| Tyr352 as a Predominant Phosphosite in the Understudied Kinase and Molecular Target, HIPK1: Implications for Cancer Therapy. | Tyr352 as a Predominant Phosphosite in the Understudied Kinase and Molecular Target, HIPK1: Implications for Cancer Therapy.
Sanjeev D, George M, John L, Gopalakrishnan AP, Priyanka P, Mendon S, Yandigeri T, Nisar M, Nisar M, Kanekar S, Balaya RDA, Raju R. | 03/31/2024 |
| HIPK1 Inhibition Protects against Pathological Cardiac Hypertrophy by Inhibiting the CREB-C/EBPbeta Axis. | HIPK1 Inhibition Protects against Pathological Cardiac Hypertrophy by Inhibiting the CREB-C/EBPβ Axis.
Bei Y, Zhu Y, Wei M, Yin M, Li L, Chen C, Huang Z, Liang X, Gao J, Yao J, van der Kraak PH, Vink A, Lei Z, Dai Y, Chen H, Liang Y, Sluijter JP, Xiao J., Free PMC Article | 06/26/2023 |
| Downregulation of circ-ZNF644 alleviates LPS-induced HK2 cell injury via miR-335-5p/HIPK1 axis. | Downregulation of circ-ZNF644 alleviates LPS-induced HK2 cell injury via miR-335-5p/HIPK1 axis.
Gong J, Zhao S, Luo S, Yin S, Li X, Feng Y. | 11/19/2022 |
| MicroRNA-889-3p restrains the proliferation and epithelial-mesenchymal transformation of lung cancer cells via down-regulation of Homeodomain-interacting protein kinase 1. | MicroRNA-889-3p restrains the proliferation and epithelial-mesenchymal transformation of lung cancer cells via down-regulation of Homeodomain-interacting protein kinase 1.
Zhu Q, Li Y, Li L, Guo M, Zou C, Xu Y, Yang Z., Free PMC Article | 02/19/2022 |
| Abemaciclib is a potent inhibitor of DYRK1A and HIP kinases involved in transcriptional regulation. | Abemaciclib is a potent inhibitor of DYRK1A and HIP kinases involved in transcriptional regulation.
Kaltheuner IH, Anand K, Moecking J, Düster R, Wang J, Gray NS, Geyer M., Free PMC Article | 12/18/2021 |
| HIPK1, HIPK2 and HIPK3 interact with the components of the carbon catabolite repressor 4 (CCR4)-negative on TATA (NOT) complex, an important regulator of all the major steps in the mRNA metabolism. it has emerged that HIPKs and their related miRNAs are involved in diabetic nephropathy, gastric cancer chemoresistance, cervical cancer progression, and recombinant protein expression in cultured cells. [Review] | Update on the Regulation of HIPK1, HIPK2 and HIPK3 Protein Kinases by microRNAs.
Conte A, Pierantoni GM. | 12/22/2018 |
| The data presented here con fi rmed that HIPK1 is involved in the increased expression of recombinant luciferase and the secreted recombinant GPC3-hFc from HEK 293 cells following transfection with miR-22-3p. | Identifying HIPK1 as Target of miR-22-3p Enhancing Recombinant Protein Production From HEK 293 Cell by Using Microarray and HTP siRNA Screen.
Inwood S, Buehler E, Betenbaugh M, Lal M, Shiloach J., Free PMC Article | 09/8/2018 |
| Analysis of these mutants revealed that HIPK1, HIPK2 and HIPK3 but not HIPK4 are capable of autophosphorylating on other tyrosines | Effect of tyrosine autophosphorylation on catalytic activity and subcellular localisation of homeodomain-interacting protein kinases (HIPK).
van der Laden J, Soppa U, Becker W., Free PMC Article | 09/26/2015 |
| PAGE4, a regulator of c-Jun transactivation, is phosphorylated by homeodomain-interacting protein kinase 1. | Cancer/testis antigen PAGE4, a regulator of c-Jun transactivation, is phosphorylated by homeodomain-interacting protein kinase 1, a component of the stress-response pathway.
Mooney SM, Qiu R, Kim JJ, Sacho EJ, Rajagopalan K, Johng D, Shiraishi T, Kulkarni P, Weninger KR., Free PMC Article | 06/21/2014 |
| HIPK1 drives p53 activation to limit colorectal cancer cell growth. | HIPK1 drives p53 activation to limit colorectal cancer cell growth.
Rey C, Soubeyran I, Mahouche I, Pedeboscq S, Bessede A, Ichas F, De Giorgi F, Lartigue L., Free PMC Article | 02/8/2014 |
| HIPK1 and HIPK2, are transcriptional corepressors that regulate TGF-beta-dependent angiogenesis during embryonic development. | Transcriptional corepressors HIPK1 and HIPK2 control angiogenesis via TGF-β-TAK1-dependent mechanism.
Shang Y, Doan CN, Arnold TD, Lee S, Tang AA, Reichardt LF, Huang EJ., Free PMC Article | 10/19/2013 |
| HIPK1 expression was identified only in invasive breast cancer cells with three different patterns: cytoplasmic, nuclear, and both cytoplasmic and nuclear. | Homeodomain-interacting protein kinase 1 (HIPK1) expression in breast cancer tissues.
Park BW, Park S, Koo JS, Kim SI, Park JM, Cho JH, Park HS. | 02/2/2013 |
| These findings indicate that the control of HIPK1 stability by Mdm2-NORE1 has a major effect on cell behaviour, and epigenetic inactivation of NORE1 enables adenocarcinoma formation in vivo through HIPK1 stabilization. | Mdm2 associates with Ras effector NORE1 to induce the degradation of oncoprotein HIPK1.
Lee D, Park SJ, Sung KS, Park J, Lee SB, Park SY, Lee HJ, Ahn JW, Choi SJ, Lee SG, Kim SH, Kim DH, Kim J, Kim Y, Choi CY., Free PMC Article | 06/2/2012 |
| c-Myb appears to be phosphorylated by HIPK1 in its negative regulatory domain as supported by both in vivo and in vitro data. | HIPK1 interacts with c-Myb and modulates its activity through phosphorylation.
Matre V, Nordgård O, Alm-Kristiansen AH, Ledsaak M, Gabrielsen OS. | 01/21/2010 |
| TNFalpha-induced desumoylation and cytoplasmic translocation of HIPK1 are critical in TNFalpha-induced ASK1-JNK/p38 activation | Tumor necrosis factor alpha-induced desumoylation and cytoplasmic translocation of homeodomain-interacting protein kinase 1 are critical for apoptosis signal-regulating kinase 1-JNK/p38 activation.
Li X, Zhang R, Luo D, Park SJ, Wang Q, Kim Y, Min W. | 01/21/2010 |