| Intact synapse structure and function after combined knockout of PTPdelta, PTPsigma, and LAR. | Intact synapse structure and function after combined knockout of PTPδ, PTPσ, and LAR.
Emperador-Melero J, de Nola G, Kaeser PS., Free PMC Article | 01/29/2022 |
| Proteoglycans regulate protein tyrosine phosphatase receptor sigma organization on hematopoietic stem/progenitor cells. | Proteoglycans regulate protein tyrosine phosphatase receptor σ organization on hematopoietic stem/progenitor cells.
Termini CM, Pang A, Batton DM, Chute JP., Free PMC Article | 10/9/2021 |
| Presynaptic PTPsigma regulates postsynaptic NMDA receptor function through direct adhesion-independent mechanisms. | Presynaptic PTPσ regulates postsynaptic NMDA receptor function through direct adhesion-independent mechanisms.
Kim K, Shin W, Kang M, Lee S, Kim D, Kang R, Jung Y, Cho Y, Yang E, Kim H, Bae YC, Kim E., Free PMC Article | 05/8/2021 |
| LAR receptor phospho-tyrosine phosphatases regulate NMDA-receptor responses. | LAR receptor phospho-tyrosine phosphatases regulate NMDA-receptor responses.
Sclip A, Südhof TC., Free PMC Article | 10/24/2020 |
| Through the heparan sulfate of Nrxn1, LRRTMs recruit PTPsigma to induce presynaptic differentiation but function to varying degrees in its absence. PTPsigma forms a robust complex with Nrxn1, revealing an unexpected interaction between the two presynaptic hubs. | LRRTMs Organize Synapses through Differential Engagement of Neurexin and PTPσ.
Roppongi RT, Dhume SH, Padmanabhan N, Silwal P, Zahra N, Karimi B, Bomkamp C, Patil CS, Champagne-Jorgensen K, Twilley RE, Zhang P, Jackson MF, Siddiqui TJ. | 08/1/2020 |
| We show that PTP-3, a LAR homolog in Caenorhabditis elegans, participates in Sema2A-regulated axon guidance. PTPdelta, a member of vertebrate LAR class PTPs, is involved in Sema3A-regulated cortical dendritic growth. In Sema3A signaling, PTPdelta activates Fyn and Src kinases by dephosphorylating their C-terminal Tyr residues. | Protein Tyrosine Phosphatase δ Mediates the Sema3A-Induced Cortical Basal Dendritic Arborization through the Activation of Fyn Tyrosine Kinase.
Nakamura F, Okada T, Shishikura M, Uetani N, Taniguchi M, Yagi T, Iwakura Y, Ohshima T, Goshima Y, Strittmatter SM., Free PMC Article | 03/11/2019 |
| This study provides evidence that chondroitin sulfate (CS) glycosaminoglycans (GAGs) rich in 4,6-O-disulfated disaccharide units known to impede axonal growth can induce RPTPsigma clustering. | Identification of novel binding sites for heparin in receptor protein-tyrosine phosphatase (RPTPσ): Implications for proteoglycan signaling.
Katagiri Y, Morgan AA, Yu P, Bangayan NJ, Junka R, Geller HM., Free PMC Article | 02/9/2019 |
| Downstream molecular target of protein tyrosine phosphatase sigma (PTPsigma) modulation in oligodendrocyte progenitor cells (OPCs) involving upregulation of the protease matrix metallopeptidase 2 (MMP-2) that allows OPCs to enzymatically digest their way through chondroitin sulfate proteoglycans (CSPGs). | Modulation of proteoglycan receptor PTPσ enhances MMP-2 activity to promote recovery from multiple sclerosis.
Luo F, Tran AP, Xin L, Sanapala C, Lang BT, Silver J, Yang Y., Free PMC Article | 01/12/2019 |
| These results demonstrate that NME2 associates with PTPsigma to elicit neurite outgrowth inhibition in response to chondroitin sulfate proteoglycans. | NME2 associates with PTPσ to transduce signals from chondroitin sulfate proteoglycans.
Hamasaki H, Fujitani M, Yamashita T. | 08/6/2016 |
| Receptor protein tyrosine phosphatase sigma (RPTPsigma) regulates neuronal extension and acts as a presynaptic nexus for multiple protein and proteoglycan interactions during synaptogenesis | Structural basis for extracellular cis and trans RPTPσ signal competition in synaptogenesis.
Coles CH, Mitakidis N, Zhang P, Elegheert J, Lu W, Stoker AW, Nakagawa T, Craig AM, Jones EY, Aricescu AR., Free PMC Article | 02/27/2016 |
| Data demonstrate that synoviocytes are regulated by an RPTPsigma-dependent proteoglycan switch in vivo, which can be targeted for rheumatoid arthritis therapy. | Targeting phosphatase-dependent proteoglycan switch for rheumatoid arthritis therapy.
Doody KM, Stanford SM, Sacchetti C, Svensson MN, Coles CH, Mitakidis N, Kiosses WB, Bartok B, Fos C, Cory E, Sah RL, Liu-Bryan R, Boyle DL, Arnett HA, Mustelin T, Corr M, Esko JD, Tremblay ML, Firestein GS, Aricescu AR, Bottini N., Free PMC Article | 02/27/2016 |
| represents an evolutionarily conserved pDC-specific inhibitory receptor, and is required to prevent spontaneous IFN production and immune-mediated intestinal inflammation | Protein Tyrosine Phosphatase PTPRS Is an Inhibitory Receptor on Human and Murine Plasmacytoid Dendritic Cells.
Bunin A, Sisirak V, Ghosh HS, Grajkowska LT, Hou ZE, Miron M, Yang C, Ceribelli M, Uetani N, Chaperot L, Plumas J, Hendriks W, Tremblay ML, Häcker H, Staudt LM, Green PH, Bhagat G, Reizis B., Free PMC Article | 11/21/2015 |
| PTPRS-deficient bone marrow cells display increased cobblestone area-forming cell capacity and augmented transendothelial migration capacity, which was abrogated by RAC inhibition. | Protein tyrosine phosphatase-σ regulates hematopoietic stem cell-repopulating capacity.
Quarmyne M, Doan PL, Himburg HA, Yan X, Nakamura M, Zhao L, Chao NJ, Chute JP., Free PMC Article | 04/25/2015 |
| the major binding sites for RPTPsigma in adult mouse brain are on neurons and are not proteoglycan GAG chains, as RPTPsigma binding overlaps with the neuronal marker NeuN and was not altered by treatments which eliminate chondroitin or heparan sulfate. | Receptor protein tyrosine phosphatase σ binds to neurons in the adult mouse brain.
Yi JH, Katagiri Y, Yu P, Lourie J, Bangayan NJ, Symes AJ, Geller HM., Free PMC Article | 06/14/2014 |
| Protein tyrosine phosphatase sigma targets apical junction complex proteins in the intestine and regulates epithelial permeability. | Protein tyrosine phosphatase σ targets apical junction complex proteins in the intestine and regulates epithelial permeability.
Murchie R, Guo CH, Persaud A, Muise A, Rotin D., Free PMC Article | 03/29/2014 |
| Ptprs and Ptprf deficiency affects mandibular cell proliferation. | Inactivation of LAR family phosphatase genes Ptprs and Ptprf causes craniofacial malformations resembling Pierre-Robin sequence.
Stewart K, Uetani N, Hendriks W, Tremblay ML, Bouchard M. | 10/19/2013 |
| The results of this study demonistrated that RPTPsigma limits synapse number and regulates synapse structure and function in the mature central nervous system. | Receptor protein tyrosine phosphatase sigma regulates synapse structure, function and plasticity.
Horn KE, Xu B, Gobert D, Hamam BN, Thompson KM, Wu CL, Bouchard JF, Uetani N, Racine RJ, Tremblay ML, Ruthazer ES, Chapman CA, Kennedy TE. | 09/1/2012 |
| Structural insights into the homology and differences between mouse protein tyrosine phosphatase-sigma and human protein tyrosine phosphatase-sigma. | Structural insights into the homology and differences between mouse protein tyrosine phosphatase-sigma and human protein tyrosine phosphatase-sigma.
Hou L, Wang J, Zhou Y, Li J, Zang Y, Li J. | 03/17/2012 |
| The cytokine midkine and its receptor RPTPzeta regulate B cell survival in a pathway induced by CD74. | The cytokine midkine and its receptor RPTPζ regulate B cell survival in a pathway induced by CD74.
Cohen S, Shoshana OY, Zelman-Toister E, Maharshak N, Binsky-Ehrenreich I, Gordin M, Hazan-Halevy I, Herishanu Y, Shvidel L, Haran M, Leng L, Bucala R, Harroch S, Shachar I., Free PMC Article | 02/18/2012 |
| study reports that RPTPsigma acts bimodally in sensory neuron extension, mediating chondroitin sulfate proteoglycan inhibition and Heparan sulfate proteoglycan growth promotion | Proteoglycan-specific molecular switch for RPTPσ clustering and neuronal extension.
Coles CH, Shen Y, Tenney AP, Siebold C, Sutton GC, Lu W, Gallagher JT, Jones EY, Flanagan JG, Aricescu AR., Free PMC Article | 05/7/2011 |
| Data suggest that postsynaptic TrkC trans interaction with presynaptic PTPsigma generates bidirectional adhesion and recruitment essential for excitatory synapse development and positions these signaling molecules at the center of synaptic pathways. | Postsynaptic TrkC and presynaptic PTPσ function as a bidirectional excitatory synaptic organizing complex.
Takahashi H, Arstikaitis P, Prasad T, Bartlett TE, Wang YT, Murphy TH, Craig AM., Free PMC Article | 03/19/2011 |
| RPTPsigma modulates the actin cytoskeleton by regulating Rac GTPase activity through p250GAP. | Receptor tyrosine phosphatase sigma (RPTPσ) regulates, p250GAP, a novel substrate that attenuates Rac signaling.
Chagnon MJ, Wu CL, Nakazawa T, Yamamoto T, Noda M, Blanchetot C, Tremblay ML. | 01/1/2011 |
| Our data suggest that RPTPsigma may function to prevent axonal growth after injury in the adult mammalian spinal cord and could be a target for promoting long distance regeneration after spinal cord injury. | Corticospinal tract regeneration after spinal cord injury in receptor protein tyrosine phosphatase sigma deficient mice.
Fry EJ, Chagnon MJ, López-Vales R, Tremblay ML, David S. | 03/15/2010 |
| PTPsigma binds with high affinity to neural chondroitin sulfate proteoglycans(CPSGs); binding involves chondroitin sulfate chains & a specific site on 1st immunoglobulin-like domain of PTPsigma; results indicate PTPsigma can act as a receptor for CSPGs | PTPsigma is a receptor for chondroitin sulfate proteoglycan, an inhibitor of neural regeneration.
Shen Y, Tenney AP, Busch SA, Horn KP, Cuascut FX, Liu K, He Z, Silver J, Flanagan JG., Free PMC Article | 01/21/2010 |
| Enhanced rate of nerve regeneration and directional errors after sciatic nerve injury in PTPsigma knockout mice | Enhanced rate of nerve regeneration and directional errors after sciatic nerve injury in receptor protein tyrosine phosphatase sigma knock-out mice.
McLean J, Batt J, Doering LC, Rotin D, Bain JR., Free PMC Article | 01/21/2010 |