| Identifying TYMP as an Immune Prognostic Marker in Clear Cell Renal Cell Carcinoma. | Identifying TYMP as an Immune Prognostic Marker in Clear Cell Renal Cell Carcinoma.
Chen SA, Zhang JP, Wang N, Chen J., Free PMC Article | 12/6/2023 |
| Distinctive metabolic remodeling in TYMP deficiency beyond mitochondrial dysfunction. | Distinctive metabolic remodeling in TYMP deficiency beyond mitochondrial dysfunction.
Du J, Zhang C, Liu F, Liu X, Wang D, Zhao D, Shui G, Zhao Y, Yan C. | 10/11/2023 |
| Impact of thymidine phosphorylase and CD163 expression on prognosis in stage II colorectal cancer. | Impact of thymidine phosphorylase and CD163 expression on prognosis in stage II colorectal cancer.
Kaidi D, Szeponik L, Yrlid U, Wettergren Y, Bexe Lindskog E., Free PMC Article | 08/6/2022 |
| Loss of thymidine phosphorylase activity disrupts adipocyte differentiation and induces insulin-resistant lipoatrophic diabetes. | Loss of thymidine phosphorylase activity disrupts adipocyte differentiation and induces insulin-resistant lipoatrophic diabetes.
Gautheron J, Lima L, Akinci B, Zammouri J, Auclair M, Ucar SK, Ozen S, Altay C, Bax BE, Nemazanyy I, Lenoir V, Prip-Buus C, Acquaviva-Bourdain C, Lascols O, Fève B, Vigouroux C, Noel E, Jéru I., Free PMC Article | 04/9/2022 |
| Novel Mutations of the TYMP Gene in Mitochondrial Neurogastrointestinal Encephalomyopathy: Case Series and Literature Review. | Novel Mutations of the TYMP Gene in Mitochondrial Neurogastrointestinal Encephalomyopathy: Case Series and Literature Review.
Mojtabavi H, Fatehi F, Shahkarami S, Rezaei N, Nafissi S. | 03/5/2022 |
| Thymidine phosphorylase promotes angiogenesis and tumour growth in intrahepatic cholangiocarcinoma. | Thymidine phosphorylase promotes angiogenesis and tumour growth in intrahepatic cholangiocarcinoma.
Li S, Yang H, Li K, Fan G, Deng L, Xu C. | 02/27/2021 |
| These results indicated that hDHFR is not the only target of Pyr. We further found that thymidine phosphorylase (TP), an enzyme that is closely associated with the EMT of cancer cells, is also a target protein of Pyr. The data retrieved from the Cancer Genome Atlas (TCGA) database revealed that TP overexpression is associated with poor prognosis of patients with lung cancer | Antimalarial Drug Pyrimethamine Plays a Dual Role in Antitumor Proliferation and Metastasis through Targeting DHFR and TP.
Liu H, Qin Y, Zhai D, Zhang Q, Gu J, Tang Y, Yang J, Li K, Yang L, Chen S, Zhong W, Meng J, Liu Y, Sun T, Yang C. | 03/14/2020 |
| Kinetics mechanism and regulation of native human hepatic thymidine phosphorylase | Kinetics mechanism and regulation of native human hepatic thymidine phosphorylase.
Oh T, El Kouni MH. | 01/11/2020 |
| Sp1-binding sites in the TP promoter were methylated in epidermoid carcinoma. 5-Aza-CdR demethylated Sp1-binding sites and enhanced sensitivity to 5-FU | 5-Aza-2-deoxycytidine Enhances the Sensitivity of 5-Fluorouracil by Demethylation of the Thymidine Phosphorylase Promoter.
Nishizawa Y, Ikeda R, Yamamoto M, Kawahara K, Shinsato Y, Minami K, Nitta M, Terazono H, Akiyama SI, Furukawa T, Takeda Y. | 08/10/2019 |
| Data show that thymidine phosphorylase (TYMP) positive patients had higher systemic immune-inflammation index (SII) score. | Systemic immune-inflammation index, thymidine phosphorylase and survival of localized gastric cancer patients after curative resection.
Huang L, Liu S, Lei Y, Wang K, Xu M, Chen Y, Liu B, Chen Y, Fu Q, Zhang P, Qin K, Cai Y, Fu S, Ge S, Yuan X., Free PMC Article | 01/13/2018 |
| Investigated the contribution of myeloma-expressed thymidine phosphorylase (TP) to bone lesions. In osteoblast progenitors, TP up-regulated the methylation of RUNX2 and osterix, leading to decreased bone formation. In osteoclast progenitors, TP up-regulated the methylation of IRF8, leading to increased bone resorption. | Thymidine phosphorylase exerts complex effects on bone resorption and formation in myeloma.
Liu H, Liu Z, Du J, He J, Lin P, Amini B, Starbuck MW, Novane N, Shah JJ, Davis RE, Hou J, Gagel RF, Yang J., Free PMC Article | 12/16/2017 |
| TP(thymidine phosphorylase ) curbed the expression of three proteins-IRF8, RUNX2, and osterix. This downregulation was epigenetically driven: High levels of 2DDR, a product of TP secreted by myeloma cells, activated PI3K/AKT signaling and increased the methyltransferase DNMT3A's expression | Pinpointing a Factor in Myeloma Bone Disease.
| 11/4/2017 |
| TP expression is associated with tumor stage, histological grade and thrombocytosis in patients with renal cell carcinoma | Poor Prognosis Associated with High Levels of Thymidine Phosphorylase and Thrombocytosis in Patients with Renal Cell Carcinoma.
Huang X, Wang L, Chen Y, Zheng X, Wang X. | 10/14/2017 |
| Studied the role of thymidine phosphorylase (TP) in promoting the invasion and metastasis of hepatocellular carcinoma (HCC). It was shown that TP correlated with MMP2 and MMP9 expression, and that TP mediated the migration of tumor cells through activity of MMPs in HCC cell lines. | Thymidine phosphorylase promotes metastasis and serves as a marker of poor prognosis in hepatocellular carcinoma.
Zhang Q, Zhang Y, Hu X, Qin Y, Zhong W, Meng J, Xiao T, Zhang C, Li M, Chen S, Liu H, Liu Y, Sun T, Yang C. | 09/2/2017 |
| Increases in gene expression levels of TYMP, DPYD, and HIF1A in tumor tissues at 7 days after the start of CRT may be useful for predicting the efficacy of CRT including S-1 or UFT | Increase in Gene Expression of TYMP, DPYD and HIF1A Are Associated with Response to Preoperative Chemoradiotherapy Including S-1 or UFT for Rectal Cancer.
Sadahiro S, Suzuki T, Tanaka A, Okada K, Saito G, Kamijo A, Nagase H. | 02/4/2017 |
| the highest expression of GGH and EGFR was noted in the left-sided colon; the highest expression of DHFR, FPGS, TOP1 and ERCC1 was noted in the rectosigmoid, whereas TYMP expression was approximately equivalent in the right-sided colon and rectum | Association between mRNA expression of chemotherapy-related genes and clinicopathological features in colorectal cancer: A large-scale population analysis.
Shimamoto Y, Nukatsuka M, Takechi T, Fukushima M., Free PMC Article | 10/29/2016 |
| High VEGF expression was subsequently correlated with a short overall survival rate for patients exhibiting lymph node metastasis (P=0.0128); however, there was no significant difference in overall survival rate regarding the expression levels of TP and CD34 | Clinicopathological significance of vascular endothelial growth factor, thymidine phosphorylase and microvessel density in colorectal cancer.
Kimura Y, Morohashi S, Yoshizawa T, Suzuki T, Morohashi H, Sakamoto Y, Koyama M, Murata A, Kijima H, Hakamada K., Free PMC Article | 10/29/2016 |
| Pretreatment expression of thymidine phosphorylase/HIF-1alpha were found to predict pathologic response and outcomes in clinical stage II/III rectal cancer receiving neoadjuvant chemoradiotherapy. | Thymidine phosphorylase and hypoxia-inducible factor 1-α expression in clinical stage II/III rectal cancer: association with response to neoadjuvant chemoradiation therapy and prognosis.
Lin S, Lai H, Qin Y, Chen J, Lin Y., Free PMC Article | 10/1/2016 |
| Gastrointestinal cancer patient carriers of the thymidine phosphorylase rs11479 T allele, with a low platelet count, could be at risk of a poor outcome. | Thymidine phosphorylase gene variant, platelet counts and survival in gastrointestinal cancer patients treated by fluoropyrimidines.
Huang L, Chen F, Chen Y, Yang X, Xu S, Ge S, Fu S, Chao T, Yu Q, Liao X, Hu G, Zhang P, Yuan X., Free PMC Article | 11/7/2015 |
| 4-methylumbelliferone exerts its antitumor effect on ovarian cancer through suppressing thymidine phosphorylase expression. | 4-Methylumbelliferone inhibits ovarian cancer growth by suppressing thymidine phosphorylase expression.
Tamura R, Yokoyama Y, Yoshida H, Imaizumi T, Mizunuma H., Free PMC Article | 10/17/2015 |
| action of thymidine phosphorylase in non-small cell lung cancer: crosstalk with Nrf2 and HO-1 | Regulation and novel action of thymidine phosphorylase in non-small cell lung cancer: crosstalk with Nrf2 and HO-1.
Tertil M, Skrzypek K, Florczyk U, Weglarczyk K, Was H, Collet G, Guichard A, Gil T, Kuzdzal J, Jozkowicz A, Kieda C, Pichon C, Dulak J., Free PMC Article | 07/4/2015 |
| These results demonstrate that the use of AAV to direct TYMP expression in liver is feasible as a potentially safe gene therapy strategy for Mitochondrial neurogastrointestinal encephalomyopathy. | Gene therapy using a liver-targeted AAV vector restores nucleoside and nucleotide homeostasis in a murine model of MNGIE.
Torres-Torronteras J, Viscomi C, Cabrera-Pérez R, Cámara Y, Di Meo I, Barquinero J, Auricchio A, Pizzorno G, Hirano M, Zeviani M, Martí R., Free PMC Article | 02/28/2015 |
| thymidine phosphorylase could strongly influence gastric cancer progression via the dual activities of angiogenesis and lymphangiogenesis | Angiogenic factor thymidine phosphorylase associates with angiogenesis and lymphangiogenesis in the intestinal-type gastric cancer.
Zhang X, Zheng Z, Shin YK, Kim KY, Rha SY, Noh SH, Chung HC, Jeung HC. | 01/3/2015 |
| We suggest that a chip including DPYD, TYMS, TYMP, TK1, and TK2 genes is a potential tool to predict response in LARC following fluoropyrimidine-based CCRT | DPYD, TYMS, TYMP, TK1, and TK2 genetic expressions as response markers in locally advanced rectal cancer patients treated with fluoropyrimidine-based chemoradiotherapy.
Huang MY, Wu CH, Huang CM, Chung FY, Huang CW, Tsai HL, Chen CF, Lin SR, Wang JY., Free PMC Article | 08/9/2014 |
| our study shows that IFN-alpha enhanced 5'-DFUR-induced apoptosis in gastric cancer cells by upregulation of TP expression, which is partially regulated by activation of ERK signaling | Interferon-α enhances 5'-deoxy-5-fluorouridine-induced apoptosis by ERK-dependant upregulation of thymidine phosphorylase.
Zhu Y, Xu L, Fan Y, Li C, Zhang Y, Zheng H, Hou K, Qu X, Liu Y., Free PMC Article | 04/12/2014 |