| Upregulated Tbeta4 expression in inflammatory bowel disease impairs the intestinal mucus barrier by inhibiting autophagy in mice. | Upregulated Tβ4 expression in inflammatory bowel disease impairs the intestinal mucus barrier by inhibiting autophagy in mice.
Hao M, Zhong K, Bai X, Wu S, Li L, He Y, Wang Z, Sun X, Wang Q, Guo Y, Sun Y, Wu L. | 03/28/2024 |
| Thymosin beta4 preserves vascular smooth muscle phenotype in atherosclerosis via regulation of low density lipoprotein related protein 1 (LRP1). | Thymosin β4 preserves vascular smooth muscle phenotype in atherosclerosis via regulation of low density lipoprotein related protein 1 (LRP1).
Munshaw S, Redpath AN, Pike BT, Smart N., Free PMC Article | 09/22/2023 |
| Mechanism of thymosin beta4 in ameliorating liver fibrosis via the MAPK/NF-kappaB pathway. | Mechanism of thymosin β4 in ameliorating liver fibrosis via the MAPK/NF-κB pathway.
Wang Z, Zhang Y, Wang Y, Mou Q, Ren T, Zhu L. | 07/23/2023 |
| Targeted Deletion of Thymosin Beta 4 in Hepatic Stellate Cells Ameliorates Liver Fibrosis in a Transgenic Mouse Model. | Targeted Deletion of Thymosin Beta 4 in Hepatic Stellate Cells Ameliorates Liver Fibrosis in a Transgenic Mouse Model.
Kim J, Lee C, Han J, Jeong H, Wang S, Choi YH, Jung Y., Free PMC Article | 07/5/2023 |
| Thymosin beta4 is essential for thrombus formation by controlling the G-actin/F-actin equilibrium in platelets. | Thymosin β4 is essential for thrombus formation by controlling the G-actin/F-actin equilibrium in platelets.
Scheller I, Beck S, Göb V, Gross C, Neagoe RAI, Aurbach K, Bender M, Stegner D, Nagy Z, Nieswandt B., Free PMC Article | 12/10/2022 |
| Promoting effect of Tmsb4x on the differentiation of peripheral blood mononuclear cells to dendritic cells during septicemia. | Promoting effect of Tmsb4x on the differentiation of peripheral blood mononuclear cells to dendritic cells during septicemia.
Liao Y, Xiao N, Wang X, Dai S, Wang G. | 10/1/2022 |
| Thymosin beta4 Suppresses LPS-Induced Murine Lung Fibrosis by Attenuating Oxidative Injury and Alleviating Inflammation. | Thymosin β4 Suppresses LPS-Induced Murine Lung Fibrosis by Attenuating Oxidative Injury and Alleviating Inflammation.
Tian Z, Yao N, Wang F, Ruan L. | 03/26/2022 |
| Thymosin beta4 reverses phenotypic polarization of glial cells and cognitive impairment via negative regulation of NF-kappaB signaling axis in APP/PS1 mice. | Thymosin β4 reverses phenotypic polarization of glial cells and cognitive impairment via negative regulation of NF-κB signaling axis in APP/PS1 mice.
Wang M, Feng LR, Li ZL, Ma KG, Chang KW, Chen XL, Yang PB, Ji SF, Ma YB, Han H, Ruganzua JB, Yang WN, Qian YH., Free PMC Article | 01/1/2022 |
| Discovery of thymosin beta4 as a human exerkine and growth factor. | Discovery of thymosin β4 as a human exerkine and growth factor.
Gonzalez-Franquesa A, Stocks B, Borg ML, Kuefner M, Dalbram E, Nielsen TS, Agrawal A, Pankratova S, Chibalin AV, Karlsson HKR, Gheibi S, Björnholm M, Jørgensen NR, Clemmensen C, Hostrup M, Treebak JT, Krook A, Zierath JR, Deshmukh AS. | 11/13/2021 |
| Di-(2-ethylhexyl) phthalate-induced tumor growth is regulated by primary cilium formation via the axis of H2O2 production-thymosin beta-4 gene expression. | Di-(2-ethylhexyl) phthalate-induced tumor growth is regulated by primary cilium formation via the axis of H(2)O(2) production-thymosin beta-4 gene expression.
Lee JW, Thuy PX, Han HK, Moon EY., Free PMC Article | 10/16/2021 |
| Thymosin beta4 protects against aortic aneurysm via endocytic regulation of growth factor signaling. | Thymosin β4 protects against aortic aneurysm via endocytic regulation of growth factor signaling.
Munshaw S, Bruche S, Redpath AN, Jones A, Patel J, Dubé KN, Lee R, Hester SS, Davies R, Neal G, Handa A, Sattler M, Fischer R, Channon KM, Smart N., Free PMC Article | 10/9/2021 |
| Thymosin beta4 is essential for adherens junction stability and epidermal planar cell polarity. | Thymosin β4 is essential for adherens junction stability and epidermal planar cell polarity.
Padmanabhan K, Grobe H, Cohen J, Soffer A, Mahly A, Adir O, Zaidel-Bar R, Luxenburg C., Free PMC Article | 02/2/2021 |
| Study indicates that thymosin beta 4 has cholinergic signaling activities through the induction of autophagy. | Thymosin beta 4-Induced Autophagy Increases Cholinergic Signaling in PrP (106-126)-Treated HT22 Cells.
Han HJ, Kim S, Kwon J. | 01/11/2020 |
| Tb4 induced BSP expression in MDPC23 cells via ERK and Smad3 signaling pathways, suggesting its role as a signaling molecule in odontoblasts for regulating BSP secretion during dentinogenesis. | Thymosin β4 is associated with bone sialoprotein expression via ERK and Smad3 signaling pathways in MDPC-23 odontoblastic cells.
Choi BD, Lim HJ, Lee SY, Lee MH, Kil KS, Lim DS, Jeong SJ, Jeong MJ. | 01/26/2019 |
| Tmsb4X was up-regulated in Crybb2 mutant brain. Additionally, Tmsb4X was co-expressed with Crybb2 at actin-enriched cell ruffles. Over-expression of Tmsb4X in cultured hippocampal neurons inhibited dendritogenesis, which phenocopied Crybb2 knock-down. | Crybb2 associates with Tmsb4X and is crucial for dendrite morphogenesis.
Sun M, Ahmad N, Zhang R, Graw J. | 12/1/2018 |
| expressed prominently in podocytes; modifier of glomerular injury | Loss of endogenous thymosin β(4) accelerates glomerular disease.
Vasilopoulou E, Kolatsi-Joannou M, Lindenmeyer MT, White KE, Robson MG, Cohen CD, Sebire NJ, Riley PR, Winyard PJ, Long DA., Free PMC Article | 11/4/2017 |
| Our data suggest that Tbeta4 is required for setting correct sarcomere length and for appropriate splicing of titin, not only in the heart but also in skeletal muscle. | Aberrant developmental titin splicing and dysregulated sarcomere length in Thymosin β4 knockout mice.
Smart N, Riegler J, Turtle CW, Lygate CA, McAndrew DJ, Gehmlich K, Dubé KN, Price AN, Muthurangu V, Taylor AM, Lythgoe MF, Redwood C, Riley PR., Free PMC Article | 06/3/2017 |
| Increased Tb4 expression was observed in ethanol treated microglia. Knockdown of Tb4 enhanced ethanol-induced inflammatory mediators tumor necrosis factor-alpha and interleukin-1beta and nitric oxide in BV-2 cells was performed. | Function of Thymosin Beta-4 in Ethanol-Induced Microglial Activation.
Zhang J, Wu J, Zeng W, Yao K, Zu H, Zhao Y. | 02/18/2017 |
| Results provide evidence that Tbeta4 regulate the levels of VEGF and MMP-2 via the Wnt/beta-catenin/Lef-1 signaling pathway to influence the growth of blood vessels around hair follicles and to activate cell migration. | Role of thymosin beta 4 in hair growth.
Gao XY, Hou F, Zhang ZP, Nuo MT, Liang H, Cang M, Wang ZG, Wang X, Xu T, Yan LY, Guo XD, Liu DJ. | 02/4/2017 |
| we identified the C-terminal four amino-acid variable end of TB4 as the essential and responsible domain for the molecule's full benefits in the hypoxic heart. | C-terminal variable AGES domain of Thymosin β4: the molecule's primary contribution in support of post-ischemic cardiac function and repair.
Hinkel R, Ball HL, DiMaio JM, Shrivastava S, Thatcher JE, Singh AN, Sun X, Faskerti G, Olson EN, Kupatt C, Bock-Marquette I. | 09/10/2016 |
| From the results, Tbeta4 increased the viability and promoted the differentiation and mineralization of MC3T3-E1 cells on Ti discs. | Effect of Thymosin beta4 on the Differentiation and Mineralization of MC3T3-E1 Cell on a Titanium Surface.
Jeong SJ, Jeong MJ. | 08/20/2016 |
| this study demonstrated, for the first time, that Tbeta4 was down-regulated in ROS-stimulated PDLCs as well as Tbeta4 activation exhibited anti-inflammatory effects and anti-osteoclastogenesis in vitro. | Thymosin Beta-4 Suppresses Osteoclastic Differentiation and Inflammatory Responses in Human Periodontal Ligament Cells.
Lee SI, Yi JK, Bae WJ, Lee S, Cha HJ, Kim EC., Free PMC Article | 07/2/2016 |
| this study demonstrates, for the first time, that Tbeta4 is expressed in developing periodontal tissue and that its expression is associated with osteoblastic/cementoblastic differentiation. | Expression of thymosin beta-4 in human periodontal ligament cells and mouse periodontal tissue and its role in osteoblastic/cementoblastic differentiation.
Lee SI, Lee DW, Yun HM, Cha HJ, Bae CH, Cho ES, Kim EC. | 06/28/2016 |
| Tbeta4 appears to regulate P38/ERK/AKT signaling via its effect on VEGF expression, with a resultant effect on the speed of hair growth, the pattern of HFs and the number of hair shafts | Thymosin Beta-4 Induces Mouse Hair Growth.
Gao X, Liang H, Hou F, Zhang Z, Nuo M, Guo X, Liu D., Free PMC Article | 04/30/2016 |
| This study provides putative information concerning the signaling pathway through which Tb4 induces RUNX2 expression, which may help to understand the regulation of tooth development and tooth regeneration. | Thymosin beta 4 is associated with RUNX2 expression through the Smad and Akt signaling pathways in mouse dental epithelial cells.
Someya H, Fujiwara H, Nagata K, Wada H, Hasegawa K, Mikami Y, Jinno A, Sakai H, Koyano K, Kiyoshima T., Free PMC Article | 12/19/2015 |