| Differential IL18 signaling via IL18 receptor and Na-Cl co-transporter discriminating thermogenesis and glucose metabolism regulation. | Differential IL18 signaling via IL18 receptor and Na-Cl co-transporter discriminating thermogenesis and glucose metabolism regulation.
Zhang X, Luo S, Wang M, Cao Q, Zhang Z, Huang Q, Li J, Deng Z, Liu T, Liu CL, Meppen M, Vromman A, Flavell RA, Hotamışlıgil GS, Liu J, Libby P, Liu Z, Shi GP., Free PMC Article | 12/31/2022 |
| Multiple molecular mechanisms are involved in the activation of the kidney sodium-chloride cotransporter by hypokalemia. | Multiple molecular mechanisms are involved in the activation of the kidney sodium-chloride cotransporter by hypokalemia.
Murillo-de-Ozores AR, Carbajal-Contreras H, Magaña-Ávila GR, Valdés R, Grajeda-Medina LI, Vázquez N, Zariñán T, López-Saavedra A, Sharma A, Lin DH, Wang WH, Delpire E, Ellison DH, Gamba G, Castañeda-Bueno M., Free PMC Article | 10/29/2022 |
| High dietary potassium causes ubiquitin-dependent degradation of the kidney sodium-chloride cotransporter. | High dietary potassium causes ubiquitin-dependent degradation of the kidney sodium-chloride cotransporter.
Kortenoeven MLA, Esteva-Font C, Dimke H, Poulsen SB, Murali SK, Fenton RA., Free PMC Article | 12/4/2021 |
| Renal Natriuretic Peptide Receptor-C Deficiency Attenuates NaCl Cotransporter Activity in Angiotensin II-Induced Hypertension. | Renal Natriuretic Peptide Receptor-C Deficiency Attenuates NaCl Cotransporter Activity in Angiotensin II-Induced Hypertension.
Shao S, Li XD, Lu YY, Li SJ, Chen XH, Zhou HD, He S, Guo YT, Lu X, Gao PJ, Wang JG. | 09/11/2021 |
| Renal Tubule Nedd4-2 Deficiency Stimulates Kir4.1/Kir5.1 and Thiazide-Sensitive NaCl Cotransporter in Distal Convoluted Tubule. | Renal Tubule Nedd4-2 Deficiency Stimulates Kir4.1/Kir5.1 and Thiazide-Sensitive NaCl Cotransporter in Distal Convoluted Tubule.
Wu P, Su XT, Gao ZX, Zhang DD, Duan XP, Xiao Y, Staub O, Wang WH, Lin DH., Free PMC Article | 01/9/2021 |
| Aldosterone acutely activates NCC to modulate renal NaCl excretion. | Rapid Aldosterone-Mediated Signaling in the DCT Increases Activity of the Thiazide-Sensitive NaCl Cotransporter.
Cheng L, Poulsen SB, Wu Q, Esteva-Font C, Olesen ETB, Peng L, Olde B, Leeb-Lundberg LMF, Pisitkun T, Rieg T, Dimke H, Fenton RA., Free PMC Article | 05/2/2020 |
| This study reveal that lack of renal NCC causes an aldosterone-mediated upregulation of circulating FGF23. | Elevated FGF23 Levels in Mice Lacking the Thiazide-Sensitive NaCl cotransporter (NCC).
Pathare G, Anderegg M, Albano G, Lang F, Fuster DG., Free PMC Article | 10/26/2019 |
| Modulation of WNK4 activity by intracellular chloride [Cl(-)]i is not the sole mechanism for regulating NCC. Increased luminal NaCl delivery upregulates NCC via yet unknown mechanism(s) that may override inhibition of WNK4 by high [Cl(-)]i. | Differential roles of WNK4 in regulation of NCC in vivo.
Yang YS, Xie J, Yang SS, Lin SH, Huang CL., Free PMC Article | 09/7/2019 |
| Aldosterone promotes increased interaction of NCC and ENaC. | Aldosterone Modulates the Association between NCC and ENaC.
Wynne BM, Mistry AC, Al-Khalili O, Mallick R, Theilig F, Eaton DC, Hoover RS., Free PMC Article | 01/12/2019 |
| Kir4.1 plays an essential role in mediating the effect of dietary potassium intake on NCC activity and potassium homeostasis. | Potassium intake modulates the thiazide-sensitive sodium-chloride cotransporter (NCC) activity via the Kir4.1 potassium channel.
Wang MX, Cuevas CA, Su XT, Wu P, Gao ZX, Lin DH, McCormick JA, Yang CL, Wang WH, Ellison DH., Free PMC Article | 01/5/2019 |
| CD8+ T cells stimulate sodium/chloride co-transporter NCC in distal convoluted tubules leading to salt-sensitive hypertension. | CD8(+) T cells stimulate Na-Cl co-transporter NCC in distal convoluted tubules leading to salt-sensitive hypertension.
Liu Y, Rafferty TM, Rhee SW, Webber JS, Song L, Ko B, Hoover RS, He B, Mu S., Free PMC Article | 11/17/2018 |
| Urine output and water intake increased significantly only in pendrin KO mice in response to hydrochlorothiazide, but not in WT or NCC KO mice. | Ablation of the Cl-/HCO3- Exchanger Pendrin Enhances Hydrochlorothiazide-Induced Diuresis.
Alshahrani S, Soleimani M., Free PMC Article | 06/30/2018 |
| Calcineurin is activated by an acute potassium load, which rapidly dephosphorylates NCC, leading to increased urinary potassium excretion. | Calcineurin inhibitors block sodium-chloride cotransporter dephosphorylation in response to high potassium intake.
Shoda W, Nomura N, Ando F, Mori Y, Mori T, Sohara E, Rai T, Uchida S. | 11/4/2017 |
| long-term aldosterone administration stimulates mouse NCC and pT58-NCC abundances in late distal convoluted kidney tubules. | Long-term aldosterone administration increases renal Na(+)-Cl(-) cotransporter abundance in late distal convoluted tubule.
Poulsen SB, Christensen BM. | 10/7/2017 |
| Potassium depletion stimulates NCC via phosphorylation and inactivation of the KLHL3 and promoting increased blood pressure. | Potassium depletion stimulates Na-Cl cotransporter via phosphorylation and inactivation of the ubiquitin ligase Kelch-like 3.
Ishizawa K, Xu N, Loffing J, Lifton RP, Fujita T, Uchida S, Shibata S., Free PMC Article | 05/20/2017 |
| the increased NCC expression and activation is present in CMA which is highly associated with the enhanced WNK4-SPAK signal pathway using WNK4-/- and SPAK-/- mice. | Chronic Metabolic Acidosis Activates Renal Tubular Sodium Chloride Cotransporter through Angiotension II-dependent WNK4-SPAK Phosphorylation Pathway.
Fang YW, Yang SS, Cheng CJ, Tseng MH, Hsu HM, Lin SH., Free PMC Article | 12/17/2016 |
| The Role of Epithelial Sodium Channel ENaC and the Apical Cl-/HCO3- Exchanger Pendrin in Compensatory Salt Reabsorption in the Setting of Na-Cl Cotransporter (NCC) Inactivation. | The Role of Epithelial Sodium Channel ENaC and the Apical Cl-/HCO3- Exchanger Pendrin in Compensatory Salt Reabsorption in the Setting of Na-Cl Cotransporter (NCC) Inactivation.
Patel-Chamberlin M, Varasteh Kia M, Xu J, Barone S, Zahedi K, Soleimani M., Free PMC Article | 08/6/2016 |
| This study identifies NCC as an IL18-binding protein that collaborates with IL18r in cell signaling, inflammatory molecule expression, and experimental atherogenesis. | Interleukin 18 function in atherosclerosis is mediated by the interleukin 18 receptor and the Na-Cl co-transporter.
Wang J, Sun C, Gerdes N, Liu C, Liao M, Liu J, Shi MA, He A, Zhou Y, Sukhova GK, Chen H, Cheng XW, Kuzuya M, Murohara T, Zhang J, Cheng X, Jiang M, Shull GE, Rogers S, Yang CL, Ke Q, Jelen S, Bindels R, Ellison DH, Jarolim P, Libby P, Shi GP., Free PMC Article | 10/3/2015 |
| Slc12a3 mRNA and protein expression levels were upregulated in kidneys of db/db mice from 6, 12, and 26 weeks at the age. | Genetic and biological effects of sodium-chloride cotransporter (SLC12A3) in diabetic nephropathy.
Abu Seman N, He B, Ojala JR, Wan Mohamud WN, Östenson CG, Brismar K, Gu HF. | 08/29/2015 |
| SPAK-kinase-deficient mice, which are unable to activate NCC by phosphorylation, use multiple common compensatory mechanisms to blunt natriuresis and chloriuresis and to protect against a major drop in blood pressure. | Integrated compensatory network is activated in the absence of NCC phosphorylation.
Grimm PR, Lazo-Fernandez Y, Delpire E, Wall SM, Dorsey SG, Weinman EJ, Coleman R, Wade JB, Welling PA., Free PMC Article | 08/22/2015 |
| NCC inhibition stimulates duodenal Ca(2+) absorption as well as osteoblast differentiation and bone Ca(2+) storage, possibly through a FAK/ERK dependent mechanism | Thiazide-sensitive Na+ -Cl- cotransporter (NCC) gene inactivation results in increased duodenal Ca2+ absorption, enhanced osteoblast differentiation and elevated bone mineral density.
Hsu YJ, Yang SS, Cheng CJ, Liu ST, Huang SM, Chau T, Chu P, Salter DM, Lee HS, Lin SH. | 07/25/2015 |
| P2Y2-mediated increase of cytoplasmic Ca(2+) concentration down-regulates the expression of NCC. | P2Y2 receptor activation inhibits the expression of the sodium-chloride cotransporter NCC in distal convoluted tubule cells.
Gailly P, Szutkowska M, Olinger E, Debaix H, Seghers F, Janas S, Vallon V, Devuyst O. | 06/27/2015 |
| Estradiol, progesterone, and prolactin increase renal NaCl cotransporter phosphorylation and activity. | Ovarian hormones and prolactin increase renal NaCl cotransporter phosphorylation.
Rojas-Vega L, Reyes-Castro LA, Ramírez V, Bautista-Pérez R, Rafael C, Castañeda-Bueno M, Meade P, de Los Heros P, Arroyo-Garza I, Bernard V, Binart N, Bobadilla NA, Hadchouel J, Zambrano E, Gamba G. | 06/20/2015 |
| SPAK is an important mediator of the increased NCC activation by phosphorylation that occurs in the distal convoluted tubule in response to a low-K(+) diet, but other low-potassium-activated kinases are likely to be involved. | SPAK-mediated NCC regulation in response to low-K+ diet.
Wade JB, Liu J, Coleman R, Grimm PR, Delpire E, Welling PA., Free PMC Article | 06/20/2015 |
| WNK4 is the major positive regulator of NCC in the kidneys. | WNK4 is the major WNK positively regulating NCC in the mouse kidney.
Takahashi D, Mori T, Nomura N, Khan MZ, Araki Y, Zeniya M, Sohara E, Rai T, Sasaki S, Uchida S., Free PMC Article | 02/14/2015 |