| Ephrin B2 (EFNB2) potentially protects against intervertebral disc degeneration through inhibiting nucleus pulposus cell apoptosis. | Ephrin B2 (EFNB2) potentially protects against intervertebral disc degeneration through inhibiting nucleus pulposus cell apoptosis.
Zhang Q, Li J, Liu F, Hu J, Liu F, Zou J, Wang X. | 05/31/2024 |
| Discovery and Characterization of Ephrin B2 and EphB4 Dysregulation and Novel Mutations in Cerebral Cavernous Malformations: In Vitro and Patient-Derived Evidence of Ephrin-Mediated Endothelial Cell Pathophysiology. | Discovery and Characterization of Ephrin B2 and EphB4 Dysregulation and Novel Mutations in Cerebral Cavernous Malformations: In Vitro and Patient-Derived Evidence of Ephrin-Mediated Endothelial Cell Pathophysiology.
Sesen J, Ghalali A, Driscoll J, Martinez T, Lupieri A, Zurakowski D, Alexandrescu S, Smith ER, Fehnel KP. | 01/11/2024 |
| EphrinB2 drives osteogenic fate of adult cardiac fibroblasts in a calcium influx dependent manner. | EphrinB2 drives osteogenic fate of adult cardiac fibroblasts in a calcium influx dependent manner.
Li W, Su SA, Chen J, Shen Y, Ma H, Xiang M. | 06/25/2023 |
| EphrinB2 promotes the human aortic smooth muscle cell growth and migration via mediating F-actin remodeling. | EphrinB2 promotes the human aortic smooth muscle cell growth and migration via mediating F-actin remodeling.
Zhu F, Chen J, Luo M, Yao D, Hu X, Guo Y. | 02/17/2023 |
| Elevated ITGA5 facilitates hyperactivated mTORC1-mediated progression of laryngeal squamous cell carcinoma via upregulation of EFNB2. | Elevated ITGA5 facilitates hyperactivated mTORC1-mediated progression of laryngeal squamous cell carcinoma via upregulation of EFNB2.
Li D, Sun A, Zhang L, Ding Z, Yi F, Yang X, Wang Z, Chen X, Liu W, Liu S, Shen H, Miao M, Zhang L, Liu P, Liu Y, Su S, Huang H, Huang C, Hu Z, Zhang H, Zha X, Liu Y., Free PMC Article | 12/10/2022 |
| EphrinB2-EphB4 Signaling in Neurooncological Disease. | EphrinB2-EphB4 Signaling in Neurooncological Disease.
Piffko A, Uhl C, Vajkoczy P, Czabanka M, Broggini T., Free PMC Article | 03/12/2022 |
| The differential expression of EPHB4 and ephrin B2 in cutaneous squamous cell carcinoma according to the grade of tumor differentiation: a clinicopathological study. | The differential expression of EPHB4 and ephrin B2 in cutaneous squamous cell carcinoma according to the grade of tumor differentiation: a clinicopathological study.
Oh ST, Yang KJ, Bae JM, Park HJ, Yoo DS, Park YM. | 07/3/2021 |
| EphrinB2 expression in prostate adenocarcinoma: Implications for targeted therapy. | EphrinB2 expression in prostate adenocarcinoma: Implications for targeted therapy.
Gupta C, Sali A, Ma B, Jackovich A, Sadeghi S, Quinn D, Gill P, Gill I., Free PMC Article | 04/3/2021 |
| Polymorphisms in the Angiogenesis-Related Genes EFNB2, MMP2 and JAG1 Are Associated with Survival of Colorectal Cancer Patients. | Polymorphisms in the Angiogenesis-Related Genes EFNB2, MMP2 and JAG1 Are Associated with Survival of Colorectal Cancer Patients.
Scherer D, Deutelmoser H, Balavarca Y, Toth R, Habermann N, Buck K, Kap EJ, Botma A, Seibold P, Jansen L, Lorenzo Bermejo J, Weigl K, Benner A, Hoffmeister M, Ulrich A, Brenner H, Burwinkel B, Chang-Claude J, Ulrich CM., Free PMC Article | 02/20/2021 |
| EPH receptor B2 stimulates human monocyte adhesion and migration independently of its EphrinB ligands. | EPH receptor B2 stimulates human monocyte adhesion and migration independently of its EphrinB ligands.
Vreeken D, Bruikman CS, Cox SML, Zhang H, Lalai R, Koudijs A, van Zonneveld AJ, Hovingh GK, van Gils JM., Free PMC Article | 02/13/2021 |
| Delta-Like 4-Notch signaling regulates trophoblast migration and invasion by targeting EphrinB2. | Delta-Like 4-Notch signaling regulates trophoblast migration and invasion by targeting EphrinB2.
Luo Q, Zhang W, Liu X, Zheng Y, Gao H, Zhao Y, Zou L. | 01/16/2021 |
| EphrinB2 overexpression enhances osteogenic differentiation of dental pulp stem cells partially through ephrinB2-mediated reverse signaling. | EphrinB2 overexpression enhances osteogenic differentiation of dental pulp stem cells partially through ephrinB2-mediated reverse signaling.
Wang W, Yuan C, Geng T, Liu Y, Zhu S, Zhang C, Liu Z, Wang P., Free PMC Article | 12/26/2020 |
| EFNB2 facilitates cell proliferation, migration, and invasion in pancreatic ductal adenocarcinoma via the p53/p21 pathway and EMT. | EFNB2 facilitates cell proliferation, migration, and invasion in pancreatic ductal adenocarcinoma via the p53/p21 pathway and EMT.
Zhu F, Dai SN, Xu DL, Hou CQ, Liu TT, Chen QY, Wu JL, Miao Y. | 11/28/2020 |
| The effects of ephrinB2 signaling on proliferation and invasion in glioblastoma multiforme. | The effects of ephrinB2 signaling on proliferation and invasion in glioblastoma multiforme.
Bhatia S, Bukkapatnam S, Van Court B, Phan A, Oweida A, Gadwa J, Mueller AC, Piper M, Darragh L, Nguyen D, Gilani A, Knitz M, Bickett T, Green A, Venkataraman S, Vibhakar R, Cittelly D, Karam SD., Free PMC Article | 11/21/2020 |
| EphrinB2/EphB4 signaling regulates the capacity of dental pulp stem cells to induce sprouting angiogenesis | EphrinB2/EphB4 Signaling Regulates DPSCs to Induce Sprouting Angiogenesis of Endothelial Cells.
Gong T, Xu J, Heng B, Qiu S, Yi B, Han Y, Lo ECM, Zhang C. | 07/18/2020 |
| In vitro study in breast cancer cells indicated that EFNB2 expression was associated with a lower cell proliferation, migration and motility. Public datasets analysis confirmed that a high EFNB2 gene expression was associated with a longer recurrence-free survival, whereas a high EPHB4 expression indicated a poor prognosis, particularly for the group of patients whose tumors expressed EPHB4 in the absence of EFNB2. | Ephrin‑B2 inhibits cell proliferation and motility in vitro and predicts longer metastasis‑free survival in breast cancer.
Magic Z, Sandström J, Perez-Tenorio G., Free PMC Article | 04/4/2020 |
| findings present EphB4-ephrin-B2 inhibition as an alternative to anti-PDL1 therapeutics that can be used in combination with radiation to induce an effective antitumor immune response in patients with HNSCC | Inhibition of EphB4-Ephrin-B2 Signaling Reprograms the Tumor Immune Microenvironment in Head and Neck Cancers.
Bhatia S, Oweida A, Lennon S, Darragh LB, Milner D, Phan AV, Mueller AC, Van Court B, Raben D, Serkova NJ, Wang XJ, Jimeno A, Clambey ET, Pasquale EB, Karam SD., Free PMC Article | 02/15/2020 |
| TAD1822-7 is a potential anti-angiogenic agent that can inhibit the viability and migration of Bel-7402 cells via suppression of EphrinB2 and the related signaling pathways. | Inhibitory effect of taspine derivative TAD1822-7 on tumor cell growth and angiogenesis via suppression of EphrinB2 and related signaling pathways.
Liu R, Yu R, Cui Y, Fan M, Wang B, Zhang Y. | 12/21/2019 |
| haploinsufficiency of the EFNB2 could be at the origin of several clinical features reported in 13qter deletions. | EFNB2 haploinsufficiency causes a syndromic neurodevelopmental disorder.
Lévy J, Haye D, Marziliano N, Casu G, Guimiot F, Dupont C, Teissier N, Benzacken B, Gressens P, Pipiras E, Verloes A, Tabet AC. | 12/7/2019 |
| induction of human liver cancer cell apoptosis by B10 could be augmented upon EphrinB2 knockdown. B10 inhibited HCC cell growth and induced HCC cell apoptosis by repressing the EphrinB2 and VEGFR2 signalling pathway | HMQ-T-B10 induces human liver cell apoptosis by competitively targeting EphrinB2 and regulating its pathway.
Dai B, Shi X, Ma N, Ma W, Zhang Y, Yang T, Zhang J, He L., Free PMC Article | 12/7/2019 |
| Silencing Ephrin-B2 in pericytes (PCs) significantly reduced PC migration and PC/endothelial cells (EC) co-culture angiogenic properties. | Inhibition of Ephrin-B2 in brain pericytes decreases cerebral pathological neovascularization in diabetic rats.
Coucha M, Barrett AC, Elgebaly M, Ergul A, Abdelsaid M., Free PMC Article | 11/23/2019 |
| Our findings underscore the importance of adopting rational drug combinations to enhance therapeutic effect. Our study documenting enhanced response of HNSCC to cetuximab-RT with EphB4-ephrin-B2 blockade has the potential to translate into the clinic to benefit this patient population | Inhibition of EphB4-Ephrin-B2 Signaling Enhances Response to Cetuximab-Radiation Therapy in Head and Neck Cancers.
Bhatia S, Sharma J, Bukkapatnam S, Oweida A, Lennon S, Phan A, Milner D, Uyanga N, Jimeno A, Raben D, Somerset H, Heasley L, Karam SD., Free PMC Article | 11/9/2019 |
| The results demonstrate that ephrin-B2 and Dll4 mediated co-dependence of hepatocellular carcinoma and endothelial progenitor cells intercellular crosstalk in the initial stages of hepatocellular carcinoma establishment and development. | Tumor-endothelial cell interaction in an experimental model of human hepatocellular carcinoma.
Jamshidi-Parsian A, Griffin RJ, Kore RA, Todorova VK, Makhoul I. | 09/21/2019 |
| In this review, we evaluate the relationship between estrogen, RANKL, and EphirinB2, and we highlight the direct relation between osteoporosis and estrogen hormone. The identification of direct or indirect pathways of bone formation and degradation in pre- and postmenopausal women could be an important tool for the development of therapeutic strategies in postmenopausal women | The Interactions between Bone Remodelling, Estrogen Hormone and EPH Family Genes.
Kalkan R, Tulay P. | 08/3/2019 |
| This is the novel report describing to demonstrate that the Runx2 expression of MSC is synergistically influenced by the hydrogels elasticity and their manner of ephrinB2 immobilized. | Effect of hydrogel elasticity and ephrinB2-immobilized manner on Runx2 expression of human mesenchymal stem cells.
Toda H, Yamamoto M, Uyama H, Tabata Y. | 02/24/2018 |