| The osteoporosis susceptibility SNP rs188303909 at 2q14.2 regulates EN1 expression by modulating DNA methylation and E2F6 binding. | The osteoporosis susceptibility SNP rs188303909 at 2q14.2 regulates EN1 expression by modulating DNA methylation and E2F6 binding.
Wang Y, Huang X, Zhang Q, Cheng C, Qin Z, Lu L, Huang Q. | 02/15/2024 |
| A hsa_circ_001726 axis regulated by E2F6 contributes to metastasis of hepatocellular carcinoma. | A hsa_circ_001726 axis regulated by E2F6 contributes to metastasis of hepatocellular carcinoma.
Ai J, Zhang W, Deng W, Yan L, Zhang L, Huang Z, Wu Z, Ai J, Jiang H., Free PMC Article | 01/17/2024 |
| lncRNA ENST00000585827 Contributes to the Progression of Endometrial Carcinoma via Regulating miR-424/E2F6/E2F7 Axis. | lncRNA ENST00000585827 Contributes to the Progression of Endometrial Carcinoma via Regulating miR-424/E2F6/E2F7 Axis.
Fang D, Zhang Q, Mu M, Deng Q, Wang Y, Li Q. | 05/7/2023 |
| The E2F6 Transcription Factor is Associated with the Mammalian SUZ12-Containing Polycomb Complex. | The E2F6 Transcription Factor is Associated with the Mammalian SUZ12-Containing Polycomb Complex.
Shirahama Y, Yamamoto K. | 02/14/2023 |
| A positive feedback loop of CENPU/E2F6/E2F1 facilitates proliferation and metastasis via ubiquitination of E2F6 in hepatocellular carcinoma. | A positive feedback loop of CENPU/E2F6/E2F1 facilitates proliferation and metastasis via ubiquitination of E2F6 in hepatocellular carcinoma.
Liu Y, Yao Y, Liao B, Zhang H, Yang Z, Xia P, Jiang X, Ma W, Wu X, Mei C, Wang G, Gao M, Xu K, GongYe X, Cheng Z, Jiang P, Chen X, Yuan Y., Free PMC Article | 07/23/2022 |
| Long Noncoding RNA LAMTOR5-AS1 Interference Affects MicroRNA-506-3p/E2F6-Mediated Behavior of Non-Small Cell Lung Cancer Cells. | Long Noncoding RNA LAMTOR5-AS1 Interference Affects MicroRNA-506-3p/E2F6-Mediated Behavior of Non-Small Cell Lung Cancer Cells.
Chen G, Wang K, Li G, Wang L, Xiao Y, Chen B., Free PMC Article | 02/5/2022 |
| Deubiquitination of the repressor E2F6 by USP22 facilitates AKT activation and tumor growth in hepatocellular carcinoma. | Deubiquitination of the repressor E2F6 by USP22 facilitates AKT activation and tumor growth in hepatocellular carcinoma.
Jing T, Wang B, Yang Z, Liu Y, Xu G, Xu X, Jiao K, Chen Z, Xiang L, Zhang L, Liu Y. | 01/8/2022 |
| Long noncoding RNA SLC9A3AS1 increases E2F6 expression by sponging microRNA4865p and thus facilitates the oncogenesis of nasopharyngeal carcinoma. | Long noncoding RNA SLC9A3‑AS1 increases E2F6 expression by sponging microRNA‑486‑5p and thus facilitates the oncogenesis of nasopharyngeal carcinoma.
Li J, Li D, Zhang X, Li C, Zhu F., Free PMC Article | 12/4/2021 |
| Circular RNA ZNF609 functions as a competing endogenous RNA in regulating E2F transcription factor 6 through competitively binding to microRNA-197-3p to promote the progression of cervical cancer progression. | Circular RNA ZNF609 functions as a competing endogenous RNA in regulating E2F transcription factor 6 through competitively binding to microRNA-197-3p to promote the progression of cervical cancer progression.
Gu Q, Hou W, Shi L, Liu H, Zhu Z, Ye W., Free PMC Article | 11/22/2021 |
| E2F6-Mediated Downregulation of MIR22HG Facilitates the Progression of Laryngocarcinoma by Targeting the miR-5000-3p/FBXW7 Axis. | E2F6-Mediated Downregulation of MIR22HG Facilitates the Progression of Laryngocarcinoma by Targeting the miR-5000-3p/FBXW7 Axis.
Chen H, Ali M, Ruben A, Stelmakh D, Pak M., Free PMC Article | 08/15/2020 |
| Target gene prediction software indicated that E2F6 was the potential downstream target gene of miR-425. E2F6 expression was found to be negatively regulated by miR-425 in clear cell renal carcinoma. | MiR-425 involves in the development and progression of renal cell carcinoma by inhibiting E2F6.
Cai Q, Zhao A, Ren LG, Chen J, Liao KS, Wang ZS, Zhang W. | 12/7/2019 |
| LINC01436 exerted biological functions by acting as a microRNA (miR)-30a-3p sponge to regulate the expression of its target gene EPAS1. | Hypoxia-sensitive LINC01436 is regulated by E2F6 and acts as an oncogene by targeting miR-30a-3p in non-small cell lung cancer.
Yuan S, Xiang Y, Wang G, Zhou M, Meng G, Liu Q, Hu Z, Li C, Xie W, Wu N, Wu L, Cai T, Ma X, Zhang Y, Yu Z, Bai L, Li Y., Free PMC Article | 12/7/2019 |
| data demonstrated that E2F6 could regulate the proliferation, invasion and apoptosis of gastric carcinoma (GC) cells via inhibiting the expression of CASC2, suggesting that E2F6/CASC2 axis is another regulator of GC progression | E2F6-mediated lncRNA CASC2 down-regulation predicts poor prognosis and promotes progression in gastric carcinoma.
Li Y, Jiang L, Lv S, Xu H, Fan Z, He Y, Wen H. | 10/12/2019 |
| An estrogen-mediated E2F6 ceRNA network epigenetically and competitively inhibits microRNA-193a activity, promoting ovarian cancer stemness and tumorigenesis. | E2F6 functions as a competing endogenous RNA, and transcriptional repressor, to promote ovarian cancer stemness.
Cheng FHC, Lin HY, Hwang TW, Chen YC, Huang RL, Chang CB, Yang W, Lin RI, Lin CW, Chen GCW, Mai SY, Lin JMJ, Chuang YM, Chou JL, Kuo LW, Li C, Cheng ASL, Lai HC, Wu SF, Tsai JC, Chan MWY., Free PMC Article | 03/9/2019 |
| This analysis showed a relative increase in the expression of E2F6 in gastric adenocarcinoma with no lymph node metastasis (chi (2), P = 0.04 and OR, P = 0.08), while overexpression of RhoA and SMUG1 was found more often in the diffuse subtype of gastric adenocarcinoma as compared to the intestinal subtype. | Differential role of Wnt signaling and base excision repair pathways in gastric adenocarcinoma aggressiveness.
Korourian A, Roudi R, Shariftabrizi A, Kalantari E, Sotoodeh K, Madjd Z. | 06/9/2018 |
| E2F1 forms a protein complex with EBNA3C and E2F6, and EBNA3C competes with E2F1 for E2F6 binding. E2F6 is also recruited by EBNA3C to the E2F1 promoter, which is critical for EBNA3C-mediated cell proliferation. | EBV Nuclear Antigen 3C Mediates Regulation of E2F6 to Inhibit E2F1 Transcription and Promote Cell Proliferation.
Pei Y, Banerjee S, Sun Z, Jha HC, Saha A, Robertson ES., Free PMC Article | 06/24/2017 |
| miR-185 suppresses tumor proliferation by directly targeting E2F6 and DNMT1 and indirectly upregulating BRCA1 in triple-negative breast cancer. | miR-185 suppresses tumor proliferation by directly targeting E2F6 and DNMT1 and indirectly upregulating BRCA1 in triple-negative breast cancer.
Tang H, Liu P, Yang L, Xie X, Ye F, Wu M, Liu X, Chen B, Zhang L, Xie X. | 08/15/2015 |
| Analysis data from a panel of cell cycle transcription factors (E2F1, E2F4, E2F6, and GABPA) finds that a set of core cell cycle genes regulated in both U2OS and HeLa cells are bound by multiple cell cycle transcription factors. | Identification of cell cycle-regulated genes periodically expressed in U2OS cells and their regulation by FOXM1 and E2F transcription factors.
Grant GD, Brooks L 3rd, Zhang X, Mahoney JM, Martyanov V, Wood TA, Sherlock G, Cheng C, Whitfield ML., Free PMC Article | 06/28/2014 |
| After replication stress, the checkpoint kinase Chk1 phosphorylates E2F6, leading to its dissociation from promoters. This promotes E2F-dependent transcription, which mediates cell survival by preventing DNA damage and cell death | Chk1 inhibits E2F6 repressor function in response to replication stress to maintain cell-cycle transcription.
Bertoli C, Klier S, McGowan C, Wittenberg C, de Bruin RA., Free PMC Article | 05/3/2014 |
| findings indicate an inhibitory role of E2F6 in the regulation of IL-13 and allergy | Combining gene expression microarray- and cluster analysis with sequence-based predictions to identify regulators of IL-13 in allergy.
Bruhn S, Katzenellenbogen M, Gustafsson M, Krönke A, Sönnichsen B, Zhang H, Benson M. | 05/18/2013 |
| E2F6 may recruit BRG1 in transcriptional regulation of genes important for G1/S phase transition of the cell cycle. | E2F6 associates with BRG1 in transcriptional regulation.
Leung JY, Nevins JR., Free PMC Article | 04/13/2013 |
| Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) | Single nucleotide polymorphisms of matrix metalloproteinase 9 (MMP9) and tumor protein 73 (TP73) interact with Epstein-Barr virus in chronic lymphocytic leukemia: results from the European case-control study EpiLymph.
Casabonne D, Reina O, Benavente Y, Becker N, Maynadié M, Foretová L, Cocco P, González-Neira A, Nieters A, Boffetta P, Middeldorp JM, de Sanjose S., Free PMC Article | 12/5/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | Cell cycle genes and ovarian cancer susceptibility: a tagSNP analysis.
Cunningham JM, Vierkant RA, Sellers TA, Phelan C, Rider DN, Liebow M, Schildkraut J, Berchuck A, Couch FJ, Wang X, Fridley BL, Ovarian Cancer Association Consortium, Gentry-Maharaj A, Menon U, Hogdall E, Kjaer S, Whittemore A, DiCioccio R, Song H, Gayther SA, Ramus SJ, Pharaoh PD, Goode EL., Free PMC Article | 04/7/2010 |
| E2F6 has a role in control of hypoxia-induced apoptosis through regulation of E2F1 | E2F6 inhibits cobalt chloride-mimetic hypoxia-induced apoptosis through E2F1.
Yang WW, Shu B, Zhu Y, Yang HT., Free PMC Article | 01/21/2010 |
| E2F6 binding sites are located within 2 kb of a transcription start site, in both normal and tumor cells | A comprehensive ChIP-chip analysis of E2F1, E2F4, and E2F6 in normal and tumor cells reveals interchangeable roles of E2F family members.
Xu X, Bieda M, Jin VX, Rabinovich A, Oberley MJ, Green R, Farnham PJ., Free PMC Article | 01/21/2010 |