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    A2M alpha-2-macroglobulin [ Homo sapiens (human) ]

    Gene ID: 2, updated on 3-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Alpha-2-Macroglobulin Is a Novel Anticancer Agent.

    Alpha-2-Macroglobulin Is a Novel Anticancer Agent.
    Facchiano F, D'Arcangelo D, Facchiano A., Free PMC Article

    07/23/2024
    CCCTC-binding factor suppresses alpha-2-macroglobulin transcription to improve vascular endothelial cell functions in lower extremity arteriosclerosis obliterans.

    CCCTC-binding factor suppresses alpha-2-macroglobulin transcription to improve vascular endothelial cell functions in lower extremity arteriosclerosis obliterans.
    He T, You M, Zhu H, Chen P, Fang S.

    06/7/2024
    Tandem Mass Tag-Labeled Quantitative Proteome Analyses Identify C1R and A2M as Novel Serum Biomarkers in Pregnant Women with Obstructive Sleep Apnea.

    Tandem Mass Tag-Labeled Quantitative Proteome Analyses Identify C1R and A2M as Novel Serum Biomarkers in Pregnant Women with Obstructive Sleep Apnea.
    Zhang Q, Yue Y, Wang X, Cui H, Liu Y, Gao M, Liu T, Xiao L.

    04/11/2024
    [Pathogenetic role of multifunctional protein alpha-2-macroglobulin and its activity in tears and serum in age-related macular degeneration and proliferative diabetic retinopathy].

    [Pathogenetic role of multifunctional protein alpha-2-macroglobulin and its activity in tears and serum in age-related macular degeneration and proliferative diabetic retinopathy].
    Neroev VV, Chesnokova NB, Neroeva NV, Beznos OV, Pavlenko TA, Okhotsimskaya TD, Utkina OA.

    01/30/2024
    Alpha-2 macroglobulin activity in SARS-CoV-2 induced infection and in the post-COVID-19 period.

    Alpha-2 macroglobulin activity in SARS-CoV-2 induced infection and in the post-COVID-19 period.
    Akbasheva OE, Mitrofanova DK, Spirina LV, Samoilova YG, Matveeva MV, Podchinenova DV, Oleynik OA.

    09/19/2023
    Alpha-2-macroglobulin prevents platelet aggregation induced by brain-derived neurotrophic factor.

    Alpha-2-macroglobulin prevents platelet aggregation induced by brain-derived neurotrophic factor.
    Jourdi G, Boukhatem I, Barcelona PF, Fleury S, Welman M, Saragovi HU, Pasquali S, Lordkipanidzé M.

    09/7/2023
    Alpha-2-Macroglobulin (A2M) and Dopamine Receptor D2 (DRD2) expression analysis and Influence of Separation from Parents in Childhood on the Suicide and Self-injury Behavior and Psychological Adjustment in Adolescence.

    Alpha-2-Macroglobulin (A2M) and Dopamine Receptor D2 (DRD2) expression analysis and Influence of Separation from Parents in Childhood on the Suicide and Self-injury Behavior and Psychological Adjustment in Adolescence.
    Xu Q, Xu H, Li S.

    05/25/2023
    Alpha-2-macroglobulin is involved in the occurrence of early-onset pre-eclampsia via its negative impact on uterine spiral artery remodeling and placental angiogenesis.

    Alpha-2-macroglobulin is involved in the occurrence of early-onset pre-eclampsia via its negative impact on uterine spiral artery remodeling and placental angiogenesis.
    Wang J, Zhang P, Liu M, Huang Z, Yang X, Ding Y, Liu J, Cheng X, Xu S, He M, Zhang F, Wang G, Li R, Yang X., Free PMC Article

    03/17/2023
    LincRNA00612 inhibits apoptosis and inflammation in LPS-induced BEAS-2B cells via enhancing interaction between p-STAT3 and A2M promoter.

    LincRNA00612 inhibits apoptosis and inflammation in LPS-induced BEAS-2B cells via enhancing interaction between p-STAT3 and A2M promoter.
    Xiao X, Cai W, Ding Z, Mao Z, Shi Y, Zhang Q., Free PMC Article

    03/9/2023
    A2M inhibits inflammatory mediators of chondrocytes by blocking IL-1beta/NF-kappaB pathway.

    A2M inhibits inflammatory mediators of chondrocytes by blocking IL-1β/NF-κB pathway.
    Sun C, Cao C, Zhao T, Guo H, Fleming BC, Owens B, Beveridge J, McAllister S, Wei L.

    12/17/2022
    Association of salivary alpha-2-macroglobulin with glycemia and glycated hemoglobin in type 2 diabetes mellitus: a systematic review and meta-analysis study.

    Association of salivary alpha-2-macroglobulin with glycemia and glycated hemoglobin in type 2 diabetes mellitus: a systematic review and meta-analysis study.
    Caixeta DC, Pennisi PRC, Moura DV, Nunes MAC, Espindola FS, Blumenberg C, Paranhos LR, Sabino-Silva R., Free PMC Article

    11/19/2022
    Association Between Common Variants of APOE, ABCA7, A2M, BACE1, and Cerebrospinal Fluid Biomarkers in Alzheimer's Disease: Data from the PUMCH Dementia Cohort.

    Association Between Common Variants of APOE, ABCA7, A2M, BACE1, and Cerebrospinal Fluid Biomarkers in Alzheimer's Disease: Data from the PUMCH Dementia Cohort.
    Dong L, Mao C, Liu C, Li J, Huang X, Wang J, Lei D, Chu S, Sha L, Xu Q, Peng B, Cui L, Gao J., Free PMC Article

    03/5/2022
    A mass spectrometric approach to study the interaction of amyloid beta peptides with human alpha-2-macroglobulin.

    A mass spectrometric approach to study the interaction of amyloid β peptides with human α-2-macroglobulin.
    Protasov AV, Mirgorodskaya OA, Kozmin YP, Gobom J.

    02/5/2022
    Production of Recombinant Polypeptides Binding alpha2-Macroglobulin and Analysis of Their Ability to Bind Human Serum alpha2-Macroglobulin.

    Production of Recombinant Polypeptides Binding α2-Macroglobulin and Analysis of Their Ability to Bind Human Serum α2-Macroglobulin.
    Bormotova EA, Gupalova TV.

    07/10/2021
    Interaction of Human Alpha-2-Macroglobulin with Pesticide Aldicarb Using Spectroscopy and Molecular Docking.

    Interaction of Human Alpha-2-Macroglobulin with Pesticide Aldicarb Using Spectroscopy and Molecular Docking.
    Dixit S, Zia MK, Siddiqui T, Ahsan H, Khan FH.

    07/3/2021
    The Role of Alpha 2 Macroglobulin in IgG-Aggregation and Chronic Activation of the Complement System in Patients With Chronic Lymphocytic Leukemia.

    The Role of Alpha 2 Macroglobulin in IgG-Aggregation and Chronic Activation of the Complement System in Patients With Chronic Lymphocytic Leukemia.
    Naseraldeen N, Michelis R, Barhoum M, Chezar J, Tadmor T, Aviv A, Shvidel L, Litmanovich A, Shehadeh M, Stemer G, Shaoul E, Braester A., Free PMC Article

    06/26/2021
    Human proteinase 3 resistance to inhibition extends to alpha-2 macroglobulin.

    Human proteinase 3 resistance to inhibition extends to alpha-2 macroglobulin.
    N'Guessan K, Grzywa R, Seren S, Gabant G, Juliano MA, Moniatte M, van Dorsselaer A, Bieth JG, Kellenberger C, Gauthier F, Wysocka M, Lesner A, Sienczyk M, Cadene M, Korkmaz B.

    05/22/2021
    The effect of adrenocorticotropic hormone on alpha-2-macroglobulin in osteoblasts derived from human mesenchymal stem cells.

    The effect of adrenocorticotropic hormone on alpha-2-macroglobulin in osteoblasts derived from human mesenchymal stem cells.
    Sadeghi F, Vahednia E, Naderi Meshkin H, Kerachian MA., Free PMC Article

    05/1/2021
    GALNT6 promotes breast cancer metastasis by increasing mucin-type O-glycosylation of alpha2M.

    GALNT6 promotes breast cancer metastasis by increasing mucin-type O-glycosylation of α2M.
    Liu C, Li Z, Xu L, Shi Y, Zhang X, Shi S, Hou K, Fan Y, Li C, Wang X, Zhou L, Liu Y, Qu X, Che X., Free PMC Article

    03/13/2021
    Activated alpha2-macroglobulin binding to cell surface GRP78 induces trophoblastic cell fusion.

    Activated α(2)-macroglobulin binding to cell surface GRP78 induces trophoblastic cell fusion.
    Bastida-Ruiz D, Wuillemin C, Pederencino A, Yaron M, Martinez de Tejada B, Pizzo SV, Cohen M., Free PMC Article

    12/12/2020
    Molecular form and concentration of serum alpha2-macroglobulin in diabetes.

    Molecular form and concentration of serum α(2)-macroglobulin in diabetes.
    Yoshino S, Fujimoto K, Takada T, Kawamura S, Ogawa J, Kamata Y, Kodera Y, Shichiri M., Free PMC Article

    10/31/2020
    The results suggest that A2M positively regulates Microvesicle shedding through the activation of LRP1 on myofibroblasts.

    α-2-Macroglobulin induces the shedding of microvesicles from cutaneous wound myofibroblasts.
    Laberge A, Ayoub A, Arif S, Larochelle S, Garnier A, Moulin VJ.

    05/9/2020
    Significantly lower levels of alpha-2-macroglobulin were found in the serum of patients with steroid-induced necrosis of the femoral head (SINFH) than in controls (P < 0.05). Immunohistochemical staining and western blotting demonstrated that the expression of alpha-2-macroglobulin was significantly decreased in the necrotic area of SINFH patients (P < 0.05).

    Relationship of α2-Macroglobulin with Steroid-Induced Femoral Head Necrosis: A Chinese Population-Based Association Study in Southeast China.
    Fang SH, Li YF, Jiang JR, Chen P., Free PMC Article

    01/11/2020
    High A2M expression is associated with Pancreatic cancer.

    Pancreatic cancer biomarker detection by two support vector strategies for recursive feature elimination.
    Wang Y, Liu K, Ma Q, Tan Y, Du W, Lv Y, Tian Y, Wang H., Free PMC Article

    01/11/2020
    Impaired fibrinolysis and lower levels of alpha2-macroglobulin might predispose to a higher rate of asthma exacerbations, suggesting new links between disturbed hemostasis and asthma.

    Impaired fibrinolysis and lower levels of plasma α(2)-macroglobulin are associated with an increased risk of severe asthma exacerbations.
    Bazan-Socha S, Mastalerz L, Cybulska A, Zareba L, Kremers R, Zabczyk M, Pulka G, Iwaniec T, Bazan JG, Hemker C, Undas A., Free PMC Article

    06/8/2019
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