| Distinct subcellular localisation of intramyocellular lipids and reduced PKCepsilon/PKCtheta; activity preserve muscle insulin sensitivity in exercise-trained mice. | Distinct subcellular localisation of intramyocellular lipids and reduced PKCε/PKCθ activity preserve muscle insulin sensitivity in exercise-trained mice.
Gaspar RC, Lyu K, Hubbard BT, Leitner BP, Luukkonen PK, Hirabara SM, Sakuma I, Nasiri A, Zhang D, Kahn M, Cline GW, Pauli JR, Perry RJ, Petersen KF, Shulman GI., Free PMC Article | 02/11/2023 |
| Protein kinase C-theta knockout decreases serum IL-10 levels and inhibits insulin secretion from islet beta cells. | Protein kinase C-θ knockout decreases serum IL-10 levels and inhibits insulin secretion from islet β cells.
Hong F, Yang Y, Chen B, Li P, Wang G, Jiang Y., Free PMC Article | 11/22/2021 |
| Annexin A5 is essential for PKCtheta translocation during T-cell activation. | Annexin A5 is essential for PKCθ translocation during T-cell activation.
Hu Z, Li L, Zhu B, Huang Y, Wang X, Lin X, Li M, Xu P, Zhang X, Zhang J, Hua Z., Free PMC Article | 02/20/2021 |
| Targeting PKCtheta Promotes Satellite Cell Self-Renewal. | Targeting PKCθ Promotes Satellite Cell Self-Renewal.
Benedetti A, Fiore PF, Madaro L, Lozanoska-Ochser B, Bouché M., Free PMC Article | 01/9/2021 |
| Lack of PKCtheta Promotes Regenerative Ability of Muscle Stem Cells in Chronic Muscle Injury. | Lack of PKCθ Promotes Regenerative Ability of Muscle Stem Cells in Chronic Muscle Injury.
Fiore PF, Benedetti A, Sandonà M, Madaro L, De Bardi M, Saccone V, Puri PL, Gargioli C, Lozanoska-Ochser B, Bouché M., Free PMC Article | 11/21/2020 |
| These findings demonstrate that PKCtheta; plays an important role in a positive feedback regulatory loop that modulates TCR-proximal signaling and, moreover, provide a mechanistic explanation for earlier reports that documented an important role for PKCtheta; in T cell Ca(2+) signaling. This PKCtheta;-Zap70 interaction could potentially serve as a promising and highly selective immunosuppressive drug target in autoimmu... | Phosphotyrosine-dependent interaction between the kinases PKCθ and Zap70 promotes proximal TCR signaling.
Xie J, Han X, Zhao C, Canonigo-Balancio AJ, Yates JR 3rd, Li Y, Lillemeier BF, Altman A., Free PMC Article | 07/4/2020 |
| The authors established that OX40L/OX40 interaction was required and sufficient to induce regulatory T-cell proliferation in vivo independent of PKC- status. Although PKC- is dispensable for T-cell receptor-independent regulatory T-cell proliferation per se, it is essential for optimum IL-2 production by effector T-cells. | PKC-ѳ is dispensable for OX40L-induced TCR-independent Treg proliferation but contributes by enabling IL-2 production from effector T-cells.
Alharshawi K, Marinelarena A, Kumar P, El-Sayed O, Bhattacharya P, Sun Z, Epstein AL, Maker AV, Prabhakar BS., Free PMC Article | 02/9/2019 |
| PKC-theta; is a regulator of lipid-induced insulin resistance in skeletal muscle. | Mice lacking PKC-θ in skeletal muscle have reduced intramyocellular lipid accumulation and increased insulin responsiveness in skeletal muscle.
Peck B, Huot J, Renzi T, Arthur S, Turner MJ, Marino JS. | 01/19/2019 |
| Comparison with expanded cord blood-derived CD4(+)CD25(hi) tTreg and expanded Teffs from the same donors indicate that iTreg are intermediate between expanded CD4(+)CD25(hi) tTregs and Teffs, whereas modulation of suppressive activities by PKC-theta; and Dlgh1 signaling pathways are shared. | Human in vitro-induced regulatory T cells display Dlgh1dependent and PKC-θ restrained suppressive activity.
Zanin-Zhorov A, Kumari S, Hippen KL, Merkel SC, MacMillan ML, Blazar BR, Dustin ML., Free PMC Article | 01/5/2019 |
| PKCtheta; selectively inactivates the negative regulator of F-actin generation, Coronin 1A, at the center of the T cell interface with the antigen presenting cell (APC). This allows for effective generation of the large actin-based lamellum required for recruitment of the Notch-processing membrane metalloproteinase ADAM10. | PKCθ links proximal T cell and Notch signaling through localized regulation of the actin cytoskeleton.
Britton GJ, Ambler R, Clark DJ, Hill EV, Tunbridge HM, McNally KE, Burton BR, Butterweck P, Sabatos-Peyton C, Hampton-O'Neil LA, Verkade P, Wülfing ChC, Wraith DC., Free PMC Article | 11/18/2017 |
| Results suggest that while PKCtheta; is involved in Treg cell differentiation in vivo, it is dispensable for Treg-mediated suppression. | Protein kinase C theta is dispensable for suppression mediated by CD25+CD4+ regulatory T cells.
Siegmund K, Thuille N, Wachowicz K, Hermann-Kleiter N, Baier G., Free PMC Article | 09/16/2017 |
| PKC-theta; is a critical factor for type 2 innate lymphoid cells activation that contributes to TH2 cell differentiation, which is associated with IRF4 and NFAT1 expression in allergic lung inflammation. | Protein kinase Cθ controls type 2 innate lymphoid cell and T(H)2 responses to house dust mite allergen.
Madouri F, Chenuet P, Beuraud C, Fauconnier L, Marchiol T, Rouxel N, Ledru A, Gallerand M, Lombardi V, Mascarell L, Marquant Q, Apetoh L, Erard F, Le Bert M, Trovero F, Quesniaux VFJ, Ryffel B, Togbe D. | 08/19/2017 |
| Data show that pharmacological inhibition of Protein Kinase C theta (PKCtheta;) in Duchenne Muscular Dystrophy (DMD) can be considered an attractive strategy to modulate immune response and prevent the progression of the disease. | Pharmacological Inhibition of PKCθ Counteracts Muscle Disease in a Mouse Model of Duchenne Muscular Dystrophy.
Marrocco V, Fiore P, Benedetti A, Pisu S, Rizzuto E, Musarò A, Madaro L, Lozanoska-Ochser B, Bouché M., Free PMC Article | 03/25/2017 |
| Sumoylation of PKC-theta; was essential for T cell activation. Desumoylation did not affect the catalytic activity of PKC-theta; but inhibited the association of CD28 with PKC-theta; and filamin A and impaired the assembly of a mature immunological synapse. | TCR-induced sumoylation of the kinase PKC-θ controls T cell synapse organization and T cell activation.
Wang XD, Gong Y, Chen ZL, Gong BN, Xie JJ, Zhong CQ, Wang QL, Diao LH, Xu A, Han J, Altman A, Li Y. | 04/23/2016 |
| Together, these findings both in Jurkat T cells as well as in primary T cells indicate a regulatory role of Coro1A on PKCtheta; recruitment and function downstream of the TCR leading to NF-kappaB transactivation. | Novel protein kinase C θ: coronin 1A complex in T lymphocytes.
Siegmund K, Thuille N, Posch N, Fresser F, Baier G., Free PMC Article | 09/26/2015 |
| Data indicate that Protein kinase C theta; (PKCtheta;) is critical for stabilizing Th17 cell phenotype. | Protein kinase C θ regulates the phenotype of murine CD4+ Th17 cells.
Wachowicz K, Hermann-Kleiter N, Meisel M, Siegmund K, Thuille N, Baier G., Free PMC Article | 06/27/2015 |
| Data suggest that protein kinase Ctheta (PKCtheta;) inhibition alone is insufficient for complete efficacy in rodent arthritis model. | Optimized protein kinase Cθ (PKCθ) inhibitors reveal only modest anti-inflammatory efficacy in a rodent model of arthritis.
George DM, Breinlinger EC, Argiriadi MA, Zhang Y, Wang J, Bansal-Pakala P, Duignan DB, Honore P, Lang Q, Mittelstadt S, Rundell L, Schwartz A, Sun J, Edmunds JJ. | 05/2/2015 |
| Inhibition of PKC-theta preserves cardiac function and reduces fibrosis in streptozotocin-induced diabetic cardiomyopathy | Inhibition of PKC-θ preserves cardiac function and reduces fibrosis in streptozotocin-induced diabetic cardiomyopathy.
Li Z, Abdullah CS, Jin ZQ., Free PMC Article | 01/3/2015 |
| DTX1, similar to Cbl-b and Itch, participates in T cell anergy-induced PKC-theta degradation. there is a coupling of DTX1 to Cbl-b in T cell anergy. | Deltex1 promotes protein kinase Cθ degradation and sustains Casitas B-lineage lymphoma expression.
Hsu TS, Hsiao HW, Wu PJ, Liu WH, Lai MZ. | 10/25/2014 |
| Therefore, TCR ligation elicits a caspase cascade involving caspase-8, caspase-9 and caspase-3 which initiates PKC-theta;-dependent pathway leading to NF-kappaB activation. | TCR-induced, PKC-θ-mediated NF-κB activation is regulated by a caspase-8-caspase-9-caspase-3 cascade.
Zhao Y, Lei M, Wang Z, Qiao G, Yang T, Zhang J., Free PMC Article | 09/27/2014 |
| PKCtheta regulates myogenic and protein synthetic signaling via the modulation of IRS1 and ERK1/ERK2 phosphorylation. | Suppression of protein kinase C theta contributes to enhanced myogenesis in vitro via IRS1 and ERK1/2 phosphorylation.
Marino JS, Hinds TD Jr, Potter RA, Ondrus E, Onion JL, Dowling A, McLoughlin TJ, Sanchez ER, Hill JW., Free PMC Article | 06/21/2014 |
| timed activation of PKCtheta;, phosphorylation of EKLF at S68 by P-PKCtheta;(S676), and sumoylation of EKLF at K74 occurs during the Pro-E to Baso-E transition | Tight regulation of a timed nuclear import wave of EKLF by PKCθ and FOE during Pro-E to Baso-E transition.
Shyu YC, Lee TL, Chen X, Hsu PH, Wen SC, Liaw YW, Lu CH, Hsu PY, Lu MJ, Hwang J, Tsai MD, Hwang MJ, Chen JR, Shen CK. | 04/26/2014 |
| Our findings indicate that PKCalpha and theta; contribute to T-cell activation with overlapping functions essential for graft-vs-host disease | Pharmacologic inhibition of PKCα and PKCθ prevents GVHD while preserving GVL activity in mice.
Haarberg KM, Li J, Heinrichs J, Wang D, Liu C, Bronk CC, Kaosaard K, Owyang AM, Holland S, Masuda E, Tso K, Blazar BR, Anasetti C, Beg AA, Yu XZ., Free PMC Article | 11/23/2013 |
| results demonstrate that PKCtheta; functions as an ER stress sensor in skeletal muscle, required for ER-stress-dependent autophagy activation, and can be proposed as a novel molecular target to maintain muscle homeostasis in response to external stimuli. | Intracellular signaling in ER stress-induced autophagy in skeletal muscle cells.
Madaro L, Marrocco V, Carnio S, Sandri M, Bouché M. | 07/6/2013 |
| PKCtheta;/beta and CYLD are antagonistic partners in the NFkappaB and NFAT transactivation pathways in primary mouse CD3+ T lymphocytes. | PKCθ/β and CYLD are antagonistic partners in the NFκB and NFAT transactivation pathways in primary mouse CD3+ T lymphocytes.
Thuille N, Wachowicz K, Hermann-Kleiter N, Kaminski S, Fresser F, Lutz-Nicoladoni C, Leitges M, Thome M, Massoumi R, Baier G., Free PMC Article | 06/29/2013 |