| Upregulation of Anti-Desmocollin 3 Antibodies in Pemphigus Diseases: A Case-control Study. | Upregulation of Anti-Desmocollin 3 Antibodies in Pemphigus Diseases: A Case-control Study.
Saleh MA, Said RM, Ahmed Rashed LA, El-Kalioby M. | 05/7/2024 |
| Two cases of Hallopeau-type pemphigus vegetans with anti-desmoglein 1 and anti-desmocollin 3 antibodies without mucosal involvement. | Two cases of Hallopeau-type pemphigus vegetans with anti-desmoglein 1 and anti-desmocollin 3 antibodies without mucosal involvement.
Kawamura T, Muramatsu K, Orita A, Mai Y, Sugai T, Haga N, Fujimura Y, Miyauchi T, Izumi K, Koga H, Ishii N, Ujiie H. | 03/23/2023 |
| Autoantibodies to DSC3 in Pemphigus Exclusively Recognize Calcium-Dependent Epitope in Extracellular Domain 2. | Autoantibodies to DSC3 in Pemphigus Exclusively Recognize Calcium-Dependent Epitope in Extracellular Domain 2.
Koga H, Teye K, Otsuji Y, Ishii N, Hashimoto T, Nakama T. | 12/18/2021 |
| DSC3 suppresses colorectal cancer cell growth through inhibition of AKT pathway and regulation of E-cadherin | Desmocollin 3 has a tumor suppressive activity through inhibition of AKT pathway in colorectal cancer.
Cui T, Yang L, Ma Y, Petersen I, Chen Y. | 05/30/2020 |
| The Findings of this study imply early alteration of the substantia nigra in XDP mutation carriers prone to develop parkinsonism. | Sonographic alteration of substantia nigra is related to parkinsonism-predominant course of X-linked dystonia-parkinsonism.
Walter U, Rosales R, Rocco A, Westenberger A, Domingo A, Go CL, Brüggemann N, Klein C, Lee LV, Dressler D. | 02/24/2018 |
| Data show that fetal pMSCs (mesenchymal stromal cells) expressing the highest levels of desmoglein 2, desmocollin 3 and plakophilin 2, followed by maternal pMSCs, while bmMSCs expressed the lowest levels. | Expression of Desmoglein 2, Desmocollin 3 and Plakophilin 2 in Placenta and Bone Marrow-Derived Mesenchymal Stromal Cells.
Hart ML, Rusch E, Kaupp M, Nieselt K, Aicher WK. | 11/11/2017 |
| Napsin-A, and Desmocollin-3 were sensitive and specific markers for the diagnosis of AC and SCC, respectively. Both markers allowed classification of 54/60 cases into either AC or SCC. | The role of Napsin-A and Desmocollin-3 in classifying poorly differentiating non-small cell lung carcinoma.
Ezzat Nel-S, Tahoun N. | 12/17/2016 |
| Suggest that Dsc3 can mediate FSH-induced ovarian cancer cell proliferation by activating the EGFR/Akt signaling pathway. | Desmocollin 3 mediates follicle stimulating hormone-induced ovarian epithelial cancer cell proliferation by activating the EGFR/Akt signaling pathway.
Yang X, Wang J, Li WP, Jin ZJ, Liu XJ., Free PMC Article | 06/11/2016 |
| data suggests that DNA methylation contributes to down-regulation of DSC3 in prostate cancer, and loss of DSC3 predicts poor clinical outcome. | Association of DSC3 mRNA down-regulation in prostate cancer with promoter hypermethylation and poor prognosis.
Pan J, Chen Y, Mo C, Wang D, Chen J, Mao X, Guo S, Zhuang J, Qiu S., Free PMC Article | 11/22/2014 |
| Low expression of DSC 1, 2, and 3 was observed in 55, 54, and 79 % of liver metastases. | The influence of desmocollin 1-3 expression on prognosis after curative resection of colorectal liver metastases.
Schüle S, Neuhäuser C, Rauchfuß F, Knösel T, Settmacher U, Altendorf-Hofmann A. | 10/4/2014 |
| The data show an important role of physiologically occurring transcript d2-d4 in normal brain function. Interference with this role by DSC3 is a likely pathological mechanism in X-chromosomal dystonia parkinsonism syndrome | X-linked dystonia parkinsonism syndrome (XDP, lubag): disease-specific sequence change DSC3 in TAF1/DYT3 affects genes in vesicular transport and dopamine metabolism.
Herzfeld T, Nolte D, Grznarova M, Hofmann A, Schultze JL, Müller U. | 07/27/2013 |
| High expression of desmocollin 1 (DSC1) was observed in 41.6%, DSC2 in 58.0%, DSC3 in 61.4%, E-cadherin in 71.4%, CDX2 in 58.0%, PITX1 in 55.0%, CDK4 in 0.2%, TLE1 in 1.3%, Factor H in 42.5%, and MDM2 in 0.2% of colorectal carcinomas. | Loss of desmocollin 1-3 and homeobox genes PITX1 and CDX2 are associated with tumor progression and survival in colorectal carcinoma.
Knösel T, Chen Y, Hotovy S, Settmacher U, Altendorf-Hofmann A, Petersen I. | 03/23/2013 |
| The p53 target gene desmocollin 3 acts as a novel tumor suppressor through inhibiting EGFR/ERK pathway in human lung cancer. | The p53 target gene desmocollin 3 acts as a novel tumor suppressor through inhibiting EGFR/ERK pathway in human lung cancer.
Cui T, Chen Y, Yang L, Knösel T, Huber O, Pacyna-Gengelbach M, Petersen I. | 03/9/2013 |
| These findings demonstrate that IgG autoantibodies against an additional component of the desmosomes, Dsc3, induce loss of keratinocyte adhesion and thus may contribute to blister formation in pemphigus. | IgG autoantibodies against desmocollin 3 in pemphigus sera induce loss of keratinocyte adhesion.
Rafei D, Müller R, Ishii N, Llamazares M, Hashimoto T, Hertl M, Eming R., Free PMC Article | 05/28/2011 |
| Methylation status of DSC3 DNA is a prognostic marker for colorectal cancer. P53 appears to have an important role in regulating DSC3 expression. | DSC3 expression is regulated by p53, and methylation of DSC3 DNA is a prognostic marker in human colorectal cancer.
Cui T, Chen Y, Yang L, Knösel T, Zöller K, Huber O, Petersen I., Free PMC Article | 05/14/2011 |
| Autoimmunity to DSC3 in Pemphigus vulgaris. | Autoimmunity to desmocollin 3 in pemphigus vulgaris.
Mao X, Nagler AR, Farber SA, Choi EJ, Jackson LH, Leiferman KM, Ishii N, Hashimoto T, Amagai M, Zone JJ, Payne AS., Free PMC Article | 03/19/2011 |
| Meta-analysis of gene-disease association. (HuGE Navigator) | Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot".
Johnatty SE, Beesley J, Chen X, Macgregor S, Duffy DL, Spurdle AB, deFazio A, Gava N, Webb PM, Rossing MA, Doherty JA, Goodman MT, Lurie G, Thompson PJ, Wilkens LR, Ness RB, Moysich KB, Chang-Claude J, Wang-Gohrke S, Cramer DW, Terry KL, Hankinson SE, Tworoger SS, Garcia-Closas M, Yang H, Lissowska J, Chanock SJ, Pharoah PD, Song H, Whitemore AS, Pearce CL, Stram DO, Wu AH, Pike MC, Gayther SA, Ramus SJ, Menon U, Gentry-Maharaj A, Anton-Culver H, Ziogas A, Hogdall E, Kjaer SK, Hogdall C, Berchuck A, Schildkraut JM, Iversen ES, Moorman PG, Phelan CM, Sellers TA, Cunningham JM, Vierkant RA, Rider DN, Goode EL, Haviv I, Chenevix-Trench G, Ovarian Cancer Association Consortium, Australian Ovarian Cancer Study Group, Australian Cancer Study (Ovarian Cancer)., Free PMC Article | 09/15/2010 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| loss of heterophilic Dsc3/Dsg1 binding may contribute to pemphigus skin blistering | Desmocollin 3-mediated binding is crucial for keratinocyte cohesion and is impaired in pemphigus.
Spindler V, Heupel WM, Efthymiadis A, Schmidt E, Eming R, Rankl C, Hinterdorfer P, Müller T, Drenckhahn D, Waschke J., Free PMC Article | 01/21/2010 |
| a human desmocollin-3 (DSC3) nonsense mutation underlies hereditary hypotrichosis and recurrent skin vesicles | A homozygous nonsense mutation in the human desmocollin-3 (DSC3) gene underlies hereditary hypotrichosis and recurrent skin vesicles.
Ayub M, Basit S, Jelani M, Ur Rehman F, Iqbal M, Yasinzai M, Ahmad W., Free PMC Article | 01/21/2010 |
| Desmocollin-3 was expressed in almost half of the undifferentiated large-cell cancers | Desmocollin-3: a new marker of squamous differentiation in undifferentiated large-cell carcinoma of the lung.
Monica V, Ceppi P, Righi L, Tavaglione V, Volante M, Pelosi G, Scagliotti GV, Papotti M. | 01/21/2010 |
| Both the binding of desmocollin 3 (Dsc3) to plakoglobin and Dsc3 phosphorylation are involved in Dsc3 binding to desmoglein 3 (Dsg3) during Ca2+ -induced desmosome assembly. | Low to high Ca2+ -switch causes phosphorylation and association of desmocollin 3 with plakoglobin and desmoglein 3 in cultured keratinocytes.
Aoyama Y, Yamamoto Y, Yamaguchi F, Kitajima Y. | 01/21/2010 |
| results suggest an abnormal expression of Dsc3, Dsg3, & beta-catenin induced in the progression of oral carcinomas & that Dsc3 expression level might be related to the regulation of beta-catenin in lymph node metastasis and cell proliferation in OSCCs. | Altered expression of desmocollin 3, desmoglein 3, and beta-catenin in oral squamous cell carcinoma: correlation with lymph node metastasis and cell proliferation.
Wang L, Liu T, Wang Y, Cao L, Nishioka M, Aguirre RL, Ishikawa A, Geng L, Okada N. | 01/21/2010 |
| Increased Dsc3 protein is associated with colorectal cancer | Desmocollin switching in colorectal cancer.
Khan K, Hardy R, Haq A, Ogunbiyi O, Morton D, Chidgey M., Free PMC Article | 01/21/2010 |
| Gene-profiling experiments of breast cancer cells infected with wt p53 revealed both MASPIN and desmocollin 3 (DSC3) to be p53-target genes, even though both genes are silenced in association with aberrant cytosine methylation of their promoters | Mutant p53 and aberrant cytosine methylation cooperate to silence gene expression.
Oshiro MM, Watts GS, Wozniak RJ, Junk DJ, Munoz-Rodriguez JL, Domann FE, Futscher BW. | 01/21/2010 |