| Cytochrome 4Z1 Expression Connotes Unfavorable Prognosis in Ovarian Cancers. | Cytochrome 4Z1 Expression Connotes Unfavorable Prognosis in Ovarian Cancers.
Al-Saraireh YM, Alshammari FOFO, Satari AO, Al-Mahdy YS, Almuhaisen GH, Abu-Azzam OH, Uwais AN, Abufraijeh SM, Al-Kharabsheh AM, Al-Dalain SM, Al-Qtaitat A, Al-Tarawneh F, Al Shuneigat JM, Al-Sarayreh SA., Free PMC Article | 10/1/2022 |
| Profiling of CYP4Z1 and CYP1B1 expression in bladder cancers. | Profiling of CYP4Z1 and CYP1B1 expression in bladder cancers.
Al-Saraireh YM, Alshammari FOFO, Youssef AMM, Al-Sarayreh S, Almuhaisen GH, Alnawaiseh N, Al Shuneigat JM, Alrawashdeh HM., Free PMC Article | 12/11/2021 |
| Cytochrome 4Z1 Expression Is Correlated with Poor Prognosis in Patients with Cervical Cancer. | Cytochrome 4Z1 Expression Is Correlated with Poor Prognosis in Patients with Cervical Cancer.
Al-Saraireh YM, Alshammari FOFO, Youssef AMM, Al-Sarayra YM, Al-Saraireh RA, Al-Muhaisen GH, Al-Mahdy YS, Al-Kharabsheh AM, Abufraijeh SM, Alrawashdeh HM., Free PMC Article | 10/30/2021 |
| New Proluciferin Substrates for Human CYP4 Family Enzymes. | New Proluciferin Substrates for Human CYP4 Family Enzymes.
Liu J, Machalz D, Wolber G, Sorensen EJ, Bureik M. | 05/29/2021 |
| Importance of asparagine-381 and arginine-487 for substrate recognition in CYP4Z1. | Importance of asparagine-381 and arginine-487 for substrate recognition in CYP4Z1.
Du W, Machalz D, Yan Q, Sorensen EJ, Wolber G, Bureik M. | 09/5/2020 |
| Transcriptional factor six2 promotes the competitive endogenous RNA network between CYP4Z1 and pseudogene CYP4Z2P responsible for maintaining the stemness of breast cancer cells. | Transcriptional factor six2 promotes the competitive endogenous RNA network between CYP4Z1 and pseudogene CYP4Z2P responsible for maintaining the stemness of breast cancer cells.
Zheng L, Guo Q, Xiang C, Liu S, Jiang Y, Gao L, Ni H, Wang T, Zhao Q, Liu H, Xing Y, Wang Y, Li X, Xi T., Free PMC Article | 05/16/2020 |
| We recently demonstrated the presence of the human CYP4Z1 on the plasma membrane of MCF-7 breast cancer cells and the detection of high titers of anti-CYP4Z1 aAbs in breast cancer patients, but not in healthy controls. In the present study we show that cells of the normal breast cell line MCF-10A do not display CYP4Z1 on their surface. | Plasma membrane localization of CYP4Z1 and CYP19A1 and the detection of anti-CYP19A1 autoantibodies in humans.
Khayeka-Wandabwa C, Ma X, Cao X, Nunna V, Pathak JL, Bernhardt R, Cai P, Bureik M. | 12/28/2019 |
| If CYP4Z1 has a role to play in modulating cancer progression, new data form yeast microsomes expressing recombinant human enzyme suggest that the mechanism does not involve direct 20-HETE generation by this enzyme. | Expression and Functional Characterization of Breast Cancer-Associated Cytochrome P450 4Z1 in Saccharomyces cerevisiae.
McDonald MG, Ray S, Amorosi CJ, Sitko KA, Kowalski JP, Paco L, Nath A, Gallis B, Totah RA, Dunham MJ, Fowler DM, Rettie AE., Free PMC Article | 07/21/2018 |
| This study reports on the creation of a new homology model of CYP4Z1 and performed molecular docking experiments, which indicate that all active substrates show a highly similar binding geometry compared to the endogenous substrates. | Efficient substrate screening and inhibitor testing of human CYP4Z1 using permeabilized recombinant fission yeast.
Yan Q, Machalz D, Zöllner A, Sorensen EJ, Wolber G, Bureik M. | 12/16/2017 |
| CYP4Z1 3'UTR could inhibit the migration and Epithelial-mesenchymal transition of breast cancer cells. | CYP4Z1 3'UTR represses migration of human breast cancer cells.
Wang B, Zheng L, Chou J, Li C, Zhang Y, Meng X, Xi T. | 06/3/2017 |
| Data show that downregulation of cytochrome P450 family 4 CYP4Z1 or the pseudogene CYP4Z2P 3'-UTR promotes cell apoptosis. | The competing endogenous RNA network of CYP4Z1 and pseudogene CYP4Z2P exerts an anti-apoptotic function in breast cancer.
Li C, Zheng L, Xin Y, Tan Z, Zhang Y, Meng X, Wang Z, Xi T. | 06/3/2017 |
| CYP4Z1 and CYP4Z2P were downregulated in MCF-7 cells compared with tamoxifen-resistant MCF-7-TamR cells | Competing endogenous RNA networks of CYP4Z1 and pseudogene CYP4Z2P confer tamoxifen resistance in breast cancer.
Zheng L, Li X, Meng X, Chou J, Hu J, Zhang F, Zhang Z, Xing Y, Liu Y, Xi T. | 01/14/2017 |
| Our findings suggest that the CYP4Z2P- and CYP4Z1-3'UTR promote breast cancer angiogenesis collectively by activating the PI3K and ERK1/2 pathways through binding multiple miRNAs. | The 3'UTR of the pseudogene CYP4Z2P promotes tumor angiogenesis in breast cancer by acting as a ceRNA for CYP4Z1.
Zheng L, Li X, Gu Y, Lv X, Xi T. | 11/21/2015 |
| CYP4Z1 overexpression promotes tumor angiogenesis and growth in breast cancer partly via PI3K/Akt and ERK1/2 activation | Increased expression of CYP4Z1 promotes tumor angiogenesis and growth in human breast cancer.
Yu W, Chai H, Li Y, Zhao H, Xie X, Zheng H, Wang C, Wang X, Yang G, Cai X, Falck JR, Yang J., Free PMC Article | 11/24/2012 |
| CYP4Z1, KIR and RDH10 could play a role in non-small-cell lung cancer progression | Identification of genes associated with non-small-cell lung cancer promotion and progression.
Bankovic J, Stojsic J, Jovanovic D, Andjelkovic T, Milinkovic V, Ruzdijic S, Tanic N. | 04/12/2010 |
| CYP4Z1-dependent in-chain hydroxylation of lauric and myristic acid, which in both cases leads to the formation of four different monohydroxylated products at positions omega-2, omega-3, omega-4, and omega-5, respectively | Human CYP4Z1 catalyzes the in-chain hydroxylation of lauric acid and myristic acid.
Zöllner A, Dragan CA, Pistorius D, Müller R, Bode HB, Peters FT, Maurer HH, Bureik M. | 01/21/2010 |
| Human cytochrome P450 (CYP), termed CYP4Z1,was identified, and the cDNA was cloned from a breast carcinoma line . | Identification of a novel mammary-restricted cytochrome P450, CYP4Z1, with overexpression in breast carcinoma.
Rieger MA, Ebner R, Bell DR, Kiessling A, Rohayem J, Schmitz M, Temme A, Rieber EP, Weigle B. | 01/21/2010 |
| PPARalpha has a role in CYP4X1 regulation, and the glucocorticoid and progesterone receptors have roles in CYP4Z1 gene activation | Conditional regulation of the human CYP4X1 and CYP4Z1 genes.
Savas U, Hsu MH, Griffin KJ, Bell DR, Johnson EF. | 01/21/2010 |