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    CELA1 chymotrypsin like elastase 1 [ Homo sapiens (human) ]

    Gene ID: 1990, updated on 17-Jun-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    High Serum Elastase 1 Level is associated with Postoperative Recurrence in Patients with Well-Differentiated Pancreatic Neuroendocrine Neoplasms.

    Serum Elastase 1 Level as a Risk Factor for Postoperative Recurrence in Patients with Well-Differentiated Pancreatic Neuroendocrine Neoplasms.
    Nanno Y, Toyama H, Zen Y, Akita M, Ando Y, Mizumoto T, Ueda Y, Ajiki T, Okano K, Suzuki Y, Fukumoto T.

    01/19/2019
    Results show that fecal elastase 1 (FE1) fails to detect steatorrhea in patients with locally advanced pancreatic cancer (LAPC) and is an inappropriate marker of exocrine pancreatic insufficiency in daily clinical practice.

    Fecal Elastase Fails to Detect Steatorrhea in Patients With Locally Advanced Pancreatic Cancer.
    Witvliet-van Nierop JE, Wierdsma NJ, Ottens-Oussoren K, Meijerink MR, Bouma G, Kazemier G, de van der Schueren MAE.

    10/20/2018
    A heterozygous frameshift variant c.419delC in exons of the CELA1 gene identified in all punctate palmoplantar keratoderma patients.

    [Molecular genetic study of a family affected with punctate palmoplantar keratoderma].
    Jia Y, Wang S, Zhu Y, Luo D.

    09/16/2017
    Inverse association of HbA1c with faecal elastase 1 in people without diabetes suggests that pancreatic exocrine dysfunction might be an early disturbance that develops in parallel with hyperglycemia.

    Inverse association of HbA1c with faecal elastase 1 in people without diabetes.
    Rathmann W, Haastert B, Oscarsson J, Berglind N, Wareham NJ.

    10/1/2016
    Results indicate that the extract of the mycelium of Tricholoma matsutake decreased elastase activity in a dose-dependent manner and reduced the levels of matrix metalloproteinase 1 (MMP-1).

    Extract of the mycelium of T. matsutake inhibits elastase activity and TPA-induced MMP-1 expression in human fibroblasts.
    Kim SY, Go KC, Song YS, Jeong YS, Kim EJ, Kim BJ.

    07/25/2015
    Mutant genes (CELA1, HSPG2, and KCNK5) in Balkan endemic nephropathy patients encode proteins involved in basement membrane/extracellular matrix and vascular tone, tightly connected to process of angiogenesis.

    NGS nominated CELA1, HSPG2, and KCNK5 as candidate genes for predisposition to Balkan endemic nephropathy.
    Toncheva D, Mihailova-Hristova M, Vazharova R, Staneva R, Karachanak S, Dimitrov P, Simeonov V, Ivanov S, Balabanski L, Serbezov D, Malinov M, Stefanovic V, Čukuranović R, Polenakovic M, Jankovic-Velickovic L, Djordjevic V, Jevtovic-Stoimenov T, Plaseska-Karanfilska D, Galabov A, Djonov V, Dimova I., Free PMC Article

    02/14/2015
    Data indicate that fecal elastase-1 was lower in the pancreaticoduodenectomy (PD) group.

    Nutritional status, fecal elastase-1, and 13C-labeled mixed triglyceride breath test in the long-term after pancreaticoduodenectomy.
    Muniz CK, dos Santos JS, Pfrimer K, Ferrioli E, Kemp R, Marchini JS, Cunha SF.

    12/20/2014
    Fecal elastase-1 is useful to identify pancreatic insufficiency. Steatorrhea is anticipated in non-operated patients only when FE-1 is below the limit for a confident measurement of our assay

    Fecal elastase-1 is useful in the detection of steatorrhea in patients with pancreatic diseases but not after pancreatic resection.
    Benini L, Amodio A, Campagnola P, Agugiaro F, Cristofori C, Micciolo R, Magro A, Gabbrielli A, Cabrini G, Moser L, Massella A, Vantini I, Frulloni L.

    08/3/2013
    Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)

    Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
    Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators., Free PMC Article

    09/15/2010
    Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)

    Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article

    06/30/2010
    Observational study of gene-disease association. (HuGE Navigator)See all PubMed (2) articles

    Genetic risk factors for hepatopulmonary syndrome in patients with advanced liver disease.
    Roberts KE, Kawut SM, Krowka MJ, Brown RS Jr, Trotter JF, Shah V, Peter I, Tighiouart H, Mitra N, Handorf E, Knowles JA, Zacks S, Fallon MB, Pulmonary Vascular Complications of Liver Disease Study Group.

    Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
    Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium.

    04/7/2010
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