| Expression of Early Growth Response 3 in Skin Cancers. | Expression of Early Growth Response 3 in Skin Cancers.
Zhou KY, Deng LJ, Luo SY, Wang QX, Fang S. | 04/10/2024 |
| EGR3 and estrone are involved in the tamoxifen resistance and progression of breast cancer. | EGR3 and estrone are involved in the tamoxifen resistance and progression of breast cancer.
Xie Y, Han X, Yu J, Yuan M, Yan Y, Qin J, Lan L, Wang Y. | 12/22/2023 |
| Egr2 and 3 maintain anti-tumour responses of exhausted tumour infiltrating CD8 + T cells. | Egr2 and 3 maintain anti-tumour responses of exhausted tumour infiltrating CD8 + T cells.
Symonds ALJ, Miao T, Busharat Z, Li S, Wang P., Free PMC Article | 08/11/2023 |
| The EGR3 regulome of infant KMT2A-r acute lymphoblastic leukemia identifies differential expression of B-lineage genes predictive for outcome. | The EGR3 regulome of infant KMT2A-r acute lymphoblastic leukemia identifies differential expression of B-lineage genes predictive for outcome.
Külp M, Larghero P, Alten J, Cario G, Eckert C, Caye-Eude A, Cavé H, Schmachtel T, Bardini M, Cazzaniga G, De Lorenzo P, Valsecchi MG, Bonig H, Meyer C, Rieger MA, Marschalek R., Free PMC Article | 06/13/2023 |
| XIST promotes apoptosis and the inflammatory response in CSE-stimulated cells via the miR-200c-3p/EGR3 axis. | XIST promotes apoptosis and the inflammatory response in CSE-stimulated cells via the miR-200c-3p/EGR3 axis.
Chen P, Jiang P, Chen J, Yang Y, Guo X., Free PMC Article | 12/4/2021 |
| Schizophrenia risk candidate EGR3 is a novel transcriptional regulator of RELN and regulates neurite outgrowth via the Reelin signal pathway in vitro. | Schizophrenia risk candidate EGR3 is a novel transcriptional regulator of RELN and regulates neurite outgrowth via the Reelin signal pathway in vitro.
Nie F, Zhang Q, Ma J, Wang P, Gu R, Han J, Zhang R. | 08/28/2021 |
| HELQ and EGR3 expression correlate with IGHV mutation status and prognosis in chronic lymphocytic leukemia. | HELQ and EGR3 expression correlate with IGHV mutation status and prognosis in chronic lymphocytic leukemia.
Guo C, Gao YY, Ju QQ, Zhang CX, Gong M, Li ZL., Free PMC Article | 07/17/2021 |
| Expression and prognostic value of the transcription factors EGR1 and EGR3 in gliomas. | Expression and prognostic value of the transcription factors EGR1 and EGR3 in gliomas.
Knudsen AM, Eilertsen I, Kielland S, Pedersen MW, Sørensen MD, Dahlrot RH, Boldt HB, Munthe S, Poulsen FR, Kristensen BW., Free PMC Article | 12/12/2020 |
| Silencing of miRNA-210 inhibits the progression of liver cancer and Hepatitis B virus-associated liver cancer via up-regulating EGR3. | Silencing of microRNA-210 inhibits the progression of liver cancer and hepatitis B virus-associated liver cancer via targeting EGR3.
Li X, Yuan M, Song L, Wang Y., Free PMC Article | 05/9/2020 |
| Study demonstrated that EGR3 expression was enhanced in prostate cancer (PC) tissues. EGR3 was proposed as a possible target of miR335, and was negatively regulated by miR335. Silencing EGR3 suppressed the viability and angiogenesis of PC cell line. | Overexpressing miR‑335 inhibits DU145 cell proliferation by targeting early growth response 3 in prostate cancer.
Zhang P, Yang X, Wang L, Zhang D, Luo Q, Wang B., Free PMC Article | 08/31/2019 |
| KSRP decreased EGR3 mRNA stability in an ARE-independent manner. | KSRP suppresses cell invasion and metastasis through miR-23a-mediated EGR3 mRNA degradation in non-small cell lung cancer.
Chien MH, Lee WJ, Yang YC, Li YL, Chen BR, Cheng TY, Yang PW, Wang MY, Jan YH, Lin YK, Lee JM, Hsiao M, Chen JS, Hua KT. | 12/23/2017 |
| miR-718 acts as a tumor suppressive microRNA in hepatocellular carcinoma via regulating the expression of EGR3, which may provide a new diagnostic marker and treatment target for HCC | Involvement of microRNA-718, a new regulator of EGR3, in regulation of malignant phenotype of HCC cells.
Wang ZD, Qu FY, Chen YY, Ran ZS, Liu HY, Zhang HD., Free PMC Article | 07/15/2017 |
| Egr2 and Egr3 have emerged as regulatory molecules that suppress excessive immune responses. Mice deficient for Egr2 and Egr3 develop a lupus-like disease with dysregulated activation of effector T cells. Egr2 and Egr3 confer suppressive activity to CD4(+) T cells and regulate the production of inhibitory cytokines such as IL-10 and TGF-beta1. | Emerging roles of Egr2 and Egr3 in the control of systemic autoimmunity.
Morita K, Okamura T, Sumitomo S, Iwasaki Y, Fujio K, Yamamoto K. | 06/24/2017 |
| EGR3 contributes to cell growth inhibition via upregulation of FasL in Hepatocellular carcinoma. | Early growth response 3 inhibits growth of hepatocellular carcinoma cells via upregulation of Fas ligand.
Zhang S, Xia C, Xu C, Liu J, Zhu H, Yang Y, Xu F, Zhao J, Chang Y, Zhao Q. | 06/24/2017 |
| In the PPI network, genes may be involved in Down syndrome (DS) by interacting with others, including nuclear receptor subfamily 4 group A member 2 (NR4A2)early growth response (EGR)2 and NR4A2EGR3. Therefore, RUNX1, NR4A2, EGR2, EGR3 and ID4 may be key genes associated with the pathogenesis of DS. | Integrated analysis of DNA methylation and RNA‑sequencing data in Down syndrome.
Zhang J, Zhou W, Liu Y, Li N. | 04/15/2017 |
| These findings support previously reported associations between EGR3 and schizophrenia. | Association of SNPs in EGR3 and ARC with Schizophrenia Supports a Biological Pathway for Schizophrenia Risk.
Huentelman MJ, Muppana L, Corneveaux JJ, Dinu V, Pruzin JJ, Reiman R, Borish CN, De Both M, Ahmed A, Todorov A, Cloninger CR, Zhang R, Ma J, Gallitano AL., Free PMC Article | 06/4/2016 |
| EGR3 promotes excessive production of IL6 and IL8 observed during the progression of prostate cancer. | Early Growth Response 3 regulates genes of inflammation and directly activates IL6 and IL8 expression in prostate cancer.
Baron VT, Pio R, Jia Z, Mercola D., Free PMC Article | 05/2/2015 |
| Data shows association of Egr3 genetic polymorphisms and coronary artery disease in the Uygur and Han of China | Association of Egr3 genetic polymorphisms and coronary artery disease in the Uygur and Han of China.
Li X, Ma YT, Xie X, Yang YN, Ma X, Zheng YY, Pan S, Liu F, Chen BD., Free PMC Article | 11/29/2014 |
| Genetic variation in EGR3 may affect prefrontal function through neurodevelopment | Association of decreased prefrontal hemodynamic response during a verbal fluency task with EGR3 gene polymorphism in patients with schizophrenia and in healthy individuals.
Nishimura Y, Takizawa R, Koike S, Kinoshita A, Satomura Y, Kawasaki S, Yamasue H, Tochigi M, Kakiuchi C, Sasaki T, Iwayama Y, Yamada K, Yoshikawa T, Kasai K. | 08/9/2014 |
| These results provide the first evidence that Egr-3, is up-regulated in scleroderma and is necessary and sufficient for profibrotic responses. | Early growth response 3 (Egr-3) is induced by transforming growth factor-β and regulates fibrogenic responses.
Fang F, Shangguan AJ, Kelly K, Wei J, Gruner K, Ye B, Wang W, Bhattacharyya S, Hinchcliff ME, Tourtellotte WG, Varga J., Free PMC Article | 04/26/2014 |
| Decreased EGR3 expression might play a critical role in the differentiation, proliferation, metastasis and progression of gastric cancer cells. | Decreased EGR3 expression is related to poor prognosis in patients with gastric cancer.
Liao F, Ji MY, Shen L, Qiu S, Guo XF, Dong WG. | 04/19/2014 |
| These data suggest that type I IFN stimulation induces a rapid recruitment of a repressive Egr3/Nab1 complex that silences transcription from the ifngr1 promoter. | Type I IFNs downregulate myeloid cell IFN-γ receptor by inducing recruitment of an early growth response 3/NGFI-A binding protein 1 complex that silences ifngr1 transcription.
Kearney SJ, Delgado C, Eshleman EM, Hill KK, O'Connor BP, Lenz LL., Free PMC Article | 11/16/2013 |
| Our results suggest that Egr-3 is a transcription factor associated with TGF-beta1 expression and in vivo regulatory activity | Transcription factor early growth response 3 is associated with the TGF-β1 expression and the regulatory activity of CD4-positive T cells in vivo.
Sumitomo S, Fujio K, Okamura T, Morita K, Ishigaki K, Suzukawa K, Kanaya K, Kondo K, Yamasoba T, Furukawa A, Kitahara N, Shoda H, Shibuya M, Okamoto A, Yamamoto K. | 11/16/2013 |
| Egr3 mRNA expression reveals that Egr3 mRNA expression is increased in tumor cells of non-relapsed samples compared to normal prostate cells, but is significantly lower in relapsed samples compared to non-relapse. | Early growth response 3 (Egr3) is highly over-expressed in non-relapsing prostate cancer but not in relapsing prostate cancer.
Pio R, Jia Z, Baron VT, Mercola D, UCI NCI SPECS Consortium of the Strategic Partners for the Evaluation of Cancer Signatures-Prostate Cancer., Free PMC Article | 08/3/2013 |
| EGR2 and EGR3 are regulated by NFkappaB and MAPK signalling pathways downstream of TNFalpha stimulation in breast adipose fibroblasts, and this in turn is upstream of CYP19A1 transcription via PI.4 | NFκB and MAPK signalling pathways mediate TNFα-induced Early Growth Response gene transcription leading to aromatase expression.
To SQ, Knower KC, Clyne CD. | 05/25/2013 |