| Proteasome gene expression is controlled by coordinated functions of multiple transcription factors. | Proteasome gene expression is controlled by coordinated functions of multiple transcription factors.
Gilda JE, Nahar A, Kasiviswanathan D, Tropp N, Gilinski T, Lahav T, Alexandrovich D, Mandel-Gutfreund Y, Park S, Shemer S., | 05/23/2024 |
| Conversion of Gastrointestinal Somatostatin-Expressing D Cells Into Insulin-Producing Beta-Like Cells Upon Pax4 Misexpression. | Conversion of Gastrointestinal Somatostatin-Expressing D Cells Into Insulin-Producing Beta-Like Cells Upon Pax4 Misexpression.
Garrido-Utrilla A, Ayachi C, Friano ME, Atlija J, Balaji S, Napolitano T, Silvano S, Druelle N, Collombat P., Free PMC Article | 05/21/2022 |
| Down-regulation of PAX4 or its target gene encoding the p97/VCP ATPase reduced myofibril disassembly. | Myofibril breakdown during atrophy is a delayed response requiring the transcription factor PAX4 and desmin depolymerization.
Volodin A, Kosti I, Goldberg AL, Cohen S., Free PMC Article | 04/14/2018 |
| Ectopic expression of Pax4 in pancreatic delta cells results in beta-like cell neogenesis. | Ectopic expression of Pax4 in pancreatic δ cells results in β-like cell neogenesis.
Druelle N, Vieira A, Shabro A, Courtney M, Mondin M, Rekima S, Napolitano T, Silvano S, Navarro-Sanz S, Hadzic B, Avolio F, Rassoulzadegan M, Schmid HA, Mansouri A, Collombat P., Free PMC Article | 12/9/2017 |
| The coordinated regulation of distinct cellular pathways particularly related to ER homeostasis by PAX4 not achieved by the mutant variant PAX4R129W alleviates beta cell degeneration and protects against diabetes mellitus. | PAX4 preserves endoplasmic reticulum integrity preventing beta cell degeneration in a mouse model of type 1 diabetes mellitus.
Mellado-Gil JM, Jiménez-Moreno CM, Martin-Montalvo A, Alvarez-Mercado AI, Fuente-Martin E, Cobo-Vuilleumier N, Lorenzo PI, Bru-Tari E, Herrera-Gómez Ide G, López-Noriega L, Pérez-Florido J, Santoyo-López J, Spyrantis A, Meda P, Boehm BO, Quesada I, Gauthier BR., Free PMC Article | 12/17/2016 |
| This work establishes the existence of a bona fide PAX4-enriched cell subpopulation nested within pancreatic islets that can expand in periods of increased functional demands, and exhibit improved viability in response to pathophysiological situations. | PAX4 Defines an Expandable β-Cell Subpopulation in the Adult Pancreatic Islet.
Lorenzo PI, Fuente-Martín E, Brun T, Cobo-Vuilleumier N, Jimenez-Moreno CM, G Herrera Gomez I, López Noriega L, Mellado-Gil JM, Martin-Montalvo A, Soria B, Gauthier BR., Free PMC Article | 09/17/2016 |
| Pax4 expression is not sufficient to transduce pancreatic alpha cells into beta cells. Overexpression of Pax4 in alpha cells may not increase functional beta cell number in diabetic patients | Pax4 Expression does not Transduce Pancreatic Alpha Cells to Beta Cells.
Chen L, Zhang J, Zhang Z, Chu Y, Song B, Cai W. | 05/21/2016 |
| Adult glucagon producing cells can be converted into beta-like cells upon Pax4 misexpression. | Adult duct-lining cells can reprogram into β-like cells able to counter repeated cycles of toxin-induced diabetes.
Al-Hasani K, Pfeifer A, Courtney M, Ben-Othman N, Gjernes E, Vieira A, Druelle N, Avolio F, Ravassard P, Leuckx G, Lacas-Gervais S, Ambrosetti D, Benizri E, Hecksher-Sorensen J, Gounon P, Ferrer J, Gradwohl G, Heimberg H, Mansouri A, Collombat P. | 09/28/2013 |
| RBM4 promoted insulin gene expression by altering the isoform balance of the transcription factors Isl1 and Pax4 via alternative splicing control. | RBM4 promotes pancreas cell differentiation and insulin expression.
Lin JC, Yan YT, Hsieh WK, Peng PJ, Su CH, Tarn WY., Free PMC Article | 02/23/2013 |
| these finding demonstrate that, downstream of Neurog3, the specification of a subset of enteroendocrine subtypes relies on both Arx and Pax4, while others depend only on Arx or Pax4. | The homeodomain-containing transcription factors Arx and Pax4 control enteroendocrine subtype specification in mice.
Beucher A, Gjernes E, Collin C, Courtney M, Meunier A, Collombat P, Gradwohl G., Free PMC Article | 01/26/2013 |
| Pax4 protects adult islets from stress-induced apoptosis by suppressing selective nuclear factor-kappaB target genes while increasing Bcl-2 levels. | In vivo conditional Pax4 overexpression in mature islet β-cells prevents stress-induced hyperglycemia in mice.
Hu He KH, Lorenzo PI, Brun T, Jimenez Moreno CM, Aeberhard D, Vallejo Ortega J, Cornu M, Thorel F, Gjinovci A, Thorens B, Herrera PL, Meda P, Wollheim CB, Gauthier BR., Free PMC Article | 07/16/2011 |
| Ectopically expressed Pax4 using different cell-specific promoters demonstrate that Pax4 forces endocrine precursor cells, as well as mature alpha cells, to adopt a beta cell destiny. | The ectopic expression of Pax4 in the mouse pancreas converts progenitor cells into alpha and subsequently beta cells.
Collombat P, Xu X, Ravassard P, Sosa-Pineda B, Dussaud S, Billestrup N, Madsen OD, Serup P, Heimberg H, Mansouri A., Free PMC Article | 01/21/2010 |
| The daily changes in Pax4 expression may contribute to daily changes in function in the differentiated retinal photoreceptor. | Developmental and daily expression of the Pax4 and Pax6 homeobox genes in the rat retina: localization of Pax4 in photoreceptor cells.
Rath MF, Bailey MJ, Kim JS, Coon SL, Klein DC, Møller M., Free PMC Article | 01/21/2010 |
| PAX4 gene is not associated with the risk of type 1 diabetes in a Han Chinese sample. | The association of the PAX4 gene with type 1 diabetes in Han Chinese.
Zhang Y, Xiao X, Liu Y, Zhu X, Wenhui L, Li N, Yuan T, Wang H. | 01/21/2010 |
| Data further support the notion that Pax4 activity is necessary to establish appropriate patterns of gene expression in endocrine progenitors of the digestive tract. | Ghrelin is a novel target of Pax4 in endocrine progenitors of the pancreas and duodenum.
Wang Q, Elghazi L, Martin S, Martins I, Srinivasan RS, Geng X, Sleeman M, Collombat P, Houghton J, Sosa-Pineda B. | 01/21/2010 |
| The higher insulin production with glucose dependent modulation suggests that pax4 expression can drive more mature insulin producing cells. | Enhancement of insulin-producing cell differentiation from embryonic stem cells using pax4-nucleofection method.
Lin HT, Kao CL, Lee KH, Chang YL, Chiou SH, Tsai FT, Tsai TH, Sheu DC, Ho LL, Ku HH., Free PMC Article | 01/21/2010 |
| Pax4 is an essential regulator of pancreatic beta-cell development [review] | The gene Pax4 is an essential regulator of pancreatic beta-cell development.
Sosa-Pineda B. | 01/21/2010 |
| Pax4 has a role in facilitating embryonic stem cell differentiation into the pancreatic lineage | Expression of Pax4 in embryonic stem cells promotes differentiation of nestin-positive progenitor and insulin-producing cells.
Blyszczuk P, Czyz J, Kania G, Wagner M, Roll U, St-Onge L, Wobus AM., Free PMC Article | 01/21/2010 |
| activity appears essential for appropriate initiation of beta-cell differentiation | The concerted activities of Pax4 and Nkx2.2 are essential to initiate pancreatic beta-cell differentiation.
Wang J, Elghazi L, Parker SE, Kizilocak H, Asano M, Sussel L, Sosa-Pineda B. | 01/21/2010 |
| A2 and E1 elements in endocrine promoters are essential for Pax4 expression | DNA sequence motifs conserved in endocrine promoters are essential for Pax4 expression.
Brink C, Gruss P. | 01/21/2010 |
| Pax-4 and Arx act as transcriptional repressors that control the expression level of one another, thereby mediating proper endocrine fate allocation in the pancreas. | The simultaneous loss of Arx and Pax4 genes promotes a somatostatin-producing cell fate specification at the expense of the alpha- and beta-cell lineages in the mouse endocrine pancreas.
Collombat P, Hecksher-Sørensen J, Broccoli V, Krull J, Ponte I, Mundiger T, Smith J, Gruss P, Serup P, Mansouri A. | 01/21/2010 |