| MiR-3666 serves as a tumor suppressor in ovarian carcinoma by down-regulating AK4 via targeting STAT3. | MiR-3666 serves as a tumor suppressor in ovarian carcinoma by down-regulating AK4 via targeting STAT3.
Tan H, Wu C, Huang B, Jin L, Jiang X. | 11/6/2021 |
| Adenylate Kinase 4-A Key Regulator of Proliferation and Metabolic Shift in Human Pulmonary Arterial Smooth Muscle Cells via Akt and HIF-1alpha Signaling Pathways. | Adenylate Kinase 4-A Key Regulator of Proliferation and Metabolic Shift in Human Pulmonary Arterial Smooth Muscle Cells via Akt and HIF-1α Signaling Pathways.
Wujak M, Veith C, Wu CY, Wilke T, Kanbagli ZI, Novoyatleva T, Guenther A, Seeger W, Grimminger F, Sommer N, Schermuly RT, Weissmann N., Free PMC Article | 10/30/2021 |
| Adenylate Kinase 4 Modulates the Resistance of Breast Cancer Cells to Tamoxifen through an m(6)A-Based Epitranscriptomic Mechanism. | Adenylate Kinase 4 Modulates the Resistance of Breast Cancer Cells to Tamoxifen through an m(6)A-Based Epitranscriptomic Mechanism.
Liu X, Gonzalez G, Dai X, Miao W, Yuan J, Huang M, Bade D, Li L, Sun Y, Wang Y., Free PMC Article | 09/18/2021 |
| Knockdown of circ-ABCB10 promotes sensitivity of lung cancer cells to cisplatin via miR-556-3p/AK4 axis. | Knockdown of circ-ABCB10 promotes sensitivity of lung cancer cells to cisplatin via miR-556-3p/AK4 axis.
Wu Z, Gong Q, Yu Y, Zhu J, Li W., Free PMC Article | 11/21/2020 |
| A co-expressed gene status of adenylate kinase 1/4 reveals prognostic gene signature associated with prognosis and sensitivity to EGFR targeted therapy in lung adenocarcinoma. | A co-expressed gene status of adenylate kinase 1/4 reveals prognostic gene signature associated with prognosis and sensitivity to EGFR targeted therapy in lung adenocarcinoma.
Jan YH, Lai TC, Yang CJ, Huang MS, Hsiao M., Free PMC Article | 10/24/2020 |
| High AK4 expression is associated with Breast Cancer by Facilitating Cell Proliferation and Invasion. | AK4 Promotes the Progression of HER2-Positive Breast Cancer by Facilitating Cell Proliferation and Invasion.
Zhang J, Yin YT, Wu CH, Qiu RL, Jiang WJ, Deng XG, Li ZX., Free PMC Article | 05/2/2020 |
| The overexpression of AK4 stabilizes HIF-1alpha protein by increasing intracellular ROS levels and induces epithelial-to-mesenchymal transition in non-small cell lung cancer. | Adenylate kinase 4 modulates oxidative stress and stabilizes HIF-1α to drive lung adenocarcinoma metastasis.
Jan YH, Lai TC, Yang CJ, Lin YF, Huang MS, Hsiao M., Free PMC Article | 03/14/2020 |
| Study found that AK4 was positively correlated with poor prognosis of bladder cancer (BC) patients. Its knockdown in bladder cancer cell lines inhibited proliferation and invasion and suppressed tumor formation and metastasis in mice. AK4 may therefore represent a potential biomarker for the prognosis of bladder cancer. | Adenylate kinase 4 promotes bladder cancer cell proliferation and invasion.
Xin F, Yao DW, Fan L, Liu JH, Liu XD. | 03/14/2020 |
| Our data revealed that both miR-199a-3p and its target gene AK4 are reversely correlated with the osteosarcoma drug resistance. | MiR-199a-3p affects the multi-chemoresistance of osteosarcoma through targeting AK4.
Lei W, Yan C, Ya J, Yong D, Yujun B, Kai L., Free PMC Article | 02/16/2019 |
| Results found that AK4 was involved in hypoxia tolerance, resistance to anti-tumor drug, and the regulation of mitochondrial activity. | Modulation of anti-cancer drug sensitivity through the regulation of mitochondrial activity by adenylate kinase 4.
Fujisawa K, Terai S, Takami T, Yamamoto N, Yamasaki T, Matsumoto T, Yamaguchi K, Owada Y, Nishina H, Noma T, Sakaida I., Free PMC Article | 10/22/2016 |
| a stress-protective function of AK4 | Differential expression of adenylate kinase 4 in the context of disparate stress response strategies of HEK293 and HepG2 cells.
Kong F, Binas B, Moon JH, Kang SS, Kim HJ. | 06/15/2013 |
| Data indicate that patients with high adenylate kinase-4 (AK4) and low transcription factor ATF3 expression showed unfavorable outcomes compared with patients with low AK4 and high ATF3 expression. | Adenylate kinase-4 is a marker of poor clinical outcomes that promotes metastasis of lung cancer by downregulating the transcription factor ATF3.
Jan YH, Tsai HY, Yang CJ, Huang MS, Yang YF, Lai TC, Lee CH, Jeng YM, Huang CY, Su JL, Chuang YJ, Hsiao M. | 12/22/2012 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| The AK4 cDNA was expressed in Escherichia coli and the substrate specificity and kinetic properties of the recombinant protein were characterized. | Evidence of an intact N-terminal translocation sequence of human mitochondrial adenylate kinase 4.
Panayiotou C, Solaroli N, Johansson M, Karlsson A. | 03/1/2010 |
| To investigate the role of hinge IV, crystal structure of human adenylate kinase 4 (AK4) L171P mutant was determined. | Crystal structure of human adenylate kinase 4 (L171P) suggests the role of hinge region in protein domain motion.
Liu R, Xu H, Wei Z, Wang Y, Lin Y, Gong W. | 01/21/2010 |