| Macrophage-derived chemokine CCL22 establishes local LN-mediated adaptive thermogenesis and energy expenditure. | Macrophage-derived chemokine CCL22 establishes local LN-mediated adaptive thermogenesis and energy expenditure.
Yuan Y, Hu R, Park J, Xiong S, Wang Z, Qian Y, Shi Z, Wu R, Han Z, Ong SG, Lin S, Varady KA, Xu P, Berry DC, Shu G, Jiang Y., Free PMC Article | 07/4/2024 |
| Activation of G-protein-coupled receptor 183 initiates inflammatory pain via macrophage CCL22 secretion. | Activation of G-protein-coupled receptor 183 initiates inflammatory pain via macrophage CCL22 secretion.
Qi Z, Zhong W, Jiao B, Chen K, Yang X, Wang L, Zeng W, Huang J, Xie J. | 10/24/2023 |
| CCL22 mutations drive natural killer cell lymphoproliferative disease by deregulating microenvironmental crosstalk. | CCL22 mutations drive natural killer cell lymphoproliferative disease by deregulating microenvironmental crosstalk.
Baer C, Kimura S, Rana MS, Kleist AB, Flerlage T, Feith DJ, Chockley P, Walter W, Meggendorfer M, Olson TL, Cheon H, Olson KC, Ratan A, Mueller ML, Foran JM, Janke LJ, Qu C, Porter SN, Pruett-Miller SM, Kalathur RC, Haferlach C, Kern W, Paietta E, Thomas PG, Babu MM, Loughran TP Jr, Iacobucci I, Haferlach T, Mullighan CG., Free PMC Article | 05/28/2022 |
| Toxoplasma gondii GRA28 Is Required for Placenta-Specific Induction of the Regulatory Chemokine CCL22 in Human and Mouse. | Toxoplasma gondii GRA28 Is Required for Placenta-Specific Induction of the Regulatory Chemokine CCL22 in Human and Mouse.
Rudzki EN, Ander SE, Coombs RS, Alrubaye HS, Cabo LF, Blank ML, Gutiérrez-Melo N, Dubey JP, Coyne CB, Boyle JP., Free PMC Article | 02/26/2022 |
| Affinity-coupled CCL22 promotes positive selection in germinal centres. | Affinity-coupled CCL22 promotes positive selection in germinal centres.
Liu B, Lin Y, Yan J, Yao J, Liu D, Ma W, Wang J, Liu W, Wang C, Zhang L, Qi H. | 07/24/2021 |
| Constitutive Expression of CCL22 Is Mediated by T Cell-Derived GM-CSF. | Constitutive Expression of CCL22 Is Mediated by T Cell-Derived GM-CSF.
Piseddu I, Röhrle N, Knott MML, Moder S, Eiber S, Schnell K, Vetter V, Meyer B, Layritz P, Kühnemuth B, Wiedemann GM, Gruen J, Perleberg C, Rapp M, Endres S, Anz D. | 04/3/2021 |
| Interferon-gamma and TNF-alpha mediate CCL22 production in alveolar macrophages after hemorrhage and resuscitation. | IFNγ and TNFα mediate CCL22/MDC production in alveolar macrophages after hemorrhage and resuscitation.
Beckmann N, Sutton JM, Hoehn RS, Jernigan PL, Friend LA, Johanningman TA, Schuster RM, Lentsch AB, Caldwell CC, Pritts TA., Free PMC Article | 07/25/2020 |
| This study shows that deficiency of CCL22 results in a reduction of dendritic cells and T regular cells contacts, and in a defect of T regular cell mediated suppression. | CCL22 controls immunity by promoting regulatory T cell communication with dendritic cells in lymph nodes.
Rapp M, Wintergerst MWM, Kunz WG, Vetter VK, Knott MML, Lisowski D, Haubner S, Moder S, Thaler R, Eiber S, Meyer B, Röhrle N, Piseddu I, Grassmann S, Layritz P, Kühnemuth B, Stutte S, Bourquin C, von Andrian UH, Endres S, Anz D., Free PMC Article | 05/9/2020 |
| the subset of peritoneal CD11b(+)CD169(+) macrophages increased and CCL22 expression level decreased significantly during the DSS-induced colitis | Macrophage Subset Expressing CD169 in Peritoneal Cavity-Regulated Mucosal Inflammation Together with Lower Levels of CCL22.
Wang D, Li Q, Yang Y, Hao S, Han X, Song J, Yin Y, Li X, Tanaka M, Qiu CH. | 03/31/2018 |
| Intratumoral administration of anti-CCL22 antibody inhibited B16F10 melanoma growth. | Immunomodulatory Effect of Imiquimod Through CCL22 Produced by Tumor-associated Macrophages in B16F10 Melanomas.
Furudate S, Fujimura T, Kambayashi Y, Kakizaki A, Hidaka T, Aiba S. | 09/2/2017 |
| this study shows that intravenous injection of apoptotic cells induces a subsequent increase in CCL22 expression and CCR4+ Treg cells, which contribute to the maintenance of immune homeostasis at least partially by splenic CD8alpha+ CD103+ dendritic cells | Critical role of CCL22/CCR4 axis in the maintenance of immune homeostasis during apoptotic cell clearance by splenic CD8α(+) CD103(+) dendritic cells.
Hao S, Han X, Wang D, Yang Y, Li Q, Li X, Qiu CH., Free PMC Article | 05/6/2017 |
| CCL22-specific antibodies reveal that engagement of two distinct binding domains on CCL22 is required for CCR4-mediated function. | CCL22-specific Antibodies Reveal That Engagement of Two Distinct Binding Domains on CCL22 Is Required for CCR4-mediated Function.
Santulli-Marotto S, Wheeler J, Lacy ER, Boakye K, Luongo J, Wu SJ, Ryan M. | 09/24/2016 |
| CCL22 was localised mainly on the cell surface and or in the cytoplasm. Within sections of omental milky spot micrometastases, CCR4 was recognised on or in gastric cancer cells, constituent cells milky spots, blood cells and blood endothelial cells | The role of the CCL22-CCR4 axis in the metastasis of gastric cancer cells into omental milky spots.
Cao L, Hu X, Zhang J, Huang G, Zhang Y., Free PMC Article | 04/16/2016 |
| results show that the IL-4/CCL22/CCR4 axis is involved in the migration of Tregs to osteolytic lesion sites, and attenuates development of lesions by inhibiting inflammatory migration and the production of proinflammatory and osteoclastogenic mediators | IL-4/CCL22/CCR4 axis controls regulatory T-cell migration that suppresses inflammatory bone loss in murine experimental periodontitis.
Araujo-Pires AC, Vieira AE, Francisconi CF, Biguetti CC, Glowacki A, Yoshizawa S, Campanelli AP, Trombone AP, Sfeir CS, Little SR, Garlet GP., Free PMC Article | 12/19/2015 |
| CCL22 has a role in Treg skin homing to suppress depigmentation | CCL22 to Activate Treg Migration and Suppress Depigmentation in Vitiligo.
Eby JM, Kang HK, Tully ST, Bindeman WE, Peiffer DS, Chatterjee S, Mehrotra S, Le Poole IC., Free PMC Article | 08/1/2015 |
| CCL22 is a novel mediator of lung inflammation following hemorrhage and resuscitation | Macrophage-derived chemokine (CCL22) is a novel mediator of lung inflammation following hemorrhage and resuscitation.
Richter JR, Sutton JM, Belizaire RM, Friend LA, Schuster RM, Johannigman TA, Miller SG, Lentsch AB, Pritts TA., Free PMC Article | 07/25/2015 |
| The immunomodulatory properties of CCL22 could be harnessed for prevention of graft rejection and type 1 diabetes as well as other autoimmune disorders. | Cellular mechanisms of CCL22-mediated attenuation of autoimmune diabetes.
Bischoff L, Alvarez S, Dai DL, Soukhatcheva G, Orban PC, Verchere CB. | 06/20/2015 |
| Data indicate macrophage-derived chemokine CCL22 as an adjuvant could enhance the immune protective effect of NTHi-P6 protein vaccine to an extent. | [Mouse macrophage-derived chemokine as an adjuvant enhances the protective effect of P6 protein vaccine of nontypeable Haemophilus influenzae].
Han X, Wang C, Qiao H, Zhang Y, Chang Y, Zhang Y. | 02/14/2015 |
| islet expression of CCL22 recruits Tregs and attenuates autoimmune destruction of beta cell | Prevention of murine autoimmune diabetes by CCL22-mediated Treg recruitment to the pancreatic islets.
Montane J, Bischoff L, Soukhatcheva G, Dai DL, Hardenberg G, Levings MK, Orban PC, Kieffer TJ, Tan R, Verchere CB., Free PMC Article | 10/8/2011 |
| Data show that the presence of the Ccr4 and Ccl22 transcripts were detected in brain slices. | Ccl22/MDC, is a prostaglandin dependent pyrogen, acting in the anterior hypothalamus to induce hyperthermia via activation of brown adipose tissue.
Osborn O, Sanchez-Alavez M, Dubins JS, Gonzalez AS, Morrison B, Hadcock JR, Bartfai T., Free PMC Article | 07/23/2011 |
| These results suggest that CCL22 functions to regulate development of experimental autoimmune encephalomyelitis through macrophage chemoattraction and effector function. | CCL22 regulates experimental autoimmune encephalomyelitis by controlling inflammatory macrophage accumulation and effector function.
Dogan RN, Long N, Forde E, Dennis K, Kohm AP, Miller SD, Karpus WJ., Free PMC Article | 02/26/2011 |
| Mice genetically deficient in CCR4 (the receptor for CCL22) show markedly reduced indoleamine dioxygenase (IDO) expression in MLN-DCs and support the involvement of the CCL22/CCR4 axis in IDO induction. | Constitutive expression of IDO by dendritic cells of mesenteric lymph nodes: functional involvement of the CTLA-4/B7 and CCL22/CCR4 interactions.
Onodera T, Jang MH, Guo Z, Yamasaki M, Hirata T, Bai Z, Tsuji NM, Nagakubo D, Yoshie O, Sakaguchi S, Takikawa O, Miyasaka M. | 01/21/2010 |
| When isolated, only natural killer (NK)-containing cellular fractions secrete CCL22, and the same fraction isolated from metastatic Lewis lung carcinoma (LLC)-bearing lungs secrete higher levels. | NK-dependent increases in CCL22 secretion selectively recruits regulatory T cells to the tumor microenvironment.
Mailloux AW, Young MR., Free PMC Article | 01/21/2010 |
| IgE appears to be capable of stimulating basophils to produce MDC in the absence of a specific Ag, which may contribute to IgE-mediated and/or Th2-predominant allergic inflammation. | Overproduction of IgE induces macrophage-derived chemokine (CCL22) secretion from basophils.
Watanabe M, Satoh T, Yamamoto Y, Kanai Y, Karasuyama H, Yokozeki H. | 01/21/2010 |
| study provides direct evidence for the presence of CCR4 and its ligands, CCL17 and CCL22, in mouse contact hypersensitivity | Expression of chemokine receptor CCR4 and its ligands (CCL17 and CCL22) in murine contact hypersensitivity.
Kusumoto M, Xu B, Shi M, Matsuyama T, Aoyama K, Takeuchi T. | 01/21/2010 |