| DUSP6 is a memory retention feedback regulator of ERK signaling for cellular resilience of human pluripotent stem cells in response to dissociation. | DUSP6 is a memory retention feedback regulator of ERK signaling for cellular resilience of human pluripotent stem cells in response to dissociation.
Yoo DH, Im YS, Oh JY, Gil D, Kim YO., Free PMC Article | 04/12/2023 |
| N6-methyadenosine modified SUV39H2 regulates homologous recombination through epigenetic repression of DUSP6 in gastric cancer. | N6-methyadenosine modified SUV39H2 regulates homologous recombination through epigenetic repression of DUSP6 in gastric cancer.
Yang J, Xu P, Chen Z, Zhang X, Xia Y, Fang L, Xie L, Li B, Xu Z. | 03/8/2023 |
| SKA1 promotes tumor metastasis via SAFB-mediated transcription repression of DUSP6 in clear cell renal cell carcinoma. | SKA1 promotes tumor metastasis via SAFB-mediated transcription repression of DUSP6 in clear cell renal cell carcinoma.
Pu Y, Han J, Zhang M, Liu M, Abdusamat G, Liu H., Free PMC Article | 12/31/2022 |
| DUSP4 Inactivation Leads to Reduced Extracellular SignalRegulated Kinase Activity through Upregulation of DUSP6 in Melanoma Cells. | DUSP4 Inactivation Leads to Reduced Extracellular Signal‒Regulated Kinase Activity through Upregulation of DUSP6 in Melanoma Cells.
Kamada H, Yasuhira S, Shibazaki M, Amano H, Maesawa C. | 08/27/2022 |
| microRNA-211-5p predicts the progression of postmenopausal osteoporosis and attenuates osteogenesis by targeting dual specific phosphatase 6. | microRNA-211-5p predicts the progression of postmenopausal osteoporosis and attenuates osteogenesis by targeting dual specific phosphatase 6.
Wang H, Shi X, Guo Z, Zhao F, He W, Kang M, Lv Z., Free PMC Article | 04/16/2022 |
| Loss of FBXO31-mediated degradation of DUSP6 dysregulates ERK and PI3K-AKT signaling and promotes prostate tumorigenesis. | Loss of FBXO31-mediated degradation of DUSP6 dysregulates ERK and PI3K-AKT signaling and promotes prostate tumorigenesis.
Duan S, Moro L, Qu R, Simoneschi D, Cho H, Jiang S, Zhao H, Chang Q, de Stanchina E, Arbini AA, Pagano M., Free PMC Article | 02/19/2022 |
| Knockdown of TRIM9 attenuates irinotecaninduced intestinal mucositis in IEC6 cells by regulating DUSP6 expression via the P38 pathway. | Knockdown of TRIM9 attenuates irinotecan‑induced intestinal mucositis in IEC‑6 cells by regulating DUSP6 expression via the P38 pathway.
Zhao W, Wang Q., Free PMC Article | 02/12/2022 |
| DUSP6 regulates radiosensitivity in glioblastoma by modulating the recruitment of phosphorylated DNAPKcs at DNA double-strand breaks. | DUSP6 regulates radiosensitivity in glioblastoma by modulating the recruitment of phosphorylated DNAPKcs at DNA double-strand breaks.
Nair J, Basha Syed S, Mahaddalkar T, Ketkar M, Thorat R, Sastri Goda J, Dutt S. | 02/5/2022 |
| DUSP6 expression is associated with osteoporosis through the regulation of osteoclast differentiation via ERK2/Smad2 signaling. | DUSP6 expression is associated with osteoporosis through the regulation of osteoclast differentiation via ERK2/Smad2 signaling.
Zhang B, Yuan P, Xu G, Chen Z, Li Z, Ye H, Wang J, Shi P, Sun X., Free PMC Article | 01/29/2022 |
| Tripartite motif protein 11 (TRIM11), an oncogene for human lung cancer via the DUSP6-mediated ERK1/2 signaling pathway. | Tripartite motif protein 11 (TRIM11), an oncogene for human lung cancer via the DUSP6-mediated ERK1/2 signaling pathway.
Wang XL, Lu SC, Sun C, Jin WG, Fan YW, Shu YS, Shi HC, Min LF., Free PMC Article | 01/22/2022 |
| Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers. | Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers.
Ito T, Young MJ, Li R, Jain S, Wernitznig A, Krill-Burger JM, Lemke CT, Monducci D, Rodriguez DJ, Chang L, Dutta S, Pal D, Paolella BR, Rothberg MV, Root DE, Johannessen CM, Parida L, Getz G, Vazquez F, Doench JG, Zamanighomi M, Sellers WR. | 01/1/2022 |
| MicroRNA-211 Modulates the DUSP6-ERK5 Signaling Axis to Promote BRAF(V600E)-Driven Melanoma Growth In Vivo and BRAF/MEK Inhibitor Resistance. | MicroRNA-211 Modulates the DUSP6-ERK5 Signaling Axis to Promote BRAF(V600E)-Driven Melanoma Growth In Vivo and BRAF/MEK Inhibitor Resistance.
Lee B, Sahoo A, Sawada J, Marchica J, Sahoo S, Layng FIAL, Finlay D, Mazar J, Joshi P, Komatsu M, Vuori K, de Jong PR, Ray A, Perera RJ., Free PMC Article | 09/18/2021 |
| Prevalence and associated phenotypes of DUSP6, IL17RD and SPRY4 variants in a large Chinese cohort with isolated hypogonadotropic hypogonadism. | Prevalence and associated phenotypes of DUSP6, IL17RD and SPRY4 variants in a large Chinese cohort with isolated hypogonadotropic hypogonadism.
Men M, Wang X, Wu J, Zeng W, Jiang F, Zheng R, Li JD. | 09/11/2021 |
| Single nucleotide polymorphisms in the dual specificity phosphatase genes and risk of necrotizing enterocolitis in premature infant. | Single nucleotide polymorphisms in the dual specificity phosphatase genes and risk of necrotizing enterocolitis in premature infant.
Talavera MM, Jin Y, Zmuda EJ, Frick J, Liu Y, McBride KL, Nelin LD, Trittmann JK., Free PMC Article | 07/31/2021 |
| Dual-specificity phosphatase (DUSP6) in human glioblastoma: epithelial-to-mesenchymal transition (EMT) involvement. | Dual-specificity phosphatase (DUSP6) in human glioblastoma: epithelial-to-mesenchymal transition (EMT) involvement.
Zuchegna C, Di Zazzo E, Moncharmont B, Messina S., Free PMC Article | 06/19/2021 |
| Dual-specificity phosphatase 6 plays a critical role in the maintenance of a cancer stem-like cell phenotype in human endometrial cancer. | Dual-specificity phosphatase 6 plays a critical role in the maintenance of a cancer stem-like cell phenotype in human endometrial cancer.
Kato M, Onoyama I, Yoshida S, Cui L, Kawamura K, Kodama K, Hori E, Matsumura Y, Yagi H, Asanoma K, Yahata H, Itakura A, Takeda S, Kato K., Free PMC Article | 04/13/2021 |
| TRIM59, amplified in ovarian cancer, promotes tumorigenesis through the MKP3/ERK pathway. | TRIM59, amplified in ovarian cancer, promotes tumorigenesis through the MKP3/ERK pathway.
Tong X, Mu P, Zhang Y, Zhao J, Wang X. | 03/13/2021 |
| TRIM11 might suppress the translation of DUSP6 via improving its ubiquitination. Additionally, TRIM11 silencing in osteosarcoma (OS) cells significantly reduced its tumorigenicity in vivo. | Tripartite Motif Containing 11 Interacts with DUSP6 to Promote the Growth of Human Osteosarcoma Cells through Regulating ERK1/2 Pathway.
Wang Z, Xu X, Tang W, Zhu Y, Hu J, Zhang X., Free PMC Article | 07/4/2020 |
| DUSP6 protein expression was predominantly nuclear in breast CTCs and the brain metastases but not pleura or lung metastases of TNBC patients. Therefore, nuclear DUSP6 may play a role in the association with cancer spreading in TNBC patients, including brain metastasis. | Nuclear-Biased DUSP6 Expression is Associated with Cancer Spreading Including Brain Metastasis in Triple-Negative Breast Cancer.
Wu F, McCuaig RD, Sutton CR, Tan AHY, Jeelall Y, Bean EG, Dai J, Prasanna T, Batham J, Malik L, Yip D, Dahlstrom JE, Rao S., Free PMC Article | 12/7/2019 |
| DUSP6 is a tumor suppressor in Non-small cell lung cancer. | Role of Dusp6 Phosphatase as a Tumor Suppressor in Non-Small Cell Lung Cancer.
Moncho-Amor V, Pintado-Berninches L, Ibañez de Cáceres I, Martín-Villar E, Quintanilla M, Chakravarty P, Cortes-Sempere M, Fernández-Varas B, Rodriguez-Antolín C, de Castro J, Sastre L, Perona R., Free PMC Article | 08/17/2019 |
| The authors that the Dusp6 mRNA, which encodes an ERK1/2 phosphatase, is translationally repressed by 4EHP and a specific miRNA, miR-145. | Translational control of ERK signaling through miRNA/4EHP-directed silencing.
Jafarnejad SM, Chapat C, Matta-Camacho E, Gelbart IA, Hesketh GG, Arguello M, Garzia A, Kim SH, Attig J, Shapiro M, Morita M, Khoutorsky A, Alain T, Gkogkas CG, Stern-Ginossar N, Tuschl T, Gingras AC, Duchaine TF, Sonenberg N., Free PMC Article | 08/10/2019 |
| Oxidative stress, ER stress, and mitochondrial dysfunction induced by Ab could be restored by DUSP6 overexpression. Additionally, the Ab-induced ERK1/2 activation was reversed. In summary, DUSP6 might have a neuroprotective effect on Abeta-induced cytotoxicity, probably via ERK1/2 activation. | Dual Specificity Phosphatase 6 Protects Neural Stem Cells from β-Amyloid-Induced Cytotoxicity through ERK1/2 Inactivation.
Liao W, Zheng Y, Fang W, Liao S, Xiong Y, Li Y, Xiao S, Zhang X, Liu J., Free PMC Article | 06/1/2019 |
| A dual specificity phosphatase, DUSP6, that negatively regulates phosphorylation of (P)-ERK is up-regulated in EGFR- or KRAS-mutant lung adenocarcinoma (LUAD), potentially protecting cells with mutations in the RAS signaling pathway, a proposal supported by experiments with DUSP6-specific siRNA and an inhibitory drug | Hyperactivation of ERK by multiple mechanisms is toxic to RTK-RAS mutation-driven lung adenocarcinoma cells.
Unni AM, Harbourne B, Oh MH, Wild S, Ferrarone JR, Lockwood WW, Varmus H., Free PMC Article | 03/30/2019 |
| In primary human umbilical vein endothelial cells in which endogenous DUSP6 was ablated, DUSP6 facilitated TNF-alpha-induced ICAM-1 expression and endothelial leukocyte interaction. DUSP6-promoted endothelial inflammation is independent of ERK signaling. Inducible DUSP6 leads to activation of canonical nuclear factor (NF)-kappaB-mediated transcription of ICAM-1 gene in TNF-alpha-stimulated human ECs. | Dual specificity phosphatase DUSP6 promotes endothelial inflammation through inducible expression of ICAM-1.
Hsu SF, Lee YB, Lee YC, Chung AL, Apaya MK, Shyur LF, Cheng CF, Ho FM, Meng TC. | 03/2/2019 |
| Individuals are carrying DUSP6 rs2279574 AA and AC genotypes associated with an increased risk in developing lung squamous carcinoma in Han Chinese and with advanced NSCLC stages. | Dual-specificity phosphatase 6 genetic variants associated with risk of lung squamous cell carcinoma in Han Chinese.
Wang TL, Song YQ, Ren YW, Zhou BS, Wang HT, Gao Y, Yu H, Zhao YX. | 09/8/2018 |