| Endothelin 3/EDNRB signaling induces thermogenic differentiation of white adipose tissue. | Endothelin 3/EDNRB signaling induces thermogenic differentiation of white adipose tissue.
Wang CH, Tsuji T, Wu LH, Yang CY, Huang TL, Sato M, Shamsi F, Tseng YH., Free PMC Article | 10/3/2024 |
| Endothelin-3 is epigenetically silenced in endometrioid endometrial cancer. | Endothelin-3 is epigenetically silenced in endometrioid endometrial cancer.
Zmarzły N, Januszyk S, Mieszczański P, Morawiec E, Buda P, Dziobek K, Opławski M, Boroń D., Free PMC Article | 07/27/2023 |
| The ratio of circulating endothelin-1 to endothelin-3 associated with TIMI risk and dynamic TIMI risk score in ST elevation acute myocardial infarction. | The ratio of circulating endothelin-1 to endothelin-3 associated with TIMI risk and dynamic TIMI risk score in ST elevation acute myocardial infarction.
Hartopo AB, Puspitawati I, Mumpuni H. | 07/10/2021 |
| miR27a3p regulates the inhibitory influence of endothelin 3 on the tumorigenesis of papillary thyroid cancer cells. | miR‑27a‑3p regulates the inhibitory influence of endothelin 3 on the tumorigenesis of papillary thyroid cancer cells.
Chen H, Cai B, Liu K, Hua Q., Free PMC Article | 05/8/2021 |
| Growth factor and receptor malfunctions associated with human genetic deafness. | Growth factor and receptor malfunctions associated with human genetic deafness.
Naz S, Friedman TB., Free PMC Article | 02/6/2021 |
| Insights into Endothelin-3 and Multiple Sclerosis. | Insights into Endothelin-3 and Multiple Sclerosis.
Monti L, Arrigucci U, Rossi A. | 02/2/2021 |
| Association of endothelin genetic variants and hospitalized infection complications in end-stage renal disease (ESRD) patients. | Association of endothelin genetic variants and hospitalized infection complications in end-stage renal disease (ESRD) patients.
Kao CC, Cheng SY, Wang YJ, Chien SC, Hsu YW, Wu MY, Lu HF, Nam S, Sun T, Wu MS, Chang WC., Free PMC Article | 10/3/2020 |
| the critical physiological role of the KIT-ET3-NO pathway in fulfilling high demand (exceeding basal level) of endothelium-dependent NO generation for coping with atherosclerosis, pregnancy, and aging, is reported. | SCF-KIT signaling induces endothelin-3 synthesis and secretion: Thereby activates and regulates endothelin-B-receptor for generating temporally- and spatially-precise nitric oxide to modulate SCF- and or KIT-expressing cell functions.
Chen LL, Zhu J, Schumacher J, Wei C, Ramdas L, Prieto VG, Jimenez A, Velasco MA, Tripp SR, Andtbacka RHI, Gouw L, Rodgers GM, Zhang L, Chan BK, Cassidy PB, Benjamin RS, Leachman SA, Frazier ML., Free PMC Article | 10/21/2017 |
| genome-wide association studies in population of women in China: Data suggest that EDN3 (endothelin 3) and EDNRB (endothelin receptor type B) play important roles in the molecular mechanisms underlying cervical cancer. | Genome-wide analysis of aberrant gene expression and methylation profiles reveals susceptibility genes and underlying mechanism of cervical cancer.
Lin H, Ma Y, Wei Y, Shang H. | 04/15/2017 |
| EDN3 expression in left internal mammary arteries depends on tissue harvesting technique. | The comparison of traditional and modified harvesting techniques of left ınternal mammary artery regarding endothelin-1/2/3 expression and free flow capacity.
Buyukates M, Barut F, Aktunc E. | 02/13/2016 |
| Down-regulated expression of ET3 attenuates the malignant behaviors of human melanoma cells partially by decreasing the expression of SPARC. | Silencing endothelin-3 expression attenuates the malignant behaviors of human melanoma cells by regulating SPARC levels.
An XJ, Li YQ, Qu XY, Zhang J, Zhang LY, Wang M, Zhu L, Chen SY, Chen HX, Tu YT, Zhou YW, Huang CZ. | 09/13/2014 |
| Waardenburg syndrome type II and mutations of EDNRB, EDN3 and SOX10 genes are responsible for Waardenburg syndrome type IV. (review) | [Hereditary hypomelanocytoses: the role of PAX3, SOX10, MITF, SNAI2, KIT, EDN3 and EDNRB genes].
Otręba M, Miliński M, Buszman E, Wrześniok D, Beberok A. | 05/31/2014 |
| Our data showed that almost all patients, regardless of individual characteristics such as gender or age, expressed the endothelin receptor genes, but did not express the genes for ET-3. | Gene expression of endothelin receptors in replaced rheumatic mitral stenotic valves.
Leão SC, Souto FM, Costa RV, Rocha Tde F, Pacheco YG, Rodrigues TM. | 11/2/2013 |
| Studies revealed hypermethylation of EDN2 and EDN3 genes in human primary colon cancers and in a panel of human colon cancer cell lines. Epigenetic inactivation of ET-2 and ET-3 occurs frequently in both rat and human colon cancers. | Epigenetic inactivation of endothelin-2 and endothelin-3 in colon cancer.
Wang R, Löhr CV, Fischer K, Dashwood WM, Greenwood JA, Ho E, Williams DE, Ashktorab H, Dashwood MR, Dashwood RH., Free PMC Article | 05/25/2013 |
| plasma levels of big ET-2, and big ET-3 are markedly increased in patients with end stage renal disease on hemodialysis | Increased plasma levels of big-endothelin-2 and big-endothelin-3 in patients with end-stage renal disease.
Miyauchi Y, Sakai S, Maeda S, Shimojo N, Watanabe S, Honma S, Kuga K, Aonuma K, Miyauchi T. | 01/12/2013 |
| A novel missense mutation in EDN3 and a deletion mutation in DMD has been found in the same Indian family members affected with Waardenburg syndrome and Duchenne muscular dystrophy. | Genetic analysis of an Indian family with members affected with Waardenburg syndrome and Duchenne muscular dystrophy.
Kapoor S, Bindu PS, Taly AB, Sinha S, Gayathri N, Rani SV, Chandak GR, Kumar A., Free PMC Article | 12/22/2012 |
| These data suggest that autocrine EDN3/EDNRB signaling is essential for maintaining GSCs. Incorporating END3/EDNRB-targeted therapies into conventional cancer treatments may have clinical implication for the prevention of tumor recurrence. | Autocrine endothelin-3/endothelin receptor B signaling maintains cellular and molecular properties of glioblastoma stem cells.
Liu Y, Ye F, Yamada K, Tso JL, Zhang Y, Nguyen DH, Dong Q, Soto H, Choe J, Dembo A, Wheeler H, Eskin A, Schmid I, Yong WH, Mischel PS, Cloughesy TF, Kornblum HI, Nelson SF, Liau LM, Tso CL., Free PMC Article | 06/23/2012 |
| ET-1 and the ET-1/ET-3 ratio are elevated in cirrhotic patients with portopulmonary hypertension (PPHT) and that ET-1 is associated with a poor outcome irrespective of PPHT. | Portopulmonary hypertension and serum endothelin levels in hospitalized patients with cirrhosis.
Tsiakalos A, Hatzis G, Moyssakis I, Karatzaferis A, Ziakas PD, Tzelepis GE. | 12/10/2011 |
| Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators., Free PMC Article | 09/15/2010 |
| Finding suggest that mutations in RET and NTRK3 acting together are necessary and sufficient for the appearance of Hirschsprung disease and that the EDN3 mutation acts as a phenotype modifier. | Contribution of RET, NTRK3 and EDN3 to the expression of Hirschsprung disease in a multiplex family.
Sánchez-Mejías A, Fernández RM, López-Alonso M, Antiñolo G, Borrego S. | 03/15/2010 |
| EDN3 may be considered as a common susceptibility gene for sporadic Hirschsprung disease in a low-penetrance fashion. | New roles of EDNRB and EDN3 in the pathogenesis of Hirschsprung disease.
Sánchez-Mejías A, Fernández RM, López-Alonso M, Antiñolo G, Borrego S, Sánchez-Mejías A, Fernández RM, López-Alonso M, Antiñolo G, Borrego S. | 03/1/2010 |
| EDN3, in contrast to EDN1 and EDN2, may act as natural tumour suppressor in the human mammary gland | Frequent loss of endothelin-3 (EDN3) expression due to epigenetic inactivation in human breast cancer.
Wiesmann F, Veeck J, Galm O, Hartmann A, Esteller M, Knüchel R, Dahl E., Free PMC Article | 01/25/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (5) articlesA candidate gene study of obstructive sleep apnea in European Americans and African Americans.
Larkin EK, Patel SR, Goodloe RJ, Li Y, Zhu X, Gray-McGuire C, Adams MD, Redline S. The correlation of genetic markers with anatomoclinical and histopathological forms in Hirschsprung's disease.
Broască V, Ciobotaru C, Dimofte I, Aşchie M, Prună A, Severin B. EDNRA variants associate with smooth muscle mRNA levels, cell proliferation rates, and cystic fibrosis pulmonary disease severity.
Darrah R, McKone E, O'Connor C, Rodgers C, Genatossio A, McNamara S, Gibson R, Stuart Elborn J, Ennis M, Gallagher CG, Kalsheker N, Aitken M, Wiese D, Dunn J, Smith P, Pace R, Londono D, Goddard KA, Knowles MR, Drumm ML. New roles of EDNRB and EDN3 in the pathogenesis of Hirschsprung disease.
Sánchez-Mejías A, Fernández RM, López-Alonso M, Antiñolo G, Borrego S, Sánchez-Mejías A, Fernández RM, López-Alonso M, Antiñolo G, Borrego S. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium. | 01/20/2010 |
| Report on spanish cases of Waardenburg syndrome type 4 with novel mutations in EDN3 and SOX 10 genes. | Genetic and phenotypic heterogeneity in two novel cases of Waardenburg syndrome type IV.
Viñuela A, Morín M, Villamar M, Morera C, Lavilla MJ, Cavallé L, Moreno-Pelayo MA, Moreno F, del Castillo I. | 01/21/2010 |
| In conclusion, Multiplex Ligation-dependent Probe Amplification assessment of rearrangements in the RET proto-oncogene and in 3 other associated genes, ZEB2, EDN3 and GDNF did not show any variants in 80 sporadic Hirschsprung disease patients. | Analysis of RET, ZEB2, EDN3 and GDNF genomic rearrangements in 80 patients with Hirschsprung disease (using multiplex ligation-dependent probe amplification).
Serra A, Görgens H, Alhadad K, Ziegler A, Fitze G, Schackert HK. | 01/21/2010 |