| FMRP regulates postnatal neuronal migration via MAP1B. | FMRP regulates postnatal neuronal migration via MAP1B.
Messaoudi S, Allam A, Stoufflet J, Paillard T, Le Ven A, Fouquet C, Doulazmi M, Trembleau A, Caille I., Free PMC Article | 07/19/2024 |
| The role of Map1b in regulating osteoblast polarity, proliferation, differentiation and migration. | The role of Map1b in regulating osteoblast polarity, proliferation, differentiation and migration.
Peng L, Zhang D, Tu H, Wu D, Xiang S, Yang W, Zhao Y, Yang J. | 03/5/2024 |
| Microtubule-associated protein 1B dysregulates microtubule dynamics and neuronal mitochondrial transport in spinal muscular atrophy. | Microtubule-associated protein 1B dysregulates microtubule dynamics and neuronal mitochondrial transport in spinal muscular atrophy.
Bora G, Hensel N, Rademacher S, Koyunoğlu D, Sunguroğlu M, Aksu-Mengeş E, Balcı-Hayta B, Claus P, Erdem-Yurter H. | 09/25/2021 |
| FMRP-absence-induced up-regulation of hypothalamic MAP1B expression decreases AgRP level linking with reduces in food intake and body weight. | FMRP-absence-induced up-regulation of hypothalamic MAP1B expression decreases AgRP level linking with reduces in food intake and body weight.
Long JY, Jiang W, Xia HB, Fu JY, Lu P, Hu F, Feng WC, Sun WW, Gao MM, Yi YH, Long YS. | 09/4/2021 |
| MAP 1B phosphorylation sites are specifically involved in axon growth. | Phosphorylation sites of microtubule-associated protein 1B (MAP 1B) are involved in axon growth and regeneration.
Ishikawa Y, Okada M, Honda A, Ito Y, Tamada A, Endo N, Igarashi M., Free PMC Article | 06/13/2020 |
| These data provide independent confirmation in a mouse model with combined PARK1/PARK4/PARK6 pathology that MAP1B/ANK2 phosphorylation events are implicated in Parkinsonian neurodegeneration. | SerThr-PhosphoProteome of Brain from Aged PINK1-KO+A53T-SNCA Mice Reveals pT1928-MAP1B and pS3781-ANK2 Deficits, as Hub between Autophagy and Synapse Changes.
Auburger G, Gispert S, Torres-Odio S, Jendrach M, Brehm N, Canet-Pons J, Key J, Sen NE., Free PMC Article | 12/14/2019 |
| Calpain-10 regulates actin dynamics by proteolysis of microtubule-associated protein 1B | Calpain-10 regulates actin dynamics by proteolysis of microtubule-associated protein 1B.
Hatta T, Iemura SI, Ohishi T, Nakayama H, Seimiya H, Yasuda T, Iizuka K, Fukuda M, Takeda J, Natsume T, Horikawa Y., Free PMC Article | 11/2/2019 |
| Data show that loss of MAP1B function affects general cognitive ability through a profound, brain-wide WM deficit with likely disordered or compromised axons. | MAP1B mutations cause intellectual disability and extensive white matter deficit.
Walters GB, Gustafsson O, Sveinbjornsson G, Eiriksdottir VK, Agustsdottir AB, Jonsdottir GA, Steinberg S, Gunnarsson AF, Magnusson MI, Unnsteinsdottir U, Lee AL, Jonasdottir A, Sigurdsson A, Jonasdottir A, Skuladottir A, Jonsson L, Nawaz MS, Sulem P, Frigge M, Ingason A, Love A, Norddhal GL, Zervas M, Gudbjartsson DF, Ulfarsson MO, Saemundsen E, Stefansson H, Stefansson K., Free PMC Article | 12/22/2018 |
| MAP1B knockout neurons display a decrease in the density of presynaptic and postsynaptic terminals, which involves a reduction in the density of synaptic contacts, and an increased proportion of orphan presynaptic terminals. MAP1B knockout neurons present altered synaptic vesicle fusion events, and a decrease in the density of both synaptic vesicles and dense core vesicles at presynaptic terminals. | Microtubule-associated protein 1B (MAP1B)-deficient neurons show structural presynaptic deficiencies in vitro and altered presynaptic physiology.
Bodaleo FJ, Montenegro-Venegas C, Henríquez DR, Court FA, Gonzalez-Billault C., Free PMC Article | 04/14/2018 |
| MAP1B restricts the access of AMPARs to dendritic spines and the postsynaptic membrane, contributing to downregulating synaptic transmission | MAP1B Light Chain Modulates Synaptic Transmission via AMPA Receptor Intracellular Trapping.
Palenzuela R, Gutiérrez Y, Draffin JE, Lario A, Benoist M, Esteban JA., Free PMC Article | 10/28/2017 |
| MAP1B confers increased stability to tyrosinated and acetylated, but not detyrosinated microtubules. | The GSK3-MAP1B pathway controls neurite branching and microtubule dynamics.
Barnat M, Benassy MN, Vincensini L, Soares S, Fassier C, Propst F, Andrieux A, von Boxberg Y, Nothias F. | 12/24/2016 |
| Both FMRP deficiency in Fmr1(I304N) mice and Fmr1 knockdown impeded the axonal delivery of miR-181d, Map1b, and Calm1 and reduced the protein levels of MAP1B and calmodulin in axons. | FMRP-Mediated Axonal Delivery of miR-181d Regulates Axon Elongation by Locally Targeting Map1b and Calm1.
Wang B, Pan L, Wei M, Wang Q, Liu WW, Wang N, Jiang XY, Zhang X, Bao L. | 11/5/2016 |
| MAP1B is a specific marker protein of the podocyte microtubular cytoskeleton. | Microtubule Associated Protein 1b (MAP1B) Is a Marker of the Microtubular Cytoskeleton in Podocytes but Is Not Essential for the Function of the Kidney Filtration Barrier in Mice.
Gödel M, Temerinac D, Grahammer F, Hartleben B, Kretz O, Riederer BM, Propst F, Kohl S, Huber TB., Free PMC Article | 06/4/2016 |
| Although MAP1A and MAP1B protein levels are not affected in the tulp1-/- retina, they are no longer localized to the outer segment of photoreceptors. | Interaction of tubby-like protein-1 (Tulp1) and microtubule-associated protein (MAP) 1A and MAP1B in the mouse retina.
Grossman GH, Beight CD, Ebke LA, Pauer GJ, Hagstrom SA. | 07/26/2014 |
| The morphology, phenotype, regional distribution, proliferative dynamics, and stage-specific marker expression of Map5 cells in the rabbit and mouse central nervous system, were characterized. | Cellular and molecular characterization of multipolar Map5-expressing cells: a subset of newly generated, stage-specific parenchymal cells in the mammalian central nervous system.
Crociara P, Parolisi R, Conte D, Fumagalli M, Bonfanti L., Free PMC Article | 12/21/2013 |
| The MAP1B-Tiam1-Rac1 relay is essential for spine structural plasticity and removal of AMPA receptors from synapses during long-term depression. | MAP1B-dependent Rac activation is required for AMPA receptor endocytosis during long-term depression.
Benoist M, Palenzuela R, Rozas C, Rojas P, Tortosa E, Morales B, González-Billault C, Ávila J, Esteban JA., Free PMC Article | 11/2/2013 |
| MAP1B interacts directly with EB1 and EB3 (EBs), two core 'microtubule plus-end tracking proteins' ( TIPs), and sequesters them in the cytosol of developing neuronal cells. | MAP1B regulates microtubule dynamics by sequestering EB1/3 in the cytosol of developing neuronal cells.
Tortosa E, Galjart N, Avila J, Sayas CL., Free PMC Article | 06/29/2013 |
| MKK7 is specifically phosphorylated in the neurite shaft which triggers Map1b phosphorylation to regulate microtubule bundling leading to neurite elongation. | Growth cone MKK7 mRNA targeting regulates MAP1b-dependent microtubule bundling to control neurite elongation.
Feltrin D, Fusco L, Witte H, Moretti F, Martin K, Letzelter M, Fluri E, Scheiffele P, Pertz O., Free PMC Article | 05/25/2013 |
| The interaction between the conserved COOH-terminal 125-amino acid domain (which is located in the light chains of MAP1A, MAP1B, and MAP1S) and alpha1-syntrophin is direct and occurs through the pleckstrin homology domain 2 (PH2). | The light chains of microtubule-associated proteins MAP1A and MAP1B interact with α1-syntrophin in the central and peripheral nervous system.
Fuhrmann-Stroissnigg H, Noiges R, Descovich L, Fischer I, Albrecht DE, Nothias F, Froehner SC, Propst F., Free PMC Article | 05/11/2013 |
| Mutation of the Map1b binding site of Na(v)1.6 prevented generation of sodium current in transfected cells. The data indicate that Map1b facilitates trafficking of Na(v)1.6 to the neuronal cell surface | Interaction of voltage-gated sodium channel Nav1.6 (SCN8A) with microtubule-associated protein Map1b.
O'Brien JE, Sharkey LM, Vallianatos CN, Han C, Blossom JC, Yu T, Waxman SG, Dib-Hajj SD, Meisler MH., Free PMC Article | 08/18/2012 |
| Microtubule associated protein 1B, a microtubule stabilizing protein, and clathrin heavy chain, the major component of the clathrin triskelion, were identified as interaction partners for dystonin-a | MAP1B and clathrin are novel interacting partners of the giant cyto-linker dystonin.
Bhanot K, Young KG, Kothary R. | 03/10/2012 |
| important role for MAP1B in the formation and maturation of dendritic spines | Microtubule-associated protein 1B (MAP1B) is required for dendritic spine development and synaptic maturation.
Tortosa E, Montenegro-Venegas C, Benoist M, Härtel S, González-Billault C, Esteban JA, Avila J., Free PMC Article | 01/21/2012 |
| HuD simultaneously binds both RNA and MAP1B-light chain 1 (MAP1B-LC1) in vitro and that it tightly associates with microtubules in cells in an LC1-dependent manner | Microtubule association of a neuronal RNA-binding protein HuD through its binding to the light chain of MAP1B.
Fujiwara Y, Kasashima K, Saito K, Fukuda M, Fukao A, Sasano Y, Inoue K, Fujiwara T, Sakamoto H. | 09/17/2011 |
| MAP1S and MAP1B both are involved in regulating trafficking of NR3A-containing NMDAR. | MAP1B binds to the NMDA receptor subunit NR3A and affects NR3A protein concentrations.
Eriksson M, Samuelsson H, Björklund S, Tortosa E, Avila J, Samuelsson EB, Benedikz E, Sundström E. | 07/5/2010 |
| Nonprimed and DYRK1A-primed GSK3 beta-phosphorylation sites on MAP1B regulate microtubule dynamics in growing axons. | Nonprimed and DYRK1A-primed GSK3 beta-phosphorylation sites on MAP1B regulate microtubule dynamics in growing axons.
Scales TM, Lin S, Kraus M, Goold RG, Gordon-Weeks PR., Free PMC Article | 01/21/2010 |