| JMJD3 is Involved in Intracranial Aneurysm Development by Regulating DLX2 Expression through H3K27me3 Modification. | JMJD3 is Involved in Intracranial Aneurysm Development by Regulating DLX2 Expression through H3K27me3 Modification.
Wang X, Li N, Li T. | 09/25/2023 |
| DLX2 Is a Potential Immune-Related Prognostic Indicator Associated with Remodeling of Tumor Microenvironment in Lung Squamous Cell Carcinoma: An Integrated Bioinformatical Analysis. | DLX2 Is a Potential Immune-Related Prognostic Indicator Associated with Remodeling of Tumor Microenvironment in Lung Squamous Cell Carcinoma: An Integrated Bioinformatical Analysis.
Huang L, Xie T, Zhao F, Feng Y, Zhu H, Tang L, Han X, Shi Y., Free PMC Article | 11/5/2022 |
| Knockdown of circ_HIPK3 inhibits tumorigenesis of hepatocellular carcinoma via the miR-582-3p/DLX2 axis. | Knockdown of circ_HIPK3 inhibits tumorigenesis of hepatocellular carcinoma via the miR-582-3p/DLX2 axis.
Zhang H, Dai Q, Zheng L, Yuan X, Pan S, Deng J. | 03/20/2021 |
| Expression of ventral telencephalon transcription factors ASCL1 and DLX2 in the early fetal human cerebral cortex. | Expression of ventral telencephalon transcription factors ASCL1 and DLX2 in the early fetal human cerebral cortex.
Alzu'bi A, Clowry GJ., Free PMC Article | 09/12/2020 |
| Results suggest that by up-regulation of Wnt/beta-Catenin signaling, DLX2 accelerated human osteogenic differentiation. | DLX2 activates Wnt1 transcription and mediates Wnt/β-catenin signal to promote osteogenic differentiation of hBMSCs.
Zeng X, Wang Y, Dong Q, Ma MX, Liu XD. | 05/30/2020 |
| Mutant Runx2 regulates amelogenesis and osteogenesis through a miR-185-5p-Dlx2 axis. | Mutant Runx2 regulates amelogenesis and osteogenesis through a miR-185-5p-Dlx2 axis.
Chang H, Wang Y, Liu H, Nan X, Wong S, Peng S, Gu Y, Zhao H, Feng H., Free PMC Article | 07/28/2018 |
| Our results provided evidence that polymorphisms in TIMP1, DLX1 and DLX2 genes may be associated with DF phenotypes. | Polymorphisms in genes involved in enamel development are associated with dental fluorosis.
Küchler EC, Tannure PN, Oliveira DS, Charone S, Nelson-Filho P, Silva RA, Costa MC, Antunes LS, Calasans Maia MD, Antunes LA. | 01/27/2018 |
| Authors characterized a BMP target gene, Distal-less homeobox 2 (DLX2), and found that DLX2 promoted apoptosis and neural differentiation of glioma-initiating cells. | Bone morphogenetic protein signaling mediated by ALK-2 and DLX2 regulates apoptosis in glioma-initiating cells.
Raja E, Komuro A, Tanabe R, Sakai S, Ino Y, Saito N, Todo T, Morikawa M, Aburatani H, Koinuma D, Iwata C, Miyazono K. | 10/14/2017 |
| DLX2 is a novel marker of poor prognosis and sorafenib resistance in patients with hepatocellular carcinoma. | Overexpression of DLX2 is associated with poor prognosis and sorafenib resistance in hepatocellular carcinoma.
Liu J, Cui X, Qu L, Hua L, Wu M, Shen Z, Lu C, Ni R. | 06/3/2017 |
| High Ki67 expression is only present in 6.8% of CaP patients and is predictive of reduced survival and increased risk of metastasis, independent of PSA, Gleason score and D'Amico risk category. DLX2 is a novel marker of increased metastasis risk found in 73% patients and 8.2% showed co-expression with a high Ki67 score | KI67 and DLX2 predict increased risk of metastasis formation in prostate cancer-a targeted molecular approach.
Green WJ, Ball G, Hulman G, Johnson C, Van Schalwyk G, Ratan HL, Soria D, Garibaldi JM, Parkinson R, Hulman J, Rees R, Powe DG., Free PMC Article | 05/20/2017 |
| High DLX-2 expression is associated with epithelial-mesenchymal transition in cancer. | Dlx-2 and glutaminase upregulate epithelial-mesenchymal transition and glycolytic switch.
Lee SY, Jeon HM, Ju MK, Jeong EK, Kim CH, Park HG, Han SI, Kang HS., Free PMC Article | 12/24/2016 |
| DLX2 plays a crucial role in radioresistance, radiation-induced epithelial to mesenchymal transition and cancer stem cell marker expression, and the expression of DLX2 is regulated by Smad2/3 signaling in A549 and MDA-MB-231 cell lines. | Smad2/3-Regulated Expression of DLX2 Is Associated with Radiation-Induced Epithelial-Mesenchymal Transition and Radioresistance of A549 and MDA-MB-231 Human Cancer Cell Lines.
Choi YJ, Baek GY, Park HR, Jo SK, Jung U., Free PMC Article | 08/6/2016 |
| DLX2 expression reduces the protein components of the TTI1/TTI2/TEL2 complex, a key complex required for the proper folding and stabilization of ATM and other members of the PIKK family kinase, leading to reduced ATM-p53 signaling and senescence bypass | A gain-of-function senescence bypass screen identifies the homeobox transcription factor DLX2 as a regulator of ATM-p53 signaling.
Wang Y, Xu Q, Sack L, Kang C, Elledge SJ., Free PMC Article | 06/28/2016 |
| Results showed that Dlx-2 is involved in TGF-beta- and Wnt-induced epithelial-mesenchymal transition, glycolytic switch, and mitochondrial repression by Snail activation. | Dlx-2 is implicated in TGF-β- and Wnt-induced epithelial-mesenchymal, glycolytic switch, and mitochondrial repression by Snail activation.
Lee SY, Jeon HM, Ju MK, Jeong EK, Kim CH, Yoo MA, Park HG, Han SI, Kang HS. | 03/26/2016 |
| The activation of DLX2 signaling might improve tissue regeneration mediated by MSCs of dental origin. Results provide insight into the mechanism underlying the directed differentiation of MSCs of dental origin. | Distal-less homeobox 2 promotes the osteogenic differentiation potential of stem cells from apical papilla.
Qu B, Liu O, Fang X, Zhang H, Wang Y, Quan H, Zhang J, Zhou J, Zuo J, Tang J, Tang Z. | 04/18/2015 |
| Increased expression of DLX2 may correlate with the advanced stage of gastric adenocarcinoma, and it may contribute to tumor development. | Increased expression of DLX2 correlates with advanced stage of gastric adenocarcinoma.
Tang P, Huang H, Chang J, Zhao GF, Lu ML, Wang Y., Free PMC Article | 01/4/2014 |
| overexpression of DLX2 indicated poor survival in the 83 glioblastoma multiforme patients | Upregulation of DLX2 confers a poor prognosis in glioblastoma patients by inducing a proliferative phenotype.
Yan ZH, Bao ZS, Yan W, Liu YW, Zhang CB, Wang HJ, Feng Y, Wang YZ, Zhang W, You G, Zhang QG, Jiang T. | 08/31/2013 |
| Dlx2 (and Dlx1) are required to generate cortical interneurons in the medial ganglionic eminence. | Dlx1&2-dependent expression of Zfhx1b (Sip1, Zeb2) regulates the fate switch between cortical and striatal interneurons.
McKinsey GL, Lindtner S, Trzcinski B, Visel A, Pennacchio LA, Huylebroeck D, Higashi Y, Rubenstein JL., Free PMC Article | 03/9/2013 |
| Dlx-2 may be involved in tumor progression via the regulation of metabolic stress-induced necrosis | Homeobox gene Dlx-2 is implicated in metabolic stress-induced necrosis.
Lee SY, Jeon HM, Kim CH, Ju MK, Bae HS, Park HG, Lim SC, Han SI, Kang HS., Free PMC Article | 02/4/2012 |
| These findings suggest that alterations in DLX1/2 contribute to the biological consequences of FLT3 activation. | Up-regulation of homeodomain genes, DLX1 and DLX2, by FLT3 signaling.
Starkova J, Gadgil S, Qiu YH, Zhang N, Hermanova I, Kornblau SM, Drabkin HA., Free PMC Article | 09/24/2011 |
| MDA-MB-231 breast neoplasms expressed DLX2. | Mutually exclusive expression of DLX2 and DLX5/6 is associated with the metastatic potential of the human breast cancer cell line MDA-MB-231.
Morini M, Astigiano S, Gitton Y, Emionite L, Mirisola V, Levi G, Barbieri O., Free PMC Article | 04/2/2011 |
| The DLX1 and DLX2 genes lie head-to-head in 2q32; the findings support the presence of two functional polymorphisms, one in or near each of the DLX genes that increase susceptibility to, or cause, autism. | The DLX1and DLX2 genes and susceptibility to autism spectrum disorders.
Liu X, Novosedlik N, Wang A, Hudson ML, Cohen IL, Chudley AE, Forster-Gibson CJ, Lewis SM, Holden JJ, Liu X, Novosedlik N, Wang A, Hudson ML, Cohen IL, Chudley AE, Forster-Gibson CJ, Lewis SM, Holden JJ., Free PMC Articles: PMC2986060, PMC2986060 | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (4) articlesMaternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia.
Jugessur A, Shi M, Gjessing HK, Lie RT, Wilcox AJ, Weinberg CR, Christensen K, Boyles AL, Daack-Hirsch S, Nguyen TT, Christiansen L, Lidral AC, Murray JC. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men.
Yerges LM, Klei L, Cauley JA, Roeder K, Kammerer CM, Moffett SP, Ensrud KE, Nestlerode CS, Marshall LM, Hoffman AR, Lewis C, Lang TF, Barrett-Connor E, Ferrell RE, Orwoll ES, Zmuda JM, MrOS Research Group. Polymorphisms of coding trinucleotide repeats of homeogenes in neurodevelopmental psychiatric disorders.
Laroche F, Ramoz N, Leroy S, Fortin C, Rousselot-Paillet B, Philippe A, Colleaux L, Bresson JL, Mogenet A, Golse B, Mouren-Simeoni MC, Gorwood P, Galli T, Simonneau M, Krebs MO, Robel L. The DLX1and DLX2 genes and susceptibility to autism spectrum disorders.
Liu X, Novosedlik N, Wang A, Hudson ML, Cohen IL, Chudley AE, Forster-Gibson CJ, Lewis SM, Holden JJ, Liu X, Novosedlik N, Wang A, Hudson ML, Cohen IL, Chudley AE, Forster-Gibson CJ, Lewis SM, Holden JJ. | 09/10/2008 |
| In corroboration with paired-like homeodomain protein 2 (PITX2) protein kinase C functional studies, a newly identified carboxyl-terminal PITX2 mutation associated with Axenfeld-Rieger syndrome demonstrates reduced phosphorylation. | Protein kinase C phosphorylation modulates N- and C-terminal regulatory activities of the PITX2 homeodomain protein.
Espinoza HM, Ganga M, Vadlamudi U, Martin DM, Brooks BP, Semina EV, Murray JC, Amendt BA. | 01/21/2010 |
| In mice, biological and biochemical observations suggest that functional antagonism through heterodimer formation is a mechanism for regulating the transcriptional actions of Msx and Dlx homeoproteins. | Heterodimerization of Msx and Dlx homeoproteins results in functional antagonism.
Zhang H, Hu G, Wang H, Sciavolino P, Iler N, Shen MM, Abate-Shen C., Free PMC Article | 12/29/2005 |