| miR-128-3p alleviates airway inflammation in asthma by targeting SIX1 to regulate mitochondrial fission and fusion. | miR-128-3p alleviates airway inflammation in asthma by targeting SIX1 to regulate mitochondrial fission and fusion.
Liu X, Cui H, Bai Q, Piao H, Song Y, Yan G. | 03/29/2024 |
| Detrimental role of SIX1 in hepatic lipogenesis and fibrosis of non-alcoholic fatty liver disease. | Detrimental role of SIX1 in hepatic lipogenesis and fibrosis of non-alcoholic fatty liver disease.
Gao X, Chu Y, Wang W, Li W, Zhang W, Cao J, Fu X, Liu H, Chen D, Fan D, Nie Y. | 06/15/2023 |
| Sine oculis homeobox homolog 1 plays a critical role in pulmonary fibrosis. | Sine oculis homeobox homolog 1 plays a critical role in pulmonary fibrosis.
Wilson C, Mertens TC, Shivshankar P, Bi W, Collum SD, Wareing N, Ko J, Weng T, Naikawadi RP, Wolters PJ, Maire P, Jyothula SS, Thandavarayan RA, Ren D, Elrod ND, Wagner EJ, Huang HJ, Dickey BF, Ford HL, Karmouty-Quintana H., Free PMC Article | 05/28/2022 |
| Hsa_circ_0017639 regulates cisplatin resistance and tumor growth via acting as a miR-1296-5p molecular sponge and modulating sine oculis homeobox 1 expression in non-small cell lung cancer. | Hsa_circ_0017639 regulates cisplatin resistance and tumor growth via acting as a miR-1296-5p molecular sponge and modulating sine oculis homeobox 1 expression in non-small cell lung cancer.
Chang F, Li J, Sun Q, Wei S, Song Y., Free PMC Article | 05/7/2022 |
| SIX1 reprograms myogenic transcription factors to maintain the rhabdomyosarcoma undifferentiated state. | SIX1 reprograms myogenic transcription factors to maintain the rhabdomyosarcoma undifferentiated state.
Hsu JY, Danis EP, Nance S, O'Brien JH, Gustafson AL, Wessells VM, Goodspeed AE, Talbot JC, Amacher SL, Jedlicka P, Black JC, Costello JC, Durbin AD, Artinger KB, Ford HL., Free PMC Article | 02/26/2022 |
| SIX1 cooperates with RUNX1 and SMAD4 in cell fate commitment of Mullerian duct epithelium. | SIX1 cooperates with RUNX1 and SMAD4 in cell fate commitment of Müllerian duct epithelium.
Terakawa J, Serna VA, Nair DM, Sato S, Kawakami K, Radovick S, Maire P, Kurita T., Free PMC Article | 12/11/2021 |
| Reciprocal regulation of pancreatic ductal adenocarcinoma growth and molecular subtype by HNF4alpha and SIX1/4. | Reciprocal regulation of pancreatic ductal adenocarcinoma growth and molecular subtype by HNF4α and SIX1/4.
Camolotto SA, Belova VK, Torre-Healy L, Vahrenkamp JM, Berrett KC, Conway H, Shea J, Stubben C, Moffitt R, Gertz J, Snyder EL., Free PMC Article | 12/4/2021 |
| Six1 is required for signaling center formation and labial-lingual asymmetry in developing lower incisors. | Six1 is required for signaling center formation and labial-lingual asymmetry in developing lower incisors.
Takahashi M, Ikeda K, Ohmuraya M, Nakagawa Y, Sakuma T, Yamamoto T, Kawakami K. | 10/9/2021 |
| Six1 Promotes Epithelial-Mesenchymal Transition in Bronchial Epithelial Cells via the TGFbeta1/Smad Signalling Pathway. | Six1 Promotes Epithelial-Mesenchymal Transition in Bronchial Epithelial Cells via the TGFβ1/Smad Signalling Pathway.
Wang W, Yang Z, Li M, Wang Z, Shan Y, Qu Z. | 09/18/2021 |
| SIX1 represses senescence and promotes SOX2-mediated cellular plasticity during tumorigenesis. | SIX1 represses senescence and promotes SOX2-mediated cellular plasticity during tumorigenesis.
De Lope C, Martín-Alonso S, Auzmendi-Iriarte J, Escudero C, Mulet I, Larrasa-Alonso J, López-Antona I, Matheu A, Palmero I., Free PMC Article | 09/12/2020 |
| Abnormal endometrial glands express the oncofetal protein sine oculis homeobox 1 (SIX1) and contain cells with basal [cytokeratin (CK)14(+)/18(-)] and poorly differentiated features (CK14(+)/18(+)), strongly associating SIX1 with aberrant differentiation and cancer | SIX1 Regulates Aberrant Endometrial Epithelial Cell Differentiation and Cancer Latency Following Developmental Estrogenic Chemical Exposure.
Suen AA, Jefferson WN, Wood CE, Williams CJ., Free PMC Article | 06/27/2020 |
| PRC2-Six1-miR-25 signaling axis is involved in heart failure. | Role of the PRC2-Six1-miR-25 signaling axis in heart failure.
Oh JG, Jang SP, Yoo J, Lee MA, Lee SH, Lim T, Jeong E, Kho C, Kook H, Hajjar RJ, Park WJ, Jeong D. | 06/27/2020 |
| This study provides a mechanistic understanding of how Six1 cooperates with distinct cofactors in feedforward loops to control lineage-specific gene expression programs during progressive differentiation of the auditory sensory epithelium. | Dynamic changes in cis-regulatory occupancy by Six1 and its cooperative interactions with distinct cofactors drive lineage-specific gene expression programs during progressive differentiation of the auditory sensory epithelium.
Li J, Zhang T, Ramakrishnan A, Fritzsch B, Xu J, Wong EYM, Loh YE, Ding J, Shen L, Xu PX., Free PMC Article | 05/23/2020 |
| the continuous and complex expression pattern of Six1 during sensory organ formation is pieced together by separate enhancers | Regulation of continuous but complex expression pattern of Six1 during early sensory development.
Sato S, Furuta Y, Kawakami K. | 07/28/2018 |
| Six1 is required for the expression of numerous genes encoding fast-type sarcomeric proteins, glycolytic enzymes and controlling intracellular calcium homeostasis. | Six1 homeoprotein drives myofiber type IIA specialization in soleus muscle.
Sakakibara I, Wurmser M, Dos Santos M, Santolini M, Ducommun S, Davaze R, Guernec A, Sakamoto K, Maire P., Free PMC Article | 02/3/2018 |
| our analyses uncover essential roles of Six1 in hair cell differentiation and formation of the organ of Corti in the mammalian cochlea | Six1 is essential for differentiation and patterning of the mammalian auditory sensory epithelium.
Zhang T, Xu J, Maire P, Xu PX., Free PMC Article | 10/14/2017 |
| SIX1 regulates dorsal arch development not only by inducing dorsal Jag1 expression but also by inhibiting endothelin 1 (Edn1) expression in the pharyngeal endoderm of the dorsal arch, thus preventing dorsal EDNRA signaling. | Negative regulation of endothelin signaling by SIX1 is required for proper maxillary development.
Tavares ALP, Cox TC, Maxson RM, Ford HL, Clouthier DE., Free PMC Article | 09/23/2017 |
| significant co-localization of binding sites for MyoD and Six proteins on over a thousand mouse genomic DNA regions, were found. | MyoD reprogramming requires Six1 and Six4 homeoproteins: genome-wide cis-regulatory module analysis.
Santolini M, Sakakibara I, Gauthier M, Ribas-Aulinas F, Takahashi H, Sawasaki T, Mouly V, Concordet JP, Defossez PA, Hakim V, Maire P., Free PMC Article | 06/10/2017 |
| we show that SIX1 binds to adipogenic and brown marker genes and interacts with C/EBPa, C/EBPb and EBF2, suggesting their functional cooperation during adipogenesis. | Comparative Transcriptomic and Epigenomic Analyses Reveal New Regulators of Murine Brown Adipogenesis.
Brunmeir R, Wu J, Peng X, Kim SY, Julien SG, Zhang Q, Xie W, Xu F., Free PMC Article | 05/13/2017 |
| Studies strongly suggest that Six1 overexpression promotes CRC growth and metastasis and remodels tumor stroma by stimulating angiogenesis and recruiting TAM. MAPK activation may be a pivotal event in Six1-associated tumor progression. | Six1 promotes colorectal cancer growth and metastasis by stimulating angiogenesis and recruiting tumor-associated macrophages.
Xu H, Zhang Y, Peña MM, Pirisi L, Creek KE., Free PMC Article | 04/22/2017 |
| results suggest that SIX1 is a key proliferation regulator in mouse DFCs and human PDLCs, which provides novel insight into Six family gene function in mammals. | Six1 is required for mouse dental follicle cell and human periodontal ligament-derived cell proliferation.
Kawasaki T, Takahashi M, Yajima H, Mori Y, Kawakami K. | 02/18/2017 |
| Our findings imply that SIX1 may play a role as an important regulator to orchestrate the dynamic of uterine endometrium in response to estrogen level during the estrous cycle. | Estrogen-dependent expression of sine oculis homeobox 1 in the mouse uterus during the estrous cycle.
Bae S, Kwon H, Yoon H, Park M, Kim HR, Song H, Hong K, Choi Y. | 08/13/2016 |
| These data suggest differential SIX-factor regulation might have contributed to species differences in nephron progenitor programs such as the duration of nephrogenesis and the final nephron count | Differential regulation of mouse and human nephron progenitors by the Six family of transcriptional regulators.
O'Brien LL, Guo Q, Lee Y, Tran T, Benazet JD, Whitney PH, Valouev A, McMahon AP., Free PMC Article | 07/16/2016 |
| Activation of Six1 Expression in Vertebrate Sensory Neurons. | Activation of Six1 Expression in Vertebrate Sensory Neurons.
Sato S, Yajima H, Furuta Y, Ikeda K, Kawakami K., Free PMC Article | 05/14/2016 |
| data support a model where Eya-Six may form a complex to regulate nephron progenitor cell development before metanephric specification and are critical mesenchymal factors for inducing nephric duct development. | Eya-six are necessary for survival of nephrogenic cord progenitors and inducing nephric duct development before ureteric bud formation.
Xu J, Xu PX., Free PMC Article | 03/19/2016 |