| Loss of PBX1 function in Leydig cells causes testicular dysgenesis and male sterility. | Loss of PBX1 function in Leydig cells causes testicular dysgenesis and male sterility.
Wang FC, Zhang XN, Wu SX, He Z, Zhang LY, Yang QE., Free PMC Article | 05/13/2024 |
| Lupus susceptibility gene Pbx1 controls the development, stability, and function of regulatory T cells via Rtkn2 expression. | Lupus susceptibility gene Pbx1 controls the development, stability, and function of regulatory T cells via Rtkn2 expression.
Choi SC, Park YP, Roach T, Jimenez D, Fisher A, Zadeh M, Ma L, Sobel ES, Ge Y, Mohamadzadeh M, Morel L., Free PMC Article | 04/3/2024 |
| Regulation of the STAT3 pathway by lupus susceptibility gene Pbx1 in T cells. | Regulation of the STAT3 pathway by lupus susceptibility gene Pbx1 in T cells.
Roach T, Park YP, Choi SC, Morel L. | 02/1/2024 |
| Involvement of Transcriptional Factor Pbx1 in Peripheral B Cell Homeostasis to Constrain Lupus Autoimmunity. | Involvement of Transcriptional Factor Pbx1 in Peripheral B Cell Homeostasis to Constrain Lupus Autoimmunity.
Gu S, Zhang J, Han X, Ding H, Yao C, Ye Z, Yin Z, Hou G, Jiang Y, Qian J, Zhou H, Guo Q, Chen S, Dai D, Shen N. | 08/2/2023 |
| A spatio-temporally constrained gene regulatory network directed by PBX1/2 acquires limb patterning specificity via HAND2. | A spatio-temporally constrained gene regulatory network directed by PBX1/2 acquires limb patterning specificity via HAND2.
Losa M, Barozzi I, Osterwalder M, Hermosilla-Aguayo V, Morabito A, Chacón BH, Zarrineh P, Girdziusaite A, Benazet JD, Zhu J, Mackem S, Capellini TD, Dickel D, Bobola N, Zuniga A, Visel A, Zeller R, Selleri L., Free PMC Article | 07/12/2023 |
| Overexpression of lipocalin 2 in PBX1-deficient decidual NK cells promotes inflammation at the maternal-fetal interface. | Overexpression of lipocalin 2 in PBX1-deficient decidual NK cells promotes inflammation at the maternal-fetal interface.
An X, Qin J, Hu X, Zhou Y, Fu B, Wei H. | 02/22/2023 |
| PBX1-directed stem cell transcriptional program drives tumor progression in myeloproliferative neoplasm. | PBX1-directed stem cell transcriptional program drives tumor progression in myeloproliferative neoplasm.
Muggeo S, Crisafulli L, Uva P, Fontana E, Ubezio M, Morenghi E, Colombo FS, Rigoni R, Peano C, Vezzoni P, Della Porta MG, Villa A, Ficara F., Free PMC Article | 03/19/2022 |
| Transcriptional cooperation of PBX1 and PAX6 in adult neural progenitor cells. | Transcriptional cooperation of PBX1 and PAX6 in adult neural progenitor cells.
Hau AC, Mommaerts E, Laub V, Müller T, Dittmar G, Schulte D., Free PMC Article | 01/29/2022 |
| Functional characterization of a novel PBX1 de novo missense variant identified in a patient with syndromic congenital heart disease. | Functional characterization of a novel PBX1 de novo missense variant identified in a patient with syndromic congenital heart disease.
Alankarage D, Szot JO, Pachter N, Slavotinek A, Selleri L, Shieh JT, Winlaw D, Giannoulatou E, Chapman G, Dunwoodie SL., Free PMC Article | 08/7/2021 |
| T cells expressing the lupus susceptibility allele Pbx1d enhance autoimmunity and atherosclerosis in dyslipidemic mice. | T cells expressing the lupus susceptibility allele Pbx1d enhance autoimmunity and atherosclerosis in dyslipidemic mice.
Li W, Elshikha AS, Cornaby C, Teng X, Abboud G, Brown J, Zou X, Zeumer-Spataro L, Robusto B, Choi SC, Fredenburg K, Major A, Morel L., Free PMC Article | 05/22/2021 |
| PBX1 promotes development of natural killer cells by binding directly to the Nfil3 promoter. | PBX1 promotes development of natural killer cells by binding directly to the Nfil3 promoter.
Xu X, Zhou Y, Fu B, Zhang J, Dong Z, Zhang X, Shen N, Sun R, Tian Z, Wei H. | 01/23/2021 |
| PBX1 acts as terminal selector for olfactory bulb dopaminergic neurons. | PBX1 acts as terminal selector for olfactory bulb dopaminergic neurons.
Remesal L, Roger-Baynat I, Chirivella L, Maicas M, Brocal-Ruiz R, Pérez-Villalba A, Cucarella C, Casado M, Flames N. | 12/19/2020 |
| mouse PBX1 and PBX2 have roles in pulmonary vascular adaptation to birth | PBX transcription factors drive pulmonary vascular adaptation to birth.
McCulley DJ, Wienhold MD, Hines EA, Hacker TA, Rogers A, Pewowaruk RJ, Zewdu R, Chesler NC, Selleri L, Sun X., Free PMC Article | 07/20/2019 |
| a mechanism by which the DNA binding-independent activity of Sp2 potentiates genomic loading of Pbx1:Prep1 and Nf-y to composite motifs present in many promoters of highly expressed genes | Transcription factor Sp2 potentiates binding of the TALE homeoproteins Pbx1:Prep1 and the histone-fold domain protein Nf-y to composite genomic sites.
Völkel S, Stielow B, Finkernagel F, Berger D, Stiewe T, Nist A, Suske G., Free PMC Article | 04/13/2019 |
| uc.40 may play an important role during the differentiation of P19 cells by regulation of PBX1 to promote proliferation and inhibit apoptosis. | LncRNA-uc.40 silence promotes P19 embryonic cells differentiation to cardiomyocyte via the PBX1 gene.
Wu R, Xue P, Wan Y, Wang S, Gu M. | 12/22/2018 |
| Expression of PBX1 in leukemia cells enhances chemo-resistance and colony formation. | The central nervous system microenvironment influences the leukemia transcriptome and enhances leukemia chemo-resistance.
Gaynes JS, Jonart LM, Zamora EA, Naumann JA, Gossai NP, Gordon PM., Free PMC Article | 08/11/2018 |
| Pbx-dependent Epithelial-mesenchymal transition programs mediate murine upper lip/primary palate morphogenesis and fusion via regulation of Snail1. | Face morphogenesis is promoted by Pbx-dependent EMT via regulation of Snail1 during frontonasal prominence fusion.
Losa M, Risolino M, Li B, Hart J, Quintana L, Grishina I, Yang H, Choi IF, Lewicki P, Khan S, Aho R, Feenstra J, Vincent CT, Brown AMC, Ferretti E, Williams T, Selleri L., Free PMC Article | 04/7/2018 |
| MEIS2 associates with chromatin-bound PBX1, recruits PARP1/ARTD1, and initiates PARP1-mediated eviction of H1 from the chromatin fiber. | MEIS homeodomain proteins facilitate PARP1/ARTD1-mediated eviction of histone H1.
Hau AC, Grebbin BM, Agoston Z, Anders-Maurer M, Müller T, Groß A, Kolb J, Langer JD, Döring C, Schulte D., Free PMC Article | 10/7/2017 |
| results indicate Pbx genes act in parallel genetic pathways to orchestrate neuronal subtype differentiation, connectivity, and organization. I | Parallel Pbx-Dependent Pathways Govern the Coalescence and Fate of Motor Columns.
Hanley O, Zewdu R, Cohen LJ, Jung H, Lacombe J, Philippidou P, Lee DH, Selleri L, Dasen JS., Free PMC Article | 09/30/2017 |
| Hoxa2, Meis and Pbx proteins act cooperatively on the ECR, via a core 32 bp sequence, to regulate Hmx1 expression. | A distal 594 bp ECR specifies Hmx1 expression in pinna and lateral facial morphogenesis and is regulated by the Hox-Pbx-Meis complex.
Rosin JM, Li W, Cox LL, Rolfe SM, Latorre V, Akiyama JA, Visel A, Kuramoto T, Bobola N, Turner EE, Cox TC., Free PMC Article | 09/9/2017 |
| PBX1 regulates adult neural cell fate determination in a manner beyond that of its heterodimerization partner MEIS2. | Pbx1 is required for adult subventricular zone neurogenesis.
Grebbin BM, Hau AC, Groß A, Anders-Maurer M, Schramm J, Koss M, Wille C, Mittelbronn M, Selleri L, Schulte D., Free PMC Article | 09/9/2017 |
| Our results suggest that Pbx1-d impacts lupus development by regulating effector T cell differentiation and promoting follicular helper T cells at the expense of regulatory T cell s and identify Pbx1 as a novel regulator of CD4(+) T cell effector function | The Lupus Susceptibility Gene Pbx1 Regulates the Balance between Follicular Helper T Cell and Regulatory T Cell Differentiation.
Choi SC, Hutchinson TE, Titov AA, Seay HR, Li S, Brusko TM, Croker BP, Salek-Ardakani S, Morel L., Free PMC Article | 08/12/2017 |
| FLT3-ITD is capable of inhibiting FLT3-ITD+ cell proliferation through the p21/Pbx1 axis | Internal Tandem Duplication in FLT3 Attenuates Proliferation and Regulates Resistance to the FLT3 Inhibitor AC220 by Modulating p21Cdkn1a and Pbx1 in Hematopoietic Cells.
Abe M, Pelus LM, Singh P, Hirade T, Onishi C, Purevsuren J, Taketani T, Yamaguchi S, Fukuda S., Free PMC Article | 07/29/2017 |
| non-cell autonomous functions of Pbx factors within the splenic niche contribute to the regulation of hematopoiesis | Spleen hypoplasia leads to abnormal stress hematopoiesis in mice with loss of Pbx homeoproteins in splenic mesenchyme.
Zewdu R, Risolino M, Barbulescu A, Ramalingam P, Butler JM, Selleri L., Free PMC Article | 03/4/2017 |
| Both histone H3 lysine 27 acetylation and recruitment of the transcription factor Pbx1 at prospective enhancers are regulated by mH2A1.2. | The Histone Variant MacroH2A1.2 Is Necessary for the Activation of Muscle Enhancers and Recruitment of the Transcription Factor Pbx1.
Dell'Orso S, Wang AH, Shih HY, Saso K, Berghella L, Gutierrez-Cruz G, Ladurner AG, O'Shea JJ, Sartorelli V, Zare H., Free PMC Article | 11/5/2016 |