| Neutrophil peptidylarginine deiminase 4 is essential for detrimental age-related cardiac remodelling and dysfunction in mice. | Neutrophil peptidylarginine deiminase 4 is essential for detrimental age-related cardiac remodelling and dysfunction in mice.
Van Bruggen S, Kraisin S, Van Wauwe J, Bomhals K, Stroobants M, Carai P, Frederix L, Van De Bruaene A, Witsch T, Martinod K., | 04/24/2024 |
| Transcriptomic analysis of PADI4 target genes during multi-lineage differentiation of embryonic stem cells. | Transcriptomic analysis of PADI4 target genes during multi-lineage differentiation of embryonic stem cells.
Singh AK, Khan S, Moore D, Andrews S, Christophorou MA., Free PMC Article | 10/4/2023 |
| An African-Specific Variant of TP53 Reveals PADI4 as a Regulator of p53-Mediated Tumor Suppression. | An African-Specific Variant of TP53 Reveals PADI4 as a Regulator of p53-Mediated Tumor Suppression.
Indeglia A, Leung JC, Miller SA, Leu JI, Dougherty JF, Clarke NL, Kirven NA, Shao C, Ke L, Lovell S, Barnoud T, Lu DY, Lin C, Kannan T, Battaile KP, Yang THL, Batista Oliva I, Claiborne DT, Vogel P, Liu L, Liu Q, Nefedova Y, Cassel J, Auslander N, Kossenkov AV, Karanicolas J, Murphy ME., Free PMC Article | 07/20/2023 |
| The Prominent Role of Hematopoietic Peptidyl Arginine Deiminase 4 in Arthritis: Collagen- and Granulocyte Colony-Stimulating Factor-Induced Arthritis Model in C57BL/6 Mice. | The Prominent Role of Hematopoietic Peptidyl Arginine Deiminase 4 in Arthritis: Collagen- and Granulocyte Colony-Stimulating Factor-Induced Arthritis Model in C57BL/6 Mice.
Fukui S, Gutch S, Fukui S, Cherpokova D, Aymonnier K, Sheehy CE, Chu L, Wagner DD., Free PMC Article | 07/2/2022 |
| Factors Associated with Promoted Proliferation of Osteosarcoma by Peptidylarginine Deiminase 4. | Factors Associated with Promoted Proliferation of Osteosarcoma by Peptidylarginine Deiminase 4.
Guo J, Yin L, Zhang X, Su P, Zhai Q., Free PMC Article | 09/25/2021 |
| Peptidylarginine Deiminase 2 Knockout Improves Survival in hemorrhagic shock. | Peptidylarginine Deiminase 2 Knockout Improves Survival in hemorrhagic shock.
Zhou J, Biesterveld BE, Li Y, Wu Z, Tian Y, Williams AM, Tian S, Gao W, Bhatti UF, Duan X, Wang T, Zhang J, Jiang B, Wang Z, Alam HB. | 08/7/2021 |
| TcpC inhibits neutrophil extracellular trap formation by enhancing ubiquitination mediated degradation of peptidylarginine deiminase 4. | TcpC inhibits neutrophil extracellular trap formation by enhancing ubiquitination mediated degradation of peptidylarginine deiminase 4.
Ou Q, Fang JQ, Zhang ZS, Chi Z, Fang J, Xu DY, Lu KZ, Qian MQ, Zhang DY, Guo JP, Gao W, Zhang NR, Pan JP., Free PMC Article | 06/26/2021 |
| Peptidylarginine Deiminase 4 Promotes the Renal Infiltration of Neutrophils and Exacerbates the TLR7 Agonist-Induced Lupus Mice. | Peptidylarginine Deiminase 4 Promotes the Renal Infiltration of Neutrophils and Exacerbates the TLR7 Agonist-Induced Lupus Mice.
Hanata N, Shoda H, Hatano H, Nagafuchi Y, Komai T, Okamura T, Suzuki A, Gunarta IK, Yoshioka K, Yamamoto K, Fujio K., Free PMC Article | 04/13/2021 |
| PAD4 exacerbates ischemic acute kidney injury and inflammation by promoting renal tubular NF-kappaB activity and inflammation via NEMO citrullination. | Peptidyl arginine deiminase-4 exacerbates ischemic AKI by finding NEMO.
Rabadi MM, Han SJ, Kim M, D'Agati V, Lee HT., Free PMC Article | 02/1/2020 |
| Data suggest that mixed lineage kinase domain-like (MLKL) activation leads to loss of intracellular architecture and chromatin decondensation, but peptidylarginine deiminase 4 (PAD4) is only required for the externalization of neutrophil extracellular trap (NET). | The pseudokinase MLKL activates PAD4-dependent NET formation in necroptotic neutrophils.
D'Cruz AA, Speir M, Bliss-Moreau M, Dietrich S, Wang S, Chen AA, Gavillet M, Al-Obeidi A, Lawlor KE, Vince JE, Kelliher MA, Hakem R, Pasparakis M, Williams DA, Ericsson M, Croker BA., Free PMC Article | 10/12/2019 |
| Our data support the notion that NETs promote atherosclerosis and that the use of specific PAD4 inhibitors may have therapeutic benefits in this potentially devastating condition. | Myeloid-Specific Deletion of Peptidylarginine Deiminase 4 Mitigates Atherosclerosis.
Liu Y, Carmona-Rivera C, Moore E, Seto NL, Knight JS, Pryor M, Yang ZH, Hemmers S, Remaley AT, Mowen KA, Kaplan MJ., Free PMC Article | 09/21/2019 |
| Renal proximal tubular PAD4 appears to contribute to ischemic acute kidney injury by promoting renal tubular apoptosis, whereas myeloid-cell PAD4 is preferentially involved in promoting neutrophil infiltration to the kidney and inflammation after renal ischemia/reperfusion. | Divergent roles for kidney proximal tubule and granulocyte PAD4 in ischemic AKI.
Li H, Han SJ, Kim M, Cho A, Choi Y, D'Agati V, Lee HT., Free PMC Article | 09/7/2019 |
| these findings lead us to conclude that although PAD4 together with CR3-mediated ROS production is required for NET formation in response to A. fumigatus, PAD4-dependent NETosis is not required for A. fumigatus killing either in vitro or during infection. | Protein Deiminase 4 and CR3 Regulate Aspergillus fumigatus and β-Glucan-Induced Neutrophil Extracellular Trap Formation, but Hyphal Killing Is Dependent Only on CR3.
Clark HL, Abbondante S, Minns MS, Greenberg EN, Sun Y, Pearlman E., Free PMC Article | 08/17/2019 |
| these data argue against a major role for PAD4 in neutrophil extracellular trap formation, host defense, or organ injury during pneumonia-derived sepsis | Role of Peptidylarginine Deiminase 4 in Neutrophil Extracellular Trap Formation and Host Defense during Klebsiella pneumoniae-Induced Pneumonia-Derived Sepsis.
Claushuis TAM, van der Donk LEH, Luitse AL, van Veen HA, van der Wel NN, van Vught LA, Roelofs JJTH, de Boer OJ, Lankelma JM, Boon L, de Vos AF, van 't Veer C, van der Poll T. | 07/6/2019 |
| Our findings suggest that PAD4-mediated RGG citrullination plays a key role in protein solubility and amyotrophic lateral sclerosis pathogenesis | Citrullination of RGG Motifs in FET Proteins by PAD4 Regulates Protein Aggregation and ALS Susceptibility.
Tanikawa C, Ueda K, Suzuki A, Iida A, Nakamura R, Atsuta N, Tohnai G, Sobue G, Saichi N, Momozawa Y, Kamatani Y, Kubo M, Yamamoto K, Nakamura Y, Matsuda K. | 05/25/2019 |
| Study reveals the potential for PAD4-dependant citrullination to drive the progression of CRC liver metastasis. | Colorectal cancer liver metastatic growth depends on PAD4-driven citrullination of the extracellular matrix.
Yuzhalin AE, Gordon-Weeks AN, Tognoli ML, Jones K, Markelc B, Konietzny R, Fischer R, Muth A, O'Neill E, Thompson PR, Venables PJ, Kessler BM, Lim SY, Muschel RJ., Free PMC Article | 04/20/2019 |
| PAD4 in neutrophils is essential for kidney NET formation and ischemic kidney injury. | Neutrophil peptidyl arginine deiminase-4 has a pivotal role in ischemia/reperfusion-induced acute kidney injury.
Raup-Konsavage WM, Wang Y, Wang WW, Feliers D, Ruan H, Reeves WB., Free PMC Article | 12/22/2018 |
| PADi4 is critical for neutrophil extracellular traps formation, but is dispensable for generalized citrullination | Peptidylarginine deiminase 2 is required for tumor necrosis factor alpha-induced citrullination and arthritis, but not neutrophil extracellular trap formation.
Bawadekar M, Shim D, Johnson CJ, Warner TF, Rebernick R, Damgaard D, Nielsen CH, Pruijn GJM, Nett JE, Shelef MA., Free PMC Article | 02/24/2018 |
| sFlt-1 overexpression in Padi4(-/-) mice resulted in dramatically lower inflammatory and thrombotic response, which was accompanied by significant reduction in pregnancy losses. Inhibition of NETosis may serve as a novel target in disorders of impaired placentation. | PAD4 Deficiency Decreases Inflammation and Susceptibility to Pregnancy Loss in a Mouse Model.
Erpenbeck L, Chowdhury CS, Zsengellér ZK, Gallant M, Burke SD, Cifuni S, Hahn S, Wagner DD, Karumanchi SA., Free PMC Article | 11/4/2017 |
| a role for NETs in cardiac fibrosis and conclude that PAD4 regulates age-related organ fibrosis and dysfunction. | Peptidylarginine deiminase 4 promotes age-related organ fibrosis.
Martinod K, Witsch T, Erpenbeck L, Savchenko A, Hayashi H, Cherpokova D, Gallant M, Mauler M, Cifuni SM, Wagner DD., Free PMC Article | 08/19/2017 |
| PADI4 exacerbates arthritis with diverse immunological modifications. | Peptidylarginine deiminase type 4 deficiency reduced arthritis severity in a glucose-6-phosphate isomerase-induced arthritis model.
Seri Y, Shoda H, Suzuki A, Matsumoto I, Sumida T, Fujio K, Yamamoto K., Free PMC Article | 09/10/2016 |
| Selective inhibition of peptidylarginine deiminase IV with Cl-amidine blocked NET formation, reduced atherosclerotic lesion area, and delayed time to carotid artery thrombosis in a photochemical injury model. | Peptidylarginine deiminase inhibition reduces vascular damage and modulates innate immune responses in murine models of atherosclerosis.
Knight JS, Luo W, O'Dell AA, Yalavarthi S, Zhao W, Subramanian V, Guo C, Grenn RC, Thompson PR, Eitzman DT, Kaplan MJ., Free PMC Article | 05/17/2014 |
| Padi4 is part of the pluripotency transcriptional network, binding to regulatory elements of key stem-cell genes and activating their expression | Citrullination regulates pluripotency and histone H1 binding to chromatin.
Christophorou MA, Castelo-Branco G, Halley-Stott RP, Oliveira CS, Loos R, Radzisheuskaya A, Mowen KA, Bertone P, Silva JC, Zernicka-Goetz M, Nielsen ML, Gurdon JB, Kouzarides T., Free PMC Article | 03/22/2014 |
| PAD4 regulates the proliferation of multipotent progenitors in the bone marrow by controlling c-myc expression. | PAD4 regulates proliferation of multipotent haematopoietic cells by controlling c-myc expression.
Nakashima K, Arai S, Suzuki A, Nariai Y, Urano T, Nakayama M, Ohara O, Yamamura K, Yamamoto K, Miyazaki T., Free PMC Article | 01/4/2014 |
| peptidyl-arginine deiminases inhibiion reverses protein-hypercitrullination and disease in mouse models of multiple sclerosis. | Inhibition of peptidyl-arginine deiminases reverses protein-hypercitrullination and disease in mouse models of multiple sclerosis.
Moscarello MA, Lei H, Mastronardi FG, Winer S, Tsui H, Li Z, Ackerley C, Zhang L, Raijmakers R, Wood DD., Free PMC Article | 09/14/2013 |