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    EFNA3 ephrin A3 [ Homo sapiens (human) ]

    Gene ID: 1944, updated on 2-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    EphrinA3 is a key regulator of malignant behaviors and a potential prognostic factor in lung adenocarcinoma.

    EphrinA3 is a key regulator of malignant behaviors and a potential prognostic factor in lung adenocarcinoma.
    Yiminniyaze R, Zhang X, Zhu N, Wang J, Li C, Wumaier G, Zhou D, Li J, Xia J, Zhang Y, Dong L, Zhang Y, Li S., Free PMC Article

    02/4/2023
    Hsa_circ_0007478 aggravates NLRP3 inflammasome activation and lipid metabolism imbalance in ox-LDL-stimulated macrophage via miR-765/EFNA3 axis.

    Hsa_circ_0007478 aggravates NLRP3 inflammasome activation and lipid metabolism imbalance in ox-LDL-stimulated macrophage via miR-765/EFNA3 axis.
    Ye B, Liang X, Zhao Y, Cai X, Wang Z, Lin S, Wang W, Shan P, Huang W, Huang Z.

    12/3/2022
    Small extracellular vesicles derived from hypoxic mesenchymal stem cells promote vascularized bone regeneration through the miR-210-3p/EFNA3/PI3K pathway.

    Small extracellular vesicles derived from hypoxic mesenchymal stem cells promote vascularized bone regeneration through the miR-210-3p/EFNA3/PI3K pathway.
    Zhuang Y, Cheng M, Li M, Cui J, Huang J, Zhang C, Si J, Lin K, Yu H.

    09/17/2022
    Ephrin-A3/EphA2 axis regulates cellular metabolic plasticity to enhance cancer stemness in hypoxic hepatocellular carcinoma.

    Ephrin-A3/EphA2 axis regulates cellular metabolic plasticity to enhance cancer stemness in hypoxic hepatocellular carcinoma.
    Husain A, Chiu YT, Sze KM, Ho DW, Tsui YM, Suarez EMS, Zhang VX, Chan LK, Lee E, Lee JM, Cheung TT, Wong CC, Chung CY, Ng IO.

    07/23/2022
    LncRNA LINC01270 aggravates the progression of gastric cancer through modulation of miR-326/EFNA3 axis.

    LncRNA LINC01270 aggravates the progression of gastric cancer through modulation of miR-326/EFNA3 axis.
    Jiang B, Yang K, Tang C, Chen R, Wang C., Free PMC Article

    05/7/2022
    Role of EphrinA3 in HIV-1 Neuropathogenesis.

    Role of EphrinA3 in HIV-1 Neuropathogenesis.
    Singal CMS, Jaiswal P, Mehta A, Saleem K, Seth P., Free PMC Article

    01/22/2022
    MiR-210-3p-EphrinA3-PI3K/AKT axis regulates the progression of oral cancer.

    MiR-210-3p-EphrinA3-PI3K/AKT axis regulates the progression of oral cancer.
    Wang L, Song Y, Wang H, Liu K, Shao Z, Shang Z., Free PMC Article

    05/8/2021
    OSCC Exosomes Regulate miR-210-3p Targeting EFNA3 to Promote Oral Cancer Angiogenesis through the PI3K/AKT Pathway.

    OSCC Exosomes Regulate miR-210-3p Targeting EFNA3 to Promote Oral Cancer Angiogenesis through the PI3K/AKT Pathway.
    Wang H, Wang L, Zhou X, Luo X, Liu K, Jiang E, Chen Y, Shao Z, Shang Z., Free PMC Article

    04/17/2021
    E2F3 and ephrin A3 are putative targets of miR-210, and their protein expression was up-regulated in the angiosarcoma cells

    The role of miR-210, E2F3 and ephrin A3 in angiosarcoma cell proliferation.
    Nakashima S, Jinnin M, Kanemaru H, Kajihara I, Igata T, Okamoto S, Tazaki Y, Harada M, Masuguchi S, Fukushima S, Masuzawa M, Amoh Y, Masuzawa M, Ihn H.

    06/2/2018
    Results show that EFNA3 serves as a tumor suppressor in malignant peripheral nerve sheath tumor cells and it may play a critical role in the FAK signaling and VEGF-associated tumor angiogenesis pathway.

    Dissecting the roles of Ephrin-A3 in malignant peripheral nerve sheath tumor by TALENs.
    Wang Z, Liu Z, Liu B, Liu G, Wu S.

    04/2/2016
    The present study provides evidence that microglia upregulates endothelial ephrin-A3 and ephrin-A4 to facilitate in vitro angiogenesis of brain endothelial cells, which is mediated by microglia-released TNF-alpha.

    Ephrin-A3 and ephrin-A4 contribute to microglia-induced angiogenesis in brain endothelial cells.
    Li Y, Liu DX, Li MY, Qin XX, Fang WG, Zhao WD, Chen YH.

    05/30/2015
    The interaction between ephrin-As, Eph receptors and integrin alpha3 is plausibly important for the crosstalk between Eph and integrin signalling pathways at the membrane protrusions and in the migration of brain cancer cells.

    Ephrin-As, Eph receptors and integrin α3 interact and colocalise at membrane protrusions of U251MG glioblastoma cells.
    Makarov A, Ylivinkka I, Nyman TA, Hyytiäinen M, Keski-Oja J.

    05/31/2014
    EphA3 mutants with constitutively-released kinase domains efficiently support shedding, even when their kinase is disabled. Our data suggest that this phosphorylation-activated conformational switch of EphA3 directly controls ADAM-mediated shedding.

    Cytoplasmic relaxation of active Eph controls ephrin shedding by ADAM10.
    Janes PW, Wimmer-Kleikamp SH, Frangakis AS, Treble K, Griesshaber B, Sabet O, Grabenbauer M, Ting AY, Saftig P, Bastiaens PI, Lackmann M., Free PMC Article

    01/21/2010
    Observational study of gene-disease association. (HuGE Navigator)

    Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer's disease.
    Chapuis J, Hot D, Hansmannel F, Kerdraon O, Ferreira S, Hubans C, Maurage CA, Huot L, Bensemain F, Laumet G, Ayral AM, Fievet N, Hauw JJ, DeKosky ST, Lemoine Y, Iwatsubo T, Wavrant-Devrièze F, Dartigues JF, Tzourio C, Buée L, Pasquier F, Berr C, Mann D, Lendon C, Alpérovitch A, Kamboh MI, Amouyel P, Lambert JC., Free PMC Article

    03/25/2009
    MicroRNA-210 modulates endothelial cell response to hypoxia and inhibits the receptor tyrosine kinase ligand Ephrin-A3.

    MicroRNA-210 modulates endothelial cell response to hypoxia and inhibits the receptor tyrosine kinase ligand Ephrin-A3.
    Fasanaro P, D'Alessandra Y, Di Stefano V, Melchionna R, Romani S, Pompilio G, Capogrossi MC, Martelli F., Free PMC Article

    01/21/2010
    Increasing ephrin-A expression enhances T-cell interactions not only with purified integrin ligands but also endothelial cells, while EphA activation down-regulates these interactions.

    EphA and ephrin-A proteins regulate integrin-mediated T lymphocyte interactions.
    Sharfe N, Nikolic M, Cimpeon L, Van De Kratts A, Freywald A, Roifman CM.

    01/21/2010
    analysis of molecular surfaces in ephrin-A5 essential for a functional interaction with EphA3

    Three distinct molecular surfaces in ephrin-A5 are essential for a functional interaction with EphA3.
    Day B, To C, Himanen JP, Smith FM, Nikolov DB, Boyd AW, Lackmann M.

    01/21/2010
    EphA2/ephrin-A3 interactions may play a role in the localization and network of Langerhans cells in the epithelium and in the regulation of their trafficking.

    Human dendritic cells express neuronal Eph receptor tyrosine kinases: role of EphA2 in regulating adhesion to fibronectin.
    de Saint-Vis B, Bouchet C, Gautier G, Valladeau J, Caux C, Garrone P.

    01/21/2010
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