| Neuronal Differentiation of Induced Pluripotent Stem Cells from Schizophrenia Patients in Two-Dimensional and in Three-Dimensional Cultures Reveals Increased Expression of the Kv4.2 Subunit DPP6 That Contributes to Decreased Neuronal Activity. | Neuronal Differentiation of Induced Pluripotent Stem Cells from Schizophrenia Patients in Two-Dimensional and in Three-Dimensional Cultures Reveals Increased Expression of the Kv4.2 Subunit DPP6 That Contributes to Decreased Neuronal Activity.
Naujock M, Speidel A, Fischer S, Kizner V, Dorner-Ciossek C, Gillardon F. | 09/4/2021 |
| Dipeptidyl peptidase like 6 promoter methylation is a potential prognostic biomarker for pancreatic ductal adenocarcinoma. | Dipeptidyl peptidase like 6 promoter methylation is a potential prognostic biomarker for pancreatic ductal adenocarcinoma.
Zhao X, Cao D, Ren Z, Liu Z, Lv S, Zhu J, Li L, Lang R, He Q., Free PMC Article | 04/17/2021 |
| In an unresolved autosomal dominant dementia family significantly linked to 7q36, there was a chromosomal inversion of ca. 4 Mb, segregating on the disease haplotype and disrupting the coding sequence of DPP6. The missense variants found in patients destabilize DPP6 and reduce its membrane expression. DPP6 loss plays a in dementia. | Loss of DPP6 in neurodegenerative dementia: a genetic player in the dysfunction of neuronal excitability.
Cacace R, Heeman B, Van Mossevelde S, De Roeck A, Hoogmartens J, De Rijk P, Gossye H, De Vos K, De Coster W, Strazisar M, De Baets G, Schymkowitz J, Rousseau F, Geerts N, De Pooter T, Peeters K, Sieben A, Martin JJ, Engelborghs S, Salmon E, Santens P, Vandenberghe R, Cras P, P De Deyn P, C van Swieten J, M van Duijn C, van der Zee J, Sleegers K, Van Broeckhoven C, BELNEU Consortium., Free PMC Article | 06/27/2020 |
| The slope of the activation curve of DPP6-L747P was slightly decreased. | A novel DPP6 variant in Chinese families causes early repolarization syndrome.
Ji CC, Yao FJ, Cheng YJ, Yao H, Fan J, Chen XM, Zheng ZH, Dong YG, Wu SH. | 06/20/2020 |
| A novel missense mutation (c.1578G>C/p.Q526H) of DPP6 was identified and co-segregated with affected patients in a family with suspicious idiopathic ventricular fibrillation. | A novel mutation of dipeptidyl aminopeptidase-like protein-6 in a family with suspicious idiopathic ventricular fibrillation.
Ding DB, Fan LL, Xiao Z, Huang H, Chen YQ, Guo S, Liu ZH, Xiang R. | 10/27/2018 |
| These data suggest that the proband's autism may be due to the inheritance of disruptions in both DPP6 and LRRC4C, and may highlight the importance of the netrin G family and potassium channel interacting molecules in neurodevelopmental disorders. | Implication of LRRC4C and DPP6 in neurodevelopmental disorders.
Maussion G, Cruceanu C, Rosenfeld JA, Bell SC, Jollant F, Szatkiewicz J, Collins RL, Hanscom C, Kolobova I, de Champfleur NM, Blumenthal I, Chiang C, Ota V, Hultman C, O'Dushlaine C, McCarroll S, Alda M, Jacquemont S, Ordulu Z, Marshall CR, Carter MT, Shaffer LG, Sklar P, Girirajan S, Morton CC, Gusella JF, Turecki G, Stavropoulos DJ, Sullivan PF, Scherer SW, Talkowski ME, Ernst C., Free PMC Article | 10/28/2017 |
| we expanded our knowledge of familial IVF linked to the DPP6 gene and discuss its (extended) clinical characteristics. In addition, its relationship with the Purkinje network is further explored. | Detailed characterization of familial idiopathic ventricular fibrillation linked to the DPP6 locus.
Ten Sande JN, Postema PG, Boekholdt SM, Tan HL, van der Heijden JF, de Groot NM, Volders PG, Zeppenfeld K, Boersma LV, Nannenberg EA, Christiaans I, Wilde AA. | 12/24/2016 |
| This first familial case provides evidence for association between DPP6 haploinsufficiency and Gilles de la Tourette syndrome. | DPP6 gene disruption in a family with Gilles de la Tourette syndrome.
Prontera P, Napolioni V, Ottaviani V, Rogaia D, Fusco C, Augello B, Serino D, Parisi V, Bernardini L, Merla G, Cavanna AE, Donti E. | 06/20/2015 |
| the cysteine-rich domain of DPP6 plays an important role in protein folding of DPP6 that is required for transport of DPP6/Kv4.2 complexes out of the ER | DPP6 domains responsible for its localization and function.
Lin L, Long LK, Hatch MM, Hoffman DA., Free PMC Article | 01/24/2015 |
| DPP6 is critical for synaptic integration and excitation. | A genome-wide association study of clinical symptoms of dissociation in a trauma-exposed sample.
Wolf EJ, Rasmusson AM, Mitchell KS, Logue MW, Baldwin CT, Miller MW., Free PMC Article | 12/20/2014 |
| Two DPP6 de novo deletions and one missense mutation in familial microcephalic patients were identified. | Loss-of-function variation in the DPP6 gene is associated with autosomal dominant microcephaly and mental retardation.
Liao C, Fu F, Li R, Yang WQ, Liao HY, Yan JR, Li J, Li SY, Yang X, Li DZ. | 03/29/2014 |
| WT PrP(C), in a DPP6-dependent manner, modulated Kv4.2 channel properties, causing an increase in peak amplitude | The prion protein modulates A-type K+ currents mediated by Kv4.2 complexes through dipeptidyl aminopeptidase-like protein 6.
Mercer RC, Ma L, Watts JC, Strome R, Wohlgemuth S, Yang J, Cashman NR, Coulthart MB, Schmitt-Ulms G, Jhamandas JH, Westaway D., Free PMC Article | 02/22/2014 |
| Findings of this study indicate that an altered response of Kv4/DPP6 to long-term neuroleptic administration is involved in neuroleptic-induced TD. | DPP6 as a candidate gene for neuroleptic-induced tardive dyskinesia.
Tanaka S, Syu A, Ishiguro H, Inada T, Horiuchi Y, Ishikawa M, Koga M, Noguchi E, Ozaki N, Someya T, Kakita A, Takahashi H, Nawa H, Arinami T. | 10/26/2013 |
| DPP6-mediated Purkinje fibers early-repolarization syndrome might be a novel molecular paradigm for some forms of idiopathic ventricular fibrillation. | Unique cardiac Purkinje fiber transient outward current β-subunit composition: a potential molecular link to idiopathic ventricular fibrillation.
Xiao L, Koopmann TT, Ördög B, Postema PG, Verkerk AO, Iyer V, Sampson KJ, Boink GJ, Mamarbachi MA, Varro A, Jordaens L, Res J, Kass RS, Wilde AA, Bezzina CR, Nattel S., Free PMC Article | 07/13/2013 |
| These results, inflated by the limited sample size determined by the rarity of this condition, suggest a possible role of this gene in the susceptibility to PrMS, at least in Southern Europeans. | Association between DPP6 polymorphism and the risk of progressive multiple sclerosis in Northern and Southern Europeans.
Brambilla P, Esposito F, Lindstrom E, Sorosina M, Giacalone G, Clarelli F, Rodegher M, Colombo B, Moiola L, Ghezzi A, Capra R, Collimedaglia L, Coniglio G, Celius EG, Galimberti D, Sørensen PS, Martinelli V, Oturai AB, Harbo HF, Hillert J, Comi G, Martinelli-Boneschi F. | 05/11/2013 |
| Antibodies to DPPX are associated with a protracted encephalitis characterized by central nervous system hyperexcitability. | Encephalitis and antibodies to dipeptidyl-peptidase-like protein-6, a subunit of Kv4.2 potassium channels.
Boronat A, Gelfand JM, Gresa-Arribas N, Jeong HY, Walsh M, Roberts K, Martinez-Hernandez E, Rosenfeld MR, Balice-Gordon R, Graus F, Rudy B, Dalmau J., Free PMC Article | 03/30/2013 |
| Results showed that DPP6, SPHKAP and ID4 were down regulated in acute myeloid leukemia (AML) patients. | Genome wide analysis of acute myeloid leukemia reveal leukemia specific methylome and subtype specific hypomethylation of repeats.
Saied MH, Marzec J, Khalid S, Smith P, Down TA, Rakyan VK, Molloy G, Raghavan M, Debernardi S, Young BD., Free PMC Article | 09/1/2012 |
| There was no evidence of association of dipeptidyl-peptidase 6 alleles with amyotrophic lateral sclerosis. Our negative results agree with those recently reported in additional Polish and Italian cohorts. | No association of DPP6 with amyotrophic lateral sclerosis in an Italian population.
Fogh I, D'Alfonso S, Gellera C, Ratti A, Cereda C, Penco S, Corrado L, Sorarù G, Castellotti B, Tiloca C, Gagliardi S, Cozzi L, Lupton MK, Ticozzi N, Mazzini L, Shaw CE, Al-Chalabi A, Powell J, Silani V. | 08/20/2011 |
| KV4.2 channel fast inactivation induced by DPP10a or DPP6a is mediated by a common N-terminal inactivation motif via a pore-blocking mechanism. | A novel N-terminal motif of dipeptidyl peptidase-like proteins produces rapid inactivation of KV4.2 channels by a pore-blocking mechanism.
Jerng HH, Dougherty K, Covarrubias M, Pfaffinger PJ., Free PMC Article | 04/16/2011 |
| a genome-wide association study of amyotrophic lateral sclerosis identified the DPP6 locus as a candidate for more in-depth studies | A large genome scan for rare CNVs in amyotrophic lateral sclerosis.
Blauw HM, Al-Chalabi A, Andersen PM, van Vught PW, Diekstra FP, van Es MA, Saris CG, Groen EJ, van Rheenen W, Koppers M, Van't Slot R, Strengman E, Estrada K, Rivadeneira F, Hofman A, Uitterlinden AG, Kiemeney LA, Vermeulen SH, Birve A, Waibel S, Meyer T, Cronin S, McLaughlin RL, Hardiman O, Sapp PC, Tobin MD, Wain LV, Tomik B, Slowik A, Lemmens R, Rujescu D, Schulte C, Gasser T, Brown RH Jr, Landers JE, Robberecht W, Ludolph AC, Ophoff RA, Veldink JH, van den Berg LH. | 03/5/2011 |
| This study indicated that mutations in dpp6 genes are unlikely to be a common cause of ALS in the French and French Canadian populations. | Analysis of DPP6 and FGGY as candidate genes for amyotrophic lateral sclerosis.
Daoud H, Valdmanis PN, Dion PA, Rouleau GA. | 09/27/2010 |
| Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators., Free PMC Article | 09/15/2010 |
| DPP6 expression seems to be critical for the expression of a high-frequency electrophysiological phenotype in cerebellar granule cells by increasing leak conductance, A-type current levels and kinetics, and Na(+) current amplitude. | Dipeptidyl peptidase-like protein 6 is required for normal electrophysiological properties of cerebellar granule cells.
Nadin BM, Pfaffinger PJ., Free PMC Article | 07/19/2010 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| The rs10260404 polymorphism is not associated with an increased risk of sporadic amyotrophic lateral sclerosis in Chinese patients. | Association between DPP6 polymorphism and the risk of sporadic amyotrophic lateral sclerosis in Chinese patients.
Li XG, Zhang JH, Xie MQ, Liu MS, Li BH, Zhao YH, Ren HT, Cui LY. | 05/3/2010 |