| Backbone resonance assignments of the C-terminal region of human translation initiation factor eIF4B. | Backbone resonance assignments of the C-terminal region of human translation initiation factor eIF4B.
Mondal S, Rousseau S, Talenton V, Thiam CAB, Aznauryan M, Mackereth CD. | 11/8/2023 |
| DOCK3-Associated Neurodevelopmental Disorder-Clinical Features and Molecular Basis. | DOCK3-Associated Neurodevelopmental Disorder-Clinical Features and Molecular Basis.
Alexander MS, Velinov M., Free PMC Article | 10/30/2023 |
| CDKN2AIP-induced cell senescence and apoptosis of testicular seminoma are associated with CARM1 and eIF4beta. | CDKN2AIP-induced cell senescence and apoptosis of testicular seminoma are associated with CARM1 and eIF4β.
Cao Y, Chen Z, Qin Z, Qian K, Liu T, Zhang Y., Free PMC Article | 10/29/2022 |
| eIF4B enhances ATF4 expression and contributes to cellular adaptation to asparagine limitation in BRAF-mutated A375 melanoma. | eIF4B enhances ATF4 expression and contributes to cellular adaptation to asparagine limitation in BRAF-mutated A375 melanoma.
Iwao Y, Okamoto Y, Shirahama H, Tsukahara S, Tomida A. | 11/22/2021 |
| Long noncoding RNA GMAN promotes hepatocellular carcinoma progression by interacting with eIF4B. | Long noncoding RNA GMAN promotes hepatocellular carcinoma progression by interacting with eIF4B.
Xu J, Lu Y, Liu Q, Xia A, Zhao J, Xu X, Sun Q, Qi F, Sun B. | 10/10/2020 |
| eIF4B and eIF4H mediate GR production from expanded G4C2 in a Drosophila model for C9orf72-associated amyotrophic lateral sclerosis. | eIF4B and eIF4H mediate GR production from expanded G4C2 in a Drosophila model for C9orf72-associated ALS.
Goodman LD, Prudencio M, Srinivasan AR, Rifai OM, Lee VM, Petrucelli L, Bonini NM., Free PMC Article | 04/25/2020 |
| High EIF4B expression is associated with Malignant Grade in Prostate Cancer. | Pim-2 Cooperates with Downstream Factor XIAP to Inhibit Apoptosis and Intensify Malignant Grade in Prostate Cancer.
Ren K, Gou X, Xiao M, He W, Kang J. | 03/2/2019 |
| FASN-induced S6 kinase facilitates USP11-eIF4B complex formation for sustained oncogenic translation in diffuse large B-cell lymphoma. | Fatty Acid Synthase induced S6Kinase facilitates USP11-eIF4B complex formation for sustained oncogenic translation in DLBCL.
Kapadia B, Nanaji NM, Bhalla K, Bhandary B, Lapidus R, Beheshti A, Evens AM, Gartenhaus RB., Free PMC Article | 11/24/2018 |
| Synthesis of MCL1, an antiapoptotic protein known to play a role in cancer cell survival during cell division, depends on the function of MELK-elF4B signaling. | Mitotic MELK-eIF4B signaling controls protein synthesis and tumor cell survival.
Wang Y, Begley M, Li Q, Huang HT, Lako A, Eck MJ, Gray NS, Mitchison TJ, Cantley LC, Zhao JJ., Free PMC Article | 01/27/2018 |
| Together, our data show that mAChRs modulate eIF4B phosphorylation via the ERK1/2 and PKC signaling pathways in SNU-407 colon cancer cells. | Muscarinic acetylcholine receptors mediate eIF4B phosphorylation in SNU-407 colon cancer cells.
Liu Z, Cho NJ. | 06/3/2017 |
| Results indicate that eIF4B integrates the signals from Pim and PI3K/Akt/mTOR pathways in Abl-expressing leukemic cells. | eIF4B is a convergent target and critical effector of oncogenic Pim and PI3K/Akt/mTOR signaling pathways in Abl transformants.
Chen K, Yang J, Li J, Wang X, Chen Y, Huang S, Chen JL., Free PMC Article | 01/28/2017 |
| MicroRNA-216a inhibits the growth and metastasis of oral squamous cell carcinoma by targeting eIF4B. | MicroRNA-216a inhibits the growth and metastasis of oral squamous cell carcinoma by targeting eukaryotic translation initiation factor 4B.
Li L, Ma HQ. | 03/5/2016 |
| S6K1 enhances c-Myc translation efficiency by modulating the phosphorylation of eukaryotic initiation factor eIF4B, which is critical to unwind its structured 5' untranslated region. | The mTORC1/S6K1 pathway regulates glutamine metabolism through the eIF4B-dependent control of c-Myc translation.
Csibi A, Lee G, Yoon SO, Tong H, Ilter D, Elia I, Fendt SM, Roberts TM, Blenis J., Free PMC Article | 06/20/2015 |
| EIF4B, as a potentially key fragile point in EGFR and mTOR inhibitor synergy. | Abrogating phosphorylation of eIF4B is required for EGFR and mTOR inhibitor synergy in triple-negative breast cancer.
Madden JM, Mueller KL, Bollig-Fischer A, Stemmer P, Mattingly RR, Boerner JL., Free PMC Article | 05/16/2015 |
| eIF4B is the RSK downstream effector responsible for elevated Lamgamma2 as well as MYC protein in neoplastic epithelial cells. | RSK activation of translation factor eIF4B drives abnormal increases of laminin γ2 and MYC protein during neoplastic progression to squamous cell carcinoma.
Degen M, Barron P, Natarajan E, Widlund HR, Rheinwald JG., Free PMC Article | 02/28/2015 |
| The protein level of eukaryotic translation initiation factor 4B (eIF4B) was dramatically reduced in A549 cells as well as in the lung, spleen, and thymus of mice infected with influenza A virus. | Influenza A virus-induced degradation of eukaryotic translation initiation factor 4B contributes to viral replication by suppressing IFITM3 protein expression.
Wang S, Chi X, Wei H, Chen Y, Chen Z, Huang S, Chen JL., Free PMC Article | 10/4/2014 |
| eIF4B-driven expression of these key survival proteins is directly correlated with patient outcome, and eIF4B, DAXX and ERCC5 are identified as novel prognostic markers for poor survival in DLBCL | A role for eukaryotic initiation factor 4B overexpression in the pathogenesis of diffuse large B-cell lymphoma.
Horvilleur E, Sbarrato T, Hill K, Spriggs RV, Screen M, Goodrem PJ, Sawicka K, Chaplin LC, Touriol C, Packham G, Potter KN, Dirnhofer S, Tzankov A, Dyer MJ, Bushell M, MacFarlane M, Willis AE., Free PMC Article | 07/12/2014 |
| Report EIF4B binding within the IRES domain V of the coxsackie virus B3 mutant strain. | Impaired binding of standard initiation factors eIF3b, eIF4G and eIF4B to domain V of the live-attenuated coxsackievirus B3 Sabin3-like IRES--alternatives for 5'UTR-related cardiovirulence mechanisms.
Souii A, Gharbi J, Ben M'hadheb-Gharbi M., Free PMC Article | 07/12/2014 |
| Overexpression of pim-2 may inhibit the apoptosis of prostate cancer cells through phosphorylation of eIF4B, thus promoting tumorigenesis. | The over-expression of Pim-2 promote the tumorigenesis of prostatic carcinoma through phosphorylating eIF4B.
Ren K, Gou X, Xiao M, Wang M, Liu C, Tang Z, He W. | 11/2/2013 |
| our results identify eIF4B as a critical substrate of Pim kinases in mediating the activity of Abl oncogenes | eIF4B phosphorylation by pim kinases plays a critical role in cellular transformation by Abl oncogenes.
Yang J, Wang J, Chen K, Guo G, Xi R, Rothman PB, Whitten D, Zhang L, Huang S, Chen JL. | 10/19/2013 |
| ORF45/RSK axis-induced eIF4B phosphorylation is involved in translational regulation and is required for optimal KSHV lytic replication. | Phosphorylation of eukaryotic translation initiation factor 4B (EIF4B) by open reading frame 45/p90 ribosomal S6 kinase (ORF45/RSK) signaling axis facilitates protein translation during Kaposi sarcoma-associated herpesvirus (KSHV) lytic replication.
Kuang E, Fu B, Liang Q, Myoung J, Zhu F., Free PMC Article | 01/28/2012 |
| Duplex unwinding and ATPase activities of the DEAD-box helicase eIF4A are coupled by eIF4G and eIF4B. | Duplex unwinding and ATPase activities of the DEAD-box helicase eIF4A are coupled by eIF4G and eIF4B.
Özeş AR, Feoktistova K, Avanzino BC, Fraser CS., Free PMC Article | 12/3/2011 |
| Studies indicate that eIF4A (DDX2), together with its accessory proteins eIF4B and eIF4H, is thought to act as a helicase that unwinds secondary structures in the mRNA 5' UTR. | mRNA helicases: the tacticians of translational control.
Parsyan A, Svitkin Y, Shahbazian D, Gkogkas C, Lasko P, Merrick WC, Sonenberg N. | 06/18/2011 |
| Data show that reduced levels of eIF4B, eIF4H, or polyA-binding protein, also trigger SG formation. | Uncoupling stress granule assembly and translation initiation inhibition.
Mokas S, Mills JR, Garreau C, Fournier MJ, Robert F, Arya P, Kaufman RJ, Pelletier J, Mazroui R., Free PMC Article | 01/21/2010 |
| The interaction of eIF4AI with two accessory factors, eIF4B and eIF4H, was studied. | Interactions between eIF4AI and its accessory factors eIF4B and eIF4H.
Rozovsky N, Butterworth AC, Moore MJ., Free PMC Article | 01/21/2010 |