| A novel DLX3 mutation causes tricho-dento-osseous syndrome with abnormal enamel structure and formation. | A novel DLX3 mutation causes tricho-dento-osseous syndrome with abnormal enamel structure and formation.
Quan J, Liu Y, Ji L, Zhao Y, Zheng S. | 12/6/2023 |
| A heterozygous missense variant in DLX3 leads to uterine leiomyomas and pregnancy losses in a consanguineous Iranian family. | A heterozygous missense variant in DLX3 leads to uterine leiomyomas and pregnancy losses in a consanguineous Iranian family.
Saboori-Darabi S, Carrera P, Akbari A, Amiri-Yekta A, Almadani N, Battista Pipitone G, Shahrokh-Tehraninejad E, Lotfi M, Mazaheri M, Totonchi M. | 03/22/2023 |
| Novel DLX3 variant identified in a family with tricho-dento-osseous syndrome. | Novel DLX3 variant identified in a family with tricho-dento-osseous syndrome.
Liu H, Wang Y, Liu H, Yu M, Zheng J, Feng H, Liu Y, Han D. | 09/10/2022 |
| Salt Dependence of DNA Binding Activity of Human Transcription Factor Dlx3. | Salt Dependence of DNA Binding Activity of Human Transcription Factor Dlx3.
Jin HS, Son J, Seo YJ, Choi SR, Ahn HB, Go Y, Lim J, Oh KI, Ryu KS, Lee JH., Free PMC Article | 09/3/2022 |
| The miR-4739/DLX3 Axis Modulates Bone Marrow-Derived Mesenchymal Stem Cell (BMSC) Osteogenesis Affecting Osteoporosis Progression. | The miR-4739/DLX3 Axis Modulates Bone Marrow-Derived Mesenchymal Stem Cell (BMSC) Osteogenesis Affecting Osteoporosis Progression.
Li D, Yuan Q, Xiong L, Li A, Xia Y., Free PMC Article | 02/12/2022 |
| Loss of DLX3 tumor suppressive function promotes progression of SCC through EGFR-ERBB2 pathway. | Loss of DLX3 tumor suppressive function promotes progression of SCC through EGFR-ERBB2 pathway.
Bajpai D, Mehdizadeh S, Uchiyama A, Inoue Y, Sawaya A, Overmiller A, Brooks SR, Hasneen K, Kellett M, Palazzo E, Motegi SI, Yuspa SH, Cataisson C, Morasso MI., Free PMC Article | 01/22/2022 |
| Effects of DLX3 on the osteogenic differentiation of induced pluripotent stem cellderived mesenchymal stem cells. | Effects of DLX3 on the osteogenic differentiation of induced pluripotent stem cell‑derived mesenchymal stem cells.
Li J, Lin Q, Lin Y, Lai R, Zhang W., Free PMC Article | 05/8/2021 |
| The data implied that DLX3 regulated Wnt/beta-catenin pathway through histone modification of DKK4 during the osteogenic differentiation of bone marrow mesenchymal stem cells. | DLX3 regulates osteogenic differentiation of bone marrow mesenchymal stem cells via Wnt/β-catenin pathway mediated histone methylation of DKK4.
Sun S, Yu M, Fan Z, Yeh IT, Feng H, Liu H, Han D. | 07/18/2020 |
| our results support a putative CD271-DLX3 connection in keratinocytes and foment further studies to identify the signaling events that orchestrate their mutual regulation in the epidermis. DLX3 and CD271 are required for fine tuning the regulation of the epidermal differentiation process. | Do DLX3 and CD271 Protect Human Keratinocytes from Squamous Tumor Development?
Palazzo E, Marconi A, Pincelli C, Morasso MI., Free PMC Article | 12/28/2019 |
| new DLX3 variants found in families with melogenesis imperfecta with attenuated tricho-dento-osseous syndrome | Novel DLX3 variants in amelogenesis imperfecta with attenuated tricho-dento-osseous syndrome.
Whitehouse LLE, Smith CEL, Poulter JA, Brown CJ, Patel A, Lamb T, Brown LR, O'Sullivan EA, Mitchell RE, Berry IR, Charlton R, Inglehearn CF, Mighell AJ., Free PMC Article | 12/28/2019 |
| suggest that MU-DLX3 significantly inhibits hDPCs differentiation via H19/miR-675 axis and provides a new mechanism insight into how MU-DLX3 epigenetically alters H19 methylation status and expression contributes to dentin hypoplasia in Tricho-Dento-Osseous syndrome | DLX3 epigenetically regulates odontoblastic differentiation of hDPCs through H19/miR-675 axis.
Zeng L, Sun S, Dong L, Liu Y, Liu H, Han D, Ma Z, Wang Y, Feng H. | 12/21/2019 |
| Variability in the BMP2 and DLX3 genes was not associated with dental caries in primary and permanent dentition in Czech children | Lack of Association between BMP2/DLX3 Gene Polymorphisms and Dental Caries in Primary and Permanent Dentitions.
Kastovsky J, Borilova Linhartova P, Musilova K, Zackova L, Kukletova M, Kukla L, Izakovicova Holla L. | 09/28/2019 |
| miR-675 regulates the odontogenic differentiation of human dental pulp cells by epigenetic regulating DLX3. | miR-675 promotes odontogenic differentiation of human dental pulp cells by epigenetic regulation of DLX3.
Zeng L, Zhao N, Li F, Han D, Liu Y, Liu H, Sun S, Wang Y, Feng H. | 04/27/2019 |
| our studies demonstrate that DLX3 physically interacts with GCM1 and inhibits its transactivation activity, suggesting that DLX3 and GCM1 may form a complex to functionally regulate placental cell function through modulation of target gene expression. | DLX3 interacts with GCM1 and inhibits its transactivation-stimulating activity in a homeodomain-dependent manner in human trophoblast-derived cells.
Li S, Roberson MS., Free PMC Article | 12/22/2018 |
| Our research of DLX3 mutation protecting aging-related bone loss opens the possibility of its therapeutic potential in bone regeneration and bone loss disease. | Senescence: novel insight into DLX3 mutations leading to enhanced bone formation in Tricho-Dento-Osseous syndrome.
Zhao N, Han D, Liu H, Li Y, Wong SW, Cao Z, Xu J, Zhang X, Cai T, Wang Y, Feng H., Free PMC Article | 06/9/2018 |
| DLX3 expression specifically modulates regulatory networks such as Wnt signaling, phosphatase activity and cell adhesion. | A novel DLX3-PKC integrated signaling network drives keratinocyte differentiation.
Palazzo E, Kellett MD, Cataisson C, Bible PW, Bhattacharya S, Sun HW, Gormley AC, Yuspa SH, Morasso MI., Free PMC Article | 02/3/2018 |
| Novel de novo mutation of DLX3 significantly decreases the proliferation rate and inhibits the odontogenic differentiation and mineralization of hDPCs, suggesting that this novel mutation of DLX3 can influence the dentinogenesis in TDO syndrome. | DLX3 mutation negatively regulates odontogenic differentiation of human dental pulp cells.
Zeng L, Zhao N, Han D, Liu H, Liu Y, Wang Y, Feng H. | 01/27/2018 |
| DLX3 regulates bone marrow mesenchymal stem cell proliferation through H19/miR-675 axis. | DLX3 promotes bone marrow mesenchymal stem cell proliferation through H19/miR-675 axis.
Zhao N, Zeng L, Liu Y, Han D, Liu H, Xu J, Jiang Y, Li C, Cai T, Feng H, Wang Y. | 12/2/2017 |
| Data establish the DLX3-p53 interplay as a major regulatory axis in epidermal differentiation and suggest that DLX3 is a modulator of skin carcinogenesis. | The homeoprotein DLX3 and tumor suppressor p53 co-regulate cell cycle progression and squamous tumor growth.
Palazzo E, Kellett M, Cataisson C, Gormley A, Bible PW, Pietroni V, Radoja N, Hwang J, Blumenberg M, Yuspa SH, Morasso MI., Free PMC Article | 09/23/2017 |
| Identify a novel cis-acting sequence (-369 to -320) at the placental growth factor promoter, which was critical for mediating the basal and DLX3/GCM1-dependent PGF promoter activities. | Dlx3 and GCM-1 functionally coordinate the regulation of placental growth factor in human trophoblast-derived cells.
Li S, Roberson MS. | 09/23/2017 |
| We showed that the supplementation of the osteogenic differentiation medium with PTHrP inhibited the alkaline phosphatase activity and the expression of the transcription factor DLX3, but the depletion of PTHrP did not support the differentiation of DFCs.We showed that SUFU (Suppressor Of Fused Homolog) was not regulated during the osteogenic differentiation in DFCs | The parathyroid hormone-related protein is secreted during the osteogenic differentiation of human dental follicle cells and inhibits the alkaline phosphatase activity and the expression of DLX3.
Klingelhöffer C, Reck A, Ettl T, Morsczeck C. | 03/25/2017 |
| we identified a recurrent 2-bp deletion in the DLX3 gene in a new family and described their mild clinical phenotype related to the DLX3 mutation. | Unexpected identification of a recurrent mutation in the DLX3 gene causing amelogenesis imperfecta.
Kim YJ, Seymen F, Koruyucu M, Kasimoglu Y, Gencay K, Shin TJ, Hyun HK, Lee ZH, Kim JW. | 02/4/2017 |
| genetic analysis revealed a novel de novo missense mutation c.533A>G (p.Q178R) in the conserved homeodomain of the DLX3 gene. This DLX3 mutation is the sixth causative mutation for TDO to be identified so far. | Morphological analyses and a novel de novo DLX3 mutation associated with tricho-dento-osseous syndrome in a Chinese family.
Li Y, Han D, Zhang H, Liu H, Wong S, Zhao N, Qiu L, Feng H. | 12/17/2016 |
| ER-alpha regulates the osteoblast differentiation through modulation of Dlx3 expression and/or interaction with Dlx3. | Estrogen Receptor α Regulates Dlx3-Mediated Osteoblast Differentiation.
Lee SH, Oh KN, Han Y, Choi YH, Lee KY., Free PMC Article | 11/5/2016 |
| Results suggest that Dlx3 is a novel target of PKA, and that PKA mediates BMP signaling during osteoblast differentiation, at least in part, by phosphorylating Dlx3 and modulating its stability and function. | Protein kinase a phosphorylates Dlx3 and regulates the function of Dlx3 during osteoblast differentiation.
Li H, Jeong HM, Choi YH, Kim JH, Choi JK, Yeo CY, Jeong HG, Jeong TC, Chun C, Lee KY. | 10/31/2015 |