| Touch receptor end-organ innervation and function require sensory neuron expression of the transcription factor Meis2. | Touch receptor end-organ innervation and function require sensory neuron expression of the transcription factor Meis2.
Desiderio S, Schwaller F, Tartour K, Padmanabhan K, Lewin GR, Carroll P, Marmigere F., Free PMC Article | 03/5/2024 |
| The neuronal transcription factor MEIS2 is a calpain-2 protease target. | The neuronal transcription factor MEIS2 is a calpain-2 protease target.
Müller T, Reichlmeir M, Hau AC, Wittig I, Schulte D., Free PMC Article | 02/29/2024 |
| The autism-associated Meis2 gene is necessary for cardiac baroreflex regulation in mice. | The autism-associated Meis2 gene is necessary for cardiac baroreflex regulation in mice.
Roussel J, Larcher R, Sicard P, Bideaux P, Richard S, Marmigère F, Thireau J., Free PMC Article | 01/28/2023 |
| Dlx1/2-dependent expression of Meis2 promotes neuronal fate determination in the mammalian striatum. | Dlx1/2-dependent expression of Meis2 promotes neuronal fate determination in the mammalian striatum.
Su Z, Wang Z, Lindtner S, Yang L, Shang Z, Tian Y, Guo R, You Y, Zhou W, Rubenstein JL, Yang Z, Zhang Z., Free PMC Article | 03/12/2022 |
| Neural crest cells require Meis2 for patterning the mandibular arch via the Sonic hedgehog pathway. | Neural crest cells require Meis2 for patterning the mandibular arch via the Sonic hedgehog pathway.
Fabik J, Kovacova K, Kozmik Z, Machon O., Free PMC Article | 10/2/2021 |
| Control of mouse limb initiation and antero-posterior patterning by Meis transcription factors. | Control of mouse limb initiation and antero-posterior patterning by Meis transcription factors.
Delgado I, Giovinazzo G, Temiño S, Gauthier Y, Balsalobre A, Drouin J, Torres M., Free PMC Article | 06/19/2021 |
| Axial skeleton anterior-posterior patterning is regulated through feedback regulation between Meis transcription factors and retinoic acid. | Axial skeleton anterior-posterior patterning is regulated through feedback regulation between Meis transcription factors and retinoic acid.
López-Delgado AC, Delgado I, Cadenas V, Sánchez-Cabo F, Torres M. | 04/24/2021 |
| The transcriptional regulator MEIS2 sets up the ground state for palatal osteogenesis in mice. | The transcriptional regulator MEIS2 sets up the ground state for palatal osteogenesis in mice.
Wang L, Tang Q, Xu J, Li H, Yang T, Li L, Machon O, Hu T, Chen Y., Free PMC Article | 12/19/2020 |
| Methylation impairs interaction with CRM1 without affecting PBX1 dimerization and thereby allows MEIS2 nuclear accumulation, a prerequisite for neuronal differentiation. | Arginine Methylation Regulates MEIS2 Nuclear Localization to Promote Neuronal Differentiation of Adult SVZ Progenitors.
Kolb J, Anders-Maurer M, Müller T, Hau AC, Grebbin BM, Kallenborn-Gerhardt W, Behrends C, Schulte D., Free PMC Article | 04/27/2019 |
| a previously unknown link between PcG proteins and downregulation of RA-related signals to mediate the phase transition of Meis2 transcriptional status during forelimb patterning, is reported. | Variant PRC1 competes with retinoic acid-related signals to repress Meis2 in the mouse distal forelimb bud.
Yakushiji-Kaminatsui N, Kondo T, Hironaka KI, Sharif J, Endo TA, Nakayama M, Masui O, Koseki Y, Kondo K, Ohara O, Vidal M, Morishita Y, Koseki H. | 02/16/2019 |
| Study identifies Meis2 as a subclass-specific marker for 5-HT3AR-containing interstitial interneurons and demonstrates that the transcriptional and anatomical parcellation of cortical interneurons is developmentally coupled. | Transcriptomic and anatomic parcellation of 5-HT(3A)R expressing cortical interneuron subtypes revealed by single-cell RNA sequencing.
Frazer S, Prados J, Niquille M, Cadilhac C, Markopoulos F, Gomez L, Tomasello U, Telley L, Holtmaat A, Jabaudon D, Dayer A., Free PMC Article | 11/24/2018 |
| identified Meis2 as critical to MN1-induced leukemia, with essential roles in proliferation, self-renewal, impairment of differentiation and disease progression in vitro and in vivo. | Meis2 as a critical player in MN1-induced leukemia.
Lai CK, Norddahl GL, Maetzig T, Rosten P, Lohr T, Sanchez Milde L, von Krosigk N, Docking TR, Heuser M, Karsan A, Humphries RK., Free PMC Article | 09/1/2018 |
| MEIS2 associates with chromatin-bound PBX1, recruits PARP1/ARTD1, and initiates PARP1-mediated eviction of H1 from the chromatin fiber. | MEIS homeodomain proteins facilitate PARP1/ARTD1-mediated eviction of histone H1.
Hau AC, Grebbin BM, Agoston Z, Anders-Maurer M, Müller T, Groß A, Kolb J, Langer JD, Döring C, Schulte D., Free PMC Article | 10/7/2017 |
| An intrinsic constitutively activated feedforward signaling circuit composed of IkappaBalpha/NF-kappaB(p65), miR-196b-3p, Meis2, and PPP3CC is formed during the emergence of castration-resistant prostate cancer. | A Constitutive Intrinsic Inflammatory Signaling Circuit Composed of miR-196b, Meis2, PPP3CC, and p65 Drives Prostate Cancer Castration Resistance.
Jeong JH, Park SJ, Dickinson SI, Luo JL., Free PMC Article | 10/7/2017 |
| Hoxa2, Meis and Pbx proteins act cooperatively on the ECR, via a core 32 bp sequence, to regulate Hmx1 expression. | A distal 594 bp ECR specifies Hmx1 expression in pinna and lateral facial morphogenesis and is regulated by the Hox-Pbx-Meis complex.
Rosin JM, Li W, Cox LL, Rolfe SM, Latorre V, Akiyama JA, Visel A, Kuramoto T, Bobola N, Turner EE, Cox TC., Free PMC Article | 09/9/2017 |
| We found that expression of Emx2 and Lhx2 initiated between neuronal progenitor and neuronal precursor stages. As far as the sensory neurons of the vomeronasal organ are concerned, Meis1 and Meis2 were only expressed in the apical layer, together with Gnai2, but not in the basal layer. | Expression patterns of homeobox genes in the mouse vomeronasal organ at postnatal stages.
Chang I, Parrilla M. | 05/27/2017 |
| we show that simultaneous deletion of Meis1 and Meis2 in presumptive lens ectoderm results in arrested lens development in the pre-placodal stage, and neither lens placode nor lens is formed. We found that in the presumptive lens ectoderm of Meis1/Meis2 deficient embryos Pax6 expression is absent | The Gene Regulatory Network of Lens Induction Is Wired through Meis-Dependent Shadow Enhancers of Pax6.
Antosova B, Smolikova J, Klimova L, Lachova J, Bendova M, Kozmikova I, Machon O, Kozmik Z., Free PMC Article | 05/13/2017 |
| Meis2-null mice are embryonic lethal. The results reveal a critical role of Meis2 during cranial and cardiac neural crest cells development in mouse. | Meis2 is essential for cranial and cardiac neural crest development.
Machon O, Masek J, Machonova O, Krauss S, Kozmik Z., Free PMC Article | 09/3/2016 |
| Data suggest that the RING1-MEIS1/2 axis is regulated by early PD signals and contributes to the initiation or maintenance of the distal signal circuitry. | RING1 proteins contribute to early proximal-distal specification of the forelimb bud by restricting Meis2 expression.
Yakushiji-Kaminatsui N, Kondo T, Endo TA, Koseki Y, Kondo K, Ohara O, Vidal M, Koseki H. | 05/28/2016 |
| Interaction of Meis2 promoter with midbrain enhancer depends on RING1. | Polycomb potentiates meis2 activation in midbrain by mediating interaction of the promoter with a tissue-specific enhancer.
Kondo T, Isono K, Kondo K, Endo TA, Itohara S, Vidal M, Koseki H. | 03/22/2014 |
| Meis2 cooperates with Pax6 in generic neurogenesis and dopaminergic fate specification in the adult subventricular zone-olfactory bulb system. | Meis2 is a Pax6 co-factor in neurogenesis and dopaminergic periglomerular fate specification in the adult olfactory bulb.
Agoston Z, Heine P, Brill MS, Grebbin BM, Hau AC, Kallenborn-Gerhardt W, Schramm J, Götz M, Schulte D. | 03/15/2014 |
| Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators., Free PMC Article | 09/15/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium., Free PMC Article | 09/15/2010 |
| Retinal progenitor cells (RPCs) in chicks and mice express two Hth-related proteins, Meis1 and Meis2. | Evidence for an evolutionary conserved role of homothorax/Meis1/2 during vertebrate retina development.
Heine P, Dohle E, Bumsted-O'Brien K, Engelkamp D, Schulte D. | 01/21/2010 |
| These data identify Meis2 as a marker for the study of amacrine cell diversity and development in addition to providing evidence for the stepwise specification of the glycinergic and GABAergic neurotransmitter phenotypes during AM cell differentiation. | Expression of the homeodomain transcription factor Meis2 in the embryonic and postnatal retina.
Bumsted-O'Brien KM, Hendrickson A, Haverkamp S, Ashery-Padan R, Schulte D. | 01/21/2010 |