | 11/3/2012 |
| essential for spermatogenesis | Complex N-glycans are essential, but core 1 and 2 mucin O-glycans, O-fucose glycans, and NOTCH1 are dispensable, for mammalian spermatogenesis.
Batista F, Lu L, Williams SA, Stanley P., Free PMC Article | 10/20/2012 |
| analysis of developmental and nutritional regulation of monoacylglycerol lipase and monoacylglycerol acyltransferase | Intestinal monoacylglycerol metabolism: developmental and nutritional regulation of monoacylglycerol lipase and monoacylglycerol acyltransferase.
Chon SH, Zhou YX, Dixon JL, Storch J. | 01/21/2010 |
| Mgat1 mutant oocytes had an altered zona pellucida (ZP) that was thinner than the control ZP, and they did not possess complex N-glycans | Inactivation of the Mgat1 gene in oocytes impairs oogenesis, but embryos lacking complex and hybrid N-glycans develop and implant.
Shi S, Williams SA, Seppo A, Kurniawan H, Chen W, Ye Z, Marth JD, Stanley P., Free PMC Article | 01/21/2010 |