| cAMP-Induced Nuclear Condensation of CRTC2 Promotes Transcription Elongation and Cystogenesis in Autosomal Dominant Polycystic Kidney Disease. | cAMP-Induced Nuclear Condensation of CRTC2 Promotes Transcription Elongation and Cystogenesis in Autosomal Dominant Polycystic Kidney Disease.
Mi Z, Song Y, Wang J, Liu Z, Cao X, Dang L, Lu Y, Sun Y, Xiong H, Zhang L, Chen Y., Free PMC Article | 07/9/2022 |
| Activation of the CREB Coactivator CRTC2 by Aberrant Mitogen Signaling promotes oncogenic functions in HPV16 positive head and neck cancer. | Activation of the CREB Coactivator CRTC2 by Aberrant Mitogen Signaling promotes oncogenic functions in HPV16 positive head and neck cancer.
Carper MB, Goel S, Zhang AM, Damrauer JS, Cohen S, Zimmerman MP, Gentile GM, Parag-Sharma K, Murphy RM, Sato K, Nickel KP, Kimple RJ, Yarbrough WG, Amelio AL., Free PMC Article | 05/14/2022 |
| TORC2/3-mediated DUSP1 upregulation is essential for human decidualization. | TORC2/3-mediated DUSP1 upregulation is essential for human decidualization.
Xu C, Zhao W, Huang X, Jiang Z, Liu L, Cui L, Li X, Li D, Du M. | 01/8/2022 |
| Phosphorylation of CREB-Specific Coactivator CRTC2 at Ser238 Promotes Proliferation, Migration, and Invasion of Colorectal Cancer Cells. | Phosphorylation of CREB-Specific Coactivator CRTC2 at Ser238 Promotes Proliferation, Migration, and Invasion of Colorectal Cancer Cells.
Wang Y, Liu Q, Zhang H., Free PMC Article | 11/6/2021 |
| The CREB Regulated Transcription Coactivator 2 Suppresses HIV-1 Transcription by Preventing RNA Pol II from Binding to HIV-1 LTR. | The CREB Regulated Transcription Coactivator 2 Suppresses HIV-1 Transcription by Preventing RNA Pol II from Binding to HIV-1 LTR.
Ma L, Chen S, Wang Z, Guo S, Zhao J, Yi D, Li Q, Liu Z, Guo F, Li X, Jia P, Ding J, Liang C, Cen S., Free PMC Article | 10/23/2021 |
| Sam68 promotes hepatic gluconeogenesis via CRTC2. | Sam68 promotes hepatic gluconeogenesis via CRTC2.
Qiao A, Zhou J, Xu S, Ma W, Boriboun C, Kim T, Yan B, Deng J, Yang L, Zhang E, Song Y, Ma YC, Richard S, Zhang C, Qiu H, Habegger KM, Zhang J, Qin G., Free PMC Article | 06/26/2021 |
| SIK1 Regulates CRTC2-Mediated Gluconeogenesis Signaling Pathway in Human and Mouse Liver Cells. | SIK1 Regulates CRTC2-Mediated Gluconeogenesis Signaling Pathway in Human and Mouse Liver Cells.
Wang C, Song D, Fu J, Wen X., Free PMC Article | 05/22/2021 |
| CRTC2 is unphosphorylated and therefore constitutively activated in LKB1-mutant non-small cell lung cance, where it promotes tumor growth, in part via the induction of the inhibitor of DNA binding 1. | The CREB coactivator CRTC2 promotes oncogenesis in LKB1-mutant non-small cell lung cancer.
Rodón L, Svensson RU, Wiater E, Chun MGH, Tsai WW, Eichner LJ, Shaw RJ, Montminy M., Free PMC Article | 05/16/2020 |
| Results identified CRTC2 as a downstream substrate of constitutively activated p38. Constitutive, rather than transient, activation of p38 led to hyperphosphorylation of CRTC2, resulting in CRTC2 cytosolic relocation and subsequent inactivation of cyclic AMP response element (CRE)-mediated transcription. | Inactivation of Cyclic AMP Response Element Transcription Caused by Constitutive p38 Activation Is Mediated by Hyperphosphorylation-Dependent CRTC2 Nucleocytoplasmic Transport.
Ma H, Liu Z, Zhong CQ, Liu Y, Zhang Z, Liang Y, Li J, Han S, Han J., Free PMC Article | 02/1/2020 |
| Data report crystal structures of a complex containing the CRTC2 CREB binding domain, the CREB basic leucine zipper domain and a CRE-containing DNA. The structures revealed that CRTC and CREB form a 2:2 complex on CRE-containing DNA, and CRTC interacts with both CREB and DNA through highly conserved residues. | Structural Insights into the CRTC2-CREB Complex Assembly on CRE.
Song Y, Zhai L, Valencia Swain J, Chen Y, Wang P, Chen L, Liu Y, Xiang S. | 06/1/2019 |
| Study suggests that Creb/Crtc2 negatively regulates the Sirt1/Pparalpha/Fgf21 axis via the induction of miR-34a under diet-induced obesity and insulin-resistant conditions. | Hepatic Crtc2 controls whole body energy metabolism via a miR-34a-Fgf21 axis.
Han HS, Choi BH, Kim JS, Kang G, Koo SH., Free PMC Article | 10/6/2018 |
| Thyroid stimulating hormone activates CRTC2 via the TSHR/cAMP/PKA pathway. | Thyroid stimulating hormone increases hepatic gluconeogenesis via CRTC2.
Li Y, Wang L, Zhou L, Song Y, Ma S, Yu C, Zhao J, Xu C, Gao L. | 11/18/2017 |
| CRTC2 polymorphism as a risk factor for the incidence of metabolic syndrome in transplant recipients after solid organ transplantation. | CRTC2 polymorphism as a risk factor for the incidence of metabolic syndrome in patients with solid organ transplantation.
Quteineh L, Bochud PY, Golshayan D, Crettol S, Venetz JP, Manuel O, Kutalik Z, Treyer A, Lehmann R, Mueller NJ, Binet I, van Delden C, Steiger J, Mohacsi P, Dufour JF, Soccal PM, Pascual M, Eap CB, The Swiss Transplant Cohort Study. | 08/5/2017 |
| CRTC2 strongly enhances GR-induced transcriptional activity of glucocorticoid-responsive genes. | CRTC2 Is a Coactivator of GR and Couples GR and CREB in the Regulation of Hepatic Gluconeogenesis.
Hill MJ, Suzuki S, Segars JH, Kino T., Free PMC Article | 10/8/2016 |
| Our results establish a role for CRTC2 as a lymphoma tumor suppressor gene | The CREB Coactivator CRTC2 Is a Lymphoma Tumor Suppressor that Preserves Genome Integrity through Transcription of DNA Mismatch Repair Genes.
Fang M, Pak ML, Chamberlain L, Xing W, Yu H, Green MR., Free PMC Article | 04/16/2016 |
| the high expression of CRTC2 and PROM1 may play an important role in the occurrence and hereditary, and also advance the potential pathways that integrate genetic variants in the development of NSCLC. | CRTC2 and PROM1 expression in non-small cell lung cancer: analysis by Western blot and immunohistochemistry.
Li Y, He Y, Qiu Z, Zhou B, Shi S, Zhang K, Luo Y, Huang Q, Li W. | 03/21/2015 |
| The data from the current study demonstrated novel PROM1 and CRTC2 mutations, which could promote lung cancer development. | Identification and validation of PROM1 and CRTC2 mutations in lung cancer patients.
He Y, Li Y, Qiu Z, Zhou B, Shi S, Zhang K, Luo Y, Huang Q, Li W., Free PMC Article | 12/20/2014 |
| These results clearly indicate that non-phosphorylated CRTC2 strongly enhances hepatitis b virus biosynthesis through inducing PGC1alpha expression. | CRTC2 enhances HBV transcription and replication by inducing PGC1α expression.
Tian X, Zhao F, Sun W, Zhi X, Cheng Z, Zhou M, Hu K., Free PMC Article | 09/13/2014 |
| Phosphorylation of CRTC2 at its AMPK target site, Ser 171, dictated its subcellular localization, and the activation of aromatase PII in preadipocytes. | CREB-regulated transcription co-activator family stimulates promoter II-driven aromatase expression in preadipocytes.
Samarajeewa NU, Docanto MM, Simpson ER, Brown KA., Free PMC Article | 01/25/2014 |
| CRTC2 enhances CREB phosphorylation through an association with the protein arginine methyltransferase 5 (PRMT5). | PRMT5 modulates the metabolic response to fasting signals.
Tsai WW, Niessen S, Goebel N, Yates JR 3rd, Guccione E, Montminy M., Free PMC Article | 08/3/2013 |
| Mechanism of CREB recognition and coactivation by the CREB-regulated transcriptional coactivator CRTC2 | Mechanism of CREB recognition and coactivation by the CREB-regulated transcriptional coactivator CRTC2.
Luo Q, Viste K, Urday-Zaa JC, Senthil Kumar G, Tsai WW, Talai A, Mayo KE, Montminy M, Radhakrishnan I., Free PMC Article | 03/2/2013 |
| The lipogenic effects of GIP in the presence of insulin are therefore at least partially mediated by upregulation of adipocyte LPL gene transcription through a pathway involving PI3-K/PKB/AMPK-dependent CREB/TORC2 activation. | GIP increases human adipocyte LPL expression through CREB and TORC2-mediated trans-activation of the LPL gene.
Kim SJ, Nian C, McIntosh CH., Free PMC Article | 01/22/2011 |
| the association of Pin1 with CRTC2 to decrease the nuclear CBP.CRTC.CREB complex. | Pin1 associates with and induces translocation of CRTC2 to the cytosol, thereby suppressing cAMP-responsive element transcriptional activity.
Nakatsu Y, Sakoda H, Kushiyama A, Ono H, Fujishiro M, Horike N, Yoneda M, Ohno H, Tsuchiya Y, Kamata H, Tahara H, Isobe T, Nishimura F, Katagiri H, Oka Y, Fukushima T, Takahashi SI, Kurihara H, Uchida T, Asano T., Free PMC Article | 11/27/2010 |
| Tax binds the cyclin D1 promoter-proximal cyclic AMP response element (CRE) in the presence of phosphorylated CREB (pCREB) in vitro, and together the Tax-pCREB complex recruits the cellular co-activator p300 to the promoter. | The HTLV-1 tax protein cooperates with phosphorylated CREB, TORC2 and p300 to activate CRE-dependent cyclin D1 transcription.
Kim YM, Geiger TR, Egan DI, Sharma N, Nyborg JK., Free PMC Article | 05/10/2010 |
| The regulation of aromatase by CRTC2, in response to the altered hormonal milieu associated with menopause and obesity, provides a critical link between obesity and breast cancer. | Subcellular localization of cyclic AMP-responsive element binding protein-regulated transcription coactivator 2 provides a link between obesity and breast cancer in postmenopausal women.
Brown KA, McInnes KJ, Hunger NI, Oakhill JS, Steinberg GR, Simpson ER. | 01/21/2010 |