| Regulation of vascular angiotensin II type 1 and type 2 receptor and angiotensin-(1-7)/MasR signaling in normal and hypertensive pregnancy. | Regulation of vascular angiotensin II type 1 and type 2 receptor and angiotensin-(1-7)/MasR signaling in normal and hypertensive pregnancy.
Clark CR, Khalil RA., | 02/1/2024 |
| Angiotensin II type 2 receptor-mediated dilation is greater in the cutaneous microvasculature of premenopausal women compared with men. | Angiotensin II type 2 receptor-mediated dilation is greater in the cutaneous microvasculature of premenopausal women compared with men.
Schwartz KS, Lang JA, Stanhewicz AE. | 11/27/2023 |
| A functional mechanism for a non-coding variant near AGTR2 associated with risk for preterm birth. | A functional mechanism for a non-coding variant near AGTR2 associated with risk for preterm birth.
Wang L, Rossi RM, Chen X, Chen J, Runyon J, Chawla M, Miller D, Forney C, Lynch A, Zhang X, Kong F, Jacobsson B, Kottyan LC, Weirauch MT, Zhang G, Muglia LJ., Free PMC Article | 09/9/2023 |
| Angiotensin II type 2 receptor prevents extracellular matrix accumulation in human peritoneal mesothelial cell by ameliorating lipid disorder via LOX-1 suppression. | Angiotensin II type 2 receptor prevents extracellular matrix accumulation in human peritoneal mesothelial cell by ameliorating lipid disorder via LOX-1 suppression.
Liu J, Jin B, Lu J, Feng Y, Li N, Wan C, Zhang QY, Jiang CM., Free PMC Article | 10/22/2022 |
| The Role of ACE, ACE2, and AGTR2 Polymorphisms in COVID-19 Severity and the Presence of COVID-19-Related Retinopathy. | The Role of ACE, ACE2, and AGTR2 Polymorphisms in COVID-19 Severity and the Presence of COVID-19-Related Retinopathy.
Jevnikar K, Lapajne L, Petrovič D, Meglič A, Logar M, Vidovič Valentinčič N, Globočnik Petrovič M, Cilenšek I, Mekjavić PJ., Free PMC Article | 08/6/2022 |
| Exploring AT2R and its Polymorphism in Different Diseases: An Approach to Develop AT2R as a Drug Target beyond Hypertension. | Exploring AT2R and its Polymorphism in Different Diseases: An Approach to Develop AT2R as a Drug Target beyond Hypertension.
Sharma B, Hussain T, Khan MA, Jaiswal V. | 05/14/2022 |
| AT2R activation increases in vitro angiogenesis in pregnant human uterine artery endothelial cells. | AT2R activation increases in vitro angiogenesis in pregnant human uterine artery endothelial cells.
Mishra JS, Chen DB, Kumar S., Free PMC Article | 05/14/2022 |
| Association of maternal angiotensin II type 1 and type 2 receptor combination genotypes with susceptibility to early-onset preeclampsia. | Association of maternal angiotensin II type 1 and type 2 receptor combination genotypes with susceptibility to early-onset preeclampsia.
Satra M, Samara M, Alatsathianos G, Vamvakopoulou D, Baka A, Tsalazidou-Founta TM, Sidiropoulos A, Vamvakopoulos KO, Garas A, Daponte A, Vamvakopoulos N, Sotiriou S. | 04/30/2022 |
| Colon adenocarcinoma-derived cells possessing stem cell function can be modulated using renin-angiotensin system inhibitors. | Colon adenocarcinoma-derived cells possessing stem cell function can be modulated using renin-angiotensin system inhibitors.
Munro MJ, Peng L, Wickremesekera SK, Tan ST., Free PMC Article | 12/11/2021 |
| GABA is a mediator of brain AT1 and AT2 receptor-mediated blood pressure responses. | GABA is a mediator of brain AT(1) and AT(2) receptor-mediated blood pressure responses.
Dupont AG, Légat L. | 10/9/2021 |
| AGTR2, One Possible Novel Key Gene for the Entry of SARS-CoV-2 Into Human Cells. | AGTR2, One Possible Novel Key Gene for the Entry of SARS-CoV-2 Into Human Cells.
Cui C, Huang C, Zhou W, Ji X, Zhang F, Wang L, Zhou Y, Cui Q. | 08/21/2021 |
| Variants in AGTR2 gene in Maya people with COVID-19. | Variants in AGTR2 gene in Maya people with COVID-19.
Totomoch-Serra A, Domínguez-Cruz MG, Manterola C, Muñoz ML., Free PMC Article | 07/17/2021 |
| Preoperative angiotensin II type 2 receptor is a predictor for developing chronic post-surgical pain after total knee arthroplasty surgery. | Preoperative angiotensin II type 2 receptor is a predictor for developing chronic post-surgical pain after total knee arthroplasty surgery.
Chen F, Gao W, Hu J, Yang X, Chai X, Wang D. | 07/3/2021 |
| The Crystal Structure of Angiotensin II Type 2 Receptor with Endogenous Peptide Hormone. | The Crystal Structure of Angiotensin II Type 2 Receptor with Endogenous Peptide Hormone.
Asada H, Inoue A, Ngako Kadji FM, Hirata K, Shiimura Y, Im D, Shimamura T, Nomura N, Iwanari H, Hamakubo T, Kusano-Arai O, Hisano H, Uemura T, Suno C, Aoki J, Iwata S. | 04/17/2021 |
| The discovery of a new antibody for BRIL-fused GPCR structure determination. | The discovery of a new antibody for BRIL-fused GPCR structure determination.
Miyagi H, Asada H, Suzuki M, Takahashi Y, Yasunaga M, Suno C, Iwata S, Saito JI., Free PMC Article | 12/12/2020 |
| Brain Angiotensin Type-1 and Type-2 Receptors in Physiological and Hypertensive Conditions: Focus on Neuroinflammation. | Brain Angiotensin Type-1 and Type-2 Receptors in Physiological and Hypertensive Conditions: Focus on Neuroinflammation.
Elsaafien K, de Kloet AD, Krause EG, Sumners C., Free PMC Article | 12/5/2020 |
| Seminal levels of angiotensin II and angiotensin II type 2 receptor expression on spermatozoa in varicocele patients: Relation to fertility status. | Seminal levels of angiotensin II and angiotensin II type 2 receptor expression on spermatozoa in varicocele patients: Relation to fertility status.
El-Ariny AF, El-Garem YF, Eid AA, Donia HM, Aly RG, Abdelmeniem IM. | 11/28/2020 |
| findings suggest that prior activation of AT2R is prophylactic in preventing LPS-induced renal immune cell infiltration and dysfunction, possibly via IL-10 pathway. | Prevention of lipopolysaccharide-induced CD11b(+) immune cell infiltration in the kidney: role of AT(2) receptors.
Patel S, Dhande I, Gray EA, Ali Q, Hussain T., Free PMC Article | 07/4/2020 |
| High ATGR2 expression is associated with cardiomyocyte hypertrophy and hypercholesterolemia. | Angiotensin II type 2 receptor mediates high fat diet-induced cardiomyocyte hypertrophy and hypercholesterolemia.
Lima VM, Lino CA, Senger N, de Oliveira Silva T, Fonseca RIB, Bader M, Santos RAS, Júnior JD, Barreto-Chaves MLM, Diniz GP. | 06/27/2020 |
| AT2R is not expressed in human dorsal root ganglia (DRG) sensory neurons. Expression/activation of AT2R on peripheral/skin macrophages constitutes a critical trigger of mouse and human DRG sensory neuron excitation. | Angiotensin II Triggers Peripheral Macrophage-to-Sensory Neuron Redox Crosstalk to Elicit Pain.
Shepherd AJ, Copits BA, Mickle AD, Karlsson P, Kadunganattil S, Haroutounian S, Tadinada SM, de Kloet AD, Valtcheva MV, McIlvried LA, Sheahan TD, Jain S, Ray PR, Usachev YM, Dussor G, Krause EG, Price TJ, Gereau RW 4th, Mohapatra DP., Free PMC Article | 11/16/2019 |
| AGT C/T and AT2 G/A polymorphisms were not significantly associated with aneurysmal subarachnoid hemorrhage (aSAH) after controlling for potential confounders. However, a strong trend was identified for a dominant effect of the G allele of the AT2 G/A SNP. Downregulation of the local RAS may contribute to the formation of cerebral aneurysms and subsequent presentation with aSAH. | Association of renin-angiotensin system genetic polymorphisms and aneurysmal subarachnoid hemorrhage.
Griessenauer CJ, Tubbs RS, Foreman PM, Chua MH, Vyas NA, Lipsky RH, Lin M, Iyer R, Haridas R, Walters BC, Chaudry S, Malieva A, Wilkins S, Harrigan MR, Fisher WS, Shoja MM. | 09/14/2019 |
| Both the ACE I/D polymorphism and the AT2 A/C single nucleotide polymorphism were associated with an age-dependent risk of delayed cerebral ischemia, whereas only the ACE I/D polymorphism was associated with poor clinical grade at presentation | Associations of renin-angiotensin system genetic polymorphisms and clinical course after aneurysmal subarachnoid hemorrhage.
Griessenauer CJ, Tubbs RS, Foreman PM, Chua MH, Vyas NA, Lipsky RH, Lin M, Iyer R, Haridas R, Walters BC, Chaudry S, Malieva A, Wilkins S, Harrigan MR, Fisher WS 3rd, Shoja MM. | 09/7/2019 |
| We have solved the crystal structure of AT2R binding the peptide ligand [Sar(1), Ile(8)]AngII and its specific antibody at 3.2-A resolution. [Sar(1), Ile(8)]AngII interacts with both the 'core' binding domain, where the small-molecule ligands of AT1R and AT2R bind, and the 'extended' binding domain, which is equivalent to the allosteric modulator binding site of muscarinic acetylcholine receptor. | Crystal structure of the human angiotensin II type 2 receptor bound to an angiotensin II analog.
Asada H, Horita S, Hirata K, Shiroishi M, Shiimura Y, Iwanari H, Hamakubo T, Shimamura T, Nomura N, Kusano-Arai O, Uemura T, Suno C, Kobayashi T, Iwata S. | 08/17/2019 |
| our study demonstrated that (i) AT2R is overexpressed in the inflamed RA synovial tissue, (ii) the expression of this receptor is strikingly modulated in FLS by pro-inflammatory stimuli, and (iii) exogenous AT2R activation with a selective agonist might represent a potential novel therapeutic strategy for dampening of synovial inflammation in RA. | Angiotensin II type 2 receptor (AT2R) as a novel modulator of inflammation in rheumatoid arthritis synovium.
Terenzi R, Manetti M, Rosa I, Romano E, Galluccio F, Guiducci S, Ibba-Manneschi L, Matucci-Cerinic M., Free PMC Article | 07/13/2019 |
| There was no association between AT2R gene polymorphisms and ACE level in serum. Moreover, there was no association between AT2R gene polymorphisms and SLE clinical manifestations in Egyptian children. | Angiotensin II type 2 receptor gene polymorphisms and serum angiotensin-converting enzyme level in Egyptian children with systemic lupus erythematosus.
Shoaib RMS, Yahia S, Elsaid A, Abdel-Malak C, Hammad A. | 05/11/2019 |