| Comparison of Brn3a and RBPMS Labeling to Assess Retinal Ganglion Cell Loss During Aging and in a Model of Optic Neuropathy. | Comparison of Brn3a and RBPMS Labeling to Assess Retinal Ganglion Cell Loss During Aging and in a Model of Optic Neuropathy.
Meng M, Chaqour B, O'Neill N, Dine K, Sarabu N, Ying GS, Shindler KS, Ross AG., Free PMC Article | 04/10/2024 |
| ISL1 and POU4F1 Directly Interact to Regulate the Differentiation and Survival of Inner Ear Sensory Neurons. | ISL1 and POU4F1 Directly Interact to Regulate the Differentiation and Survival of Inner Ear Sensory Neurons.
Xu M, Li S, Xie X, Guo L, Yu D, Zhuo J, Lin J, Kol L, Gan L., Free PMC Article | 02/24/2024 |
| Brn3a controls the soma localization and axonal extension patterns of developing spinal dorsal horn neurons. | Brn3a controls the soma localization and axonal extension patterns of developing spinal dorsal horn neurons.
Nishida K, Matsumura S, Uchida H, Abe M, Sakimura K, Badea TC, Kobayashi T., Free PMC Article | 09/26/2023 |
| Pou4f1 Defines a Subgroup of Type I Spiral Ganglion Neurons and Is Necessary for Normal Inner Hair Cell Presynaptic Ca(2+) Signaling. | Pou4f1 Defines a Subgroup of Type I Spiral Ganglion Neurons and Is Necessary for Normal Inner Hair Cell Presynaptic Ca(2+) Signaling.
Sherrill HE, Jean P, Driver EC, Sanders TR, Fitzgerald TS, Moser T, Kelley MW., Free PMC Article | 06/20/2020 |
| analyzed the morphology, number, and general architecture of various neuronal types presynaptic to ganglion cells(Brn3a and Brn3b knockout mice), searching for changes secondary to the decrement in the number of their postsynaptic partners | Brn3a and Brn3b knockout mice display unvaried retinal fine structure despite major morphological and numerical alterations of ganglion cells.
Ghinia MG, Novelli E, Sajgo S, Badea TC, Strettoi E., Free PMC Article | 04/18/2020 |
| This study showed that three genes were found to be consistently regulated by Brn3a throughout postnatal retina development - Mapk10, Tusc5 and Cdh4. | Postnatal developmental dynamics of cell type specification genes in Brn3a/Pou4f1 Retinal Ganglion Cells.
Muzyka VV, Brooks M, Badea TC., Free PMC Article | 11/17/2018 |
| Double morphant embryos targeted with morpholino oligonucleotides to both TFs develop significant cardiac defects (looping abnormalities and valve defects) suggesting essential roles for Brn-3a and Brn-3b in developing hearts. | Essential but partially redundant roles for POU4F1/Brn-3a and POU4F2/Brn-3b transcription factors in the developing heart.
Maskell LJ, Qamar K, Babakr AA, Hawkins TA, Heads RJ, Budhram-Mahadeo VS., Free PMC Article | 03/10/2018 |
| Study demonstrates a sequential expression order of NEUROD1>ISL1>POU4F1>POU4F2 during the inner ear neurogenesis. | Comparative expression analysis of POU4F1, POU4F2 and ISL1 in developing mouse cochleovestibular ganglion neurons.
Deng M, Yang H, Xie X, Liang G, Gan L., Free PMC Article | 02/7/2015 |
| Pou4f1 and pou4f2 are dispensable for the long-term survival of adult retinal ganglion cells in mice. | Pou4f1 and pou4f2 are dispensable for the long-term survival of adult retinal ganglion cells in mice.
Huang L, Hu F, Xie X, Harder J, Fernandes K, Zeng XY, Libby R, Gan L., Free PMC Article | 01/10/2015 |
| The deficiency of Pou4f1 who perform poorly in motivation-based locomotor behaviors, such as voluntary wheel running and the accelerating rotarod, but show only minor abnormalities in gait and balance and exhibit normal levels of basal locomotion. | Role of the dorsal medial habenula in the regulation of voluntary activity, motor function, hedonic state, and primary reinforcement.
Hsu YW, Wang SD, Wang S, Morton G, Zariwala HA, de la Iglesia HO, Turner EE., Free PMC Article | 12/27/2014 |
| Data indicate that Brn3 transcription factors Brn3b affects Brn3a and Brn3c positive Retinal Ganglion Cells (RGCs) in cell autonomous and non-cell autonomous fashion. | Genetic interactions between Brn3 transcription factors in retinal ganglion cell type specification.
Shi M, Kumar SR, Motajo O, Kretschmer F, Mu X, Badea TC., Free PMC Article | 08/9/2014 |
| The results demonstrated a critical role for Brn3a in generating dorsal root ganglia sensory neuron diversity and regulating sensory afferent projections to the central targets. | Brn3a/Pou4f1 regulates dorsal root ganglion sensory neuron specification and axonal projection into the spinal cord.
Zou M, Li S, Klein WH, Xiang M., Free PMC Article | 05/5/2012 |
| neither Brn3a nor Brn3c are expressed in intrinsically photosensitive retinal ganglion cells | Differential expression of Brn3 transcription factors in intrinsically photosensitive retinal ganglion cells in mouse.
Jain V, Ravindran E, Dhingra NK. | 04/28/2012 |
| Brn3 gene expression patterns in the retina and inner ear, these experiments suggest a deep functional similarity among primary somatosensory neurons, spiral and vestibular ganglion neurons, and retinal ganglion cells | Combinatorial expression of Brn3 transcription factors in somatosensory neurons: genetic and morphologic analysis.
Badea TC, Williams J, Smallwood P, Shi M, Motajo O, Nathans J., Free PMC Article | 03/10/2012 |
| Progressive increase in IOP and loss of Brn3a signals in D2 animals were consistent with glaucoma progression starting after 6 months of age. | Missing optomotor head-turning reflex in the DBA/2J mouse.
Barabas P, Huang W, Chen H, Koehler CL, Howell G, John SW, Tian N, Rentería RC, Krizaj D., Free PMC Article | 11/5/2011 |
| This study demonistrated that Brn3a and Islet1 act epistatically to regulate the gene expression program of sensory differentiation. | Brn3a and Islet1 act epistatically to regulate the gene expression program of sensory differentiation.
Dykes IM, Tempest L, Lee SI, Turner EE, Dykes IM, Tempest L, Lee SI, Turner EE., Free PMC Articles: PMC3143040, PMC3143040 | 09/10/2011 |
| An epistatic interaction between Brn3a and Isl1 is key to sensory neuron specification, in their absence almost all known markers of sensory neurons are lost. Data support the hypothesis that Brn3a and Isl1 bind to shared enhancers in target genes. | Brn3a and Islet1 act epistatically to regulate the gene expression program of sensory differentiation.
Dykes IM, Tempest L, Lee SI, Turner EE, Dykes IM, Tempest L, Lee SI, Turner EE., Free PMC Articles: PMC3143040, PMC3143040 | 07/22/2011 |
| Data show a longitudinal domain positive for both Nkx6.1 and Nkx6.2 that is medial to the Pou4f1-positive red nucleus. This domain could correspond to part of the reticular formation, which extends from the diencephalon and the mesencephalon. | Dynamic expression patterns of Nkx6.1 and Nkx6.2 in the developing mes-diencephalic basal plate.
Moreno-Bravo JA, Perez-Balaguer A, Martinez S, Puelles E. | 09/27/2010 |
| data define AR as a direct Brn-3a interactor and verify a simple interacting protein prediction methodology that is likely to be useful for many other proteins | A simple technique for the prediction of interacting proteins reveals a direct Brn-3a-androgen receptor interaction.
Berwick DC, Diss JKJ, Budhram-Mahadeo VS, Latchman DS., Free PMC Article | 06/28/2010 |
| Data show that Brn3a acts upstream of the Runx factors, which then repress TrkB expression to allow establishment of the non-overlapping Trk receptor profiles and correct terminally differentiated phenotypes. | Brn3a regulates neuronal subtype specification in the trigeminal ganglion by promoting Runx expression during sensory differentiation.
Dykes IM, Lanier J, Eng SR, Turner EE., Free PMC Article | 05/31/2010 |
| Brn3a regulates the transition from neurogenesis to terminal differentiation and represses non-neural gene expression in the trigeminal ganglion. | Brn3a regulates the transition from neurogenesis to terminal differentiation and represses non-neural gene expression in the trigeminal ganglion.
Lanier J, Dykes IM, Nissen S, Eng SR, Turner EE., Free PMC Article | 03/22/2010 |
| these findings begin to define a gene regulatory pathway for habenula development in mammals, and the roles of Nurr1 and Brn3a therein. | Brn3a and Nurr1 mediate a gene regulatory pathway for habenula development.
Quina LA, Wang S, Ng L, Turner EE., Free PMC Article | 01/21/2010 |
| Brn-3a deficiency affects the number and cell size of CGRP- and calcium-binding protein-containing neurons. | Brn-3a deficiency transiently increases expression of calbindin D-28 k and calretinin in the trigeminal ganglion during embryonic development.
Ichikawa H, Terayama R, Yamaai T, Jacobowitz DM, Qiu F, Xiang M, Sugimoto T. | 01/21/2010 |
| Loss of Brn3a leads to an increase in the ratio of bistratified to monostratified RGCs, with only modest RGC loss and little effect on central projections. | Distinct roles of transcription factors brn3a and brn3b in controlling the development, morphology, and function of retinal ganglion cells.
Badea TC, Cahill H, Ecker J, Hattar S, Nathans J., Free PMC Article | 01/21/2010 |
| Brn3a represses differences in gene expression between sensory neurons generated at different axial levels, and regulates developmental gene expression; functionally similar populations of neurons are generated from different embryological substrates. | POU-domain factor Brn3a regulates both distinct and common programs of gene expression in the spinal and trigeminal sensory ganglia.
Eng SR, Dykes IM, Lanier J, Fedtsova N, Turner EE., Free PMC Article | 01/21/2010 |