| Unraveling the Potential of EphA4: A Breakthrough Target and Beacon of Hope for Neurological Diseases. | Unraveling the Potential of EphA4: A Breakthrough Target and Beacon of Hope for Neurological Diseases.
Verma M, Chopra M, Kumar H. | 09/6/2023 |
| EphA4 signaling is involved in the phenotype of well-differentiated oral squamous cell arcinoma with decreased tumor immunity. | EphA4 signaling is involved in the phenotype of well-differentiated oral squamous cell arcinoma with decreased tumor immunity.
Kina S, Kawabata-Iwakawa R, Miyamoto S, Kato T, Kina-Tanada M, Arasaki A. | 03/30/2023 |
| Mechanistic and therapeutic implications of EphA-4 receptor tyrosine kinase in the pathogenesis of Alzheimer's disease. | Mechanistic and therapeutic implications of EphA-4 receptor tyrosine kinase in the pathogenesis of Alzheimer's disease.
Ganguly D, Thomas JA, Ali A, Kumar R. | 11/26/2022 |
| EphA4 regulates white matter remyelination after ischemic stroke through Ephexin-1/RhoA/ROCK signaling pathway. | EphA4 regulates white matter remyelination after ischemic stroke through Ephexin-1/RhoA/ROCK signaling pathway.
Liu C, Han S, Zheng J, Wang H, Li S, Li J. | 09/17/2022 |
| Exosomal miR-106b-5p derived from melanoma cell promotes primary melanocytes epithelial-mesenchymal transition through targeting EphA4. | Exosomal miR-106b-5p derived from melanoma cell promotes primary melanocytes epithelial-mesenchymal transition through targeting EphA4.
Luan W, Ding Y, Xi H, Ruan H, Lu F, Ma S, Wang J., Free PMC Article | 11/6/2021 |
| A cancer mutation promotes EphA4 oligomerization and signaling by altering the conformation of the SAM domain. | A cancer mutation promotes EphA4 oligomerization and signaling by altering the conformation of the SAM domain.
Light TP, Gomez-Soler M, Wang Z, Karl K, Zapata-Mercado E, Gehring MP, Lechtenberg BC, Pogorelov TV, Hristova K, Pasquale EB., Free PMC Article | 08/28/2021 |
| EphA4 regulates Abeta production via BACE1 expression in neurons. | EphA4 regulates Aβ production via BACE1 expression in neurons.
Tamura K, Chiu YW, Shiohara A, Hori Y, Tomita T. | 04/24/2021 |
| Ephrin Receptor A4 Expression Enhances Migration, Invasion and Neurotropism in Pancreatic Ductal Adenocarcinoma Cells. | Ephrin Receptor A4 Expression Enhances Migration, Invasion and Neurotropism in Pancreatic Ductal Adenocarcinoma Cells.
Furuhashi S, Morita Y, Ida S, Muraki R, Kitajima R, Takeda M, Kikuchi H, Hiramatsu Y, Setou M, Takeuchi H. | 04/17/2021 |
| EPHA4 signaling might function to maintain homeostasis of vascular smooth muscle cell contractility and BP in a fine-tuning capacity, for which estrogen is an effective modifier. | EPHA4 regulates vascular smooth muscle cell contractility and is a sex-specific hypertension risk gene in individuals with type 2 diabetes.
Zhang Z, Tremblay J, Raelson J, Sofer T, Du L, Fang Q, Argos M, Marois-Blanchet FC, Wang Y, Yan L, Chalmers J, Woodward M, Harrap S, Hamet P, Luo H, Wu J. | 06/13/2020 |
| Overall, these findings implicate EphA4 as a novel mediator of cortical tissue damage and neuroinflammation following traumatic brain injury. | Peripheral loss of EphA4 ameliorates TBI-induced neuroinflammation and tissue damage.
Kowalski EA, Chen J, Hazy A, Fritsch LE, Gudenschwager-Basso EK, Chen M, Wang X, Qian Y, Zhou M, Byerly M, Pickrell AM, Matson JB, Allen IC, Theus MH., Free PMC Article | 04/18/2020 |
| MiR-145 exerted a protective effects in cell viability in the OGD model by downregulating EPHA4, which suggested their potential roles in ischemic stroke. | MiR-145 protected the cell viability of human cerebral cortical neurons after oxygen-glucose deprivation by downregulating EPHA4.
Cai D, Wei D, Chen S, Chen X, Li S, Chen W, He W. | 09/21/2019 |
| blockage of EphA4/ephrin signaling between neuron and microglia decreased in oxygen-glucose deprivation and reperfusion -induced injury by promoting alternative activation of microglia via RhoA/ROCK2 signaling. | Neuronal EphA4 Regulates OGD/R-Induced Apoptosis by Promoting Alternative Activation of Microglia.
Wei HX, Yao PS, Chen PP, Guan JH, Zhuang JH, Zhu JB, Wu G, Yang JS. | 08/3/2019 |
| our data revealed a strong association between high EPHA4 expression and advanced tumor stage, aggressive BLBC molecular subtype and poor prognosis. Importantly, we found significant co-expression of EPHA4 and the TGFbeta receptor type-2 (TGFbetaR2) in breast cancer subtypes associated with increased tumor relapse and drug resistance. | Transforming Growth Factor-beta Regulation of Ephrin Type-A Receptor 4 Signaling in Breast Cancer Cellular Migration.
Hachim IY, Villatoro M, Canaff L, Hachim MY, Boudreault J, Haiub H, Ali S, Lebrun JJ., Free PMC Article | 07/13/2019 |
| Taken together, these results identify EphA4 as a new entry receptor for Kaposi's sarcoma-associated herpesvirus. | Ephrin Receptor A4 is a New Kaposi's Sarcoma-Associated Herpesvirus Virus Entry Receptor.
Chen J, Zhang X, Schaller S, Jardetzky TS, Longnecker R., Free PMC Article | 03/30/2019 |
| MiR-519d down-regulates EphA4 expression in melanoma. | miR-519d Promotes Melanoma Progression by Downregulating EphA4.
Hua KT, Hong JB, Sheen YS, Huang HY, Huang YL, Chen JS, Liao YH. | 11/10/2018 |
| These findings confirmed that EphA4 is a direct target gene of miR-335 and that miR-335 suppresses breast cancer cell proliferation and motility in part by directly inhibiting EphA4 expression. | MicroRNA-335 suppresses the proliferation, migration, and invasion of breast cancer cells by targeting EphA4.
Dong Y, Liu Y, Jiang A, Li R, Yin M, Wang Y. | 07/14/2018 |
| Therefore EphA4 is an emerging AbetaOs receptor and the activation of the EphA4/c-Abl axis would explain the synaptic spine alterations found in Alzheimer's disease. | Amyloid-β oligomers synaptotoxicity: The emerging role of EphA4/c-Abl signaling in Alzheimer's disease.
Vargas LM, Cerpa W, Muñoz FJ, Zanlungo S, Alvarez AR. | 06/16/2018 |
| High erythropoietin-producing hepatocellular carcinoma receptor A (EphA) 1, 2, and 4 expression levels were significantly related to recurrence. | Prognostic Significance of High EphA1-4 Expression Levels in Locally Advanced Gastric Cancer.
Inokuchi M, Nakagawa M, Baogok N, Takagi Y, Tanioka T, Gokita K, Okuno K, Kojima K. | 03/17/2018 |
| These results demonstrate a novel role for SORLA as a physiological and pathological EphA4 modulator. | SORLA attenuates EphA4 signaling and amyloid β-induced neurodegeneration.
Huang TY, Zhao Y, Jiang LL, Li X, Liu Y, Sun Y, Piña-Crespo JC, Zhu B, Masliah E, Willnow TE, Pasquale EB, Xu H., Free PMC Article | 12/23/2017 |
| The expression of both EphA4-FL and EphA4-N was significantly higher in the nervous tissue of SOD1(G93A) compared to wild-type mice suggesting that both forms are modulated during the disease process. | The identification of a novel isoform of EphA4 and ITS expression in SOD1(G93A) mice.
Zhao J, Boyd AW, Bartlett PF. | 11/11/2017 |
| the PI3K/AKT, Wnt/beta-catenin signaling pathways as well as ERK1/2 downstream of EPHA4 receptor activation, play an important role in the regulation of events related with the EMT development, which may be associated with the therapeutic failure in rectal cancer after radiotherapy. | The Role of EphA4 Signaling in Radiation-Induced EMT-Like Phenotype in Colorectal Cancer Cells.
de Marcondes PG, Morgado-Díaz JA. | 11/4/2017 |
| Molecular interactions of EphA4, growth hormone receptor, Jak2, and STAT5B have been described. | Molecular interactions of EphA4, growth hormone receptor, Janus kinase 2, and signal transducer and activator of transcription 5B.
Sawada T, Arai D, Jing X, Miyajima M, Frank SJ, Sakaguchi K., Free PMC Article | 09/23/2017 |
| Findings demonstrated that mutant alpha2-chimaerin and EphA4 have different genetic interactions in distinct motor neuron pools: abducens neurons use bidirectional ephrin signaling via mutant alpha2-chimaerin to direct growth, while cervical spinal neurons use only ephrin forward signaling | Mutant α2-chimaerin signals via bidirectional ephrin pathways in Duane retraction syndrome.
Nugent AA, Park JG, Wei Y, Tenney AP, Gilette NM, DeLisle MM, Chan WM, Cheng L, Engle EC., Free PMC Article | 09/16/2017 |
| Reduced EphA4 expression is associated with EBV-associated B lymphoma. | Regulation of EBV LMP1-triggered EphA4 downregulation in EBV-associated B lymphoma and its impact on patients' survival.
Huang YC, Lin SJ, Lin KM, Chou YC, Lin CW, Yu SC, Chen CL, Shen TL, Chen CK, Lu J, Chen MR, Tsai CH. | 09/2/2017 |
| No difference was found in the expression of EPHA4 in morphologically normal glands, HGPIN, or prostatic cancer. | [Estimation of the diagnostic potential of APOD, PTOV1, and EPHA4 for prostatic neoplasms].
Allina DO, Andreeva YY, Zavalishina LE, Moskvina LV, Frank GA. | 07/1/2017 |