| DMT1 ubiquitination by Nedd4 protects against ferroptosis after intracerebral hemorrhage. | DMT1 ubiquitination by Nedd4 protects against ferroptosis after intracerebral hemorrhage.
Lv B, Fu P, Wang M, Cui L, Bao L, Wang X, Yu L, Zhou C, Zhu M, Wang F, Pang Y, Qi S, Zhang Z, Cui G., Free PMC Article | 05/2/2024 |
| DMT1-mediated iron overload accelerates cartilage degeneration in Hemophilic Arthropathy through the mtDNA-cGAS-STING axis. | DMT1-mediated iron overload accelerates cartilage degeneration in Hemophilic Arthropathy through the mtDNA-cGAS-STING axis.
Liu H, Chi R, Xu J, Guo J, Guo Z, Zhang X, Hou L, Zheng Z, Lu F, Xu T, Sun K, Guo F. | 04/15/2024 |
| Microglial-specific knockdown of iron import gene, Slc11a2, blunts LPS-induced neuroinflammatory responses in a sex-specific manner. | Microglial-specific knockdown of iron import gene, Slc11a2, blunts LPS-induced neuroinflammatory responses in a sex-specific manner.
Volk Robertson K, Schleh MW, Harrison FE, Hasty AH., | 01/28/2024 |
| DMT1 Protects Macrophages from Salmonella Infection by Controlling Cellular Iron Turnover and Lipocalin 2 Expression. | DMT1 Protects Macrophages from Salmonella Infection by Controlling Cellular Iron Turnover and Lipocalin 2 Expression.
Grander M, Hoffmann A, Seifert M, Demetz E, Grubwieser P, Pfeifhofer-Obermair C, Haschka D, Weiss G., Free PMC Article | 07/2/2022 |
| Iron from nanostructured ferric phosphate: absorption and biodistribution in mice and bioavailability in iron deficient anemic women. | Iron from nanostructured ferric phosphate: absorption and biodistribution in mice and bioavailability in iron deficient anemic women.
Baumgartner J, Winkler HC, Zandberg L, Tuntipopipat S, Mankong P, Bester C, Hilty F, Zeevaart JR, Gowachirapant S, Zimmermann MB., Free PMC Article | 03/12/2022 |
| Divalent Metal Transporter 1 Knock-Down Modulates IL-1beta Mediated Pancreatic Beta-Cell Pro-Apoptotic Signaling Pathways through the Autophagic Machinery. | Divalent Metal Transporter 1 Knock-Down Modulates IL-1β Mediated Pancreatic Beta-Cell Pro-Apoptotic Signaling Pathways through the Autophagic Machinery.
Kang T, Huang H, Mandrup-Poulsen T, Larsen MR., Free PMC Article | 09/11/2021 |
| Spinal NR2B phosphorylation at Tyr1472 regulates IRE(-)DMT1-mediated iron accumulation and spine morphogenesis via kalirin-7 in tibial fracture-associated postoperative pain after orthopedic surgery in female mice. | Spinal NR2B phosphorylation at Tyr1472 regulates IRE(-)DMT1-mediated iron accumulation and spine morphogenesis via kalirin-7 in tibial fracture-associated postoperative pain after orthopedic surgery in female mice.
Zhang L, Wang Z, Song C, Liu H, Li Y, Li J, Yu Y, Wang G, Cui W. | 08/21/2021 |
| Oral Administration of Ginger-Derived Lipid Nanoparticles and Dmt1 siRNA Potentiates the Effect of Dietary Iron Restriction and Mitigates Pre-Existing Iron Overload in Hamp KO Mice. | Oral Administration of Ginger-Derived Lipid Nanoparticles and Dmt1 siRNA Potentiates the Effect of Dietary Iron Restriction and Mitigates Pre-Existing Iron Overload in Hamp KO Mice.
Wang X, Zhang M, Woloshun RR, Yu Y, Lee JK, Flores SRL, Merlin D, Collins JF., Free PMC Article | 08/7/2021 |
| Deleting DMT1 in vitro significantly reduce SC proliferation, maturation, and the myelination of DRG axons. This was accompanied by an important reduction in iron incorporation and storage. | Iron Metabolism in the Peripheral Nervous System: The Role of DMT1, Ferritin, and Transferrin Receptor in Schwann Cell Maturation and Myelination.
Santiago González DA, Cheli VT, Wan R, Paez PM., Free PMC Article | 07/11/2020 |
| DMT1 is necessary for normal oligodendrocyte progenitor cell maturation and is required for efficient remyelination of the adult brain. | The Divalent Metal Transporter 1 (DMT1) Is Required for Iron Uptake and Normal Development of Oligodendrocyte Progenitor Cells.
Cheli VT, Santiago González DA, Marziali LN, Zamora NN, Guitart ME, Spreuer V, Pasquini JM, Paez PM., Free PMC Article | 10/12/2019 |
| The results indicate that global DMT1 overexpression causes decreased superoxide generation upon stimulation in inflammatory cells, which presumably delayed the promotional stage of crocidolite-induced mesothelial carcinogenesis. DMT1Tg mice with low-stamina inflammatory cells may be helpful to evaluate the involvement of inflammation in various pathologies | Global overexpression of divalent metal transporter 1 delays crocidolite-induced mesothelial carcinogenesis in male mice.
Funahashi S, Okazaki Y, Nishiyama T, Ohyoshi H, Yasui H, Nishida K, Matsui S, Toyokuni S. | 03/30/2019 |
| IL-6 likely up-regulates IRP1 and DMT1 expression and down-regulates FPN1 expression in BV2 microglial cells through JNK signaling pathways | Interleukin-6 regulates iron-related proteins through c-Jun N-terminal kinase activation in BV2 microglial cell lines.
Zhou S, Du X, Xie J, Wang J., Free PMC Article | 10/7/2017 |
| the cellular iron importer, divalent metal transporter 1 (DMT1), is highly expressed in colorectal cancer through hypoxia-inducible factor 2alpha-dependent transcription. | Iron Uptake via DMT1 Integrates Cell Cycle with JAK-STAT3 Signaling to Promote Colorectal Tumorigenesis.
Xue X, Ramakrishnan SK, Weisz K, Triner D, Xie L, Attili D, Pant A, Győrffy B, Zhan M, Carter-Su C, Hardiman KM, Wang TD, Dame MK, Varani J, Brenner D, Fearon ER, Shah YM., Free PMC Article | 07/1/2017 |
| Ndfip2 controls DMT1 in the liver with female mice showing a greater response to altered dietary iron than the male mice | Ndfip2 is a potential regulator of the iron transporter DMT1 in the liver.
Foot NJ, Gembus KM, Mackenzie K, Kumar S., Free PMC Article | 04/1/2017 |
| PrP(C) promotes, and possibly regulates, the uptake of iron through DMT1 and Zip14 via its ferrireductase activity. | Prion protein functions as a ferrireductase partner for ZIP14 and DMT1.
Tripathi AK, Haldar S, Qian J, Beserra A, Suda S, Singh A, Hopfer U, Chen SG, Garrick MD, Turner JR, Knutson MD, Singh N., Free PMC Article | 03/5/2016 |
| This study reveals a critical function for DMT1 in intestinal nonheme-iron absorption for normal growth and development, and that it is not required for the transport of copper, manganese, or zinc. | Intestinal DMT1 is critical for iron absorption in the mouse but is not required for the absorption of copper or manganese.
Shawki A, Anthony SR, Nose Y, Engevik MA, Niespodzany EJ, Barrientos T, Öhrvik H, Worrell RT, Thiele DJ, Mackenzie B., Free PMC Article | 01/30/2016 |
| We propose that DMT1 deficiency negatively affects metabolism and life span of mature erythrocytes; two other aspects of defective erythropoiesis which contribute to the pathophysiology of the disease | DMT1-mutant erythrocytes have shortened life span, accelerated glycolysis and increased oxidative stress.
Zidova Z, Kapralova K, Koralkova P, Mojzikova R, Dolezal D, Divoky V, Horvathova M. | 10/3/2015 |
| Misregulation of DMT1 is implicated in Parkinson's disease. | Ndfip1 attenuated 6-OHDA-induced iron accumulation via regulating the degradation of DMT1.
Jia W, Xu H, Du X, Jiang H, Xie J. | 09/26/2015 |
| Suggest role for divalent cation transporter DMT1 in the entry of Hg(II) into the intestinal epithelium. | Participation of divalent cation transporter DMT1 in the uptake of inorganic mercury.
Vázquez M, Vélez D, Devesa V, Puig S. | 07/4/2015 |
| The Cu uptake in HEK293 cells that over-expressed the 2/-IRE isoform of DMT1 transporter supports our earlier contention that DMT1 transports Cu as Cu(1+). | Mouse divalent metal transporter 1 is a copper transporter in HEK293 cells.
Arredondo M, Mendiburo MJ, Flores S, Singleton ST, Garrick MD. | 02/14/2015 |
| Hepatocyte divalent metal-ion transporter-1 is dispensable for hepatic iron accumulation and non-transferrin-bound iron uptake in mice. | Hepatocyte divalent metal-ion transporter-1 is dispensable for hepatic iron accumulation and non-transferrin-bound iron uptake in mice.
Wang CY, Knutson MD., Free PMC Article | 01/18/2014 |
| DMT-1 expression in hypothalamic subregions is cre recombinase sensitive, and that central-peripheral pathways may impact beta cell function in the Dmt1 null mouse. | Divalent metal transporter 1 regulates iron-mediated ROS and pancreatic β cell fate in response to cytokines.
Hansen JB, Tonnesen MF, Madsen AN, Hagedorn PH, Friberg J, Grunnet LG, Heller RS, Nielsen AØ, Størling J, Baeyens L, Anker-Kitai L, Qvortrup K, Bouwens L, Efrat S, Aalund M, Andrews NC, Billestrup N, Karlsen AE, Holst B, Pociot F, Mandrup-Poulsen T. | 03/9/2013 |
| CD61 regulates the expression of Slc11a2, which is involved in iron transportation in epithelial tissues. | Requirement of integrin β3 for iron transportation during enamel formation.
Yoshida T, Kumashiro Y, Iwata T, Ishihara J, Umemoto T, Shiratsuchi Y, Kawashima N, Sugiyama T, Yamato M, Okano T. | 02/2/2013 |
| that 1B/(-)IRE DMT1 expression and intracellular iron influx are early downstream responses to NF-kappaB/RelA activation and acetylation during brain ischemia and contribute to the pathogenesis of stroke-induced neuronal damage | 1B/(-)IRE DMT1 expression during brain ischemia contributes to cell death mediated by NF-κB/RelA acetylation at Lys310.
Ingrassia R, Lanzillotta A, Sarnico I, Benarese M, Blasi F, Borgese L, Bilo F, Depero L, Chiarugi A, Spano PF, Pizzi M., Free PMC Article | 11/3/2012 |
| The knockdown of ZIP8, ZIP14 or DMT1 by siRNA transfection significantly reduced the uptake of Cd(2+) and Mn(2+) from the apical membrane. | Roles of ZIP8, ZIP14, and DMT1 in transport of cadmium and manganese in mouse kidney proximal tubule cells.
Fujishiro H, Yano Y, Takada Y, Tanihara M, Himeno S. | 11/3/2012 |