| A dual-acting DNASE1/DNASE1L3 biologic prevents autoimmunity and death in genetic and induced lupus models. | A dual-acting DNASE1/DNASE1L3 biologic prevents autoimmunity and death in genetic and induced lupus models.
Stabach PR, Sims D, Gomez-Bañuelos E, Zehentmeier S, Dammen-Brower K, Bernhisel A, Kujawski S, Lopez SG, Petri M, Goldman DW, Lester ER, Le Q, Ishaq T, Kim H, Srivastava S, Kumar D, Pereira JP, Yarema KJ, Koumpouras F, Andrade F, Braddock DT., Free PMC Article | 09/20/2024 |
| Double-negative B cells and DNASE1L3 colocalise with microbiota in gut-associated lymphoid tissue. | Double-negative B cells and DNASE1L3 colocalise with microbiota in gut-associated lymphoid tissue.
Montorsi L, Pitcher MJ, Zhao Y, Dionisi C, Demonti A, Tull TJ, Dhami P, Ellis RJ, Bishop C, Sanderson JD, Jain S, D'Cruz D, Gibbons DL, Winkler TH, Bemark M, Ciccarelli FD, Spencer J., Free PMC Article | 07/16/2024 |
| Deoxyribonuclease 1-like 3 inhibits colorectal malignancy through antagonizing NEDD4-triggered CDKN1A ubiquitination. | Deoxyribonuclease 1-like 3 inhibits colorectal malignancy through antagonizing NEDD4-triggered CDKN1A ubiquitination.
Yu L, Huang J. | 02/16/2024 |
| [Decreased DNase1L3 secretion and associated antibodies induce impaired degradation of NETs in patients with sporadic SLE]. | [Decreased DNase1L3 secretion and associated antibodies induce impaired degradation of NETs in patients with sporadic SLE].
Huang J, Mao T, Zhang J, Li Z, Wu Q. | 01/29/2024 |
| Reduced digestion of circulating genomic DNA in systemic sclerosis patients with the DNASE1L3 R206C variant. | Reduced digestion of circulating genomic DNA in systemic sclerosis patients with the DNASE1L3 R206C variant.
Skaug B, Guo X, Li YJ, Charles J, Pham KT, Couturier J, Lewis DE, Bracaglia C, Caiello I, Mayes MD, Assassi S., Free PMC Article | 11/6/2023 |
| DNASE1L3 inhibits hepatocellular carcinoma by delaying cell cycle progression through CDK2. | DNASE1L3 inhibits hepatocellular carcinoma by delaying cell cycle progression through CDK2.
Sun J, Wang X, Shen Q, Wang M, Chen S, Zhang X, Huang Y, Zhang Z, Li W, Yuan Y, Huang Z. | 12/24/2022 |
| DNASE1L3 deficiency, new phenotypes, and evidence for a transient type I IFN signaling. | DNASE1L3 deficiency, new phenotypes, and evidence for a transient type I IFN signaling.
Tusseau M, Lovšin E, Samaille C, Pescarmona R, Mathieu AL, Maggio MC, Selmanović V, Debeljak M, Dachy A, Novljan G, Janin A, Januel L, Gibier JB, Chopin E, Rouvet I, Goncalves D, Fabien N, Rice GI, Lesca G, Labalme A, Romagnani P, Walzer T, Viel S, Perret M, Crow YJ, Avčin T, Cimaz R, Belot A. | 10/15/2022 |
| DNASE1L3 inhibits proliferation, invasion and metastasis of hepatocellular carcinoma by interacting with beta-catenin to promote its ubiquitin degradation pathway. | DNASE1L3 inhibits proliferation, invasion and metastasis of hepatocellular carcinoma by interacting with β-catenin to promote its ubiquitin degradation pathway.
Li B, Ge YZ, Yan WW, Gong B, Cao K, Zhao R, Li C, Zhang YW, Jiang YH, Zuo S., Free PMC Article | 09/17/2022 |
| Arg206Cys substitution in DNASE1L3 causes a defect in DNASE1L3 protein secretion that confers risk of systemic lupus erythematosus. | Arg206Cys substitution in DNASE1L3 causes a defect in DNASE1L3 protein secretion that confers risk of systemic lupus erythematosus.
Coke LN, Wen H, Comeau M, Ghanem MH, Shih A, Metz CN, Li W, Langefeld CD, Gregersen PK, Simpfendorfer KR., Free PMC Article | 07/2/2022 |
| Autoantibody-mediated impairment of DNASE1L3 activity in sporadic systemic lupus erythematosus. | Autoantibody-mediated impairment of DNASE1L3 activity in sporadic systemic lupus erythematosus.
Hartl J, Serpas L, Wang Y, Rashidfarrokhi A, Perez OA, Sally B, Sisirak V, Soni C, Khodadadi-Jamayran A, Tsirigos A, Caiello I, Bracaglia C, Volpi S, Ghiggeri GM, Chida AS, Sanz I, Kim MY, Belmont HM, Silverman GJ, Clancy RM, Izmirly PM, Buyon JP, Reizis B., Free PMC Article | 10/9/2021 |
| A deoxyribonuclease 1-like 3 genetic variant associates with asthma exacerbations. | A deoxyribonuclease 1-like 3 genetic variant associates with asthma exacerbations.
Herrera-Luis E, Lorenzo-Diaz F, Samedy-Bates LA, Eng C, Villar J, Rodriguez-Santana JR, Burchard EG, Pino-Yanes M., Free PMC Article | 09/25/2021 |
| The Nexus of cfDNA and Nuclease Biology. | The Nexus of cfDNA and Nuclease Biology.
Han DSC, Lo YMD. | 09/11/2021 |
| DNase1L3 suppresses hepatocellular carcinoma growth via inhibiting complement autocrine effect. | DNase1L3 suppresses hepatocellular carcinoma growth via inhibiting complement autocrine effect.
Chen QY, Li L, Suo DQ. | 08/14/2021 |
| DNASE1L3 arrests tumor angiogenesis by impairing the senescence-associated secretory phenotype in response to stress. | DNASE1L3 arrests tumor angiogenesis by impairing the senescence-associated secretory phenotype in response to stress.
Guo D, Ma D, Liu P, Lan J, Liu Z, Liu Q., Free PMC Article | 07/31/2021 |
| Deoxyribonuclease 1-like 3 may be a potential prognostic biomarker associated with immune infiltration in colon cancer. | Deoxyribonuclease 1-like 3 may be a potential prognostic biomarker associated with immune infiltration in colon cancer.
Liu J, Yi J, Zhang Z, Cao D, Li L, Yao Y., Free PMC Article | 07/24/2021 |
| Association of the DNASE1L3 rs35677470 polymorphism with systemic lupus erythematosus, rheumatoid arthritis and systemic sclerosis: Structural biological insights. | Association of the DNASE1L3 rs35677470 polymorphism with systemic lupus erythematosus, rheumatoid arthritis and systemic sclerosis: Structural biological insights.
Zervou MI, Andreou A, Matalliotakis M, Spandidos DA, Goulielmos GN, Eliopoulos EE., Free PMC Article | 05/15/2021 |
| Homeostatic Milieu Induces Production of Deoxyribonuclease 1-like 3 from Myeloid Cells. | Homeostatic Milieu Induces Production of Deoxyribonuclease 1-like 3 from Myeloid Cells.
Inokuchi S, Mitoma H, Kawano S, Nakano S, Ayano M, Kimoto Y, Akahoshi M, Arinobu Y, Tsukamoto H, Akashi K, Horiuchi T, Niiro H. | 01/2/2021 |
| Plasma DNA Profile Associated with DNASE1L3 Gene Mutations: Clinical Observations, Relationships to Nuclease Substrate Preference, and In Vivo Correction. | Plasma DNA Profile Associated with DNASE1L3 Gene Mutations: Clinical Observations, Relationships to Nuclease Substrate Preference, and In Vivo Correction.
Chan RWY, Serpas L, Ni M, Volpi S, Hiraki LT, Tam LS, Rashidfarrokhi A, Wong PCH, Tam LHP, Wang Y, Jiang P, Cheng ASH, Peng W, Han DSC, Tse PPP, Lau PK, Lee WS, Magnasco A, Buti E, Sisirak V, AlMutairi N, Chan KCA, Chiu RWK, Reizis B, Lo YMD., Free PMC Article | 12/12/2020 |
| Six gene and TH2 signature expression in endobronchial biopsies of participants with asthma. | Six gene and TH2 signature expression in endobronchial biopsies of participants with asthma.
Sánchez-Ovando S, Baines KJ, Barker D, Wark PA, Simpson JL., Free PMC Article | 12/12/2020 |
| Serum Deoxyribonuclease 1-like 3 is a potential biomarker for diagnosis of ankylosing spondylitis. | Serum Deoxyribonuclease 1-like 3 is a potential biomarker for diagnosis of ankylosing spondylitis.
Sun Y, Ouyang B, Xie Q, Wang L, Zhu S, Jia Y. | 09/26/2020 |
| Study of the copy number variations (CNVs) for DNASE1L3 and DNASE2 in Japanese and German populations found that only 2 diploid copy numbers for these DNASE CNVs was distributed in both populations; no copy loss or gain was evident for any of the autoimmune-related DNase genes. These human autoimmune-related DNase genes show low genetic diversity of CNVs resulting in alterations of the in vivo levels of DNase activity. | Low genetic heterogeneity of copy number variations (CNVs) in the genes encoding the human deoxyribonucleases 1-like 3 and II potentially relevant to autoimmunity.
Ueki M, Fujihara J, Kimura-Kataoka K, Yamada K, Takinami Y, Takeshita H, Iida R, Yasuda T., Free PMC Article | 02/15/2020 |
| The authors found a significant reduction in serum DNase1l3 level in dermatomyositis/polymyositis and systemic lupus erythematosus, which may associate with clinic features and disease activity. | Serum level of DNase1l3 in patients with dermatomyositis/polymyositis, systemic lupus erythematosus and rheumatoid arthritis, and its association with disease activity.
Zhao Q, Yang C, Wang J, Li Y, Yang P. | 06/9/2018 |
| Single nucleotide polymorphisms producing a loss-of-function variant of the enzymes in DNASE1, DNASE1L3, and DNASE2, possibly serving as a genetic risk factor for autoimmune diseases, were confirmed. | Functional Single Nucleotide Polymorphisms (SNPs) in the Genes Encoding the Human Deoxyribonuclease (DNase) Family Potentially Relevant to Autoimmunity.
Fujihara J, Ueki M, Kimura-Kataoka K, Iida R, Takeshita H, Yasuda T. | 04/1/2017 |
| Data indicate a likely functional variant influencing scleroderma susceptibility at deoxyribonuclease I-like 3 protein DNASE1L3 missense polymorphism rs35677470. | An Immunochip-based interrogation of scleroderma susceptibility variants identifies a novel association at DNASE1L3.
Zochling J, Newell F, Charlesworth JC, Leo P, Stankovich J, Cortes A, Zhou Y, Stevens W, Sahhar J, Roddy J, Nash P, Tymms K, Rischmueller M, Lester S, Proudman S, Brown MA., Free PMC Article | 08/8/2015 |
| Single nucleotide polymorphisms in the DNASE1L3 is associated with autoimmune diseases. | Evaluation of all non-synonymous single nucleotide polymorphisms (SNPs) in the genes encoding human deoxyribonuclease I and I-like 3 as a functional SNP potentially implicated in autoimmunity.
Ueki M, Kimura-Kataoka K, Takeshita H, Fujihara J, Iida R, Sano R, Nakajima T, Kominato Y, Kawai Y, Yasuda T. | 03/8/2014 |