| XPO1-Mediated EIF1AX Cytoplasmic Relocation Promotes Tumor Migration and Invasion in Endometrial Carcinoma. | XPO1-Mediated EIF1AX Cytoplasmic Relocation Promotes Tumor Migration and Invasion in Endometrial Carcinoma.
Ye Y, Lv C, Sun J, Lin Z, Liu Y, Huang Y, Chen Y, Li H, Lian X, Jiang X, Zhang S, Wang S., Free PMC Article | 01/11/2023 |
| EIF1AX mutation in thyroid tumors: a retrospective analysis of cytology, histopathology and co-mutation profiles. | EIF1AX mutation in thyroid tumors: a retrospective analysis of cytology, histopathology and co-mutation profiles.
Elsherbini N, Kim DH, Payne RJ, Hudson T, Forest VI, Hier MP, Payne AE, Pusztaszeri MP., Free PMC Article | 11/19/2022 |
| Clinicopathological features and outcomes of thyroid nodules with EIF1AX mutations. | Clinicopathological features and outcomes of thyroid nodules with EIF1AX mutations.
Karslioglu French E, Nikitski AV, Yip L, Nikiforova MN, Nikiforov YE, Carty SE. | 08/6/2022 |
| eIF5B and eIF1A reorient initiator tRNA to allow ribosomal subunit joining. | eIF5B and eIF1A reorient initiator tRNA to allow ribosomal subunit joining.
Lapointe CP, Grosely R, Sokabe M, Alvarado C, Wang J, Montabana E, Villa N, Shin BS, Dever TE, Fraser CS, Fernández IS, Puglisi JD., Free PMC Article | 07/16/2022 |
| Long noncoding RNA EIF1AX-AS1 promotes endometrial cancer cell apoptosis by affecting EIF1AX mRNA stabilization. | Long noncoding RNA EIF1AX-AS1 promotes endometrial cancer cell apoptosis by affecting EIF1AX mRNA stabilization.
Lv C, Sun J, Ye Y, Lin Z, Li H, Liu Y, Mo K, Xu W, Hu W, Draz E, Wang S., Free PMC Article | 04/23/2022 |
| Characterization and Clinical Significance of EIF1AX Mutations and Co-Mutations in Cytologically Indeterminate Thyroid Nodules: A 5-Year Retrospective Analysis. | Characterization and Clinical Significance of EIF1AX Mutations and Co-Mutations in Cytologically Indeterminate Thyroid Nodules: A 5-Year Retrospective Analysis.
Gargano SM, Badjatia N, Nikolaus Y, Peiper SC, Wang ZX. | 10/30/2021 |
| Mutations of GNAQ, GNA11, SF3B1, EIF1AX, PLCB4 and CYSLTR in Uveal Melanoma in Chinese Patients. | Mutations of GNAQ, GNA11, SF3B1, EIF1AX, PLCB4 and CYSLTR in Uveal Melanoma in Chinese Patients.
Hou C, Xiao L, Ren X, Tang F, Guo B, Zeng W, Liang C, Yan N. | 03/27/2021 |
| Transcriptional repression of p21 by EIF1AX promotes the proliferation of breast cancer cells. | Transcriptional repression of p21 by EIF1AX promotes the proliferation of breast cancer cells.
Li Y, Guo L, Ying S, Feng GH, Zhang Y., Free PMC Article | 10/31/2020 |
| Five clusters with distinct copy number variations patterns and concomitant mutations in BAP1, SF3B1, or EIF1AX were identified. Incorporating clinico-histopathological, cluster and mutation data in the analysis results in good performance for uveal melanoma-related disease free survival prediction. | Multi-Modality Analysis Improves Survival Prediction in Enucleated Uveal Melanoma Patients.
Drabarek W, Yavuzyigitoglu S, Obulkasim A, van Riet J, Smit KN, van Poppelen NM, Vaarwater J, Brands T, Eussen B, Verdijk RM, Naus NC, Mensink HW, Paridaens D, Boersma E, van de Werken HJG, Kilic E, de Klein A, Rotterdam Ocular Melanoma Study Group. | 12/28/2019 |
| Regarding time to clinically detected metastases, the first 2 peaks appear to be associated with BAP1-mutated tumors and the late peak to SF3B1-mutated tumors. None of the tumors with only an EIF1AX mutation metastasized. | Association of Uveal Melanoma Metastatic Rate With Stochastic Mutation Rate and Type of Mutation.
Szalai E, Jiang Y, van Poppelen NM, Jager MJ, de Klein A, Kilic E, Grossniklaus HE., Free PMC Article | 10/12/2019 |
| EIF1AX p.Ala113_splice mutation is associated with thyroid cancer tumourigenesis and progression. | The role of EIF1AX in thyroid cancer tumourigenesis and progression.
Simões-Pereira J, Moura MM, Marques IJ, Rito M, Cabrera RA, Leite V, Cavaco BM. | 07/13/2019 |
| We found only one of the 301 tumors (0.3%) harboring A113_splice site mutation at the intron 5/exon 6 splice site of EIF1AX gene | Absence of EIF1AX, PPM1D, and CHEK2 mutations reported in Thyroid Cancer Genome Atlas (TCGA) in a large series of thyroid cancer.
Alzahrani AS, Murugan AK, Qasem E, Alswailem MM, AlGhamdi B, Moria Y, Al-Hindi H. | 06/1/2019 |
| Results identified a mutation in EIF1AX in non-aggressive primary orbital melanoma (POM) tumors suggesting a role in determining the clinical course of POM. | Detection of mutations in SF3B1, EIF1AX and GNAQ in primary orbital melanoma by candidate gene analysis.
Rose AM, Luo R, Radia UK, Kalirai H, Thornton S, Luthert PJ, Jayasena CN, Verity DH, Coupland SE, Rose GE., Free PMC Article | 03/30/2019 |
| Its mutation is found in patients with meningeal melanocytic tumor. | Whole-exome sequencing of a meningeal melanocytic tumour reveals activating CYSLTR2 and EIF1AX hotspot mutations and similarities to uveal melanoma.
Küsters-Vandevelde HVN, Germans MR, Rabbie R, Rashid M, Ten Broek R, Blokx WAM, Prinsen CFM, Adams DJ, Ter Laan M. | 12/1/2018 |
| Study identified a new RNA-induced silencing complex component, eIF1A, which directly interacts with the MID-domain of Ago2 and functions in DICER-independent miRNA biogenesis and miRNA-mediated RNA interference. | Identifying RISC Components Using Ago2 Immunoprecipitation and Mass Spectrometry.
Yi T. | 07/21/2018 |
| EIF1AX alterations occurred infrequently in low-grade gliomas (1.4%), uterus endometrial carcinoma (1.25%), thyroid carcinoma (1%), and lung adenocarcinoma (0.4%). | Comparative analysis of the GNAQ, GNA11, SF3B1, and EIF1AX driver mutations in melanoma and across the cancer spectrum.
Johnson DB, Roszik J, Shoushtari AN, Eroglu Z, Balko JM, Higham C, Puzanov I, Patel SP, Sosman JA, Woodman SE., Free PMC Article | 06/2/2018 |
| In this report we show that patients with uveal melanoma harbor mutation-specific chromosomal patterns in the tumor. These chromosomal patterns are characterized by different types of chromosomal anomalies, thus illustrating that distinct biological mechanisms underlie uveal melanoma pathogenesis. | Correlation of Gene Mutation Status with Copy Number Profile in Uveal Melanoma.
Yavuzyigitoglu S, Drabarek W, Smit KN, van Poppelen N, Koopmans AE, Vaarwater J, Brands T, Eussen B, Dubbink HJ, van Riet J, van de Werken HJ, Beverloo B, Verdijk RM, Naus N, Paridaens D, Kilic E, de Klein A, Rotterdam Ocular Melanoma Study Group. | 05/26/2018 |
| Coexpression of mutant NRAS and EIF1AX proteins promoted proliferation and clonogenic survival in LGSC cells, providing the first example of co-occurring, growth-promoting mutational events in ovarian cancer. | EIF1AX and NRAS Mutations Co-occur and Cooperate in Low-Grade Serous Ovarian Carcinomas.
Etemadmoghadam D, Azar WJ, Lei Y, Moujaber T, Garsed DW, Kennedy CJ, Fereday S, Mitchell C, Chiew YE, Hendley J, Sharma R, Harnett PR, Li J, Christie EL, Patch AM, George J, Au-Yeung G, Mir Arnau G, Holloway TP, Semple T, Pearson JV, Waddell N, Grimmond SM, Köbel M, Rizos H, Lomakin IB, Bowtell DDL, deFazio A, Australian Ovarian Cancer Study Group. | 09/30/2017 |
| Short 5'UTR mRNAs are enriched with TISU (translation initiator of short 5'UTR), a 12-nucleotide element directing efficient scanning-independent translation. This study demonstrate that TISU is particularly dependent on eukaryotic initiation factor 1A (eIF1A) which interacts with both RPS3 and RPS10e. | Efficient and Accurate Translation Initiation Directed by TISU Involves RPS3 and RPS10e Binding and Differential Eukaryotic Initiation Factor 1A Regulation.
Haimov O, Sinvani H, Martin F, Ulitsky I, Emmanuel R, Tamarkin-Ben-Harush A, Vardy A, Dikstein R., Free PMC Article | 09/23/2017 |
| Mutation in EIF1AX gene is associated with Uveal Melanoma. | Integrative Analysis Identifies Four Molecular and Clinical Subsets in Uveal Melanoma.
Robertson AG, Shih J, Yau C, Gibb EA, Oba J, Mungall KL, Hess JM, Uzunangelov V, Walter V, Danilova L, Lichtenberg TM, Kucherlapati M, Kimes PK, Tang M, Penson A, Babur O, Akbani R, Bristow CA, Hoadley KA, Iype L, Chang MT, TCGA Research Network, Cherniack AD, Benz C, Mills GB, Verhaak RGW, Griewank KG, Felau I, Zenklusen JC, Gershenwald JE, Schoenfield L, Lazar AJ, Abdel-Rahman MH, Roman-Roman S, Stern MH, Cebulla CM, Williams MD, Jager MJ, Coupland SE, Esmaeli B, Kandoth C, Woodman SE., Free PMC Article | 09/16/2017 |
| we find iris melanomas to be related genetically to choroidal and ciliary body melanomas, frequently harboring GNAQ, GNA11, and EIF1AX mutations. | Frequent GNAQ, GNA11, and EIF1AX Mutations in Iris Melanoma.
Scholz SL, Möller I, Reis H, Süßkind D, van de Nes JAP, Leonardelli S, Schilling B, Livingstone E, Schimming T, Paschen A, Sucker A, Murali R, Steuhl KP, Schadendorf D, Westekemper H, Griewank KG. | 08/12/2017 |
| results indicate that the interactions between eIF1A and eIF5B are being continuously rearranged during translation initiation; presentation of a model how the dynamic eIF1A/eIF5B interaction network can promote remodeling of the translation initiation complexes, and the roles in the process played by intrinsically disordered protein segments | eIF1A/eIF5B interaction network and its functions in translation initiation complex assembly and remodeling.
Nag N, Lin KY, Edmonds KA, Yu J, Nadkarni D, Marintcheva B, Marintchev A., Free PMC Article | 06/24/2017 |
| Patients with uveal melanoma can be classified into 3 groups, of which EIF1AX-mutated tumors and tumors without BAP1, SF3B1, or EIF1AX mutations are associated with prolonged survival and low metastatic risk, SF3B1-mutated tumors are associated with late metastasis | Uveal Melanomas with SF3B1 Mutations: A Distinct Subclass Associated with Late-Onset Metastases.
Yavuzyigitoglu S, Koopmans AE, Verdijk RM, Vaarwater J, Eussen B, van Bodegom A, Paridaens D, Kiliç E, de Klein A, Rotterdam Ocular Melanoma Study Group. | 06/3/2017 |
| BAP1, SF3B1, and EIF1AX mutations occur during uveal melanoma tumor progression in an almost mutually exclusive manner and are associated with different levels of metastatic risk. | Driver Mutations in Uveal Melanoma: Associations With Gene Expression Profile and Patient Outcomes.
Decatur CL, Ong E, Garg N, Anbunathan H, Bowcock AM, Field MG, Harbour JW., Free PMC Article | 05/6/2017 |
| We report here the occurrence of EIF1AX mutations not only in thyroid cancer, but also in benign thyroid nodules, and demonstrate that phenotypically these mutations are associated with the encapsulated follicular variant of papillary thyroid carcinoma and benign follicular-pattern nodules. | Prevalence and phenotypic correlations of EIF1AX mutations in thyroid nodules.
Karunamurthy A, Panebianco F, J Hsiao S, Vorhauer J, Nikiforova MN, Chiosea S, Nikiforov YE., Free PMC Article | 01/28/2017 |