| Suppression of adaptive NK cell expansion by macrophage-mediated phagocytosis inhibited by 2B4-CD48. | Suppression of adaptive NK cell expansion by macrophage-mediated phagocytosis inhibited by 2B4-CD48.
Li R, Galindo CC, Davidson D, Guo H, Zhong MC, Qian J, Li B, Ruzsics Z, Lau CM, O'Sullivan TE, Vidal SM, Sun JC, Veillette A. | 04/1/2024 |
| 2B4: A potential target in Staphylococcus aureus associated allergic inflammation. | 2B4: A potential target in Staphylococcus aureus associated allergic inflammation.
Gaur P, Seaf M, Trabelsi N, Marcu O, Gafarov D, Schueler-Furman O, Mandelboim O, Ben-Zimra M, Levi-Schaffer F., | 01/12/2024 |
| A novel 2B4 receptor leads to worse pregnancy outcomes by facilitating TNF-alpha and IFN-gamma production in dNK cells during Toxoplasma gondii infection. | A novel 2B4 receptor leads to worse pregnancy outcomes by facilitating TNF-α and IFN-γ production in dNK cells during Toxoplasma gondii infection.
Xu X, Zheng G, Ren Y, He X, Peng B, Hu X, Liu W., Free PMC Article | 10/15/2022 |
| SLAMF3 and SLAMF4 are immune checkpoints that constrain macrophage phagocytosis of hematopoietic tumors. | SLAMF3 and SLAMF4 are immune checkpoints that constrain macrophage phagocytosis of hematopoietic tumors.
Li D, Xiong W, Wang Y, Feng J, He Y, Du J, Wang J, Yang M, Zeng H, Yang YG, Wu N, Chen S, Dong Z. | 03/12/2022 |
| 2B4 but not PD-1 blockade improves mortality in septic animals with preexisting malignancy. | 2B4 but not PD-1 blockade improves mortality in septic animals with preexisting malignancy.
Chen CW, Xue M, Zhang W, Xie J, Coopersmith CM, Ford ML., Free PMC Article | 10/24/2020 |
| Increased attrition of memory T cells during sepsis requires 2B4. | Increased attrition of memory T cells during sepsis requires 2B4.
Xie J, Chen CW, Sun Y, Laurie SJ, Zhang W, Otani S, Martin GS, Coopersmith CM, Ford ML., Free PMC Article | 09/12/2020 |
| Phenotypic analysis revealed an increased frequency of murine EBV homolog-specific CD8(+) T cells expressing the 2B4 coinhibitory receptor in septic animals compared with sham controls. | Sepsis erodes CD8(+) memory T cell-protective immunity against an EBV homolog in a 2B4-dependent manner.
Xie J, Crepeau RL, Chen CW, Zhang W, Otani S, Coopersmith CM, Ford ML., Free PMC Article | 10/19/2019 |
| these data indicate that 2B4 signals function to alter T cell glucose metabolism, thereby limiting the proliferation and accumulation of CD8(+) T cells. | 2B4 Mediates Inhibition of CD8(+) T Cell Responses via Attenuation of Glycolysis and Cell Division.
Laurie SJ, Liu D, Wagener ME, Stark PC, Terhorst C, Ford ML., Free PMC Article | 07/6/2019 |
| SLAMF4 is a marker of intestinal immune cells which contributes to the protection against enteric pathogens and whose expression is dependent on the presence of the gut microbiota | Gut symbiotic microbes imprint intestinal immune cells with the innate receptor SLAMF4 which contributes to gut immune protection against enteric pathogens.
Cabinian A, Sinsimer D, Tang M, Jang Y, Choi B, Laouar Y, Laouar A., Free PMC Article | 06/23/2018 |
| 2B4 expression is increased on CD4+ T cells in septic animals | Cutting Edge: 2B4-Mediated Coinhibition of CD4(+) T Cells Underlies Mortality in Experimental Sepsis.
Chen CW, Mittal R, Klingensmith NJ, Burd EM, Terhorst C, Martin GS, Coopersmith CM, Ford ML., Free PMC Article | 10/14/2017 |
| 2B4 dampens T-independent B cell responses. | 2B4 Is Dispensable for T-Dependent B Cell Immune Responses, but Its Deficiency Leads to Enhanced T-Independent Responses Due to an Increase in Peritoneal Cavity B1b Cells.
Ray A, Yuan CY, Miller NM, Mei H, Dittel BN., Free PMC Article | 05/21/2016 |
| DCs from CD244(-/-) mice elicited increased NK cell activation in vitro. These data add CD244 to a growing list of immuno-modulatory receptors found on DCs. | CD244 is expressed on dendritic cells and regulates their functions.
Georgoudaki AM, Khodabandeh S, Puiac S, Persson CM, Larsson MK, Lind M, Hammarfjord O, Nabatti TH, Wallin RP, Yrlid U, Rhen M, Kumar V, Chambers BJ. | 04/9/2016 |
| Data show that enforced expression of inhibitor of differentiation protein Id3 specifically increased the persistence of Cd244 protein 2B4(+) virus-specific CD8(+) T cells. | Id3 Controls Cell Death of 2B4+ Virus-Specific CD8+ T Cells in Chronic Viral Infection.
Menner AJ, Rauch KS, Aichele P, Pircher H, Schachtrup C, Schachtrup K. | 12/19/2015 |
| Molecular dynamic simulation explains unbinding and unfolding of CD48-2B4 protein complexes. | Unbinding and unfolding of adhesion protein complexes through stretching: interplay between shear and tensile mechanical clamps.
Różycki B, Mioduszewski Ł, Cieplak M. | 10/31/2015 |
| Signaling via SLAMF4 controls expansion of cytotoxic CD8alphabeta(+) IELs, which regulate the reversible depletion of lamina propria phagocytes and inflammation in the small intestine. | SLAMF4 Is a Negative Regulator of Expansion of Cytotoxic Intraepithelial CD8+ T Cells That Maintains Homeostasis in the Small Intestine.
O'Keeffe MS, Song JH, Liao G, De Calisto J, Halibozek PJ, Mora JR, Bhan AK, Wang N, Reinecker HC, Terhorst C., Free PMC Article | 07/4/2015 |
| CD244 (2B4) has a regulatory effect on mast cells and eosinophils in murine allergic inflammation. | Complex 2B4 regulation of mast cells and eosinophils in murine allergic inflammation.
Elishmereni M, Fyhrquist N, Singh Gangwar R, Lehtimäki S, Alenius H, Levi-Schaffer F. | 02/21/2015 |
| NKG2D ligation relieves 2B4-mediated NK-cell self-tolerance in mice. | NKG2D ligation relieves 2B4-mediated NK-cell self-tolerance in mice.
Lee JE, Lim SA, Kim TJ, Kim K, Ng J, Kim YH, Jang IJ, Oh SB, Lee JC, Yee C, Kumar V, Lee KM. | 07/26/2014 |
| blockade of CD28 signals in the presence of preserved CTLA-4 signals results in the unique up-regulation of 2B4 on primary CD8(+) effectors, and that this 2B4 expression plays a critical functional role in controlling antigen-specific T8 cell responses | 2B4 (CD244) induced by selective CD28 blockade functionally regulates allograft-specific CD8+ T cell responses.
Liu D, Krummey SM, Badell IR, Wagener M, Schneeweis LA, Stetsko DK, Suchard SJ, Nadler SG, Ford ML., Free PMC Article | 04/19/2014 |
| In the absence of SAP, signaling through the SLAM family members Ly108 and 2B4 resulted in increased recruitment of the SHP-1 phosphatase, associated with altered SHP-1 localization and decreased activation of Src kinases at the synapse. | Positive and negative signaling through SLAM receptors regulate synapse organization and thresholds of cytolysis.
Zhao F, Cannons JL, Dutta M, Griffiths GM, Schwartzberg PL., Free PMC Article | 09/15/2012 |
| Ox-LDL significantly promoted the interaction of natural killer cells and dendritic cells via CD48-2B4 contact-dependent mechanisms. | Ox-LDL can enhance the interaction of mice natural killer cells and dendritic cells via the CD48-2B4 pathway.
Dong K, Ge JH, Gu SL, Li S, Zhu WG, Fan FY, Zhu JH. | 03/17/2012 |
| Slamf4 has a natural killer (NK) cell-independent negative regulatory function in vivo and can contribute to tolerance to chromatin in murine models of systemic lupus erythematosus. | Cutting edge: an NK cell-independent role for Slamf4 in controlling humoral autoimmunity.
Brown DR, Calpe S, Keszei M, Wang N, McArdel S, Terhorst C, Sharpe AH., Free PMC Article | 09/3/2011 |
| CD48 on surrounding NK or non-NK cells serves primarily as a ligand to stimulate 2B4 on the adjacent NK cells in mice | Unidirectional signaling triggered through 2B4 (CD244), not CD48, in murine NK cells.
Kim EO, Kim N, Kim TJ, Kim K, Kim TW, Kumar V, Lee KM. | 10/30/2010 |
| The interaction of SHIP, 2B4 activating receptor, and the major histocompatibility complex influence the regulation of natural killer (NK) cell receptor repertoire, cytolytic function, and interferon-gamma production. | SHIP influences signals from CD48 and MHC class I ligands that regulate NK cell homeostasis, effector function, and repertoire formation.
Fortenbery NR, Paraiso KH, Taniguchi M, Brooks C, Ibrahim L, Kerr WG. | 07/5/2010 |
| CD244 inhibition and activation depends on CD2 and phospholipase C-gamma1 | Inhibition and activation by CD244 depends on CD2 and phospholipase C-gamma1.
Clarkson NG, Brown MH., Free PMC Article | 01/21/2010 |
| Studies under identical and controlled conditions reveal that both human and mouse 2B4 can activate or inhibit natural killer (NK) cells. | Molecular basis of the dual functions of 2B4 (CD244).
Chlewicki LK, Velikovsky CA, Balakrishnan V, Mariuzza RA, Kumar V. | 01/21/2010 |