| The loss of endothelin-2 exhibits an anticancer effect in A549 human lung adenocarcinoma cell line. | The loss of endothelin-2 exhibits an anticancer effect in A549 human lung adenocarcinoma cell line.
Suprapto RP, Suzuki Y, Nagano T, Hirata KI, Emoto N. | 10/1/2022 |
| Reduced Endothelin-2 and Hypoxic Signaling Pathways in Granulosa-Lutein Cells of PCOS Women. | Reduced Endothelin-2 and Hypoxic Signaling Pathways in Granulosa-Lutein Cells of PCOS Women.
Szymanska M, Shrestha K, Girsh E, Harlev A, Eisenberg I, Imbar T, Meidan R., Free PMC Article | 09/11/2021 |
| EDN2 expression in left internal mammary arteries depends on tissue harvesting technique. | The comparison of traditional and modified harvesting techniques of left ınternal mammary artery regarding endothelin-1/2/3 expression and free flow capacity.
Buyukates M, Barut F, Aktunc E. | 02/13/2016 |
| Overexpression of Edn2 in the mouse retina causes an excess of tip cells and inhibits vascular growth. Overexpression of Edn2 in the brain and skin had no effect, but vascular development was inhibited in midgestation mouse embryos. | Endothelin-2 signaling in the neural retina promotes the endothelial tip cell state and inhibits angiogenesis.
Rattner A, Yu H, Williams J, Smallwood PM, Nathans J., Free PMC Article | 10/20/2014 |
| Endothelin 2 and endothelin receptor type B may be a regenerative pathway for central nervous system myelination and remyelination. | Identification of endothelin 2 as an inflammatory factor that promotes central nervous system remyelination.
Yuen TJ, Johnson KR, Miron VE, Zhao C, Quandt J, Harrisingh MC, Swire M, Williams A, McFarland HF, Franklin RJ, Ffrench-Constant C., Free PMC Article | 06/1/2013 |
| Studies revealed hypermethylation of EDN2 and EDN3 genes in human primary colon cancers and in a panel of human colon cancer cell lines. Epigenetic inactivation of ET-2 and ET-3 occurs frequently in both rat and human colon cancers. | Epigenetic inactivation of endothelin-2 and endothelin-3 in colon cancer.
Wang R, Löhr CV, Fischer K, Dashwood WM, Greenwood JA, Ho E, Williams DE, Ashktorab H, Dashwood MR, Dashwood RH., Free PMC Article | 05/25/2013 |
| plasma levels of big ET-2, and big ET-3 are markedly increased in patients with end stage renal disease on hemodialysis | Increased plasma levels of big-endothelin-2 and big-endothelin-3 in patients with end-stage renal disease.
Miyauchi Y, Sakai S, Maeda S, Shimojo N, Watanabe S, Honma S, Kuga K, Aonuma K, Miyauchi T. | 01/12/2013 |
| In granulosa lutein cells from women with polycystic ovary syndrome, endothelin-2 mRNA was reduced as compared with normally ovulating women | Altered endothelin expression in granulosa-lutein cells of women with polycystic ovary syndrome.
Imbar T, Klipper E, Greenfield C, Hurwitz A, Haimov-Kochman R, Meidan R. | 01/12/2013 |
| although endothelin 2 does not appear to be an independent prognostic marker, there is evidence of a putative role in clear cell renal cell carcinoma progression | Expression of endothelin 2 and localized clear cell renal cell carcinoma.
Bot BM, Eckel-Passow JE, LeGrand SN, Hilton T, Cheville JC, Igel T, Parker AS., Free PMC Article | 07/21/2012 |
| Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators., Free PMC Article | 09/15/2010 |
| EDN3, in contrast to EDN1 and EDN2, may act as natural tumour suppressor in the human mammary gland | Frequent loss of endothelin-3 (EDN3) expression due to epigenetic inactivation in human breast cancer.
Wiesmann F, Veeck J, Galm O, Hartmann A, Esteller M, Knüchel R, Dahl E., Free PMC Article | 01/25/2010 |
| Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) | Preterm birth in Caucasians is associated with coagulation and inflammation pathway gene variants.
Velez DR, Fortunato SJ, Thorsen P, Lombardi SJ, Williams SM, Menon R., Free PMC Article | 10/8/2008 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (7) articlesMaternal and fetal genetic associations of PTGER3 and PON1 with preterm birth.
Ryckman KK, Morken NH, White MJ, Velez DR, Menon R, Fortunato SJ, Magnus P, Williams SM, Jacobsson B. EDNRA variants associate with smooth muscle mRNA levels, cell proliferation rates, and cystic fibrosis pulmonary disease severity.
Darrah R, McKone E, O'Connor C, Rodgers C, Genatossio A, McNamara S, Gibson R, Stuart Elborn J, Ennis M, Gallagher CG, Kalsheker N, Aitken M, Wiese D, Dunn J, Smith P, Pace R, Londono D, Goddard KA, Knowles MR, Drumm ML. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium. Racial disparity in pathophysiologic pathways of preterm birth based on genetic variants.
Menon R, Pearce B, Velez DR, Merialdi M, Williams SM, Fortunato SJ, Thorsen P. Determination of genetic predisposition to patent ductus arteriosus in preterm infants.
Dagle JM, Lepp NT, Cooper ME, Schaa KL, Kelsey KJ, Orr KL, Caprau D, Zimmerman CR, Steffen KM, Johnson KJ, Marazita ML, Murray JC. Spontaneous preterm birth in African Americans is associated with infection and inflammatory response gene variants.
Velez DR, Fortunato S, Thorsen P, Lombardi SJ, Williams SM, Menon R. A985G polymorphism of the endothelin-2 gene and atrial fibrillation in patients with hypertrophic cardiomyopathy.
Nagai T, Ogimoto A, Okayama H, Ohtsuka T, Shigematsu Y, Hamada M, Miki T, Higaki J, Nagai T, Ogimoto A, Okayama H, Ohtsuka T, Shigematsu Y, Hamada M, Miki T, Higaki J. | 03/13/2008 |
| The EDN2 A985 allele, which is considered to be protective in cardiovascular disease, may be a risk factor for atrial fibrillation in patients with hypertrophic cardiomyopathy. | A985G polymorphism of the endothelin-2 gene and atrial fibrillation in patients with hypertrophic cardiomyopathy.
Nagai T, Ogimoto A, Okayama H, Ohtsuka T, Shigematsu Y, Hamada M, Miki T, Higaki J, Nagai T, Ogimoto A, Okayama H, Ohtsuka T, Shigematsu Y, Hamada M, Miki T, Higaki J. | 01/21/2010 |
| Endothelin-2 is a hypoxia-induced autocrine survival factor for breast tumor cells | Endothelin-2 is a hypoxia-induced autocrine survival factor for breast tumor cells.
Grimshaw MJ, Naylor S, Balkwill FR. | 01/21/2010 |
| Endothelin-2 is a macrophage chemoattractant. ET-2 expression by tumors may modulate the behavior of macrophages such that activated cells accumulate in areas of hypoxia. | Endothelin-2 is a macrophage chemoattractant: implications for macrophage distribution in tumors.
Grimshaw MJ, Wilson JL, Balkwill FR. | 01/21/2010 |