| Slc11a1 gene polymorphism influences dextran sulfate sodium (DSS)-induced colitis in a murine model of acute inflammation. | Slc11a1 gene polymorphism influences dextran sulfate sodium (DSS)-induced colitis in a murine model of acute inflammation.
de Andrade STQ, Guidugli TI, Borrego A, Rodrigues BLC, Fernandes NCCA, Guerra JM, de Sousa JG, Starobinas N, Jensen JR, Cabrera WHK, De Franco M, Ibañez OM, Massa S, Ribeiro OG., Free PMC Article | 04/20/2023 |
| Nrf2 Regulates Granuloma Formation and Macrophage Activation during Mycobacterium avium Infection via Mediating Nramp1 and HO-1 Expressions. | Nrf2 Regulates Granuloma Formation and Macrophage Activation during Mycobacterium avium Infection via Mediating Nramp1 and HO-1 Expressions.
Nakajima M, Matsuyama M, Kawaguchi M, Kiwamoto T, Matsuno Y, Morishima Y, Yoshida K, Sherpa M, Yazaki K, Osawa H, Muratani M, Ishii Y, Hizawa N., Free PMC Article | 08/28/2021 |
| Leishmania infection triggers hepcidin-mediated proteasomal degradation of Nramp1 to increase phagolysosomal iron availability. | Leishmania infection triggers hepcidin-mediated proteasomal degradation of Nramp1 to increase phagolysosomal iron availability.
Banerjee S, Datta R. | 08/7/2021 |
| A specific role for Lsh in guarding and preserving chromatin structure to prevent access to tissue specific enhancers or regulatory regions.Lsh mediated changes in nucleosome occupancy are independent of DNA methylation level and are characterized by reduced H3 occupancy. | The chromatin remodeling protein Lsh alters nucleosome occupancy at putative enhancers and modulates binding of lineage specific transcription factors.
Ren J, Finney R, Ni K, Cam M, Muegge K., Free PMC Article | 06/6/2020 |
| findings identify deprivation of the main group metal magnesium as the main resistance mechanism of SLC11A1 against Salmonella | Host resistance factor SLC11A1 restricts Salmonella growth through magnesium deprivation.
Cunrath O, Bumann D. | 05/23/2020 |
| SLC11A1 polymorphisms are associated with with susceptibility to leishmaniasis. | Susceptibility to leishmaniasis is affected by host SLC11A1 gene polymorphisms: a systematic review and meta-analysis.
Braliou GG, Kontou PI, Boleti H, Bagos PG. | 10/26/2019 |
| Our data demonstrated the fine-tuning roles of Slc11a1 alleles modulating macrophage activation, and consequent pristane-induced arthritis susceptibility. | Slc11a1 (Nramp-1) gene modulates immune-inflammation genes in macrophages during pristane-induced arthritis in mice.
Correa MA, Canhamero T, Borrego A, Katz ISS, Jensen JR, Guerra JL, Cabrera WHK, Starobinas N, Fernandes JG, Ribeiro OG, Ibañez OM, De Franco M. | 07/28/2018 |
| Here, the authors show that genetic inactivation of a single DDM1/Lsh family nucleosome remodeler biases methylation toward inter-nucleosomal linker DNA in Arabidopsis thaliana and mouse. The results indicate that in the absence of remodeling, nucleosomes are strong barriers to DNA methyltransferases. | DDM1 and Lsh remodelers allow methylation of DNA wrapped in nucleosomes.
Lyons DB, Zilberman D., Free PMC Article | 07/21/2018 |
| discrete, anatomically localized host resistance is conferred by Nramp1 expression; restriction of systemic bacterial growth in the spleen is enhanced by Nramp1 expression | Temporal and anatomical host resistance to chronic Salmonella infection is quantitatively dictated by Nramp1 and influenced by host genetic background.
Loomis WP, Johnson ML, Brasfield A, Blanc MP, Yi J, Miller SI, Cookson BT, Hajjar AM., Free PMC Article | 01/16/2016 |
| Data shows that Lsh plays an essential Dnmt3b-independent role to ensure that the host genome integrity is protected from potentially deleterious LTR retroelements. | Lsh regulates LTR retrotransposon repression independently of Dnmt3b function.
Dunican DS, Cruickshanks HA, Suzuki M, Semple CA, Davey T, Arceci RJ, Greally J, Adams IR, Meehan RR., Free PMC Article | 04/25/2015 |
| Gene expression profiles of the two arthritis quantitative trait loci (on chromosomes 5 and 8) correlate with Slc11a1 alleles, resulting in enhanced AIRmax(SS) mice susceptibility to Pristane-induced arthritis. | Pristane-induced arthritis loci interact with the Slc11a1 gene to determine susceptibility in mice selected for high inflammation.
De Franco M, Peters LC, Correa MA, Galvan A, Canhamero T, Borrego A, Jensen JR, Gonçalves J, Cabrera WH, Starobinas N, Ribeiro OG, Dragani TA, Ibañez OM., Free PMC Article | 10/4/2014 |
| In the absence of LSH, the histone variant H2AX is not efficiently phosphorylated in response to DNA damage. | The SNF2 family ATPase LSH promotes phosphorylation of H2AX and efficient repair of DNA double-strand breaks in mammalian cells.
Burrage J, Termanis A, Geissner A, Myant K, Gordon K, Stancheva I., Free PMC Article | 07/20/2013 |
| These observations indicate a bifunctional protective role of secretory Prx; first it reduces redox activation of macrophages, and secondly it allows iron access to Leishmania by down regulating NRAMP1 expression. | Identification and functional characterization of Leishmania donovani secretory peroxidase: delineating its role in NRAMP1 regulation.
Singh N, Bajpai S, Kumar V, Gour JK, Singh RK., Free PMC Article | 07/6/2013 |
| Preferential expression of SLC11A1 transcripts in gammadelta T cells is detected in bovine, human, and mouse gammadelta T cells. | Solute carrier 11A1 is expressed by innate lymphocytes and augments their activation.
Hedges JF, Kimmel E, Snyder DT, Jerome M, Jutila MA., Free PMC Article | 06/8/2013 |
| Stimulation of Lcn2 expression is a novel mechanism by which Nramp1 confers resistance against infection with Salmonella typhimurium. | Slc11a1 (Nramp1) impairs growth of Salmonella enterica serovar typhimurium in macrophages via stimulation of lipocalin-2 expression.
Fritsche G, Nairz M, Libby SJ, Fang FC, Weiss G., Free PMC Article | 09/22/2012 |
| High inflammatory AIRmax mice homozygous for Slc11a1 R and S alleles were produced. The Slc11a1 gene modulated the early inflammatory events of ear tissue regeneration. | Distinct early inflammatory events during ear tissue regeneration in mice selected for high inflammation bearing Slc11a1 R and S alleles.
Canhamero T, Reines B, Peters LC, Borrego A, Carneiro PS, Albuquerque LL, Cabrera WH, Ribeiro OG, Jensen JR, Starobinas N, Ibañez OM, De Franco M. | 01/21/2012 |
| anaemia due to a chronic mycobacterial infection may develop in the absence of elevated hepcidin expression, is influenced by Nramp1 and may involve lipocalin-2. | Mycobacteria-induced anaemia revisited: a molecular approach reveals the involvement of NRAMP1 and lipocalin-2, but not of hepcidin.
Rodrigues PN, Gomes SS, Neves JV, Gomes-Pereira S, Correia-Neves M, Nunes-Alves C, Stolte J, Sanchez M, Appelberg R, Muckenthaler MU, Gomes MS. | 12/31/2011 |
| The Yersinia pseudotuberculosis mntH mutant was defective in survival and growth in macrophages expressing functional Nramp1, but in macrophages deficient in Nramp the bacteria were able to survive and replicate. | Yersinia pseudotuberculosis mntH functions in intracellular manganese accumulation, which is essential for virulence and survival in cells expressing functional Nramp1.
Champion OL, Karlyshev A, Cooper IAM, Ford DC, Wren BW, Duffield M, Oyston PCF, Titball RW. | 12/31/2011 |
| conclude that rs3731685 (INT4) in the SLC11A1 gene may be associated with T1D susceptibility in the European ancestry population studied | Evidence of association with type 1 diabetes in the SLC11A1 gene region.
Yang JH, Downes K, Howson JM, Nutland S, Stevens HE, Walker NM, Todd JA., Free PMC Article | 08/20/2011 |
| Lsh, chromatin remodeling family member, modulates genome-wide cytosine methylation patterns at nonrepeat sequences. | Lsh, chromatin remodeling family member, modulates genome-wide cytosine methylation patterns at nonrepeat sequences.
Tao Y, Xi S, Shan J, Maunakea A, Che A, Briones V, Lee EY, Geiman T, Huang J, Stephens R, Leighty RM, Zhao K, Muegge K., Free PMC Article | 07/2/2011 |
| Findings indicate that DeltaNp63alpha is an oncogene that cooperates with Ras to promote tumor-initiating stem-like proliferation and suggest that Lsh-mediated chromatin-remodeling events are critical to this process. | ΔNp63α is an oncogene that targets chromatin remodeler Lsh to drive skin stem cell proliferation and tumorigenesis.
Keyes WM, Pecoraro M, Aranda V, Vernersson-Lindahl E, Li W, Vogel H, Guo X, Garcia EL, Michurina TV, Enikolopov G, Muthuswamy SK, Mills AA., Free PMC Article | 05/14/2011 |
| Both Nramp1 and DMT1 are necessary for efficient macrophage iron recycling. | Both Nramp1 and DMT1 are necessary for efficient macrophage iron recycling.
Soe-Lin S, Apte SS, Mikhael MR, Kayembe LK, Nie G, Ponka P. | 08/2/2010 |
| Results indicate that Lsh is involved in the control of stem cell genes and suggest that Lsh is an important epigenetic modulator during early stem cell differentiation. | Lsh participates in DNA methylation and silencing of stem cell genes.
Xi S, Geiman TM, Briones V, Guang Tao Y, Xu H, Muegge K., Free PMC Article | 02/8/2010 |
| The authors report that macrophages lacking functional Slc11a1 displayed an increased expression of transferrin receptor 1, resulting in enhanced acquisition of transferrin-bound iron. | Slc11a1 limits intracellular growth of Salmonella enterica sv. Typhimurium by promoting macrophage immune effector functions and impairing bacterial iron acquisition.
Nairz M, Fritsche G, Crouch ML, Barton HC, Fang FC, Weiss G., Free PMC Article | 01/21/2010 |
| without Nramp1, iron accumulates within the liver and spleen during erythrophagocytosis and hemolytic anemia, supporting the hypothesis that Nramp1 promotes efficient hemoglobin iron recycling in macrophages | Nramp1 promotes efficient macrophage recycling of iron following erythrophagocytosis in vivo.
Soe-Lin S, Apte SS, Andriopoulos B Jr, Andrews MC, Schranzhofer M, Kahawita T, Garcia-Santos D, Ponka P., Free PMC Article | 01/21/2010 |