| Dishevelled2 activates WGEF via its interaction with a unique internal peptide motif of the GEF. | Dishevelled2 activates WGEF via its interaction with a unique internal peptide motif of the GEF.
Omble A, Mahajan S, Bhoite A, Kulkarni K., Free PMC Article | 05/28/2024 |
| Dishevelled segment polarity protein 2 promotes gastric cancer progression through Wnt/beta-catenin pathway. | Dishevelled segment polarity protein 2 promotes gastric cancer progression through Wnt/β-catenin pathway.
He R, Chen Y, Qian C, Hu Y, Huang X, Tao R. | 07/7/2023 |
| Overexpressions of RHOA, CSNK1A1, DVL2, FZD8, and LRP5 genes enhance gastric cancer development in the presence of Helicobacter pylori. | Overexpressions of RHOA, CSNK1A1, DVL2, FZD8, and LRP5 genes enhance gastric cancer development in the presence of Helicobacter pylori.
Demirci U, Orenay-Boyacioglu S, Kasap E, Gerçeker E, Bilgiç F, Yüceyar H, Yildirim H, Baykan AR, Ellidokuz EB, Korkmaz M. | 06/22/2023 |
| Inhibiting von Hippel-Lindau protein-mediated Dishevelled ubiquitination protects against experimental parkinsonism. | Inhibiting von Hippel‒Lindau protein-mediated Dishevelled ubiquitination protects against experimental parkinsonism.
Shen J, Zha Q, Yang QH, Zhou YQ, Liang X, Chen YJ, Qi GX, Zhang XJ, Yao WB, Gao XD, Chen S., Free PMC Article | 04/19/2023 |
| Dishevelled phase separation promotes Wnt signalosome assembly and destruction complex disassembly. | Dishevelled phase separation promotes Wnt signalosome assembly and destruction complex disassembly.
Kang K, Shi Q, Wang X, Chen YG., Free PMC Article | 11/19/2022 |
| DACT3 has a tumor-inhibiting role in acute myeloid leukemia via the suppression of Wnt/beta-catenin signaling by DVL2. | DACT3 has a tumor-inhibiting role in acute myeloid leukemia via the suppression of Wnt/β-catenin signaling by DVL2.
Gao Q, Hou L, Wang H, Xun L. | 05/21/2022 |
| HBx increases chromatin accessibility and ETV4 expression to regulate dishevelled-2 and promote HCC progression. | HBx increases chromatin accessibility and ETV4 expression to regulate dishevelled-2 and promote HCC progression.
Zheng C, Liu M, Ge Y, Qian Y, Fan H., Free PMC Article | 04/16/2022 |
| Cumulus cells of euploid versus whole chromosome 21 aneuploid embryos reveal differentially expressed genes. | Cumulus cells of euploid versus whole chromosome 21 aneuploid embryos reveal differentially expressed genes.
Tiegs AW, Titus S, Mehta S, Garcia-Milian R, Seli E, Scott RT Jr. | 02/12/2022 |
| Dvl2 facilitates the coordination of NF-kappaB and Wnt signaling to promote colitis-associated colorectal progression. | Dvl2 facilitates the coordination of NF-κB and Wnt signaling to promote colitis-associated colorectal progression.
Tang F, Cao F, Lu C, He X, Weng L, Sun L., Free PMC Article | 02/12/2022 |
| Targeting E3 Ubiquitin Ligase WWP1 Prevents Cardiac Hypertrophy Through Destabilizing DVL2 via Inhibition of K27-Linked Ubiquitination. | Targeting E3 Ubiquitin Ligase WWP1 Prevents Cardiac Hypertrophy Through Destabilizing DVL2 via Inhibition of K27-Linked Ubiquitination.
Zhao D, Zhong G, Li J, Pan J, Zhao Y, Song H, Sun W, Jin X, Li Y, Du R, Nie J, Liu T, Zheng J, Jia Y, Liu Z, Liu W, Yuan X, Liu Z, Song J, Kan G, Li Y, Liu C, Gao X, Xing W, Chang YZ, Li Y, Ling S. | 01/8/2022 |
| Regulation of Dishevelled DEP domain swapping by conserved phosphorylation sites. | Regulation of Dishevelled DEP domain swapping by conserved phosphorylation sites.
Beitia GJ, Rutherford TJ, Freund SMV, Pelham HR, Bienz M, Gammons MV., Free PMC Article | 12/4/2021 |
| Reversible acetylation modulates dishevelled-2 puncta formation in canonical Wnt signaling activation. | Reversible acetylation modulates dishevelled-2 puncta formation in canonical Wnt signaling activation.
Shen J, Hu L, Yang L, Zhang M, Sun W, Lu X, Lin G, Huang C, Zhang X, Chin YE., Free PMC Article | 10/9/2021 |
| TM4SF1, a binding protein of DVL2 in hepatocellular carcinoma, positively regulates beta-catenin/TCF signalling. | TM4SF1, a binding protein of DVL2 in hepatocellular carcinoma, positively regulates beta-catenin/TCF signalling.
Zhu C, Luo X, Wu J, Liu Y, Liu L, Ma S, Xie R, Wang S, Ji W., Free PMC Article | 09/25/2021 |
| Cullin 1 (CUL1) Promotes Primary Ciliogenesis through the Induction of Ubiquitin-Proteasome-Dependent Dvl2 Degradation. | Cullin 1 (CUL1) Promotes Primary Ciliogenesis through the Induction of Ubiquitin-Proteasome-Dependent Dvl2 Degradation.
Kim SO, Cho KS, Kim BY, Lee KH., Free PMC Article | 08/21/2021 |
| Low fluid shear stress promoted ciliogenesis via Dvl2 in hUVECs. | Low fluid shear stress promoted ciliogenesis via Dvl2 in hUVECs.
Sheng X, Sheng Y, Gao S, Fan F, Wang J. | 07/17/2021 |
| DVL mutations identified from human neural tube defects and Dandy-Walker malformation obstruct the Wnt signaling pathway. | DVL mutations identified from human neural tube defects and Dandy-Walker malformation obstruct the Wnt signaling pathway.
Liu L, Liu W, Shi Y, Li L, Gao Y, Lei Y, Finnell R, Zhang T, Zhang F, Jin L, Li H, Tao W, Wang H. | 06/12/2021 |
| Characterization of the aberrant splicing of DVL2 induced by cancer-associated SF3B1 mutation. | Characterization of the aberrant splicing of DVL2 induced by cancer-associated SF3B1 mutation.
Zhao B, Hu X, Zhou Y, Shi Y, Qian R, Wan Y. | 05/22/2021 |
| The Daple-CK1epsilon complex regulates Dvl2 phosphorylation and canonical Wnt signaling. | The Daple-CK1ε complex regulates Dvl2 phosphorylation and canonical Wnt signaling.
Esaki N, Enomoto A, Takagishi M, Mizutani Y, Iida T, Ushida K, Shiraki Y, Mii S, Takahashi M. | 03/20/2021 |
| TBX1 and Basal Cell Carcinoma: Expression and Interactions with Gli2 and Dvl2 Signaling. | TBX1 and Basal Cell Carcinoma: Expression and Interactions with Gli2 and Dvl2 Signaling.
Caprio C, Varricchio S, Bilio M, Feo F, Ferrentino R, Russo D, Staibano S, Alfano D, Missero C, Ilardi G, Baldini A., Free PMC Article | 10/24/2020 |
| Single-molecule dynamics of Dishevelled at the plasma membrane and Wnt pathway activation. | Single-molecule dynamics of Dishevelled at the plasma membrane and Wnt pathway activation.
Ma W, Chen M, Kang H, Steinhart Z, Angers S, He X, Kirschner MW., Free PMC Article | 09/26/2020 |
| USP9X Deubiquitylates DVL2 to Regulate WNT Pathway Specification. | USP9X Deubiquitylates DVL2 to Regulate WNT Pathway Specification.
Nielsen CP, Jernigan KK, Diggins NL, Webb DJ, MacGurn JA., Free PMC Article | 08/29/2020 |
| This study aims to determine the contribution of polymorphisms in the genes of the beta-catenin destruction complex to develop colorectal cancer, specifically adenomatous polyposis coli (APC) (rs11954856 G>T and rs459552 A>T), axis inhibition protein 1 (AXIN1) (rs9921222 C>T and rs1805105 C>T), AXIN2 (rs7224837 A>G), and dishevelled 2 (DVL2) (2074222 G>A and rs222836 C>T). | Genetic Polymorphisms in APC, DVL2, and AXIN1 Are Associated with Susceptibility, Advanced TNM Stage or Tumor Location in Colorectal Cancer.
Rosales-Reynoso MA, Saucedo-Sariñana AM, Contreras-Díaz KB, Márquez-González RM, Barros-Núñez P, Pineda-Razo TD, Marin-Contreras ME, Durán-Anguiano Ó, Gallegos-Arreola MP, Flores-Martínez SE, Sánchez-Corona J. | 04/25/2020 |
| CFTR is involved in the regulation of Wnt-dependent hematopoiesis through its interaction with and regulation of the degradation process of a key adaptor protein of Wnt signaling, Dvl2. | CFTR mutation enhances Dishevelled degradation and results in impairment of Wnt-dependent hematopoiesis.
Sun H, Wang Y, Zhang J, Chen Y, Liu Y, Lin Z, Liu M, Sheng K, Liao H, Tsang KS, Zhang X, Jiang X, Xu W, Mao M, Chan HC., Free PMC Article | 04/11/2020 |
| High Dvl-2 expression is associated with hepatoblastoma. | Down-regulation of dishevelled-2 inhibits cell proliferation and invasion in hepatoblastoma.
Huang S, Chen J, Tian R, Wang J, Xie C, Gao H, Shan Y, Hong J, Zhang Z, Xu M, Gu S. | 05/11/2019 |
| TRIM14 promotes chemoresistance in gliomas by activating Wnt/beta-catenin signaling via stabilizing Dvl2 | TRIM14 promotes chemoresistance in gliomas by activating Wnt/β-catenin signaling via stabilizing Dvl2.
Tan Z, Song L, Wu W, Zhou Y, Zhu J, Wu G, Cao L, Song J, Li J, Zhang W. | 02/23/2019 |